GLB1L2 (galactosidase beta 1 like 2)

Gene

• Entrez ID: 89944
• Gene name: Galactosidase beta 1 like 2
• Gene symbol: GLB1L2
• Synonyms (NCBI Gene): MST114, MSTP114
• Chromosome: 11
• Chromosome location: 11q25

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1020367	hsa-miR-1268	CLIP-seq
MIRT1020368	hsa-miR-1268b	CLIP-seq
MIRT1020369	hsa-miR-130a	CLIP-seq
MIRT1020370	hsa-miR-130b	CLIP-seq
MIRT1020371	hsa-miR-148a	CLIP-seq
MIRT1020372	hsa-miR-148b	CLIP-seq
MIRT1020373	hsa-miR-152	CLIP-seq
MIRT1020374	hsa-miR-1825	CLIP-seq
MIRT1020375	hsa-miR-199a-5p	CLIP-seq
MIRT1020376	hsa-miR-199b-5p	CLIP-seq
MIRT1020377	hsa-miR-301a	CLIP-seq
MIRT1020378	hsa-miR-301b	CLIP-seq
MIRT1020379	hsa-miR-3173-3p	CLIP-seq
MIRT1020380	hsa-miR-3181	CLIP-seq
MIRT1020381	hsa-miR-3194-3p	CLIP-seq
MIRT1020382	hsa-miR-338-3p	CLIP-seq
MIRT1020383	hsa-miR-3666	CLIP-seq
MIRT1020384	hsa-miR-3944-3p	CLIP-seq
MIRT1020385	hsa-miR-4295	CLIP-seq
MIRT1020386	hsa-miR-4446-3p	CLIP-seq
MIRT1020387	hsa-miR-4447	CLIP-seq
MIRT1020388	hsa-miR-4472	CLIP-seq
MIRT1020389	hsa-miR-4530	CLIP-seq
MIRT1020390	hsa-miR-454	CLIP-seq
MIRT1020391	hsa-miR-4651	CLIP-seq
MIRT1020392	hsa-miR-4675	CLIP-seq
MIRT1020393	hsa-miR-4708-3p	CLIP-seq
MIRT1020394	hsa-miR-4721	CLIP-seq
MIRT1020395	hsa-miR-4741	CLIP-seq
MIRT1020396	hsa-miR-4750	CLIP-seq
MIRT1020397	hsa-miR-4779	CLIP-seq
MIRT1020398	hsa-miR-603	CLIP-seq
MIRT1020399	hsa-miR-608	CLIP-seq
MIRT1020400	hsa-miR-922	CLIP-seq
MIRT2002163	hsa-miR-10a	CLIP-seq
MIRT2002164	hsa-miR-10b	CLIP-seq
MIRT2002165	hsa-miR-224	CLIP-seq
MIRT2002166	hsa-miR-3153	CLIP-seq
MIRT2002167	hsa-miR-3202	CLIP-seq
MIRT2002168	hsa-miR-3620	CLIP-seq
MIRT2002169	hsa-miR-4271	CLIP-seq
MIRT2002170	hsa-miR-4481	CLIP-seq
MIRT2002171	hsa-miR-4648	CLIP-seq
MIRT2002172	hsa-miR-4654	CLIP-seq
MIRT2002173	hsa-miR-4717-3p	CLIP-seq
MIRT2002174	hsa-miR-4725-3p	CLIP-seq
MIRT2002175	hsa-miR-4745-5p	CLIP-seq
MIRT2002176	hsa-miR-4747-5p	CLIP-seq
MIRT2002177	hsa-miR-4769-5p	CLIP-seq
MIRT2002178	hsa-miR-503	CLIP-seq
MIRT2235179	hsa-miR-135a	CLIP-seq
MIRT2235180	hsa-miR-135b	CLIP-seq
MIRT2002173	hsa-miR-4717-3p	CLIP-seq
MIRT2388485	hsa-miR-3925-3p	CLIP-seq
MIRT2388486	hsa-miR-515-5p	CLIP-seq
MIRT2388487	hsa-miR-766	CLIP-seq
MIRT2450318	hsa-miR-3167	CLIP-seq
MIRT2450319	hsa-miR-329	CLIP-seq
MIRT2450320	hsa-miR-362-3p	CLIP-seq
MIRT2450321	hsa-miR-542-5p	CLIP-seq
MIRT2450322	hsa-miR-642b	CLIP-seq
MIRT2450323	hsa-miR-876-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004553	Function	Hydrolase activity, hydrolyzing O-glycosyl compounds	IEA
GO:0004565	Function	Beta-galactosidase activity	IBA
GO:0004565	Function	Beta-galactosidase activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005773	Component	Vacuole	IBA
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016798	Function	Hydrolase activity, acting on glycosyl bonds	IEA
GO:0019388	Process	Galactose catabolic process	IBA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q8IW92
• Protein name: Beta-galactosidase-1-like protein 2 (EC 3.2.1.-)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01301	Glyco_hydro_35	53 → 368	Glycosyl hydrolases family 35	Domain

• Sequence:

  MTTWSLRRRPARTLGLLLLVVLGFLVLRRLDWSTLVPLRLRHRQLGLQAKGWNFMLEDST
  FWIFGGSIHYFRVPREYWRDRLLKMKACGLNTLTTYVPWNLHEPERGKFDFSGNLDLEAF
  VLMAAEIGLWVILRPGPYICSEMDLGGLPSWLLQDPGMRLRTTYKGFTEAVDLYFDHLMS
  RVVPLQYKRGGPIIAVQVENEYGSYNKDPAYMPYVKKALEDRGIVELLLTSDNKDGLSKG
  IVQGVLATINLQSTHELQLLTTFLFNVQGTQPKMVMEYWTGWFDSWGGPHNILDSSEVLK
  TVSAIVDAGSSINLYMFHGGTNFGFMNGAMHFHDYKSDVTSYDYDAVLTEAGDYTAKYMK
  LRDFFGSISGIPLPPPPDLLPKMPYEPLTPVLYLSLWDALKYLGEPIKSEKPINMENLPV
  NGGNGQSFGYILYETSITSSGILSGHVHDRGQVFVNTVSIGFLDYKTTKIAVPLIQGYTV
  LRILVENRGRVNYGENIDDQRKGLIGNLYLNDSPLKNFRIYSLDMKKSFFQRFGLDKWSS
  LPETPTLPAFFLGSLSISSTPCDTFLKLEGWEKGVVFINGQNLGRYWNIGPQKTLYLPGP
  WLSSGINQVIVFEETMAGPALQFTETPHLGRNQYIK

• Sequence length: 636

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Cervical cancer	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Leukemia, Myelocytic, Acute	Leukemia	GWASCAT_DG	27903959		★☆☆☆☆ Found in Text Mining only