Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	8896
Gene name	BUD31 spliceosome associated protein
Gene symbol	BUD31
Synonyms (NCBI Gene)	Cwc14EDG-2EDG2G10YCR063WfSAP17
Chromosome	7
Chromosome location	7q22.1

Show/Hide all (55)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020651	hsa-miR-155-5p	Proteomics	18668040
MIRT029348	hsa-miR-26b-5p	Microarray	19088304
MIRT441091	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT441091	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT827723	hsa-miR-2277-3p	CLIP-seq
MIRT827724	hsa-miR-2355-5p	CLIP-seq
MIRT827725	hsa-miR-2861	CLIP-seq
MIRT827726	hsa-miR-3181	CLIP-seq
MIRT827727	hsa-miR-3614-3p	CLIP-seq
MIRT827728	hsa-miR-3914	CLIP-seq
MIRT827729	hsa-miR-3976	CLIP-seq
MIRT827730	hsa-miR-4297	CLIP-seq
MIRT827731	hsa-miR-4514	CLIP-seq
MIRT827732	hsa-miR-4651	CLIP-seq
MIRT827733	hsa-miR-4692	CLIP-seq
MIRT827734	hsa-miR-486-3p	CLIP-seq
MIRT827735	hsa-miR-520d-5p	CLIP-seq
MIRT827736	hsa-miR-524-5p	CLIP-seq
MIRT827737	hsa-miR-542-3p	CLIP-seq
MIRT827738	hsa-miR-608	CLIP-seq
MIRT827739	hsa-miR-661	CLIP-seq
MIRT827740	hsa-miR-873	CLIP-seq
MIRT827741	hsa-miR-940	CLIP-seq
MIRT1944919	hsa-miR-1915	CLIP-seq
MIRT827725	hsa-miR-2861	CLIP-seq
MIRT1944920	hsa-miR-3179	CLIP-seq
MIRT827726	hsa-miR-3181	CLIP-seq
MIRT1944921	hsa-miR-3202	CLIP-seq
MIRT827728	hsa-miR-3914	CLIP-seq
MIRT1944922	hsa-miR-4476	CLIP-seq
MIRT827731	hsa-miR-4514	CLIP-seq
MIRT827732	hsa-miR-4651	CLIP-seq
MIRT827733	hsa-miR-4692	CLIP-seq
MIRT1944923	hsa-miR-4726-3p	CLIP-seq
MIRT827734	hsa-miR-486-3p	CLIP-seq
MIRT827735	hsa-miR-520d-5p	CLIP-seq
MIRT827736	hsa-miR-524-5p	CLIP-seq
MIRT827737	hsa-miR-542-3p	CLIP-seq
MIRT827738	hsa-miR-608	CLIP-seq
MIRT1944924	hsa-miR-639	CLIP-seq
MIRT827739	hsa-miR-661	CLIP-seq
MIRT1944925	hsa-miR-720	CLIP-seq
MIRT827740	hsa-miR-873	CLIP-seq
MIRT827741	hsa-miR-940	CLIP-seq
MIRT827723	hsa-miR-2277-3p	CLIP-seq
MIRT827724	hsa-miR-2355-5p	CLIP-seq
MIRT827725	hsa-miR-2861	CLIP-seq
MIRT827726	hsa-miR-3181	CLIP-seq
MIRT827727	hsa-miR-3614-3p	CLIP-seq
MIRT827729	hsa-miR-3976	CLIP-seq
MIRT827730	hsa-miR-4297	CLIP-seq
MIRT827734	hsa-miR-486-3p	CLIP-seq
MIRT827735	hsa-miR-520d-5p	CLIP-seq
MIRT827736	hsa-miR-524-5p	CLIP-seq
MIRT827739	hsa-miR-661	CLIP-seq

Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000398	Process	MRNA splicing, via spliceosome	IBA
GO:0000398	Process	MRNA splicing, via spliceosome	IDA	28076346
GO:0000785	Component	Chromatin	IDA	25091737
GO:0003713	Function	Transcription coactivator activity	IDA	25091737
GO:0005515	Function	Protein binding	IPI	25091737, 25416956, 32296183
GO:0005634	Component	Nucleus	IDA	28076346
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	7841202
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IBA
GO:0005681	Component	Spliceosomal complex	IEA
GO:0005813	Component	Centrosome	IDA
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0015630	Component	Microtubule cytoskeleton	IDA
GO:0016922	Function	Nuclear receptor binding	IDA	25091737
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0071007	Component	U2-type catalytic step 2 spliceosome	IDA	28076346

MIM	HGNC	e!Ensembl
603477	29629	ENSG00000106245

P41223

Protein name

Protein BUD31 homolog (Protein EDG-2) (Protein G10 homolog)

Protein function

Involved in the pre-mRNA splicing process (PubMed:28076346, PubMed:28502770). May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity (PubMed:25091737). {ECO:0000269|PubMed:28076346, ECO:0000269|PubM

PDB

4OED , 4OH6 , 4OKB , 5MQF , 5XJC , 5YZG , 5Z56 , 5Z57 , 6FF4 , 6FF7 , 6ICZ , 6ID0 , 6ID1 , 6QDV , 6ZYM , 7AAV , 7ABF , 7ABG , 7ABI , 7QTT , 7W59 , 7W5A , 7W5B , 8C6J , 8CH6 , 8I0P , 8I0R , 8I0S , 8I0T , 8I0U , 8I0V , 8I0W , 8Q7N , 8QO9 , 8RO2 , 9FMD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01125	G10	1 → 144	G10 protein	Domain

Tissue specificity

TISSUE SPECIFICITY: Detected in epithelial and stromal cells in benign prostate hyperplasia tissue (at protein level). {ECO:0000269|PubMed:25091737}.

Sequence

MPKVKRSRKAPPDGWELIEPTLDELDQKMREAETEPHEGKRKVESLWPIFRIHHQKTRYI
FDLFYKRKAISRELYEYCIKEGYADKNLIAKWKKQGYENLCCLRCIQTRDTNFGTNCICR
VPKSKLEVGRIIECTHCGCRGCSG

Sequence length

144

Interactions

View interactions

	KEGG		Reactome
	Spliceosome		mRNA Splicing - Major Pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
NON-ALCOHOLIC FATTY LIVER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (19)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Carcinoma	Breast Carcinoma	BEFREE	18089805		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	31278301	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	10537322		★★★★★ ★☆☆☆☆ Found in Text Mining only
Charcot-Marie-Tooth Disease	Charcot-Marie-Tooth Disease	BEFREE	10384882		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cyanosis	Cyanosis	Pubtator	36867085	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	BEFREE	18325907, 18625619		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	29029500		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	10537322		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	31057123		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	11291053, 31278301		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	31278301		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mucocutaneous Lymph Node Syndrome	Kawasaki disease	GWASDB_DG	23677057		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	17671192		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthritis, Knee	Knee osteoarthritis	BEFREE	18325907		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	10961347		★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	10537322		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	36271053	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	31057123		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	31057123, 37047027	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only

BUD31 (BUD31 spliceosome associated protein)