Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	8859
Gene name	Winged helix repair factor 1
Gene symbol	WHR1
Synonyms (NCBI Gene)	D6S60D6S60EG11HLA-RP1RP1STK19TWH19
Chromosome	6
Chromosome location	6p21.33

193

Show/Hide all (193)

miRTarBase ID	miRNA	Experiments	Reference
MIRT044241	hsa-miR-29c-3p	CLASH	23622248
MIRT1397463	hsa-miR-1271	CLIP-seq
MIRT1397464	hsa-miR-15a	CLIP-seq
MIRT1397465	hsa-miR-15b	CLIP-seq
MIRT1397466	hsa-miR-16	CLIP-seq
MIRT1397467	hsa-miR-182	CLIP-seq
MIRT1397468	hsa-miR-195	CLIP-seq
MIRT1397469	hsa-miR-2467-3p	CLIP-seq
MIRT1397470	hsa-miR-3143	CLIP-seq
MIRT1397471	hsa-miR-424	CLIP-seq
MIRT1397472	hsa-miR-4256	CLIP-seq
MIRT1397473	hsa-miR-4257	CLIP-seq
MIRT1397474	hsa-miR-4274	CLIP-seq
MIRT1397475	hsa-miR-4514	CLIP-seq
MIRT1397476	hsa-miR-4692	CLIP-seq
MIRT1397477	hsa-miR-4704-3p	CLIP-seq
MIRT1397478	hsa-miR-497	CLIP-seq
MIRT1397479	hsa-miR-513a-5p	CLIP-seq
MIRT1397480	hsa-miR-590-3p	CLIP-seq
MIRT1397481	hsa-miR-96	CLIP-seq
MIRT1397464	hsa-miR-15a	CLIP-seq
MIRT1397465	hsa-miR-15b	CLIP-seq
MIRT1397466	hsa-miR-16	CLIP-seq
MIRT1397468	hsa-miR-195	CLIP-seq
MIRT1397471	hsa-miR-424	CLIP-seq
MIRT1397474	hsa-miR-4274	CLIP-seq
MIRT1397482	hsa-miR-4470	CLIP-seq
MIRT1397483	hsa-miR-4645-5p	CLIP-seq
MIRT1397484	hsa-miR-4673	CLIP-seq
MIRT1397477	hsa-miR-4704-3p	CLIP-seq
MIRT1397485	hsa-miR-4742-5p	CLIP-seq
MIRT1397478	hsa-miR-497	CLIP-seq
MIRT2341323	hsa-miR-1226	CLIP-seq
MIRT2341324	hsa-miR-1272	CLIP-seq
MIRT2341325	hsa-miR-1277	CLIP-seq
MIRT1397464	hsa-miR-15a	CLIP-seq
MIRT1397465	hsa-miR-15b	CLIP-seq
MIRT1397466	hsa-miR-16	CLIP-seq
MIRT1397468	hsa-miR-195	CLIP-seq
MIRT2341326	hsa-miR-197	CLIP-seq
MIRT2341327	hsa-miR-205	CLIP-seq
MIRT2341328	hsa-miR-28-5p	CLIP-seq
MIRT2341329	hsa-miR-3123	CLIP-seq
MIRT2341330	hsa-miR-3133	CLIP-seq
MIRT2341331	hsa-miR-3139	CLIP-seq
MIRT2341332	hsa-miR-3150b-3p	CLIP-seq
MIRT2341333	hsa-miR-3160-3p	CLIP-seq
MIRT2341334	hsa-miR-3908	CLIP-seq
MIRT2341335	hsa-miR-3921	CLIP-seq
MIRT2341336	hsa-miR-3925-5p	CLIP-seq
MIRT2341337	hsa-miR-412	CLIP-seq
MIRT1397471	hsa-miR-424	CLIP-seq
MIRT1397474	hsa-miR-4274	CLIP-seq
MIRT2341338	hsa-miR-4290	CLIP-seq
MIRT2341339	hsa-miR-4462	CLIP-seq
MIRT1397482	hsa-miR-4470	CLIP-seq
MIRT1397483	hsa-miR-4645-5p	CLIP-seq
MIRT2341340	hsa-miR-4649-3p	CLIP-seq
MIRT2341341	hsa-miR-4653-5p	CLIP-seq
MIRT2341342	hsa-miR-4663	CLIP-seq
MIRT2341343	hsa-miR-4667-3p	CLIP-seq
MIRT1397484	hsa-miR-4673	CLIP-seq
MIRT2341344	hsa-miR-4689	CLIP-seq
MIRT1397477	hsa-miR-4704-3p	CLIP-seq
MIRT2341345	hsa-miR-4714-5p	CLIP-seq
MIRT2341346	hsa-miR-4733-3p	CLIP-seq
MIRT1397485	hsa-miR-4742-5p	CLIP-seq
MIRT2341347	hsa-miR-4784	CLIP-seq
MIRT1397478	hsa-miR-497	CLIP-seq
MIRT2341348	hsa-miR-548b-3p	CLIP-seq
MIRT2341349	hsa-miR-708	CLIP-seq
MIRT2635296	hsa-miR-10a	CLIP-seq
MIRT2635297	hsa-miR-10b	CLIP-seq
MIRT2635298	hsa-miR-1178	CLIP-seq
MIRT2635299	hsa-miR-1224-3p	CLIP-seq
MIRT2341323	hsa-miR-1226	CLIP-seq
MIRT2635300	hsa-miR-1260	CLIP-seq
MIRT2635301	hsa-miR-1260b	CLIP-seq
MIRT1397463	hsa-miR-1271	CLIP-seq
MIRT2341325	hsa-miR-1277	CLIP-seq
MIRT2635302	hsa-miR-1280	CLIP-seq
MIRT2635303	hsa-miR-1301	CLIP-seq
MIRT2635304	hsa-miR-149	CLIP-seq
MIRT2635305	hsa-miR-150	CLIP-seq
MIRT2341326	hsa-miR-197	CLIP-seq
MIRT2341327	hsa-miR-205	CLIP-seq
MIRT2635306	hsa-miR-2114	CLIP-seq
MIRT2635307	hsa-miR-2355-5p	CLIP-seq
MIRT2341328	hsa-miR-28-5p	CLIP-seq
MIRT2635308	hsa-miR-29a	CLIP-seq
MIRT2635309	hsa-miR-29b	CLIP-seq
MIRT2635310	hsa-miR-29c	CLIP-seq
MIRT2635311	hsa-miR-3065-3p	CLIP-seq
MIRT2341329	hsa-miR-3123	CLIP-seq
MIRT2341330	hsa-miR-3133	CLIP-seq
MIRT2341331	hsa-miR-3139	CLIP-seq
MIRT2341332	hsa-miR-3150b-3p	CLIP-seq
MIRT2635312	hsa-miR-3157-5p	CLIP-seq
MIRT2341333	hsa-miR-3160-3p	CLIP-seq
MIRT2635313	hsa-miR-3202	CLIP-seq
MIRT2635314	hsa-miR-337-3p	CLIP-seq
MIRT2635315	hsa-miR-339-5p	CLIP-seq
MIRT2635316	hsa-miR-3614-3p	CLIP-seq
MIRT2635317	hsa-miR-3667-3p	CLIP-seq
MIRT2635318	hsa-miR-371-5p	CLIP-seq
MIRT2635319	hsa-miR-3919	CLIP-seq
MIRT2341335	hsa-miR-3921	CLIP-seq
MIRT2341336	hsa-miR-3925-5p	CLIP-seq
MIRT2341337	hsa-miR-412	CLIP-seq
MIRT2341338	hsa-miR-4290	CLIP-seq
MIRT2635320	hsa-miR-4297	CLIP-seq
MIRT2635321	hsa-miR-4421	CLIP-seq
MIRT2635322	hsa-miR-4436b-3p	CLIP-seq
MIRT2635323	hsa-miR-4436b-5p	CLIP-seq
MIRT2341339	hsa-miR-4462	CLIP-seq
MIRT2635324	hsa-miR-4533	CLIP-seq
MIRT1397483	hsa-miR-4645-5p	CLIP-seq
MIRT2341340	hsa-miR-4649-3p	CLIP-seq
MIRT2341341	hsa-miR-4653-5p	CLIP-seq
MIRT2635325	hsa-miR-4660	CLIP-seq
MIRT2341342	hsa-miR-4663	CLIP-seq
MIRT2341343	hsa-miR-4667-3p	CLIP-seq
MIRT1397484	hsa-miR-4673	CLIP-seq
MIRT2341344	hsa-miR-4689	CLIP-seq
MIRT2635326	hsa-miR-4691-3p	CLIP-seq
MIRT2341345	hsa-miR-4714-5p	CLIP-seq
MIRT2635327	hsa-miR-4725-5p	CLIP-seq
MIRT2341346	hsa-miR-4733-3p	CLIP-seq
MIRT1397485	hsa-miR-4742-5p	CLIP-seq
MIRT2635328	hsa-miR-4761-5p	CLIP-seq
MIRT2341347	hsa-miR-4784	CLIP-seq
MIRT2635329	hsa-miR-4793-5p	CLIP-seq
MIRT2635330	hsa-miR-4797-5p	CLIP-seq
MIRT2635331	hsa-miR-498	CLIP-seq
MIRT2635332	hsa-miR-504	CLIP-seq
MIRT2635333	hsa-miR-5047	CLIP-seq
MIRT2341348	hsa-miR-548b-3p	CLIP-seq
MIRT2635334	hsa-miR-554	CLIP-seq
MIRT2635335	hsa-miR-587	CLIP-seq
MIRT2635336	hsa-miR-605	CLIP-seq
MIRT2341349	hsa-miR-708	CLIP-seq
MIRT2635337	hsa-miR-767-5p	CLIP-seq
MIRT1397481	hsa-miR-96	CLIP-seq
MIRT2635296	hsa-miR-10a	CLIP-seq
MIRT2635297	hsa-miR-10b	CLIP-seq
MIRT2635298	hsa-miR-1178	CLIP-seq
MIRT2635299	hsa-miR-1224-3p	CLIP-seq
MIRT2341323	hsa-miR-1226	CLIP-seq
MIRT2635300	hsa-miR-1260	CLIP-seq
MIRT2635301	hsa-miR-1260b	CLIP-seq
MIRT2341325	hsa-miR-1277	CLIP-seq
MIRT2635302	hsa-miR-1280	CLIP-seq
MIRT2635304	hsa-miR-149	CLIP-seq
MIRT2635305	hsa-miR-150	CLIP-seq
MIRT2341326	hsa-miR-197	CLIP-seq
MIRT2341327	hsa-miR-205	CLIP-seq
MIRT2635307	hsa-miR-2355-5p	CLIP-seq
MIRT2635308	hsa-miR-29a	CLIP-seq
MIRT2635309	hsa-miR-29b	CLIP-seq
MIRT2635310	hsa-miR-29c	CLIP-seq
MIRT2635311	hsa-miR-3065-3p	CLIP-seq
MIRT2341329	hsa-miR-3123	CLIP-seq
MIRT2341330	hsa-miR-3133	CLIP-seq
MIRT2635312	hsa-miR-3157-5p	CLIP-seq
MIRT2635313	hsa-miR-3202	CLIP-seq
MIRT2635314	hsa-miR-337-3p	CLIP-seq
MIRT2635315	hsa-miR-339-5p	CLIP-seq
MIRT2635316	hsa-miR-3614-3p	CLIP-seq
MIRT2635317	hsa-miR-3667-3p	CLIP-seq
MIRT2635318	hsa-miR-371-5p	CLIP-seq
MIRT2635319	hsa-miR-3919	CLIP-seq
MIRT2341336	hsa-miR-3925-5p	CLIP-seq
MIRT2341337	hsa-miR-412	CLIP-seq
MIRT2341338	hsa-miR-4290	CLIP-seq
MIRT2635320	hsa-miR-4297	CLIP-seq
MIRT2635321	hsa-miR-4421	CLIP-seq
MIRT2635322	hsa-miR-4436b-3p	CLIP-seq
MIRT2635323	hsa-miR-4436b-5p	CLIP-seq
MIRT2341339	hsa-miR-4462	CLIP-seq
MIRT2635324	hsa-miR-4533	CLIP-seq
MIRT2341343	hsa-miR-4667-3p	CLIP-seq
MIRT2635326	hsa-miR-4691-3p	CLIP-seq
MIRT2635327	hsa-miR-4725-5p	CLIP-seq
MIRT2341346	hsa-miR-4733-3p	CLIP-seq
MIRT2635328	hsa-miR-4761-5p	CLIP-seq
MIRT2635329	hsa-miR-4793-5p	CLIP-seq
MIRT2635330	hsa-miR-4797-5p	CLIP-seq
MIRT2635331	hsa-miR-498	CLIP-seq
MIRT2635332	hsa-miR-504	CLIP-seq
MIRT2341348	hsa-miR-548b-3p	CLIP-seq
MIRT2635335	hsa-miR-587	CLIP-seq
MIRT2635336	hsa-miR-605	CLIP-seq
MIRT2635337	hsa-miR-767-5p	CLIP-seq

Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IEA
GO:0003690	Function	Double-stranded DNA binding	IDA	38252411, 38890355
GO:0003723	Function	RNA binding	IEA
GO:0003725	Function	Double-stranded RNA binding	IDA	38890355
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	32531245, 38252411
GO:0005515	Function	Protein binding	IPI	33961781
GO:0005634	Component	Nucleus	IDA	32531245, 38252411
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	9812991
GO:0005737	Component	Cytoplasm	IDA	32531245
GO:0005737	Component	Cytoplasm	IEA
GO:0006281	Process	DNA repair	IEA
GO:0006974	Process	DNA damage response	IEA
GO:0016607	Component	Nuclear speck	IDA
GO:0042803	Function	Protein homodimerization activity	IDA	38252411
GO:0046579	Process	Positive regulation of Ras protein signal transduction	IBA
GO:0046579	Process	Positive regulation of Ras protein signal transduction	IDA	30712867
GO:1903518	Process	Positive regulation of single strand break repair	IMP	38252411

MIM	HGNC	e!Ensembl
604977	11398	ENSG00000204344

P49842

Protein name

Winged helix repair factor 1 (Inactive serine/threonine-protein kinase 19) (Protein G11) (Protein RP1) (Tandem winged helix protein formerly known as STK19)

Protein function

DNA-binding protein which is required for efficient transcription-coupled nucleotide excision repair (TC-NER) (PubMed:38252411, PubMed:38890355, PubMed:39353615, PubMed:39547223, PubMed:39547228, PubMed:39547229). Acts as part of a TC-NER comple

PDB

7XRB , 8YCM , 9BZ0 , 9ER2 , 9FD2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10494	Stk19	147 → 365	Serine-threonine protein kinase 19	Family

Tissue specificity

TISSUE SPECIFICITY: Monocytes, hepatocytes, epithelial cells, T- and B-lymphocytes. {ECO:0000269|PubMed:8012361}.

Sequence

MQKWFSAFDDAIIQRQWRANPSRGGGGVSFTKEVDTNVATGAPPRRQRVPGRACPWREPI
RGRRGARPGGGDAGGTPGETVRHCSAPEDPIFRFSSLHSYPFPGTIKSRDMSWKRHHLIP
ETFGVKRRRKRGPVESDPLRGEPGSARAAVSELMQLFPRGLFEDALPPIVLRSQVYSLVP
DRTVADRQLKELQEQGEIRIVQLGFDLDAHGIIFTEDYRTRVCDCVLKACDGRPYAGAVQ
KFLASVLPACGDLSFQQDQMTQTFGFRDSEITHLVNAGVLTVRDAGSWWLAVPGAGRFIK
YFVKGRQAVLSMVRKAKYRELLLSELLGRRAPVVVRLGLTYHVHDLIGAQLVDCISTTSG
TLLRLPET

Sequence length

368

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (16)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATROPHIC MACULAR DEGENERATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BULLOUS PEMPHIGOID	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, BASAL CELL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CERVICAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CERVICAL CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTROESOPHAGEAL REFLUX DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPOTHYROIDISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MEMBRANOUS GLOMERULONEPHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SARCOIDOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UPPER AERODIGESTIVE TRACT NEOPLASM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
URTICARIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
WET MACULAR DEGENERATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (23)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	GWASDB_DG	19836008		★★★★★ ★☆☆☆☆ Found in Text Mining only
Age related macular degeneration	Age-related macular degeneration	GWASCAT_DG	26691988		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Basal Cell	Carcinoma	CTD_human_DG	26950094		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cutaneous Melanoma	Melanoma	CLINVAR_DG	26619011		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus	GWASDB_DG	17632545		★★★★★ ★☆☆☆☆ Found in Text Mining only
Exudative age-related macular degeneration	Exudative Macular Degeneration	GWASCAT_DG	26691988		★★★★★ ★☆☆☆☆ Found in Text Mining only
exudative macular degeneration	Exudative macular degeneration	GWASCAT_DG	26691988		★★★★★ ★☆☆☆☆ Found in Text Mining only
Geographic Atrophy	Geographic Atrophy	GWASCAT_DG	26691988		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Systemic	Lupus Erythematosus	GWASDB_DG	24871463		★★★★★ ★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	GWASCAT_DG	30626913		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant neoplasm of lung	Lung Cancer	GWASDB_DG	22899653		★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	22817889, 32531245	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	30509087, 30712867		★★★★★ ★☆☆☆☆ Found in Text Mining only
Membranous glomerulonephritis	Membranous Glomerulonephritis	GWASCAT_DG	21323541		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Multiple Sclerosis	Multiple Sclerosis	GWASDB_DG	20598377		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myasthenia Gravis	Myasthenia Gravis	GWASDB_DG	23055271		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pemphigus Vulgaris	Pemphigus Vulgaris	GWASDB_DG	22437316		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	GWASDB_DG	17804836, 19503088, 21156761		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoidosis	Sarcoidosis	GWASCAT_DG	26651848		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	GWASCAT_DG	30285260, 30626913		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	Pubtator	30626913	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Squamous cell carcinoma of skin	Skin carcinoma	CLINVAR_DG	26619011		★★★★★ ★☆☆☆☆ Found in Text Mining only
Systemic Scleroderma	Scleroderma	GWASDB_DG	20383147		★★★★★ ★☆☆☆☆ Found in Text Mining only

WHR1 (winged helix repair factor 1)