Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	89953
Gene name	Kinesin light chain 4
Gene symbol	KLC4
Synonyms (NCBI Gene)	CONDRHNKNSL8bA387M24.3
Chromosome	6
Chromosome location	6p21.1

115

Show/Hide all (115)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018861	hsa-miR-335-5p	Microarray	18185580
MIRT035911	hsa-miR-1180-3p	CLASH	23622248
MIRT1095681	hsa-miR-15a	CLIP-seq
MIRT1095682	hsa-miR-15b	CLIP-seq
MIRT1095683	hsa-miR-16	CLIP-seq
MIRT1095684	hsa-miR-195	CLIP-seq
MIRT1095685	hsa-miR-214	CLIP-seq
MIRT1095686	hsa-miR-3182	CLIP-seq
MIRT1095687	hsa-miR-3616-3p	CLIP-seq
MIRT1095688	hsa-miR-3619-5p	CLIP-seq
MIRT1095689	hsa-miR-3921	CLIP-seq
MIRT1095690	hsa-miR-424	CLIP-seq
MIRT1095691	hsa-miR-4436b-3p	CLIP-seq
MIRT1095692	hsa-miR-4530	CLIP-seq
MIRT1095693	hsa-miR-4649-3p	CLIP-seq
MIRT1095694	hsa-miR-4653-5p	CLIP-seq
MIRT1095695	hsa-miR-4690-5p	CLIP-seq
MIRT1095696	hsa-miR-4721	CLIP-seq
MIRT1095697	hsa-miR-497	CLIP-seq
MIRT1095698	hsa-miR-761	CLIP-seq
MIRT2025705	hsa-miR-4260	CLIP-seq
MIRT2025706	hsa-miR-4324	CLIP-seq
MIRT2256889	hsa-miR-3144-5p	CLIP-seq
MIRT2256890	hsa-miR-711	CLIP-seq
MIRT2558294	hsa-miR-1208	CLIP-seq
MIRT2558295	hsa-miR-1224-3p	CLIP-seq
MIRT2558296	hsa-miR-1260	CLIP-seq
MIRT2558297	hsa-miR-1260b	CLIP-seq
MIRT2558298	hsa-miR-1280	CLIP-seq
MIRT2558299	hsa-miR-1294	CLIP-seq
MIRT1095681	hsa-miR-15a	CLIP-seq
MIRT1095682	hsa-miR-15b	CLIP-seq
MIRT1095683	hsa-miR-16	CLIP-seq
MIRT1095684	hsa-miR-195	CLIP-seq
MIRT2558300	hsa-miR-2110	CLIP-seq
MIRT1095685	hsa-miR-214	CLIP-seq
MIRT2558301	hsa-miR-3127-3p	CLIP-seq
MIRT1095686	hsa-miR-3182	CLIP-seq
MIRT2558302	hsa-miR-3189-3p	CLIP-seq
MIRT1095687	hsa-miR-3616-3p	CLIP-seq
MIRT1095688	hsa-miR-3619-5p	CLIP-seq
MIRT2558303	hsa-miR-3908	CLIP-seq
MIRT1095689	hsa-miR-3921	CLIP-seq
MIRT1095690	hsa-miR-424	CLIP-seq
MIRT2025705	hsa-miR-4260	CLIP-seq
MIRT2558304	hsa-miR-4271	CLIP-seq
MIRT2558305	hsa-miR-4316	CLIP-seq
MIRT2558306	hsa-miR-4420	CLIP-seq
MIRT1095691	hsa-miR-4436b-3p	CLIP-seq
MIRT1095692	hsa-miR-4530	CLIP-seq
MIRT1095693	hsa-miR-4649-3p	CLIP-seq
MIRT2558307	hsa-miR-4651	CLIP-seq
MIRT1095694	hsa-miR-4653-5p	CLIP-seq
MIRT2558308	hsa-miR-4677-3p	CLIP-seq
MIRT1095695	hsa-miR-4690-5p	CLIP-seq
MIRT1095696	hsa-miR-4721	CLIP-seq
MIRT2558309	hsa-miR-4725-3p	CLIP-seq
MIRT2558310	hsa-miR-4786-5p	CLIP-seq
MIRT2558311	hsa-miR-491-5p	CLIP-seq
MIRT1095697	hsa-miR-497	CLIP-seq
MIRT2558312	hsa-miR-548g	CLIP-seq
MIRT2558313	hsa-miR-608	CLIP-seq
MIRT2558314	hsa-miR-665	CLIP-seq
MIRT1095698	hsa-miR-761	CLIP-seq
MIRT2558315	hsa-miR-769-5p	CLIP-seq
MIRT2558294	hsa-miR-1208	CLIP-seq
MIRT2558295	hsa-miR-1224-3p	CLIP-seq
MIRT2558296	hsa-miR-1260	CLIP-seq
MIRT2558297	hsa-miR-1260b	CLIP-seq
MIRT2558298	hsa-miR-1280	CLIP-seq
MIRT2683531	hsa-miR-140-3p	CLIP-seq
MIRT1095681	hsa-miR-15a	CLIP-seq
MIRT1095682	hsa-miR-15b	CLIP-seq
MIRT1095683	hsa-miR-16	CLIP-seq
MIRT1095684	hsa-miR-195	CLIP-seq
MIRT2558300	hsa-miR-2110	CLIP-seq
MIRT1095685	hsa-miR-214	CLIP-seq
MIRT2683532	hsa-miR-2467-3p	CLIP-seq
MIRT2683533	hsa-miR-3125	CLIP-seq
MIRT2558301	hsa-miR-3127-3p	CLIP-seq
MIRT1095686	hsa-miR-3182	CLIP-seq
MIRT2558302	hsa-miR-3189-3p	CLIP-seq
MIRT1095687	hsa-miR-3616-3p	CLIP-seq
MIRT1095688	hsa-miR-3619-5p	CLIP-seq
MIRT2683534	hsa-miR-3678-3p	CLIP-seq
MIRT2558303	hsa-miR-3908	CLIP-seq
MIRT2683535	hsa-miR-3916	CLIP-seq
MIRT1095689	hsa-miR-3921	CLIP-seq
MIRT1095690	hsa-miR-424	CLIP-seq
MIRT2025705	hsa-miR-4260	CLIP-seq
MIRT2558304	hsa-miR-4271	CLIP-seq
MIRT2558306	hsa-miR-4420	CLIP-seq
MIRT1095691	hsa-miR-4436b-3p	CLIP-seq
MIRT1095692	hsa-miR-4530	CLIP-seq
MIRT1095693	hsa-miR-4649-3p	CLIP-seq
MIRT2558307	hsa-miR-4651	CLIP-seq
MIRT1095694	hsa-miR-4653-5p	CLIP-seq
MIRT1095695	hsa-miR-4690-5p	CLIP-seq
MIRT1095696	hsa-miR-4721	CLIP-seq
MIRT2558309	hsa-miR-4725-3p	CLIP-seq
MIRT2683536	hsa-miR-4751	CLIP-seq
MIRT2558310	hsa-miR-4786-5p	CLIP-seq
MIRT2558311	hsa-miR-491-5p	CLIP-seq
MIRT1095697	hsa-miR-497	CLIP-seq
MIRT2683537	hsa-miR-518d-5p	CLIP-seq
MIRT2683538	hsa-miR-519b-5p	CLIP-seq
MIRT2683539	hsa-miR-519c-5p	CLIP-seq
MIRT2683540	hsa-miR-520c-5p	CLIP-seq
MIRT2683541	hsa-miR-526a	CLIP-seq
MIRT2558312	hsa-miR-548g	CLIP-seq
MIRT2558313	hsa-miR-608	CLIP-seq
MIRT2558314	hsa-miR-665	CLIP-seq
MIRT1095698	hsa-miR-761	CLIP-seq
MIRT2558315	hsa-miR-769-5p	CLIP-seq
MIRT2683542	hsa-miR-877	CLIP-seq

Show/Hide all (8)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183, 33961781, 35271311, 36217029, 36931259
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005871	Component	Kinesin complex	IEA
GO:0005874	Component	Microtubule	IEA
GO:0007018	Process	Microtubule-based movement	IBA
GO:0019894	Function	Kinesin binding	IBA

MIM	HGNC	e!Ensembl
620909	21624	ENSG00000137171

Q9NSK0

Protein name

Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8)

Protein function

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). {ECO:00002

Family and domains

Pfam

Accession	ID	Position in sequence	Type
PF13424	TPR_12	209 → 285	Repeat
PF13424	TPR_12	293 → 369	Repeat
PF13374	TPR_10	294 → 335	Repeat
PF13424	TPR_12	335 → 409	Repeat
PF13374	TPR_10	465 → 496	Repeat

Sequence

MSGLVLGQRDEPAGHRLSQEEILGSTRLVSQGLEALRSEHQAVLQSLSQTIECLQQGGHE
EGLVHEKARQLRRSMENIELGLSEAQVMLALASHLSTVESEKQKLRAQVRRLCQENQWLR
DELAGTQQRLQRSEQAVAQLEEEKKHLEFLGQLRQYDEDGHTSEEKEGDATKDSLDDLFP
NEEEEDPSNGLSRGQGATAAQQGGYEIPARLRTLHNLVIQYAAQGRYEVAVPLCKQALED
LERTSGRGHPDVATMLNILALVYRDQNKYKEAAHLLNDALSIRESTLGPDHPAVAATLNN
LAVLYGKRGKYKEAEPLCQRALEIREKVLGTNHPDVAKQLNNLALLCQNQGKYEAVERYY
QRALAIYEGQLGPDNPNVARTKNNLASCYLKQGKYAEAETLYKEILTRAHVQEFGSVDDD
HKPIWMHAEEREEMSKSRHHEGGTPYAEYGGWYKACKVSSPTVNTTLRNLGALYRRQGKL
EAAETLEECALRSRRQGTDPISQTKVAELLGESDGRRTSQEGPGDSVKFEGGEDASVAVE
WSGDGSGTLQRSGSLGKIRDVLRRSSELLVRKLQGTEPRPSSSNMKRAASLNYLNQPSAA
PLQVSRGLSASTMDLSSSS

Sequence length

619

Interactions

View interactions

	KEGG		Reactome
	Motor proteins Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Salmonella infection		MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
NEURODEGENERATION, EARLY-CHILDHOOD-ONSET, WITH RETINITIS PIGMENTOSA, SENSORINEURAL HEARING LOSS, AND DEMYELINATING PERIPHERAL NEUROPATHY	—	HPO	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (14)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinoma of lung	Lung carcinoma	BEFREE	29717133		★★★★★ ★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	31235251		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	31235251		★★★★★ ★☆☆☆☆ Found in Text Mining only
Frontal bossing	Frontal bossing	CLINVAR_DG	30980518		★★★★★ ★☆☆☆☆ Found in Text Mining only
Long narrow head	Dolichocephaly	CLINVAR_DG	30980518		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	32457423	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	29717133		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29717133		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of cervix	Cervical Tumor	BEFREE	31235251		★★★★★ ★☆☆☆☆ Found in Text Mining only
Miller-McKusick-Malvaux-Syndrome (3M Syndrome)	3M Syndrome	CLINVAR_DG	30980518		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	29717133		★★★★★ ★☆☆☆☆ Found in Text Mining only
Scoliosis, unspecified	Scoliosis	CLINVAR_DG	30980518		★★★★★ ★☆☆☆☆ Found in Text Mining only
Spastic Paraplegia	Spastic Paraplegia	BEFREE	26423925		★★★★★ ★☆☆☆☆ Found in Text Mining only
Spastic Paraplegia	Spastic Paraplegia	GENOMICS_ENGLAND_DG	26423925		★★★★★ ★☆☆☆☆ Found in Text Mining only

KLC4 (kinesin light chain 4)