Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	8872
Gene name	Cell division cycle 123
Gene symbol	CDC123
Synonyms (NCBI Gene)	C10orf7D123
Chromosome	10
Chromosome location	10p14-p13

Show/Hide all (67)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020104	hsa-miR-361-5p	Sequencing	20371350
MIRT027249	hsa-miR-101-3p	Sequencing	20371350
MIRT028390	hsa-miR-30a-5p	Proteomics	18668040
MIRT031400	hsa-miR-16-5p	Proteomics	18668040
MIRT043215	hsa-miR-324-5p	CLASH	23622248
MIRT039270	hsa-miR-671-5p	CLASH	23622248
MIRT036838	hsa-miR-877-3p	CLASH	23622248
MIRT036838	hsa-miR-877-3p	CLASH	23622248
MIRT036407	hsa-miR-1227-3p	CLASH	23622248
MIRT876762	hsa-miR-1257	CLIP-seq
MIRT876763	hsa-miR-125a-3p	CLIP-seq
MIRT876764	hsa-miR-1468	CLIP-seq
MIRT876765	hsa-miR-1470	CLIP-seq
MIRT876766	hsa-miR-2114	CLIP-seq
MIRT876767	hsa-miR-2355-5p	CLIP-seq
MIRT876768	hsa-miR-2964a-5p	CLIP-seq
MIRT876769	hsa-miR-3156-5p	CLIP-seq
MIRT876770	hsa-miR-3679-3p	CLIP-seq
MIRT876771	hsa-miR-4446-5p	CLIP-seq
MIRT876772	hsa-miR-4667-3p	CLIP-seq
MIRT876773	hsa-miR-4726-3p	CLIP-seq
MIRT876774	hsa-miR-4795-3p	CLIP-seq
MIRT876775	hsa-miR-4796-3p	CLIP-seq
MIRT876776	hsa-miR-548p	CLIP-seq
MIRT876777	hsa-miR-548t	CLIP-seq
MIRT876778	hsa-miR-562	CLIP-seq
MIRT876762	hsa-miR-1257	CLIP-seq
MIRT876763	hsa-miR-125a-3p	CLIP-seq
MIRT876764	hsa-miR-1468	CLIP-seq
MIRT876765	hsa-miR-1470	CLIP-seq
MIRT876766	hsa-miR-2114	CLIP-seq
MIRT876767	hsa-miR-2355-5p	CLIP-seq
MIRT876770	hsa-miR-3679-3p	CLIP-seq
MIRT1959802	hsa-miR-376a	CLIP-seq
MIRT1959803	hsa-miR-376b	CLIP-seq
MIRT1959804	hsa-miR-4422	CLIP-seq
MIRT876771	hsa-miR-4446-5p	CLIP-seq
MIRT876772	hsa-miR-4667-3p	CLIP-seq
MIRT876773	hsa-miR-4726-3p	CLIP-seq
MIRT876774	hsa-miR-4795-3p	CLIP-seq
MIRT876776	hsa-miR-548p	CLIP-seq
MIRT876778	hsa-miR-562	CLIP-seq
MIRT876762	hsa-miR-1257	CLIP-seq
MIRT876763	hsa-miR-125a-3p	CLIP-seq
MIRT2196849	hsa-miR-145	CLIP-seq
MIRT876764	hsa-miR-1468	CLIP-seq
MIRT876765	hsa-miR-1470	CLIP-seq
MIRT876766	hsa-miR-2114	CLIP-seq
MIRT876767	hsa-miR-2355-5p	CLIP-seq
MIRT876768	hsa-miR-2964a-5p	CLIP-seq
MIRT2196850	hsa-miR-3163	CLIP-seq
MIRT876770	hsa-miR-3679-3p	CLIP-seq
MIRT2196851	hsa-miR-3925-3p	CLIP-seq
MIRT2196852	hsa-miR-423-3p	CLIP-seq
MIRT876771	hsa-miR-4446-5p	CLIP-seq
MIRT876772	hsa-miR-4667-3p	CLIP-seq
MIRT2196853	hsa-miR-4712-5p	CLIP-seq
MIRT876773	hsa-miR-4726-3p	CLIP-seq
MIRT876774	hsa-miR-4795-3p	CLIP-seq
MIRT876775	hsa-miR-4796-3p	CLIP-seq
MIRT2196854	hsa-miR-515-5p	CLIP-seq
MIRT876776	hsa-miR-548p	CLIP-seq
MIRT876777	hsa-miR-548t	CLIP-seq
MIRT2196855	hsa-miR-574-3p	CLIP-seq
MIRT2196856	hsa-miR-766	CLIP-seq
MIRT2196857	hsa-miR-770-5p	CLIP-seq
MIRT2196858	hsa-miR-942	CLIP-seq

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000287	Function	Magnesium ion binding	IDA	37507029
GO:0005515	Function	Protein binding	IPI	28514442, 33961781, 35271311, 37507029
GO:0005524	Function	ATP binding	IDA	37507029
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	10942595
GO:0005737	Component	Cytoplasm	IEA
GO:0006457	Process	Protein folding	IEA
GO:0044183	Function	Protein folding chaperone	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:1905143	Process	Eukaryotic translation initiation factor 2 complex assembly	IDA	37507029
GO:1905143	Process	Eukaryotic translation initiation factor 2 complex assembly	IMP	37507029

MIM	HGNC	e!Ensembl
617708	16827	ENSG00000151465

O75794

Protein name

Translation initiation factor eIF2 assembly protein (Cell division cycle protein 123 homolog) (Protein D123) (HT-1080) (PZ32)

Protein function

ATP-dependent protein-folding chaperone for the eIF2 complex (PubMed:35031321, PubMed:37507029). Binds to the gamma subunit of the eIF2 complex which allows the subunit to assemble with the alpha and beta subunits (By similarity). {ECO:0000250|U

PDB

8PHD , 8PHV

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07065	D123	14 → 314	D123	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes with the highest expression in testis. {ECO:0000269|PubMed:9683532}.

Sequence

MKKEHVLHCQFSAWYPFFRGVTIKSVILPLPQNVKDYLLDDGTLVVSGRDDPPTHSQPDS
DDEAEEIQWSDDENTATLTAPEFPEFATKVQEAINSLGGSVFPKLNWSAPRDAYWIAMNS
SLKCKTLSDIFLLFKSSDFITRDFTQPFIHCTDDSPDPCIEYELVLRKWCELIPGAEFRC
FVKENKLIGISQRDYTQYYDHISKQKEEIRRCIQDFFKKHIQYKFLDEDFVFDIYRDSRG
KVWLIDFNPFGEVTDSLLFTWEELISENNLNGDFSEVDAQEQDSPAFRCTNSEVTVQPSP
YLSYRLPKDFVDLSTGEDAHKLIDFLKLKRNQQEDD

Sequence length

336

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (17)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Adrenocortical carcinoma, hereditary	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETIC EYE DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETIC NEUROPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETIC RETINOPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STROKE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (18)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	30396106		★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Obstructive Airway Disease	Chronic Obstructive Pulmonary Disease	GWASCAT_DG	30804561		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	18567820, 19833888, 24135527		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	18567820, 19833888, 24135527		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diabetes Mellitus	Diabetes mellitus	Pubtator	18567820, 19833888, 24135527, 33479058	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	18567820, 19833888, 22923468, 22961080, 24637646, 27281091, 29412141, 33706321	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	18567820, 19247373, 19833888, 21909839, 25839936, 28079868		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	GWASDB_DG	22158537		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	GWASCAT_DG	31118516		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fibrosarcoma	Fibrosarcoma	BEFREE	10591631, 11774035, 12492372, 12606037, 1400481, 15486970, 17999771, 21437769, 295042, 648198, 9728747		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glaucoma Open Angle	Open angle glaucoma	Pubtator	9497264	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Immunologic Deficiency Syndromes	Immunologic Deficiency Syndromes	BEFREE	29273518		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	17520257		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver neoplasms	Liver neoplasms	BEFREE	17520257		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	30396106		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	11774035, 12492372, 17520257, 29273518		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	18567820	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	30396106		★★★★★ ★☆☆☆☆ Found in Text Mining only

CDC123 (cell division cycle 123)