Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	8844
Gene name	Kinase suppressor of ras 1
Gene symbol	KSR1
Synonyms (NCBI Gene)	KSRRSU2
Chromosome	17
Chromosome location	17q11.2

Show/Hide all (64)

miRTarBase ID	miRNA	Experiments	Reference
MIRT437886	hsa-miR-378a-3p	Luciferase reporter assay	23625957
MIRT437886	hsa-miR-378a-3p	Luciferase reporter assay	23625957
MIRT441642	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT441641	hsa-miR-140-3p	PAR-CLIP	22100165
MIRT441640	hsa-miR-4286	PAR-CLIP	22100165
MIRT440348	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440348	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT441642	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT441641	hsa-miR-140-3p	PAR-CLIP	22100165
MIRT441640	hsa-miR-4286	PAR-CLIP	22100165
MIRT1102163	hsa-miR-1915	CLIP-seq
MIRT1102164	hsa-miR-198	CLIP-seq
MIRT1102165	hsa-miR-2278	CLIP-seq
MIRT1102166	hsa-miR-3921	CLIP-seq
MIRT1102167	hsa-miR-4251	CLIP-seq
MIRT1102168	hsa-miR-4274	CLIP-seq
MIRT1102169	hsa-miR-4329	CLIP-seq
MIRT1102170	hsa-miR-4476	CLIP-seq
MIRT1102171	hsa-miR-450b-3p	CLIP-seq
MIRT1102172	hsa-miR-4519	CLIP-seq
MIRT1102173	hsa-miR-4524	CLIP-seq
MIRT1102174	hsa-miR-4653-5p	CLIP-seq
MIRT1102175	hsa-miR-4654	CLIP-seq
MIRT1102176	hsa-miR-4704-3p	CLIP-seq
MIRT1102177	hsa-miR-4713-3p	CLIP-seq
MIRT1102178	hsa-miR-4726-3p	CLIP-seq
MIRT1102179	hsa-miR-4769-5p	CLIP-seq
MIRT1102180	hsa-miR-494	CLIP-seq
MIRT1102181	hsa-miR-638	CLIP-seq
MIRT1102182	hsa-miR-665	CLIP-seq
MIRT1102183	hsa-miR-769-3p	CLIP-seq
MIRT1102184	hsa-miR-935	CLIP-seq
MIRT2027853	hsa-miR-224	CLIP-seq
MIRT2027854	hsa-miR-298	CLIP-seq
MIRT2027855	hsa-miR-33a	CLIP-seq
MIRT2027856	hsa-miR-33b	CLIP-seq
MIRT2027857	hsa-miR-3664-3p	CLIP-seq
MIRT2027858	hsa-miR-4433	CLIP-seq
MIRT2027859	hsa-miR-4459	CLIP-seq
MIRT1102173	hsa-miR-4524	CLIP-seq
MIRT2027860	hsa-miR-4768-3p	CLIP-seq
MIRT2027861	hsa-miR-4795-3p	CLIP-seq
MIRT2027862	hsa-miR-657	CLIP-seq
MIRT2259120	hsa-miR-1301	CLIP-seq
MIRT2259121	hsa-miR-219-2-3p	CLIP-seq
MIRT2027853	hsa-miR-224	CLIP-seq
MIRT2027854	hsa-miR-298	CLIP-seq
MIRT2027855	hsa-miR-33a	CLIP-seq
MIRT2027856	hsa-miR-33b	CLIP-seq
MIRT1102173	hsa-miR-4524	CLIP-seq
MIRT2259122	hsa-miR-4687-5p	CLIP-seq
MIRT2259123	hsa-miR-4690-3p	CLIP-seq
MIRT2259124	hsa-miR-5047	CLIP-seq
MIRT2259125	hsa-miR-579	CLIP-seq
MIRT2259126	hsa-miR-602	CLIP-seq
MIRT2390047	hsa-miR-141	CLIP-seq
MIRT2390048	hsa-miR-200a	CLIP-seq
MIRT2390049	hsa-miR-4661-5p	CLIP-seq
MIRT2390050	hsa-miR-4704-5p	CLIP-seq
MIRT2259126	hsa-miR-602	CLIP-seq
MIRT2259120	hsa-miR-1301	CLIP-seq
MIRT2259123	hsa-miR-4690-3p	CLIP-seq
MIRT2259124	hsa-miR-5047	CLIP-seq
MIRT2259125	hsa-miR-579	CLIP-seq

Show/Hide all (39)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	IEA
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IBA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005078	Function	MAP-kinase scaffold activity	ISS
GO:0005515	Function	Protein binding	IDA	22572157
GO:0005515	Function	Protein binding	IPI	11909642, 20679487, 22752157, 24929361, 27086506, 29433126, 31980649, 32707033, 35271311, 36931259, 37045861
GO:0005524	Function	ATP binding	IDA	29433126
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA	22572157
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IEA
GO:0007265	Process	Ras protein signal transduction	IBA
GO:0007265	Process	Ras protein signal transduction	ISS
GO:0007265	Process	Ras protein signal transduction	NAS	8521512
GO:0008270	Function	Zinc ion binding	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IDA	22572157
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0032587	Component	Ruffle membrane	IEA
GO:0032991	Component	Protein-containing complex	IDA	22572157
GO:0042127	Process	Regulation of cell population proliferation	ISS
GO:0042995	Component	Cell projection	IEA
GO:0043405	Process	Regulation of MAP kinase activity	ISS
GO:0043410	Process	Positive regulation of MAPK cascade	IDA	29433126
GO:0043410	Process	Positive regulation of MAPK cascade	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0071889	Function	14-3-3 protein binding	IDA	29433126
GO:0106310	Function	Protein serine kinase activity	IEA

MIM	HGNC	e!Ensembl
601132	6465	ENSG00000141068

Q8IVT5

Protein name

Kinase suppressor of Ras 1 (EC 2.7.11.1)

Protein function

Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteri

PDB

5VYK , 7JUW , 7JUX , 7JUY , 7JUZ , 7JV0 , 7JV1 , 9AXH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13543	SAM_KSR1	41 → 168	SAM like domain present in kinase suppressor RAS 1	Domain
PF07714	PK_Tyr_Ser-Thr	613 → 877	Protein tyrosine and serine/threonine kinase	Domain

Sequence

MDRAALRAAAMGEKKEGGGGGDAAAAEGGAGAAASRALQQCGQLQKLIDISIGSLRGLRT
KCAVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVAPGERTPELNSYPRFSDWLYTFNVRP
EVVQEIPRDLTLDALLEMNEAKVKETLRRCGASGDECGRLQYALTCLRKVTGLGGEHKED
SSWSSLDARRESGSGPSTDTLSAASLPWPPGSSQLGRAGNSAQGPRSISVSALPASDSPT
PSFSEGLSDTCIPLHASGRLTPRALHSFITPPTTPQLRRHTKLKPPRTPPPPSRKVFQLL
PSFPTLTRSKSHESQLGNRIDDVSSMRFDLSHGSPQMVRRDIGLSVTHRFSTKSWLSQVC
HVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPLTRLRRTESVPSDINNPVDRAAE
PHFGTLPKALTKKEHPPAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSPG
QRDSRFNFPAAYFIHHRQQFIFPVPSAGHCWKCLLIAESLKENAFNISAFAHAAPLPEAA
DGTRLDDQPKADVLEAHEAEAEEPEAGKSEAEDDEDEVDDLPSSRRPWRGPISRKASQTS
VYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISGVVREGRRENQLKLSHDWLCYLA
PEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLKNQAAEASIWQIGSGEGMK
RVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEKLPKLNRRLSHPGHFWKSADIN
SSKVVPRFERFGLGVLESSNPKM

Sequence length

923

Interactions

View interactions

	KEGG		Reactome
	Ras signaling pathway C-type lectin receptor signaling pathway Tuberculosis		RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ANKYLOSING SPONDYLITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCLEROSING CHOLANGITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ULCERATIVE COLITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (40)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Ankylosing spondylitis	Ankylosing Spondylitis	GWASCAT_DG	26974007		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Arthritis Juvenile	Juvenile arthritis	Pubtator	24886659	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	Pubtator	32512817	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	24129246, 24909178, 25287073, 26022350		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	15684389, 24129246, 26022350	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	21435442	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	24909178, 26022350		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	18723074, 20600897		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholangitis, Sclerosing	Cholangitis	GWASCAT_DG	26974007		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic neoplasm	Pubtator	27273865	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	26673620, 29980571		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal Neoplasms	BEFREE	27273865		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	27273865, 33970103	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital Hypothyroidism	Congenital Hypothyroidism	BEFREE	6574136		★★★★★ ★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	GWASDB_DG	23128233		★★★★★ ★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	GWASCAT_DG	23128233, 26192919, 26974007, 28067908		★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	21435442	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Epithelial ovarian cancer	Ovarian cancer	BEFREE	20600897		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypothyroidism	Hypothyroidism	BEFREE	6574136		★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	GWASCAT_DG	26192919		★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory bowel disease	Pubtator	34758847	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Juvenile arthritis	Arthritis	BEFREE	24886659		★★★★★ ★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	16732322		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	38511641	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	24129246, 24909178, 25287073, 26022350		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	12960962, 29596465		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of thyroid	Thyroid cancer	BEFREE	25608512		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	12960962, 25608512, 26673620, 27422710, 27556948, 28333549		★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	37511580	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	12361724, 18719367, 20553947, 24909178, 25608512, 26022350, 26549023, 26673620, 27273865, 29596465		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurilemmoma	Neurilemmoma	BEFREE	26549023		★★★★★ ★☆☆☆☆ Found in Text Mining only
Oligoarticular Juvenile Idiopathic Arthritis	Oligoarticular Arthritis	BEFREE	24886659		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	12960962, 29596465		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Carcinoma	Pancreatic cancer	Pubtator	26022350	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasm	Pancreatic Neoplasm	LHGDN	18719367		★★★★★ ★☆☆☆☆ Found in Text Mining only
Papillary thyroid carcinoma	Papillary thyroid carcinoma	BEFREE	25608512		★★★★★ ★☆☆☆☆ Found in Text Mining only
Psoriasis	Psoriasis	GWASCAT_DG	26974007		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid carcinoma	Thyroid Carcinoma	BEFREE	25608512		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasm	Thyroid Neoplasm	BEFREE	25608512		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ulcerative Colitis	Ulcerative colitis	GWASCAT_DG	26974007		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

KSR1 (kinase suppressor of ras 1)