Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	89795
Gene name	Neuron navigator 3
Gene symbol	NAV3
Synonyms (NCBI Gene)	NEDSFBPOMFIL1STEERIN3unc53H3
Chromosome	12
Chromosome location	12q21.2
Summary	This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities.

293

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miRTarBase ID	miRNA	Experiments	Reference
MIRT006549	hsa-miR-29a-3p	Luciferase reporter assay	20202123
MIRT1174690	hsa-miR-1237	CLIP-seq
MIRT1174691	hsa-miR-1270	CLIP-seq
MIRT1174692	hsa-miR-1304	CLIP-seq
MIRT1174693	hsa-miR-155	CLIP-seq
MIRT1174694	hsa-miR-2116	CLIP-seq
MIRT1174695	hsa-miR-2467-5p	CLIP-seq
MIRT1174696	hsa-miR-3163	CLIP-seq
MIRT1174697	hsa-miR-3168	CLIP-seq
MIRT1174698	hsa-miR-3188	CLIP-seq
MIRT1174699	hsa-miR-3189-3p	CLIP-seq
MIRT1174700	hsa-miR-3908	CLIP-seq
MIRT1174701	hsa-miR-3942-5p	CLIP-seq
MIRT1174702	hsa-miR-3973	CLIP-seq
MIRT1174703	hsa-miR-3975	CLIP-seq
MIRT1174704	hsa-miR-4297	CLIP-seq
MIRT1174705	hsa-miR-432	CLIP-seq
MIRT1174706	hsa-miR-4531	CLIP-seq
MIRT1174707	hsa-miR-4677-5p	CLIP-seq
MIRT1174708	hsa-miR-4680-3p	CLIP-seq
MIRT1174709	hsa-miR-4698	CLIP-seq
MIRT1174710	hsa-miR-4703-5p	CLIP-seq
MIRT1174711	hsa-miR-4728-3p	CLIP-seq
MIRT1174712	hsa-miR-4738-3p	CLIP-seq
MIRT1174713	hsa-miR-4766-3p	CLIP-seq
MIRT1174714	hsa-miR-4766-5p	CLIP-seq
MIRT1174715	hsa-miR-4786-5p	CLIP-seq
MIRT1174716	hsa-miR-485-5p	CLIP-seq
MIRT1174717	hsa-miR-499-3p	CLIP-seq
MIRT1174718	hsa-miR-499a-3p	CLIP-seq
MIRT1174719	hsa-miR-520g	CLIP-seq
MIRT1174720	hsa-miR-520h	CLIP-seq
MIRT1174721	hsa-miR-620	CLIP-seq
MIRT1174690	hsa-miR-1237	CLIP-seq
MIRT2050542	hsa-miR-1248	CLIP-seq
MIRT2050543	hsa-miR-29a	CLIP-seq
MIRT2050544	hsa-miR-29b	CLIP-seq
MIRT2050545	hsa-miR-29c	CLIP-seq
MIRT2279710	hsa-miR-513b	CLIP-seq
MIRT2279711	hsa-miR-640	CLIP-seq
MIRT2391398	hsa-miR-4328	CLIP-seq
MIRT2431483	hsa-miR-1208	CLIP-seq
MIRT2431484	hsa-miR-1245b-3p	CLIP-seq
MIRT2431485	hsa-miR-1283	CLIP-seq
MIRT2431486	hsa-miR-1323	CLIP-seq
MIRT2431487	hsa-miR-3613-3p	CLIP-seq
MIRT2431488	hsa-miR-3942-3p	CLIP-seq
MIRT2431489	hsa-miR-4420	CLIP-seq
MIRT2431490	hsa-miR-450b-5p	CLIP-seq
MIRT2431491	hsa-miR-452	CLIP-seq
MIRT2431492	hsa-miR-4676-3p	CLIP-seq
MIRT2431493	hsa-miR-4699-3p	CLIP-seq
MIRT2431494	hsa-miR-4727-5p	CLIP-seq
MIRT2431495	hsa-miR-518a-5p	CLIP-seq
MIRT2431496	hsa-miR-527	CLIP-seq
MIRT2431497	hsa-miR-544	CLIP-seq
MIRT2431498	hsa-miR-548o	CLIP-seq
MIRT2431499	hsa-miR-548u	CLIP-seq
MIRT2454887	hsa-miR-1254	CLIP-seq
MIRT2454888	hsa-miR-3116	CLIP-seq
MIRT2454889	hsa-miR-3180	CLIP-seq
MIRT2454890	hsa-miR-3180-3p	CLIP-seq
MIRT2454891	hsa-miR-3196	CLIP-seq
MIRT2454892	hsa-miR-320e	CLIP-seq
MIRT2431487	hsa-miR-3613-3p	CLIP-seq
MIRT2454893	hsa-miR-4426	CLIP-seq
MIRT2454894	hsa-miR-4647	CLIP-seq
MIRT2454895	hsa-miR-4662b	CLIP-seq
MIRT2454896	hsa-miR-4725-5p	CLIP-seq
MIRT2454897	hsa-miR-504	CLIP-seq
MIRT2431495	hsa-miR-518a-5p	CLIP-seq
MIRT2431496	hsa-miR-527	CLIP-seq
MIRT2454898	hsa-miR-661	CLIP-seq
MIRT2454899	hsa-miR-711	CLIP-seq
MIRT2454887	hsa-miR-1254	CLIP-seq
MIRT2454888	hsa-miR-3116	CLIP-seq
MIRT2454889	hsa-miR-3180	CLIP-seq
MIRT2454890	hsa-miR-3180-3p	CLIP-seq
MIRT2454891	hsa-miR-3196	CLIP-seq
MIRT2454892	hsa-miR-320e	CLIP-seq
MIRT2431487	hsa-miR-3613-3p	CLIP-seq
MIRT2454893	hsa-miR-4426	CLIP-seq
MIRT2454894	hsa-miR-4647	CLIP-seq
MIRT2454895	hsa-miR-4662b	CLIP-seq
MIRT2454896	hsa-miR-4725-5p	CLIP-seq
MIRT2454897	hsa-miR-504	CLIP-seq
MIRT2431495	hsa-miR-518a-5p	CLIP-seq
MIRT2431496	hsa-miR-527	CLIP-seq
MIRT2454898	hsa-miR-661	CLIP-seq
MIRT2454899	hsa-miR-711	CLIP-seq
MIRT2578192	hsa-miR-1185	CLIP-seq
MIRT2578193	hsa-miR-1193	CLIP-seq
MIRT2431483	hsa-miR-1208	CLIP-seq
MIRT2578194	hsa-miR-1243	CLIP-seq
MIRT2431484	hsa-miR-1245b-3p	CLIP-seq
MIRT2578195	hsa-miR-1269	CLIP-seq
MIRT2578196	hsa-miR-1269b	CLIP-seq
MIRT2578197	hsa-miR-1276	CLIP-seq
MIRT2431485	hsa-miR-1283	CLIP-seq
MIRT2578198	hsa-miR-1284	CLIP-seq
MIRT2578199	hsa-miR-1286	CLIP-seq
MIRT2578200	hsa-miR-1288	CLIP-seq
MIRT2578201	hsa-miR-129-3p	CLIP-seq
MIRT1174692	hsa-miR-1304	CLIP-seq
MIRT2431486	hsa-miR-1323	CLIP-seq
MIRT2578202	hsa-miR-190	CLIP-seq
MIRT2578203	hsa-miR-190b	CLIP-seq
MIRT2578204	hsa-miR-204	CLIP-seq
MIRT2578205	hsa-miR-211	CLIP-seq
MIRT2578206	hsa-miR-2113	CLIP-seq
MIRT2578207	hsa-miR-216a	CLIP-seq
MIRT2578208	hsa-miR-218	CLIP-seq
MIRT2578209	hsa-miR-25	CLIP-seq
MIRT2050543	hsa-miR-29a	CLIP-seq
MIRT2050544	hsa-miR-29b	CLIP-seq
MIRT2050545	hsa-miR-29c	CLIP-seq
MIRT2578210	hsa-miR-30a	CLIP-seq
MIRT2578211	hsa-miR-30b	CLIP-seq
MIRT2578212	hsa-miR-30c	CLIP-seq
MIRT2578213	hsa-miR-30d	CLIP-seq
MIRT2578214	hsa-miR-30e	CLIP-seq
MIRT2578215	hsa-miR-3117-5p	CLIP-seq
MIRT2578216	hsa-miR-3147	CLIP-seq
MIRT1174696	hsa-miR-3163	CLIP-seq
MIRT2578217	hsa-miR-3167	CLIP-seq
MIRT2578218	hsa-miR-3171	CLIP-seq
MIRT2578219	hsa-miR-3185	CLIP-seq
MIRT1174699	hsa-miR-3189-3p	CLIP-seq
MIRT2578220	hsa-miR-32	CLIP-seq
MIRT2454892	hsa-miR-320e	CLIP-seq
MIRT2578221	hsa-miR-323-5p	CLIP-seq
MIRT2578222	hsa-miR-329	CLIP-seq
MIRT2578223	hsa-miR-33a	CLIP-seq
MIRT2578224	hsa-miR-33b	CLIP-seq
MIRT2578225	hsa-miR-3591-3p	CLIP-seq
MIRT2431487	hsa-miR-3613-3p	CLIP-seq
MIRT2578226	hsa-miR-362-3p	CLIP-seq
MIRT2578227	hsa-miR-363	CLIP-seq
MIRT2578228	hsa-miR-367	CLIP-seq
MIRT2578229	hsa-miR-3679-5p	CLIP-seq
MIRT2578230	hsa-miR-3686	CLIP-seq
MIRT2578231	hsa-miR-369-3p	CLIP-seq
MIRT2578232	hsa-miR-374c	CLIP-seq
MIRT2578233	hsa-miR-376a	CLIP-seq
MIRT2578234	hsa-miR-376b	CLIP-seq
MIRT2578235	hsa-miR-377	CLIP-seq
MIRT2578236	hsa-miR-382	CLIP-seq
MIRT2578237	hsa-miR-3940-5p	CLIP-seq
MIRT2431488	hsa-miR-3942-3p	CLIP-seq
MIRT2578238	hsa-miR-4260	CLIP-seq
MIRT2578239	hsa-miR-4277	CLIP-seq
MIRT2578240	hsa-miR-4283	CLIP-seq
MIRT2578241	hsa-miR-4314	CLIP-seq
MIRT2431489	hsa-miR-4420	CLIP-seq
MIRT2578242	hsa-miR-4425	CLIP-seq
MIRT2578243	hsa-miR-4443	CLIP-seq
MIRT2578244	hsa-miR-4446-5p	CLIP-seq
MIRT2578245	hsa-miR-4489	CLIP-seq
MIRT2578246	hsa-miR-4507	CLIP-seq
MIRT2431490	hsa-miR-450b-5p	CLIP-seq
MIRT2578247	hsa-miR-4515	CLIP-seq
MIRT2431491	hsa-miR-452	CLIP-seq
MIRT2578248	hsa-miR-4520b-3p	CLIP-seq
MIRT2578249	hsa-miR-4529-3p	CLIP-seq
MIRT2578250	hsa-miR-4535	CLIP-seq
MIRT2578251	hsa-miR-455-5p	CLIP-seq
MIRT2578252	hsa-miR-4652-3p	CLIP-seq
MIRT2578253	hsa-miR-4666-5p	CLIP-seq
MIRT2431492	hsa-miR-4676-3p	CLIP-seq
MIRT1174707	hsa-miR-4677-5p	CLIP-seq
MIRT2578254	hsa-miR-4687-5p	CLIP-seq
MIRT1174709	hsa-miR-4698	CLIP-seq
MIRT2431493	hsa-miR-4699-3p	CLIP-seq
MIRT2578255	hsa-miR-4700-3p	CLIP-seq
MIRT2578256	hsa-miR-4714-5p	CLIP-seq
MIRT2578257	hsa-miR-4719	CLIP-seq
MIRT2578258	hsa-miR-4722-5p	CLIP-seq
MIRT2431494	hsa-miR-4727-5p	CLIP-seq
MIRT1174712	hsa-miR-4738-3p	CLIP-seq
MIRT2578259	hsa-miR-4740-5p	CLIP-seq
MIRT2578260	hsa-miR-4742-3p	CLIP-seq
MIRT2578261	hsa-miR-4755-5p	CLIP-seq
MIRT1174714	hsa-miR-4766-5p	CLIP-seq
MIRT2578262	hsa-miR-4778-5p	CLIP-seq
MIRT2578263	hsa-miR-4796-5p	CLIP-seq
MIRT2578264	hsa-miR-4800-5p	CLIP-seq
MIRT2578265	hsa-miR-491-3p	CLIP-seq
MIRT2578266	hsa-miR-492	CLIP-seq
MIRT2578267	hsa-miR-494	CLIP-seq
MIRT1174717	hsa-miR-499-3p	CLIP-seq
MIRT1174718	hsa-miR-499a-3p	CLIP-seq
MIRT2578268	hsa-miR-5096	CLIP-seq
MIRT2279710	hsa-miR-513b	CLIP-seq
MIRT2431495	hsa-miR-518a-5p	CLIP-seq
MIRT2578269	hsa-miR-520d-5p	CLIP-seq
MIRT2578270	hsa-miR-524-5p	CLIP-seq
MIRT2431496	hsa-miR-527	CLIP-seq
MIRT2431497	hsa-miR-544	CLIP-seq
MIRT2578271	hsa-miR-545	CLIP-seq
MIRT2578272	hsa-miR-548a-3p	CLIP-seq
MIRT2578273	hsa-miR-548a-5p	CLIP-seq
MIRT2578274	hsa-miR-548ab	CLIP-seq
MIRT2578275	hsa-miR-548ak	CLIP-seq
MIRT2578276	hsa-miR-548b-5p	CLIP-seq
MIRT2578277	hsa-miR-548c-5p	CLIP-seq
MIRT2578278	hsa-miR-548d-5p	CLIP-seq
MIRT2578279	hsa-miR-548e	CLIP-seq
MIRT2578280	hsa-miR-548f	CLIP-seq
MIRT2578281	hsa-miR-548h	CLIP-seq
MIRT2578282	hsa-miR-548i	CLIP-seq
MIRT2578283	hsa-miR-548j	CLIP-seq
MIRT2578284	hsa-miR-548n	CLIP-seq
MIRT2431498	hsa-miR-548o	CLIP-seq
MIRT2578285	hsa-miR-548t	CLIP-seq
MIRT2431499	hsa-miR-548u	CLIP-seq
MIRT2578286	hsa-miR-548w	CLIP-seq
MIRT2578287	hsa-miR-548y	CLIP-seq
MIRT2578288	hsa-miR-559	CLIP-seq
MIRT2578289	hsa-miR-570	CLIP-seq
MIRT2578290	hsa-miR-603	CLIP-seq
MIRT2578291	hsa-miR-623	CLIP-seq
MIRT2578292	hsa-miR-629	CLIP-seq
MIRT2578293	hsa-miR-636	CLIP-seq
MIRT2578294	hsa-miR-655	CLIP-seq
MIRT2578295	hsa-miR-660	CLIP-seq
MIRT2578296	hsa-miR-765	CLIP-seq
MIRT2578297	hsa-miR-802	CLIP-seq
MIRT2578298	hsa-miR-876-3p	CLIP-seq
MIRT2578299	hsa-miR-876-5p	CLIP-seq
MIRT2578300	hsa-miR-889	CLIP-seq
MIRT2578301	hsa-miR-892a	CLIP-seq
MIRT2578302	hsa-miR-92a	CLIP-seq
MIRT2578303	hsa-miR-92b	CLIP-seq
MIRT2685850	hsa-miR-1296	CLIP-seq
MIRT1174692	hsa-miR-1304	CLIP-seq
MIRT2578204	hsa-miR-204	CLIP-seq
MIRT2578205	hsa-miR-211	CLIP-seq
MIRT2578207	hsa-miR-216a	CLIP-seq
MIRT2685851	hsa-miR-2909	CLIP-seq
MIRT2050543	hsa-miR-29a	CLIP-seq
MIRT2050544	hsa-miR-29b	CLIP-seq
MIRT2050545	hsa-miR-29c	CLIP-seq
MIRT2578216	hsa-miR-3147	CLIP-seq
MIRT2578217	hsa-miR-3167	CLIP-seq
MIRT2578221	hsa-miR-323-5p	CLIP-seq
MIRT2578222	hsa-miR-329	CLIP-seq
MIRT2578223	hsa-miR-33a	CLIP-seq
MIRT2578224	hsa-miR-33b	CLIP-seq
MIRT2578226	hsa-miR-362-3p	CLIP-seq
MIRT2578230	hsa-miR-3686	CLIP-seq
MIRT2578231	hsa-miR-369-3p	CLIP-seq
MIRT2578232	hsa-miR-374c	CLIP-seq
MIRT2578233	hsa-miR-376a	CLIP-seq
MIRT2578234	hsa-miR-376b	CLIP-seq
MIRT2578235	hsa-miR-377	CLIP-seq
MIRT2578238	hsa-miR-4260	CLIP-seq
MIRT2578239	hsa-miR-4277	CLIP-seq
MIRT2578240	hsa-miR-4283	CLIP-seq
MIRT2578242	hsa-miR-4425	CLIP-seq
MIRT2685852	hsa-miR-4436b-3p	CLIP-seq
MIRT2578244	hsa-miR-4446-5p	CLIP-seq
MIRT2578245	hsa-miR-4489	CLIP-seq
MIRT2431490	hsa-miR-450b-5p	CLIP-seq
MIRT2578251	hsa-miR-455-5p	CLIP-seq
MIRT2578255	hsa-miR-4700-3p	CLIP-seq
MIRT2578260	hsa-miR-4742-3p	CLIP-seq
MIRT2578261	hsa-miR-4755-5p	CLIP-seq
MIRT2685853	hsa-miR-4761-3p	CLIP-seq
MIRT2578262	hsa-miR-4778-5p	CLIP-seq
MIRT2578268	hsa-miR-5096	CLIP-seq
MIRT2578269	hsa-miR-520d-5p	CLIP-seq
MIRT2578270	hsa-miR-524-5p	CLIP-seq
MIRT2578273	hsa-miR-548a-5p	CLIP-seq
MIRT2578274	hsa-miR-548ab	CLIP-seq
MIRT2578275	hsa-miR-548ak	CLIP-seq
MIRT2578276	hsa-miR-548b-5p	CLIP-seq
MIRT2578277	hsa-miR-548c-5p	CLIP-seq
MIRT2578278	hsa-miR-548d-5p	CLIP-seq
MIRT2578281	hsa-miR-548h	CLIP-seq
MIRT2578282	hsa-miR-548i	CLIP-seq
MIRT2578283	hsa-miR-548j	CLIP-seq
MIRT2578284	hsa-miR-548n	CLIP-seq
MIRT2578285	hsa-miR-548t	CLIP-seq
MIRT2578286	hsa-miR-548w	CLIP-seq
MIRT2578287	hsa-miR-548y	CLIP-seq
MIRT2578288	hsa-miR-559	CLIP-seq
MIRT2578290	hsa-miR-603	CLIP-seq
MIRT2578291	hsa-miR-623	CLIP-seq
MIRT2578294	hsa-miR-655	CLIP-seq
MIRT2578295	hsa-miR-660	CLIP-seq
MIRT2578297	hsa-miR-802	CLIP-seq
MIRT2578298	hsa-miR-876-3p	CLIP-seq
MIRT2578299	hsa-miR-876-5p	CLIP-seq

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005640	Component	Nuclear outer membrane	IEA
GO:0007026	Process	Negative regulation of microtubule depolymerization	IMP	25678558
GO:0007399	Process	Nervous system development	IBA
GO:0008017	Function	Microtubule binding	IDA	25678558
GO:0016020	Component	Membrane	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0022008	Process	Neurogenesis	IEA
GO:0030336	Process	Negative regulation of cell migration	IMP	25678558
GO:0031116	Process	Positive regulation of microtubule polymerization	IMP	25678558
GO:0032703	Process	Negative regulation of interleukin-2 production	IMP	16166283
GO:1990752	Component	Microtubule end	IMP	25678558

MIM	HGNC	e!Ensembl
611629	15998	ENSG00000067798

Q8IVL0

Protein name

Neuron navigator 3 (Pore membrane and/or filament-interacting-like protein 1) (Steerin-3) (Unc-53 homolog 3) (unc53H3)

Protein function

Plays a role in cell migration (PubMed:21471154). May be involved in neuron regeneration. May regulate IL2 production by T-cells.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00307	CH	77 → 185	Calponin homology (CH) domain	Domain
PF00004	AAA	2052 → 2184	ATPase family associated with various cellular activities (AAA)	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in brain. Expressed at low levels in heart and placenta. Present in activated T-cells but not in resting T-cells (at protein level). Down-regulated in primary neuroblastoma. {ECO:0000269|PubMed:12062803, ECO:0000269|Pu

Sequence

MPVLGVASKLRQPAVGSKPVHTALPIPNLGTTGSQHCSSRPLELTETESSMLSCQLALKS
TCEFGEKKPLQGKAKEKEDSKIYTDWANHYLAKSGHKRLIKDLQQDIADGVLLAEIIQII
ANEKVEDINGCPRSQSQMIENVDVCLSFLAARGVNVQGLSAEEIRNGNLKAILGLFFSLS
RYKQQQHHQQQYYQSLVELQQRVTHASPPSEASQAKTQQDMQSSLAARYATQSNHSGIAT
SQKKPTRLPGPSRVPAAGSSSKVQGASNLNRRSQSFNSIDKNKPPNYANGNEKDSSKGPQ
SSSGVNGNVQPPSTAGQPPASAIPSPSASKPWRSKSMNVKHSATSTMLTVKQSSTATSPT
PSSDRLKPPVSEGVKTAPSGQKSMLEKFKLVNARTALRPPQPPSSGPSDGGKDDDAFSES
GEMEGFNSGLNSGGSTNSSPKVSPKLAPPKAGSKNLSNKKSLLQPKEKEEKNRDKNKVCT
EKPVKEEKDQVTEMAPKKTSKIASLIPKGSKTTAAKKESLIPSSSGIPKPGSKVPTVKQT
ISPGSTASKESEKFRTTKGSPSQSLSKPITMEKASASSCPAPLEGREAGQASPSGSCTMT
VAQSSGQSTGNGAVQLPQQQQHSHPNTATVAPFIYRAHSENEGTALPSADSCTSPTKMDL
SYSKTAKQCLEEISGEDPETRRMRTVKNIADLRQNLEETMSSLRGTQISHSTLETTFDST
VTTEVNGRTIPNLTSRPTPMTWRLGQACPRLQAGDAPSLGAGYPRSGTSRFIHTDPSRFM
YTTPLRRAAVSRLGNMSQIDMSEKASSDLDMSSEVDVGGYMSDGDILGKSLRTDDINSGY
MTDGGLNLYTRSLNRIPDTATSRDIIQRGVHDVTVDADSWDDSSSVSSGLSDTLDNISTD
DLNTTSSVSSYSNITVPSRKNTQLRTDSEKRSTTDETWDSPEELKKPEEDFDSHGDAGGK
WKTVSSGLPEDPEKAGQKASLSVSQTGSWRRGMSAQGGAPSRQKAGTSALKTPGKTDDAK
ASEKGKAPLKGSSLQRSPSDAGKSSGDEGKKPPSGIGRSTATSSFGFKKPSGVGSSAMIT
SSGATITSGSATLGKIPKSAAIGGKSNAGRKTSLDGSQNQDDVVLHVSSKTTLQYRSLPR
PSKSSTSGIPGRGGHRSSTSSIDSNVSSKSAGATTSKLREPTKIGSGRSSPVTVNQTDKE
KEKVAVSDSESVSLSGSPKSSPTSASACGAQGLRQPGSKYPDIASPTFRRLFGAKAGGKS
ASAPNTEGVKSSSVMPSPSTTLARQGSLESPSSGTGSMGSAGGLSGSSSPLFNKPSDLTT
DVISLSHSLASSPASVHSFTSGGLVWAANMSSSSAGSKDTPSYQSMTSLHTSSESIDLPL
SHHGSLSGLTTGTHEVQSLLMRTGSVRSTLSESMQLDRNTLPKKGLRYTPSSRQANQEEG
KEWLRSHSTGGLQDTGNQSPLVSPSAMSSSAAGKYHFSNLVSPTNLSQFNLPGPSMMRSN
SIPAQDSSFDLYDDSQLCGSATSLEERPRAISHSGSFRDSMEEVHGSSLSLVSSTSSLYS
TAEEKAHSEQIHKLRRELVASQEKVATLTSQLSANAHLVAAFEKSLGNMTGRLQSLTMTA
EQKESELIELRETIEMLKAQNSAAQAAIQGALNGPDHPPKDLRIRRQHSSESVSSINSAT
SHSSIGSGNDADSKKKKKKNWVNSRGSELRSSFKQAFGKKKSTKPPSSHSDIEELTDSSL
PASPKLPHNAGDCGSASMKPSQSASASPLVWPPKKRQNGPVIYKHRSRICECTEAEAEII
LQLKSELREKELKLTDIRLEALSSAHHLDQIREAMNRMQNEIEILKAENDRLKAETGNTA
KPTRPPSESSSSTSSSSSRQSLGLSLNNLNITEAVSSDILLDDAGDATGHKDGRSVKIIV
SISKGYGRAKDQKSQAYLIGSIGVSGKTKWDVLDGVIRRLFKEYVFRIDTSTSLGLSSDC
IASYCIGDLIRSHNLEVPELLPCGYLVGDNNIITVNLKGVEENSLDSFVFDTLIPKPITQ
RYFNLLMEHHRIILSGPSGTGKTYLANKLAEYVITKSGRKKTEDAIATFNVDHKSSKELQ
QYLANLAEQCSADNNGVELPVVIILDNLHHVGSLSDIFNGFLNCKYNKCPYIIGTMNQGV
SSSPNLELHHNFRWVLCANHTEPVKGFLGRYLRRKLIEIEIERNIRNNDLVKIIDWIPKT
WHHLNSFLETHSSSDVTIGPRLFLPCPMDVEGSRVWFMDLWNYSLVPYILEAVREGLQMY
GKRTPWEDPSKWVLDTYPWSSATLPQESPALLQLRPEDVGYESCTSTKEATTSKHIPQTD
TEGDPLMNMLMKLQEAANYSSTQSCDSESTSHHEDILDSSLESTL

Sequence length

2385

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (26)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
APPENDICITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISTIC DISORDER	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, RENAL CELL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIAC ARRHYTHMIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIAC EMBOLISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIOEMBOLIC STROKE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COMPLEX NEURODEVELOPMENTAL DISORDER	—	GenCC	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETIC NEPHROPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIAL CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIAL NEOPLASM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EYE DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTROESOPHAGEAL REFLUX DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEARING IMPAIRMENT	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MOOD DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDER	—	GenCC	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-SPECIFIC SYNDROMIC INTELLECTUAL DISABILITY	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SLEEP APNEA SYNDROMES	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC MASTOCYTOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TRIGONOCEPHALY	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (44)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenoma	Adenoma	BEFREE	22173670		★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	35812247	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Amyloidosis	Amyloidosis	BEFREE	27324898		★★★★★ ★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis	Amyotrophic lateral sclerosis	Pubtator	35812247	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	GWASDB_DG	22843504		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Autistic Disorder	Autism	Pubtator	35982159	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Carcinoma	Carcinoma	BEFREE	22173670		★★★★★ ★☆☆☆☆ Found in Text Mining only
Chromophobe Renal Cell Carcinoma	Chromophobe Carcinoma	CTD_human_DG	22138691		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cognition Disorders	Cognition disorder	Pubtator	35982159	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Collecting Duct Carcinoma of the Kidney	Renal Carcinoma	CTD_human_DG	22138691		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	22173670		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	22173670, 35812247	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	CTD_human_DG	22138691		★★★★★ ★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	GWASDB_DG	22763110		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathy	Diabetic Nephropathy	GWASCAT_DG	26305897		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Endometrial Carcinoma	Endometrial carcinoma	GWASCAT_DG	30093612		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Huntington Disease	Huntington disease	Pubtator	35812247	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leiomyoma	Leiomyoma	Pubtator	32046415	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	GWASCAT_DG	27903959		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	22173670	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma, T-Cell, Cutaneous	Lymphoma	BEFREE	16166283, 17985357, 21547336		★★★★★ ★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	GWASCAT_DG	27622933		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant neoplasm of lung	Lung Cancer	BEFREE	17985357		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	22173670, 23097141		★★★★★ ★☆☆☆☆ Found in Text Mining only
Marinesco-Sjogren syndrome	Marinesco-Sjogren Syndrome	BEFREE	22173670		★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	19058223		★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	36883877	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mood Disorders	Mood Disorder	GWASCAT_DG	27622933		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mycosis Fungoides	Mycosis fungoides	Pubtator	18337827, 18509363, 26918607	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myopia, Degenerative	Myopia	GWASCAT_DG	23049088		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	16166283, 23097141		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nervous System Neoplasms	Nervous System Neoplasms	BEFREE	23097141		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	23097141		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	27009842	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	25579119		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	30786925	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Papillary Renal Cell Carcinoma	Papillary Renal Carcinoma	CTD_human_DG	22138691		★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal Cell Carcinoma	Renal Carcinoma	CTD_human_DG	22138691		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcomatoid Renal Cell Carcinoma	Renal Carcinoma	CTD_human_DG	22138691		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sezary Syndrome	Sezary Syndrome	BEFREE	16166283, 18509363		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sezary Syndrome	Sezary syndrome	Pubtator	18337827, 18509363	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Skin lesion	Skin Lesion	BEFREE	16166283		★★★★★ ★☆☆☆☆ Found in Text Mining only
T-Cell Lymphoma	T-Cell Lymphoma	LHGDN	18337827		★★★★★ ★☆☆☆☆ Found in Text Mining only
Unipolar Depression	Mental Depression	GWASCAT_DG	27622933		★★★★★ ★☆☆☆☆ Found in Text Mining only

NAV3 (neuron navigator 3)