Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	8824
Gene name	Carboxylesterase 2
Gene symbol	CES2
Synonyms (NCBI Gene)	CE-2CES2A1PCE-2iCE
Chromosome	16
Chromosome location	16q22.1
Summary	This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bon

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Show/Hide all (254)

miRTarBase ID	miRNA	Experiments	Reference
MIRT049577	hsa-miR-92a-3p	CLASH	23622248
MIRT044342	hsa-miR-106b-5p	CLASH	23622248
MIRT040956	hsa-miR-18a-3p	CLASH	23622248
MIRT035859	hsa-miR-1254	CLASH	23622248
MIRT714348	hsa-miR-1252-5p	HITS-CLIP	19536157
MIRT458759	hsa-miR-4279	HITS-CLIP	19536157
MIRT714347	hsa-miR-629-3p	HITS-CLIP	19536157
MIRT458780	hsa-miR-5571-5p	PAR-CLIP	23592263
MIRT458779	hsa-miR-5697	PAR-CLIP	23592263
MIRT458778	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT458777	hsa-miR-1915-3p	PAR-CLIP	23592263
MIRT458776	hsa-miR-6764-5p	PAR-CLIP	23592263
MIRT458775	hsa-miR-4726-3p	PAR-CLIP	23592263
MIRT458774	hsa-miR-660-3p	PAR-CLIP	23592263
MIRT458773	hsa-miR-4324	PAR-CLIP	23592263
MIRT458772	hsa-miR-544b	PAR-CLIP	23592263
MIRT458771	hsa-miR-4722-3p	PAR-CLIP	23592263
MIRT458770	hsa-miR-6727-3p	PAR-CLIP	23592263
MIRT458769	hsa-miR-6747-3p	PAR-CLIP	23592263
MIRT458768	hsa-miR-3653-5p	PAR-CLIP	23592263
MIRT458767	hsa-miR-1976	PAR-CLIP	23592263
MIRT458766	hsa-miR-6791-3p	PAR-CLIP	23592263
MIRT458765	hsa-miR-6829-3p	PAR-CLIP	23592263
MIRT458764	hsa-miR-1297	PAR-CLIP	23592263
MIRT458763	hsa-miR-26a-5p	PAR-CLIP	23592263
MIRT458762	hsa-miR-26b-5p	PAR-CLIP	23592263
MIRT458760	hsa-miR-4465	PAR-CLIP	23592263
MIRT458761	hsa-miR-1200	PAR-CLIP	23592263
MIRT458759	hsa-miR-4279	PAR-CLIP	23592263
MIRT458758	hsa-miR-6869-5p	PAR-CLIP	23592263
MIRT458757	hsa-miR-3714	PAR-CLIP	23592263
MIRT458756	hsa-miR-4476	PAR-CLIP	23592263
MIRT458755	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT458754	hsa-miR-4779	PAR-CLIP	23592263
MIRT458753	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT458751	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT458752	hsa-miR-940	PAR-CLIP	23592263
MIRT458749	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT458750	hsa-miR-1321	PAR-CLIP	23592263
MIRT458748	hsa-miR-4739	PAR-CLIP	23592263
MIRT458747	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT458746	hsa-miR-6805-5p	PAR-CLIP	23592263
MIRT458745	hsa-miR-4270	PAR-CLIP	23592263
MIRT458744	hsa-miR-4441	PAR-CLIP	23592263
MIRT458743	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT458742	hsa-miR-605-3p	PAR-CLIP	23592263
MIRT458741	hsa-miR-7515	PAR-CLIP	23592263
MIRT458740	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT458739	hsa-miR-3928-3p	PAR-CLIP	23592263
MIRT458738	hsa-miR-7854-3p	PAR-CLIP	23592263
MIRT458737	hsa-miR-3202	PAR-CLIP	23592263
MIRT458736	hsa-miR-4434	PAR-CLIP	23592263
MIRT458735	hsa-miR-4516	PAR-CLIP	23592263
MIRT458734	hsa-miR-5703	PAR-CLIP	23592263
MIRT458733	hsa-miR-765	PAR-CLIP	23592263
MIRT458732	hsa-miR-3689d	PAR-CLIP	23592263
MIRT458731	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT458730	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT458729	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT458728	hsa-miR-6878-5p	PAR-CLIP	23592263
MIRT458727	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT458726	hsa-miR-4710	PAR-CLIP	23592263
MIRT458725	hsa-miR-6880-5p	PAR-CLIP	23592263
MIRT458724	hsa-miR-7847-3p	PAR-CLIP	23592263
MIRT458723	hsa-miR-3915	PAR-CLIP	23592263
MIRT714348	hsa-miR-1252-5p	HITS-CLIP	19536157
MIRT458759	hsa-miR-4279	HITS-CLIP	19536157
MIRT714347	hsa-miR-629-3p	HITS-CLIP	19536157
MIRT458780	hsa-miR-5571-5p	PAR-CLIP	23592263
MIRT458779	hsa-miR-5697	PAR-CLIP	23592263
MIRT458778	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT458777	hsa-miR-1915-3p	PAR-CLIP	23592263
MIRT458776	hsa-miR-6764-5p	PAR-CLIP	23592263
MIRT458775	hsa-miR-4726-3p	PAR-CLIP	23592263
MIRT458774	hsa-miR-660-3p	PAR-CLIP	23592263
MIRT458773	hsa-miR-4324	PAR-CLIP	23592263
MIRT458772	hsa-miR-544b	PAR-CLIP	23592263
MIRT458771	hsa-miR-4722-3p	PAR-CLIP	23592263
MIRT458770	hsa-miR-6727-3p	PAR-CLIP	23592263
MIRT458769	hsa-miR-6747-3p	PAR-CLIP	23592263
MIRT458768	hsa-miR-3653-5p	PAR-CLIP	23592263
MIRT458767	hsa-miR-1976	PAR-CLIP	23592263
MIRT458766	hsa-miR-6791-3p	PAR-CLIP	23592263
MIRT458765	hsa-miR-6829-3p	PAR-CLIP	23592263
MIRT458764	hsa-miR-1297	PAR-CLIP	23592263
MIRT458763	hsa-miR-26a-5p	PAR-CLIP	23592263
MIRT458762	hsa-miR-26b-5p	PAR-CLIP	23592263
MIRT458760	hsa-miR-4465	PAR-CLIP	23592263
MIRT458761	hsa-miR-1200	PAR-CLIP	23592263
MIRT458759	hsa-miR-4279	PAR-CLIP	23592263
MIRT458758	hsa-miR-6869-5p	PAR-CLIP	23592263
MIRT458757	hsa-miR-3714	PAR-CLIP	23592263
MIRT458756	hsa-miR-4476	PAR-CLIP	23592263
MIRT458755	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT458754	hsa-miR-4779	PAR-CLIP	23592263
MIRT458753	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT458751	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT458752	hsa-miR-940	PAR-CLIP	23592263
MIRT458749	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT458750	hsa-miR-1321	PAR-CLIP	23592263
MIRT458748	hsa-miR-4739	PAR-CLIP	23592263
MIRT458747	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT458746	hsa-miR-6805-5p	PAR-CLIP	23592263
MIRT458745	hsa-miR-4270	PAR-CLIP	23592263
MIRT458744	hsa-miR-4441	PAR-CLIP	23592263
MIRT458743	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT458742	hsa-miR-605-3p	PAR-CLIP	23592263
MIRT458741	hsa-miR-7515	PAR-CLIP	23592263
MIRT458740	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT458739	hsa-miR-3928-3p	PAR-CLIP	23592263
MIRT458738	hsa-miR-7854-3p	PAR-CLIP	23592263
MIRT458737	hsa-miR-3202	PAR-CLIP	23592263
MIRT458736	hsa-miR-4434	PAR-CLIP	23592263
MIRT458735	hsa-miR-4516	PAR-CLIP	23592263
MIRT458734	hsa-miR-5703	PAR-CLIP	23592263
MIRT458733	hsa-miR-765	PAR-CLIP	23592263
MIRT458732	hsa-miR-3689d	PAR-CLIP	23592263
MIRT458731	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT458730	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT458729	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT458728	hsa-miR-6878-5p	PAR-CLIP	23592263
MIRT458727	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT458726	hsa-miR-4710	PAR-CLIP	23592263
MIRT458725	hsa-miR-6880-5p	PAR-CLIP	23592263
MIRT458724	hsa-miR-7847-3p	PAR-CLIP	23592263
MIRT458723	hsa-miR-3915	PAR-CLIP	23592263
MIRT887166	hsa-miR-1915	CLIP-seq
MIRT887167	hsa-miR-216a	CLIP-seq
MIRT887168	hsa-miR-26a	CLIP-seq
MIRT887169	hsa-miR-26b	CLIP-seq
MIRT887170	hsa-miR-4772-3p	CLIP-seq
MIRT887171	hsa-miR-1193	CLIP-seq
MIRT887172	hsa-miR-1266	CLIP-seq
MIRT887173	hsa-miR-129-5p	CLIP-seq
MIRT887174	hsa-miR-2110	CLIP-seq
MIRT887167	hsa-miR-216a	CLIP-seq
MIRT887175	hsa-miR-302a	CLIP-seq
MIRT887176	hsa-miR-302b	CLIP-seq
MIRT887177	hsa-miR-302c	CLIP-seq
MIRT887178	hsa-miR-302d	CLIP-seq
MIRT887179	hsa-miR-302e	CLIP-seq
MIRT887180	hsa-miR-3135b	CLIP-seq
MIRT887181	hsa-miR-3147	CLIP-seq
MIRT887182	hsa-miR-3150a-3p	CLIP-seq
MIRT887183	hsa-miR-3160-5p	CLIP-seq
MIRT887184	hsa-miR-3175	CLIP-seq
MIRT887185	hsa-miR-3652	CLIP-seq
MIRT887186	hsa-miR-3664-3p	CLIP-seq
MIRT887187	hsa-miR-372	CLIP-seq
MIRT887188	hsa-miR-373	CLIP-seq
MIRT887189	hsa-miR-4253	CLIP-seq
MIRT887190	hsa-miR-4278	CLIP-seq
MIRT887191	hsa-miR-4423-5p	CLIP-seq
MIRT887192	hsa-miR-4425	CLIP-seq
MIRT887193	hsa-miR-4427	CLIP-seq
MIRT887194	hsa-miR-4430	CLIP-seq
MIRT887195	hsa-miR-4518	CLIP-seq
MIRT887196	hsa-miR-4654	CLIP-seq
MIRT887197	hsa-miR-4680-3p	CLIP-seq
MIRT887198	hsa-miR-4688	CLIP-seq
MIRT887199	hsa-miR-4728-5p	CLIP-seq
MIRT887200	hsa-miR-4731-5p	CLIP-seq
MIRT887201	hsa-miR-4762-3p	CLIP-seq
MIRT887202	hsa-miR-4768-5p	CLIP-seq
MIRT887203	hsa-miR-4769-5p	CLIP-seq
MIRT887204	hsa-miR-4790-3p	CLIP-seq
MIRT887205	hsa-miR-512-3p	CLIP-seq
MIRT887206	hsa-miR-520a-3p	CLIP-seq
MIRT887207	hsa-miR-520b	CLIP-seq
MIRT887208	hsa-miR-520c-3p	CLIP-seq
MIRT887209	hsa-miR-520d-3p	CLIP-seq
MIRT887210	hsa-miR-520e	CLIP-seq
MIRT887211	hsa-miR-887	CLIP-seq
MIRT887212	hsa-miR-939	CLIP-seq
MIRT887166	hsa-miR-1915	CLIP-seq
MIRT887167	hsa-miR-216a	CLIP-seq
MIRT887168	hsa-miR-26a	CLIP-seq
MIRT887169	hsa-miR-26b	CLIP-seq
MIRT887180	hsa-miR-3135b	CLIP-seq
MIRT887185	hsa-miR-3652	CLIP-seq
MIRT887191	hsa-miR-4423-5p	CLIP-seq
MIRT887194	hsa-miR-4430	CLIP-seq
MIRT1963179	hsa-miR-450b-3p	CLIP-seq
MIRT1963180	hsa-miR-4713-3p	CLIP-seq
MIRT887170	hsa-miR-4772-3p	CLIP-seq
MIRT1963181	hsa-miR-513a-5p	CLIP-seq
MIRT1963182	hsa-miR-541	CLIP-seq
MIRT1963183	hsa-miR-552	CLIP-seq
MIRT1963184	hsa-miR-638	CLIP-seq
MIRT1963185	hsa-miR-654-5p	CLIP-seq
MIRT1963186	hsa-miR-769-3p	CLIP-seq
MIRT887166	hsa-miR-1915	CLIP-seq
MIRT887167	hsa-miR-216a	CLIP-seq
MIRT887180	hsa-miR-3135b	CLIP-seq
MIRT887185	hsa-miR-3652	CLIP-seq
MIRT887191	hsa-miR-4423-5p	CLIP-seq
MIRT887194	hsa-miR-4430	CLIP-seq
MIRT887170	hsa-miR-4772-3p	CLIP-seq
MIRT2502208	hsa-miR-1253	CLIP-seq
MIRT2502209	hsa-miR-141	CLIP-seq
MIRT887166	hsa-miR-1915	CLIP-seq
MIRT2502210	hsa-miR-200a	CLIP-seq
MIRT2502211	hsa-miR-24	CLIP-seq
MIRT887168	hsa-miR-26a	CLIP-seq
MIRT887169	hsa-miR-26b	CLIP-seq
MIRT887180	hsa-miR-3135b	CLIP-seq
MIRT2502212	hsa-miR-3148	CLIP-seq
MIRT887185	hsa-miR-3652	CLIP-seq
MIRT2502213	hsa-miR-3928	CLIP-seq
MIRT2502214	hsa-miR-3973	CLIP-seq
MIRT2502215	hsa-miR-4265	CLIP-seq
MIRT2502216	hsa-miR-4283	CLIP-seq
MIRT2502217	hsa-miR-4296	CLIP-seq
MIRT2502218	hsa-miR-4322	CLIP-seq
MIRT2502219	hsa-miR-4417	CLIP-seq
MIRT887191	hsa-miR-4423-5p	CLIP-seq
MIRT887194	hsa-miR-4430	CLIP-seq
MIRT2502220	hsa-miR-4437	CLIP-seq
MIRT2502221	hsa-miR-4469	CLIP-seq
MIRT2502222	hsa-miR-4488	CLIP-seq
MIRT2502223	hsa-miR-4697-5p	CLIP-seq
MIRT2502224	hsa-miR-4796-3p	CLIP-seq
MIRT2502225	hsa-miR-520g	CLIP-seq
MIRT2502226	hsa-miR-520h	CLIP-seq
MIRT2502227	hsa-miR-543	CLIP-seq
MIRT2502228	hsa-miR-637	CLIP-seq
MIRT2502229	hsa-miR-661	CLIP-seq
MIRT2502209	hsa-miR-141	CLIP-seq
MIRT887166	hsa-miR-1915	CLIP-seq
MIRT2502210	hsa-miR-200a	CLIP-seq
MIRT2502211	hsa-miR-24	CLIP-seq
MIRT887168	hsa-miR-26a	CLIP-seq
MIRT887169	hsa-miR-26b	CLIP-seq
MIRT2502212	hsa-miR-3148	CLIP-seq
MIRT2502214	hsa-miR-3973	CLIP-seq
MIRT2502215	hsa-miR-4265	CLIP-seq
MIRT2502216	hsa-miR-4283	CLIP-seq
MIRT2502217	hsa-miR-4296	CLIP-seq
MIRT2502218	hsa-miR-4322	CLIP-seq
MIRT2502219	hsa-miR-4417	CLIP-seq
MIRT2502220	hsa-miR-4437	CLIP-seq
MIRT2502221	hsa-miR-4469	CLIP-seq
MIRT2502222	hsa-miR-4488	CLIP-seq
MIRT1963179	hsa-miR-450b-3p	CLIP-seq
MIRT2502223	hsa-miR-4697-5p	CLIP-seq
MIRT1963180	hsa-miR-4713-3p	CLIP-seq
MIRT2502224	hsa-miR-4796-3p	CLIP-seq
MIRT2502225	hsa-miR-520g	CLIP-seq
MIRT2502226	hsa-miR-520h	CLIP-seq
MIRT2502227	hsa-miR-543	CLIP-seq
MIRT2502228	hsa-miR-637	CLIP-seq
MIRT1963184	hsa-miR-638	CLIP-seq
MIRT2502229	hsa-miR-661	CLIP-seq
MIRT1963186	hsa-miR-769-3p	CLIP-seq

Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005783	Component	Endoplasmic reticulum	TAS	9144407
GO:0005788	Component	Endoplasmic reticulum lumen	IEA
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006693	Process	Prostaglandin metabolic process	IDA	21049984
GO:0006805	Process	Xenobiotic metabolic process	TAS
GO:0009056	Process	Catabolic process	TAS	9169443
GO:0016787	Function	Hydrolase activity	IEA
GO:0043231	Component	Intracellular membrane-bounded organelle	IBA
GO:0047374	Function	Methylumbelliferyl-acetate deacetylase activity	IEA
GO:0052689	Function	Carboxylic ester hydrolase activity	IBA
GO:0052689	Function	Carboxylic ester hydrolase activity	IEA
GO:0052689	Function	Carboxylic ester hydrolase activity	TAS	9169443
GO:0106435	Function	Carboxylesterase activity	IDA	21049984
GO:0106435	Function	Carboxylesterase activity	IEA
GO:0106435	Function	Carboxylesterase activity	TAS

MIM	HGNC	e!Ensembl
605278	1864	ENSG00000172831

O00748

Protein name

Cocaine esterase (EC 3.1.1.84) (Carboxylesterase 2) (CE-2) (hCE-2) (EC 3.1.1.1) (Methylumbelliferyl-acetate deacetylase 2) (EC 3.1.1.56)

Protein function

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443). Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine (PubMed:91

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00135	COesterase	30 → 538	Carboxylesterase family	Domain

Tissue specificity

TISSUE SPECIFICITY: Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum. {ECO:0000269|PubMed:9144407}.

Sequence

MRLHRLRARLSAVACGLLLLLVRGQGQDSASPIRTTHTGQVLGSLVHVKGANAGVQTFLG
IPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMS
EDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVVIIQYRLG
VLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVS
PISQGLFHGAIMESGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGKSKEEI
LAINKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVMRIYDTQ
KEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADSMFVIPA
LQVAHFQCSRAPVYFYEFQHQPSWLKNIRPPHMKADHGDELPFVFRSFFGGNYIKFTEEE
EQLSRKMMKYWANFARNGNPNGEGLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQFWKK
ALPQKIQELEEPEERHTEL

Sequence length

559

Interactions

View interactions

	KEGG		Reactome
	Drug metabolism - other enzymes		Phase I - Functionalization of compounds

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AUTISM SPECTRUM DISORDER	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (65)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma	Adenocarcinoma	LHGDN	15967118		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adult Diffuse Large B-Cell Lymphoma	B-cell Lymphoma	BEFREE	22408263, 28143954		★★★★★ ★☆☆☆☆ Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Syndromic microphthalmia	BEFREE	26025324, 27023625		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anxiety	Anxiety Disorder	BEFREE	22414631		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anxiety Disorders	Anxiety Disorder	BEFREE	22414631		★★★★★ ★☆☆☆☆ Found in Text Mining only
Atrial Fibrillation	Atrial Fibrillation	BEFREE	30444763		★★★★★ ★☆☆☆☆ Found in Text Mining only
B-Cell Lymphomas	B-Cell Lymphoma	LHGDN	16690525		★★★★★ ★☆☆☆☆ Found in Text Mining only
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	30086544		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	30016861		★★★★★ ★☆☆☆☆ Found in Text Mining only
Burkitt Leukemia	Burkitt`s Lymphoma	BEFREE	22258345		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	26025324	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Childhood Acute Myeloid Leukemia	Acute Myeloid Leukemia	BEFREE	30039912		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	BEFREE	30867471		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	Pubtator	30867471	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Obstructive Airway Disease	Chronic Obstructive Pulmonary Disease	BEFREE	30072504		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colitis Ulcerative	Ulcerative colitis	Pubtator	33686088	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	15756257, 16963839		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic neoplasm	Pubtator	15756257, 16963839	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic Neoplasms	LHGDN	16963839		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	24195516, 27149931, 29651325		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal Neoplasms	BEFREE	15475243		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal Neoplasms	LHGDN	15475243, 18259949		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	15756257, 18797458, 25198900, 27661117, 29261002	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	29651325	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital contractural arachnodactyly	Congenital Contractural Arachnodactyly	BEFREE	30867471		★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	BEFREE	30673706		★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary heart disease	Coronary Heart Disease	BEFREE	30673706		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	24672804, 26806650		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	24672804, 26806650		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diffuse Large B-Cell Lymphoma	Diffuse Lymphoma	BEFREE	22408263, 28143954, 29386196		★★★★★ ★☆☆☆☆ Found in Text Mining only
Erectile dysfunction	Erectile Dysfunction	BEFREE	31803101		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fatty Liver	Fatty Liver	BEFREE	26806650, 28099843		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fatty Liver Disease	Fatty Liver	BEFREE	26806650		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	31444232	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	9409814		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hematologic Neoplasms	Hematologic Neoplasms	BEFREE	28716155		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyalinosis, Systemic	Hyalinosis	BEFREE	18473752, 25601966		★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	BEFREE	27149931		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	9322679		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver Diseases	Liver disease	Pubtator	37686209	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	BEFREE	30596402		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma, Large-Cell, Follicular	Lymphoma	BEFREE	29663029		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma, Non-Hodgkin	Non-Hodgkin lymphoma	BEFREE	29663029		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma, Non-Hodgkin, Familial	Lymphoma	BEFREE	29663029		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	30016861		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	26025324, 27023625, 31803422		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	27149931, 30640520		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	15756257		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mesothelioma Malignant	Mesothelioma	Pubtator	32961616	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mitochondrial Diseases	Mitochondrial disease	Pubtator	36113774	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myeloid Leukemia, Chronic	Myeloid Leukemia	BEFREE	9529127, 9760148		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	12939466, 17483951, 17636009, 23325581, 23756919, 24195516, 24687871, 26025324, 27149931, 29261002		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	10715578, 23480903, 9516857		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-alcoholic Fatty Liver Disease	Non-Alcoholic Fatty Liver Disease	BEFREE	26806650		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	28099843		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	12939466		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	26025324, 27023625, 31803422		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Ductal Adenocarcinoma	Pancreatic adenocarcinoma	BEFREE	26025324		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	26025324	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	18806920		★★★★★ ★☆☆☆☆ Found in Text Mining only
Secondary malignant neoplasm of colon and/or rectum	Colorectal Neoplasms	BEFREE	18797458, 25198900, 29261002		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	31444232, 36113774	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Steatohepatitis	Fatty Liver	BEFREE	26806650, 28099843		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ventricular arrhythmia	Ventricular arrhythmia	BEFREE	30729374		★★★★★ ★☆☆☆☆ Found in Text Mining only
Werner Syndrome	Werner Syndrome	BEFREE	9681877		★★★★★ ★☆☆☆☆ Found in Text Mining only

CES2 (carboxylesterase 2)