Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	8833
Gene name	Guanine monophosphate synthase
Gene symbol	GMPS
Synonyms (NCBI Gene)	GATD7
Chromosome	3
Chromosome location	3q25.31
Summary	In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting

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Show/Hide all (186)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020772	hsa-miR-155-5p	Proteomics	18668040
MIRT051523	hsa-let-7e-5p	CLASH	23622248
MIRT050438	hsa-miR-23a-3p	CLASH	23622248
MIRT040905	hsa-miR-18a-3p	CLASH	23622248
MIRT716114	hsa-miR-5586-5p	HITS-CLIP	19536157
MIRT716113	hsa-miR-4778-5p	HITS-CLIP	19536157
MIRT716112	hsa-miR-4267	HITS-CLIP	19536157
MIRT716111	hsa-miR-136-5p	HITS-CLIP	19536157
MIRT716110	hsa-miR-3120-5p	HITS-CLIP	19536157
MIRT716109	hsa-miR-515-5p	HITS-CLIP	19536157
MIRT716108	hsa-miR-519e-5p	HITS-CLIP	19536157
MIRT716107	hsa-miR-6888-3p	HITS-CLIP	19536157
MIRT716106	hsa-miR-4743-3p	HITS-CLIP	19536157
MIRT706625	hsa-miR-4438	HITS-CLIP	21572407
MIRT706624	hsa-miR-4269	HITS-CLIP	21572407
MIRT706623	hsa-miR-6715b-5p	HITS-CLIP	21572407
MIRT706622	hsa-miR-4740-3p	HITS-CLIP	21572407
MIRT706621	hsa-miR-4258	HITS-CLIP	21572407
MIRT706620	hsa-miR-1292-3p	HITS-CLIP	21572407
MIRT706619	hsa-miR-6778-3p	HITS-CLIP	21572407
MIRT706618	hsa-miR-3199	HITS-CLIP	21572407
MIRT706617	hsa-miR-8052	HITS-CLIP	21572407
MIRT706616	hsa-miR-365a-5p	HITS-CLIP	21572407
MIRT706615	hsa-miR-365b-5p	HITS-CLIP	21572407
MIRT706614	hsa-miR-5095	HITS-CLIP	21572407
MIRT706613	hsa-miR-7151-3p	HITS-CLIP	21572407
MIRT630462	hsa-miR-4714-5p	HITS-CLIP	23824327
MIRT630461	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT630460	hsa-miR-3921	HITS-CLIP	23824327
MIRT630459	hsa-miR-4653-5p	HITS-CLIP	23824327
MIRT630458	hsa-miR-4251	HITS-CLIP	23824327
MIRT630457	hsa-miR-4329	HITS-CLIP	23824327
MIRT630456	hsa-miR-6761-5p	HITS-CLIP	23824327
MIRT630455	hsa-miR-6089	HITS-CLIP	23824327
MIRT668075	hsa-miR-4284	HITS-CLIP	23824327
MIRT668074	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT668073	hsa-miR-1268a	HITS-CLIP	23824327
MIRT668072	hsa-miR-1268b	HITS-CLIP	23824327
MIRT630454	hsa-miR-7977	HITS-CLIP	23824327
MIRT668071	hsa-miR-6821-5p	HITS-CLIP	23824327
MIRT630462	hsa-miR-4714-5p	HITS-CLIP	23824327
MIRT630461	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT630460	hsa-miR-3921	HITS-CLIP	23824327
MIRT630459	hsa-miR-4653-5p	HITS-CLIP	23824327
MIRT630458	hsa-miR-4251	HITS-CLIP	23824327
MIRT630457	hsa-miR-4329	HITS-CLIP	23824327
MIRT630456	hsa-miR-6761-5p	HITS-CLIP	23824327
MIRT630455	hsa-miR-6089	HITS-CLIP	23824327
MIRT630454	hsa-miR-7977	HITS-CLIP	23824327
MIRT630462	hsa-miR-4714-5p	HITS-CLIP	23824327
MIRT630461	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT630460	hsa-miR-3921	HITS-CLIP	23824327
MIRT630459	hsa-miR-4653-5p	HITS-CLIP	23824327
MIRT630458	hsa-miR-4251	HITS-CLIP	23824327
MIRT630457	hsa-miR-4329	HITS-CLIP	23824327
MIRT630456	hsa-miR-6761-5p	HITS-CLIP	23824327
MIRT630455	hsa-miR-6089	HITS-CLIP	23824327
MIRT630454	hsa-miR-7977	HITS-CLIP	23824327
MIRT630462	hsa-miR-4714-5p	HITS-CLIP	23824327
MIRT630461	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT630460	hsa-miR-3921	HITS-CLIP	23824327
MIRT630459	hsa-miR-4653-5p	HITS-CLIP	23824327
MIRT630458	hsa-miR-4251	HITS-CLIP	23824327
MIRT630457	hsa-miR-4329	HITS-CLIP	23824327
MIRT630456	hsa-miR-6761-5p	HITS-CLIP	23824327
MIRT630455	hsa-miR-6089	HITS-CLIP	23824327
MIRT630454	hsa-miR-7977	HITS-CLIP	23824327
MIRT523508	hsa-miR-5680	PAR-CLIP	21572407
MIRT523507	hsa-miR-6890-5p	PAR-CLIP	21572407
MIRT523505	hsa-miR-4781-3p	PAR-CLIP	21572407
MIRT523506	hsa-miR-4716-5p	PAR-CLIP	21572407
MIRT523504	hsa-miR-193b-5p	PAR-CLIP	21572407
MIRT523503	hsa-miR-197-3p	PAR-CLIP	21572407
MIRT523502	hsa-miR-548s	PAR-CLIP	21572407
MIRT523500	hsa-miR-4701-5p	PAR-CLIP	21572407
MIRT523501	hsa-miR-588	PAR-CLIP	21572407
MIRT523499	hsa-miR-4435	PAR-CLIP	21572407
MIRT523498	hsa-miR-3187-3p	PAR-CLIP	21572407
MIRT523497	hsa-miR-3170	PAR-CLIP	21572407
MIRT523496	hsa-miR-6855-5p	PAR-CLIP	21572407
MIRT523495	hsa-miR-5096	PAR-CLIP	21572407
MIRT523508	hsa-miR-5680	PAR-CLIP	23446348
MIRT523507	hsa-miR-6890-5p	PAR-CLIP	23446348
MIRT523505	hsa-miR-4781-3p	PAR-CLIP	23446348
MIRT523506	hsa-miR-4716-5p	PAR-CLIP	23446348
MIRT523504	hsa-miR-193b-5p	PAR-CLIP	23446348
MIRT523503	hsa-miR-197-3p	PAR-CLIP	23446348
MIRT523502	hsa-miR-548s	PAR-CLIP	23446348
MIRT523500	hsa-miR-4701-5p	PAR-CLIP	23446348
MIRT523501	hsa-miR-588	PAR-CLIP	23446348
MIRT523499	hsa-miR-4435	PAR-CLIP	23446348
MIRT523498	hsa-miR-3187-3p	PAR-CLIP	23446348
MIRT523497	hsa-miR-3170	PAR-CLIP	23446348
MIRT523496	hsa-miR-6855-5p	PAR-CLIP	23446348
MIRT523495	hsa-miR-5096	PAR-CLIP	23446348
MIRT716114	hsa-miR-5586-5p	HITS-CLIP	19536157
MIRT716113	hsa-miR-4778-5p	HITS-CLIP	19536157
MIRT716112	hsa-miR-4267	HITS-CLIP	19536157
MIRT716111	hsa-miR-136-5p	HITS-CLIP	19536157
MIRT716110	hsa-miR-3120-5p	HITS-CLIP	19536157
MIRT716109	hsa-miR-515-5p	HITS-CLIP	19536157
MIRT716108	hsa-miR-519e-5p	HITS-CLIP	19536157
MIRT716107	hsa-miR-6888-3p	HITS-CLIP	19536157
MIRT716106	hsa-miR-4743-3p	HITS-CLIP	19536157
MIRT575447	hsa-miR-4438	HITS-CLIP	21572407
MIRT575446	hsa-miR-4269	HITS-CLIP	21572407
MIRT575444	hsa-miR-6715b-5p	HITS-CLIP	21572407
MIRT575445	hsa-miR-4740-3p	HITS-CLIP	21572407
MIRT575443	hsa-miR-4258	HITS-CLIP	21572407
MIRT575442	hsa-miR-1292-3p	HITS-CLIP	21572407
MIRT575441	hsa-miR-6778-3p	HITS-CLIP	21572407
MIRT575440	hsa-miR-3199	HITS-CLIP	21572407
MIRT575438	hsa-miR-8052	HITS-CLIP	21572407
MIRT575439	hsa-miR-365a-5p	HITS-CLIP	21572407
MIRT575437	hsa-miR-365b-5p	HITS-CLIP	21572407
MIRT575436	hsa-miR-5095	HITS-CLIP	21572407
MIRT575435	hsa-miR-7151-3p	HITS-CLIP	21572407
MIRT630462	hsa-miR-4714-5p	HITS-CLIP	23824327
MIRT630461	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT630460	hsa-miR-3921	HITS-CLIP	23824327
MIRT630459	hsa-miR-4653-5p	HITS-CLIP	23824327
MIRT630458	hsa-miR-4251	HITS-CLIP	23824327
MIRT630457	hsa-miR-4329	HITS-CLIP	23824327
MIRT630456	hsa-miR-6761-5p	HITS-CLIP	23824327
MIRT630455	hsa-miR-6089	HITS-CLIP	23824327
MIRT668075	hsa-miR-4284	HITS-CLIP	23824327
MIRT668074	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT668073	hsa-miR-1268a	HITS-CLIP	23824327
MIRT668072	hsa-miR-1268b	HITS-CLIP	23824327
MIRT630454	hsa-miR-7977	HITS-CLIP	23824327
MIRT668071	hsa-miR-6821-5p	HITS-CLIP	23824327
MIRT630462	hsa-miR-4714-5p	HITS-CLIP	23824327
MIRT630461	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT630460	hsa-miR-3921	HITS-CLIP	23824327
MIRT630459	hsa-miR-4653-5p	HITS-CLIP	23824327
MIRT630458	hsa-miR-4251	HITS-CLIP	23824327
MIRT630457	hsa-miR-4329	HITS-CLIP	23824327
MIRT630456	hsa-miR-6761-5p	HITS-CLIP	23824327
MIRT630455	hsa-miR-6089	HITS-CLIP	23824327
MIRT630454	hsa-miR-7977	HITS-CLIP	23824327
MIRT630462	hsa-miR-4714-5p	HITS-CLIP	23824327
MIRT630461	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT630460	hsa-miR-3921	HITS-CLIP	23824327
MIRT630459	hsa-miR-4653-5p	HITS-CLIP	23824327
MIRT630458	hsa-miR-4251	HITS-CLIP	23824327
MIRT630457	hsa-miR-4329	HITS-CLIP	23824327
MIRT630456	hsa-miR-6761-5p	HITS-CLIP	23824327
MIRT630455	hsa-miR-6089	HITS-CLIP	23824327
MIRT630454	hsa-miR-7977	HITS-CLIP	23824327
MIRT630462	hsa-miR-4714-5p	HITS-CLIP	23824327
MIRT630461	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT630460	hsa-miR-3921	HITS-CLIP	23824327
MIRT630459	hsa-miR-4653-5p	HITS-CLIP	23824327
MIRT630458	hsa-miR-4251	HITS-CLIP	23824327
MIRT630457	hsa-miR-4329	HITS-CLIP	23824327
MIRT630456	hsa-miR-6761-5p	HITS-CLIP	23824327
MIRT630455	hsa-miR-6089	HITS-CLIP	23824327
MIRT630454	hsa-miR-7977	HITS-CLIP	23824327
MIRT523508	hsa-miR-5680	PAR-CLIP	21572407
MIRT523507	hsa-miR-6890-5p	PAR-CLIP	21572407
MIRT523505	hsa-miR-4781-3p	PAR-CLIP	21572407
MIRT523506	hsa-miR-4716-5p	PAR-CLIP	21572407
MIRT523504	hsa-miR-193b-5p	PAR-CLIP	21572407
MIRT523503	hsa-miR-197-3p	PAR-CLIP	21572407
MIRT523502	hsa-miR-548s	PAR-CLIP	21572407
MIRT523500	hsa-miR-4701-5p	PAR-CLIP	21572407
MIRT523501	hsa-miR-588	PAR-CLIP	21572407
MIRT523499	hsa-miR-4435	PAR-CLIP	21572407
MIRT523498	hsa-miR-3187-3p	PAR-CLIP	21572407
MIRT523497	hsa-miR-3170	PAR-CLIP	21572407
MIRT523496	hsa-miR-6855-5p	PAR-CLIP	21572407
MIRT523495	hsa-miR-5096	PAR-CLIP	21572407
MIRT523508	hsa-miR-5680	PAR-CLIP	23446348
MIRT523507	hsa-miR-6890-5p	PAR-CLIP	23446348
MIRT523505	hsa-miR-4781-3p	PAR-CLIP	23446348
MIRT523506	hsa-miR-4716-5p	PAR-CLIP	23446348
MIRT523504	hsa-miR-193b-5p	PAR-CLIP	23446348
MIRT523503	hsa-miR-197-3p	PAR-CLIP	23446348
MIRT523502	hsa-miR-548s	PAR-CLIP	23446348
MIRT523500	hsa-miR-4701-5p	PAR-CLIP	23446348
MIRT523501	hsa-miR-588	PAR-CLIP	23446348
MIRT523499	hsa-miR-4435	PAR-CLIP	23446348
MIRT523498	hsa-miR-3187-3p	PAR-CLIP	23446348
MIRT523497	hsa-miR-3170	PAR-CLIP	23446348
MIRT523496	hsa-miR-6855-5p	PAR-CLIP	23446348
MIRT523495	hsa-miR-5096	PAR-CLIP	23446348

Show/Hide all (2)

Transcription factor	Regulation	Reference
APBB1	Repression	21453247
KAT5	Repression	21453247

Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003921	Function	GMP synthase activity	IBA
GO:0003921	Function	GMP synthase activity	IDA	8081953
GO:0003921	Function	GMP synthase activity	IEA
GO:0003921	Function	GMP synthase activity	TAS	8089153
GO:0003922	Function	GMP synthase (glutamine-hydrolyzing) activity	EXP	7706277
GO:0003922	Function	GMP synthase (glutamine-hydrolyzing) activity	IDA	8089153
GO:0003922	Function	GMP synthase (glutamine-hydrolyzing) activity	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	8089153
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006164	Process	Purine nucleotide biosynthetic process	IEA
GO:0006177	Process	GMP biosynthetic process	IBA
GO:0006177	Process	GMP biosynthetic process	IDA	8089153
GO:0006177	Process	GMP biosynthetic process	IEA
GO:0009113	Process	Purine nucleobase biosynthetic process	TAS	8089153
GO:0009168	Process	Purine ribonucleoside monophosphate biosynthetic process	TAS
GO:0016874	Function	Ligase activity	IEA

MIM	HGNC	e!Ensembl
600358	4378	ENSG00000163655

P49915

Protein name

GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (GMP synthetase) (Glutamine amidotransferase)

Protein function

Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.

PDB

2VPI , 2VXO

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00117	GATase	29 → 210	Glutamine amidotransferase class-I	Domain
PF02540	NAD_synthase	219 → 339	NAD synthase	Domain
PF00958	GMP_synt_C	597 → 692	GMP synthase C terminal domain	Domain

Sequence

MALCNGDSKLENAGGDLKDGHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETP
AFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHK
KSVREDGVFNISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANE
SKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVL
VLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAA
HSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPE
EVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVR
ILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPH
TLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDW
ESLIFLARLIPRMCHNVNRVVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILR
ESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVE
VVLKMVTEIKKIPGISRIMYDLTSKPPGTTEWE

Sequence length

693

Interactions

View interactions

	KEGG		Reactome
	Purine metabolism Drug metabolism - other enzymes Metabolic pathways Nucleotide metabolism		Purine ribonucleoside monophosphate biosynthesis

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CATARACT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (12)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Autoimmune Diseases	Autoimmune Diseases	BEFREE	24462112		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	22552268	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	31072138	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophageal neoplasm	Pubtator	34520390	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	34520390	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hepatitis B	Hepatitis b	Pubtator	22552268	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	BEFREE	29788244		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	11110714	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	11110714	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	36087034	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	27939741		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	32005234	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

GMPS (guanine monophosphate synthase)