Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	89792
Gene name	Galactose-3-O-sulfotransferase 3
Gene symbol	GAL3ST3
Synonyms (NCBI Gene)	GAL3ST-3GAL3ST2
Chromosome	11
Chromosome location	11q13.1
Summary	This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the 3` position of galactose in N-acetyllactosamine in both type 2 (Gal-beta-1-4GlcNAc-R) ol

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miRTarBase ID	miRNA	Experiments	Reference
MIRT560868	hsa-miR-548ac	PAR-CLIP	20371350
MIRT560867	hsa-miR-548bb-3p	PAR-CLIP	20371350
MIRT560866	hsa-miR-548d-3p	PAR-CLIP	20371350
MIRT560865	hsa-miR-548h-3p	PAR-CLIP	20371350
MIRT560864	hsa-miR-548z	PAR-CLIP	20371350
MIRT560863	hsa-miR-548aa	PAR-CLIP	20371350
MIRT560862	hsa-miR-548ap-3p	PAR-CLIP	20371350
MIRT560861	hsa-miR-548t-3p	PAR-CLIP	20371350
MIRT560859	hsa-miR-4307	PAR-CLIP	20371350
MIRT560860	hsa-miR-4477a	PAR-CLIP	20371350
MIRT560868	hsa-miR-548ac	PAR-CLIP	20371350
MIRT560867	hsa-miR-548bb-3p	PAR-CLIP	20371350
MIRT560866	hsa-miR-548d-3p	PAR-CLIP	20371350
MIRT560865	hsa-miR-548h-3p	PAR-CLIP	20371350
MIRT560864	hsa-miR-548z	PAR-CLIP	20371350
MIRT560863	hsa-miR-548aa	PAR-CLIP	20371350
MIRT560862	hsa-miR-548ap-3p	PAR-CLIP	20371350
MIRT560861	hsa-miR-548t-3p	PAR-CLIP	20371350
MIRT560859	hsa-miR-4307	PAR-CLIP	20371350
MIRT560860	hsa-miR-4477a	PAR-CLIP	20371350
MIRT1010411	hsa-miR-1207-3p	CLIP-seq
MIRT1010412	hsa-miR-1207-5p	CLIP-seq
MIRT1010413	hsa-miR-1286	CLIP-seq
MIRT1010414	hsa-miR-1343	CLIP-seq
MIRT1010415	hsa-miR-3192	CLIP-seq
MIRT1010416	hsa-miR-3616-3p	CLIP-seq
MIRT1010417	hsa-miR-3689a-3p	CLIP-seq
MIRT1010418	hsa-miR-3689c	CLIP-seq
MIRT1010419	hsa-miR-4428	CLIP-seq
MIRT1010420	hsa-miR-4436b-3p	CLIP-seq
MIRT1010421	hsa-miR-4533	CLIP-seq
MIRT1010422	hsa-miR-4646-5p	CLIP-seq
MIRT1010423	hsa-miR-4728-5p	CLIP-seq
MIRT1010424	hsa-miR-4747-5p	CLIP-seq
MIRT1010425	hsa-miR-4763-3p	CLIP-seq
MIRT1010426	hsa-miR-711	CLIP-seq
MIRT1010412	hsa-miR-1207-5p	CLIP-seq
MIRT1999234	hsa-miR-204	CLIP-seq
MIRT1999235	hsa-miR-211	CLIP-seq
MIRT1999236	hsa-miR-361-3p	CLIP-seq
MIRT1999237	hsa-miR-3652	CLIP-seq
MIRT1999238	hsa-miR-3714	CLIP-seq
MIRT1999239	hsa-miR-3943	CLIP-seq
MIRT1999240	hsa-miR-4430	CLIP-seq
MIRT1999241	hsa-miR-4468	CLIP-seq
MIRT1999242	hsa-miR-4505	CLIP-seq
MIRT1010425	hsa-miR-4763-3p	CLIP-seq
MIRT1999243	hsa-miR-4792	CLIP-seq
MIRT1999244	hsa-miR-548an	CLIP-seq
MIRT1999245	hsa-miR-940	CLIP-seq
MIRT2232940	hsa-miR-1322	CLIP-seq
MIRT2232941	hsa-miR-143	CLIP-seq
MIRT2232942	hsa-miR-3151	CLIP-seq
MIRT2232943	hsa-miR-4756-3p	CLIP-seq
MIRT2232944	hsa-miR-4770	CLIP-seq
MIRT2232945	hsa-miR-4797-3p	CLIP-seq
MIRT2232946	hsa-miR-4797-5p	CLIP-seq
MIRT2450020	hsa-miR-4283	CLIP-seq
MIRT2450021	hsa-miR-4690-3p	CLIP-seq
MIRT2450022	hsa-miR-4781-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001733	Function	Galactosylceramide sulfotransferase activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005794	Component	Golgi apparatus	IEA
GO:0005996	Process	Monosaccharide metabolic process	NAS	11323440
GO:0006790	Process	Sulfur compound metabolic process	NAS	11323440
GO:0008146	Function	Sulfotransferase activity	IEA
GO:0009247	Process	Glycolipid biosynthetic process	IEA
GO:0009311	Process	Oligosaccharide metabolic process	NAS	11323440, 11356829
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	11323440
GO:0016740	Function	Transferase activity	IEA
GO:0030166	Process	Proteoglycan biosynthetic process	NAS	11356829
GO:0030246	Function	Carbohydrate binding	NAS	11323440
GO:0030309	Process	Poly-N-acetyllactosamine metabolic process	NAS	11323440, 11356829
GO:0032580	Component	Golgi cisterna membrane	IEA
GO:0050656	Function	3'-phosphoadenosine 5'-phosphosulfate binding	NAS	11323440
GO:0050694	Function	Galactose 3-O-sulfotransferase activity	IBA
GO:0050694	Function	Galactose 3-O-sulfotransferase activity	IDA	11323440
GO:0050694	Function	Galactose 3-O-sulfotransferase activity	IMP	11356829
GO:0050698	Function	Proteoglycan sulfotransferase activity	NAS	11323440

MIM	HGNC	e!Ensembl
608234	24144	ENSG00000175229

Q96A11

Protein name

Galactose-3-O-sulfotransferase 3 (Gal3ST-3) (EC 2.8.2.-) (Beta-galactose-3-O-sulfotransferase 3) (Gal3ST3) (Gal-beta-1, 3-GalNAc 3'-sulfotransferase 3)

Protein function

Transfers a sulfate to position 3 of non-reducing beta-galactosyl residues in N-glycans and core2-branched O-glycans. Has high activity towards Gal-beta-1,4-GlcNAc, Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc and lower activity towards Gal-beta-1,3(Fuc-al

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06990	Gal-3-0_sulfotr	1 → 399	Galactose-3-O-sulfotransferase	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in thyroid, brain, kidney, heart and spinal cord. {ECO:0000269|PubMed:11323440, ECO:0000269|PubMed:11356829}.

Sequence

MPPILQRLQQATKMMSRRKILLLVLGCSTVSLLIHQGAQLSWYPKLFPLSCPPLRNSPPR
PKHMTVAFLKTHKTAGTTVQNILFRFAERHNLTVALPHPSCEHQFCYPRNFSAHFVHPAT
RPPHVLASHLRFDRAELERLMPPSTVYVTILREPAAMFESLFSYYNQYCPAFRRVPNASL
EAFLRAPEAYYRAGEHFAMFAHNTLAYDLGGDNERSPRDDAAYLAGLIRQVEEVFSLVMI
AEYFDESLVLLRRLLAWDLDDVLYAKLNARAASSRLAAIPAALARAARTWNALDAGLYDH
FNATFWRHVARAGRACVEREARELREARQRLLRRCFGDEPLLRPAAQIRTKQLQPWQPSR
KVDIMGYDLPGGGAGPATEACLKLAMPEVQYSNYLLRKQKRRGGARARPEPVLDNPPPRP
IRVLPRGPQGP

Sequence length

431

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AUTISM SPECTRUM DISORDER	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (8)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Ankylosing spondylitis	Ankylosing Spondylitis	GWASCAT_DG	26974007		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholangitis, Sclerosing	Cholangitis	GWASCAT_DG	26974007		★★★★★ ★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	GWASCAT_DG	26192919, 26974007		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	27322736		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	27322736		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	27322736	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Psoriasis	Psoriasis	GWASCAT_DG	26974007		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ulcerative Colitis	Ulcerative colitis	GWASCAT_DG	26974007		★★★★★ ★☆☆☆☆ Found in Text Mining only

GAL3ST3 (galactose-3-O-sulfotransferase 3)