TRIM15 (tripartite motif containing 15)

Gene

• Entrez ID: 89870
• Gene name: Tripartite motif containing 15
• Gene symbol: TRIM15
• Synonyms (NCBI Gene): RNF93, ZNF178, ZNFB7
• Chromosome: 6
• Chromosome location: 6p22.1
• Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. Alternativ

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1453174	hsa-miR-1321	CLIP-seq
MIRT1453175	hsa-miR-24	CLIP-seq
MIRT1453176	hsa-miR-2467-5p	CLIP-seq
MIRT1453177	hsa-miR-3664-3p	CLIP-seq
MIRT1453178	hsa-miR-4270	CLIP-seq
MIRT1453179	hsa-miR-4436a	CLIP-seq
MIRT1453180	hsa-miR-4441	CLIP-seq
MIRT1453181	hsa-miR-4739	CLIP-seq
MIRT1453182	hsa-miR-4756-5p	CLIP-seq
MIRT1453183	hsa-miR-513a-5p	CLIP-seq
MIRT1453174	hsa-miR-1321	CLIP-seq
MIRT1453176	hsa-miR-2467-5p	CLIP-seq
MIRT1453178	hsa-miR-4270	CLIP-seq
MIRT1453180	hsa-miR-4441	CLIP-seq
MIRT1453181	hsa-miR-4739	CLIP-seq
MIRT1453182	hsa-miR-4756-5p	CLIP-seq
MIRT1453183	hsa-miR-513a-5p	CLIP-seq
MIRT2356894	hsa-miR-494	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003713	Function	Transcription coactivator activity	IDA	23077300
GO:0005515	Function	Protein binding	IPI	25416956, 26871637, 32296183
GO:0005634	Component	Nucleus	IDA	34871740
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005925	Component	Focal adhesion	IEA
GO:0007249	Process	Canonical NF-kappaB signal transduction	IDA	27995356, 34871740
GO:0007500	Process	Mesodermal cell fate determination	TAS	10207104
GO:0008270	Function	Zinc ion binding	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0032481	Process	Positive regulation of type I interferon production	IMP	23077300
GO:0044790	Process	Suppression of viral release by host	IDA	18248090
GO:0044790	Process	Suppression of viral release by host	IMP	18248090
GO:0045087	Process	Innate immune response	IBA
GO:0045087	Process	Innate immune response	IEA
GO:0045087	Process	Innate immune response	IMP	18248090
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0070161	Component	Anchoring junction	IEA
GO:0070534	Process	Protein K63-linked ubiquitination	IDA	27995356
GO:0140313	Function	Molecular sequestering activity	IDA	34871740
GO:1900246	Process	Positive regulation of RIG-I signaling pathway	IMP	23077300
GO:1901223	Process	Negative regulation of non-canonical NF-kappaB signal transduction	IDA	34871740
GO:1901253	Process	Negative regulation of intracellular transport of viral material	IMP	18248090

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q9C019
• Protein name: E3 ubiquitin-protein ligase TRIM15 (EC 2.3.2.27) (RING finger protein 93) (Zinc finger protein 178) (Zinc finger protein B7)
• Protein function: E3 ubiquitin ligase that plays a role in several processes including innate antiviral immnity, cell migration and chemotaxis (PubMed:23077300, PubMed:34142270). Acts as a 'Lys-63'-specific ubiquitin ligase for MAPK1/ERK2 and MAPK3/ERK1, promotin
• PDB: 7QS2
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00097	zf-C3HC4	16 → 60	Zinc finger, C3HC4 type (RING finger)	Domain
  PF00643	zf-B_box	79 → 120	B-box zinc finger	Domain
  PF13765	PRY	296 → 344	SPRY-associated domain	Family
  PF00622	SPRY	348 → 465	SPRY domain	Family

• Sequence:

  MPATPSLKVVHELPACTLCAGPLEDAVTIPCGHTFCRLCLPALSQMGAQSSGKILLCPLC
  QEEEQAETPMAPVPLGPLGETYCEEHGEKIYFFCENDAEFLCVFCREGPTHQAHTVGFLD
  EAIQPYRDRLRSRLEALSTERDEIEDVKCQEDQKLQVLLTQIESKKHQVETAFERLQQEL
  EQQRCLLLARLRELEQQIWKERDEYITKVSEEVTRLGAQVKELEEKCQQPASELLQDVRV
  NQSRCEMKTFVSPEAISPDLVKKIRDFHRKILTLPEMMRMFSENLAHHLEIDSGVITLDP
  QTASRSLVLSEDRKSVRYTRQKKSLPDSPLRFDGLPAVLGFPGFSSGRHRWQVDLQLGDG
  GGCTVGVAGEGVRRKGEMGLSAEDGVWAVIISHQQCWASTSPGTDLPLSEIPRGVRVALD
  YEAGQVTLHNAQTQEPIFTFTASFSGKVFPFFAVWKKGSCLTLKG

• Sequence length: 465

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DRY EYE SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OROPHARYNX CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ULCERATIVE COLITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	30854090		★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	34867944	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	36670097	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	30854090		★☆☆☆☆ Found in Text Mining only
Colitis Ulcerative	Ulcerative colitis	Pubtator	29562276	Associate	★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	25450970		★☆☆☆☆ Found in Text Mining only
Gastric Adenocarcinoma	Gastric Cancer	BEFREE	30412518		★☆☆☆☆ Found in Text Mining only
Kidney Neoplasms	Kidney neoplasm	Pubtator	36189312	Associate	★☆☆☆☆ Found in Text Mining only
Lupus Nephritis	Lupus Nephritis	BEFREE	29953444		★☆☆☆☆ Found in Text Mining only
Lupus Nephritis	Lupus nephritis	Pubtator	29953444	Associate	★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	31906745	Stimulate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	30854090		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	30412518		★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	25450970		★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	34497368	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	25450970		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	30854090		★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	GWASDB_DG	17804836, 19503088		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of lung	Lung carcinoma	BEFREE	30854090		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	30412518, 31906745, 36661663	Associate	★☆☆☆☆ Found in Text Mining only
Ulcerative Colitis	Ulcerative colitis	GWASCAT_DG	29562276		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Vitiligo	Vitiligo	GWASDB_DG	20526339		★☆☆☆☆ Found in Text Mining only