Gene Gene information from NCBI Gene database.
Entrez ID 90007
Gene name Midnolin
Gene symbol MIDN
Synonyms (NCBI Gene)
Stx
Chromosome 19
Chromosome location 19p13.3
miRNA miRNA information provided by mirtarbase database.
1833
miRTarBase ID miRNA Experiments Reference
MIRT016654 hsa-miR-425-5p Sequencing 20371350
MIRT020160 hsa-miR-130b-3p Sequencing 20371350
MIRT020705 hsa-miR-155-5p Other 18262046
MIRT024200 hsa-miR-221-3p Sequencing 20371350
MIRT028077 hsa-miR-93-5p Sequencing 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
13
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32296183
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IDA 24187134, 37616343
GO:0005634 Component Nucleus IEA
GO:0005730 Component Nucleolus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606700 16298 ENSG00000167470
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q504T8
Protein name Midnolin (Midbrain nucleolar protein)
Protein function Facilitates the ubiquitin-independent proteasomal degradation of stimulus-induced transcription factors such as FOSB, EGR1, NR4A1, and IRF4 to the proteasome for degradation (PubMed:37616343). Promotes also the degradation of other substrates su
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00240 ubiquitin 33 102 Ubiquitin family Domain
Sequence
MEPQPGGARSCRRGAPGGACELGPAAEAAPMSLAIHSTTGTRYDLAVPPDETVEGLRKRL
SQRLKVPKERLALLHKDTRLSSGKLQEFGVGDGSKLTLVPTV
EAGLMSQASRPEQSVMQA
LESLTETQVSDFLSGRSPLTLALRVGDHMMFVQLQLAAQHAPLQHRHVLAAAAAAAAARG
DPSIASPVSSPCRPVSSAARVPPVPTSPSPASPSPITAGSFRSHAASTTCPEQMDCSPTA
SSSASPGASTTSTPGASPAPRSRKPGAVIESFVNHAPGVFSGTFSGTLHPNCQDSSGRPR
RDIGTILQILNDLLSATRHYQGMPPSLAQLRCHAQCSPASPAPDLAPRTTSCEKLTAAPS
ASLLQGQSQIRMCKPPGDRLRQTENRATRCKVERLQLLLQQKRLRRKARRDARGPYHWSP
SRKAGRSDSSSSGGGGSPSEASGLGLDFEDSVWKPEVNPDIKSEFVVA
Sequence length 468
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
FAMILIAL LONG QT SYNDROME Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MIDN-related disorder Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
NEPHROTIC SYNDROME GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Multiple Myeloma Multiple myeloma Pubtator 40532701 Associate
★☆☆☆☆
Found in Text Mining only
Neuroblastoma Neuroblastoma Pubtator 40058942 Associate
★☆☆☆☆
Found in Text Mining only
Parkinson Disease Parkinson disease BEFREE 28724963, 31588691
★☆☆☆☆
Found in Text Mining only
Parkinson Disease Parkinson disease Pubtator 31588691, 36858566, 40058942 Associate
★☆☆☆☆
Found in Text Mining only
PARKINSON DISEASE, LATE-ONSET Parkinson disease BEFREE 29311479
★☆☆☆☆
Found in Text Mining only
Peripheral Nervous System Diseases Peripheral nervous system disease Pubtator 28611204 Associate
★☆☆☆☆
Found in Text Mining only