Gene Gene information from NCBI Gene database.
Entrez ID 8804
Gene name Cellular repressor of E1A stimulated genes 1
Gene symbol CREG1
Synonyms (NCBI Gene)
CREG
Chromosome 1
Chromosome location 1q24.2
Summary The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein
miRNA miRNA information provided by mirtarbase database.
400
miRTarBase ID miRNA Experiments Reference
MIRT007367 hsa-miR-31-5p ImmunofluorescenceLuciferase reporter assayqRT-PCRWestern blot 23518389
MIRT028971 hsa-miR-26b-5p Microarray 19088304
MIRT036577 hsa-miR-941 CLASH 23622248
MIRT727936 hsa-miR-15a-5p HITS-CLIP 22473208
MIRT727937 hsa-miR-15b-5p HITS-CLIP 22473208
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
19
GO ID Ontology Definition Evidence Reference
GO:0003714 Function Transcription corepressor activity TAS 9710587
GO:0005576 Component Extracellular region IEA
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space IBA
GO:0005615 Component Extracellular space IDA 25645918
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
618055 2351 ENSG00000143162
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O75629
Protein name Protein CREG1 (Cellular repressor of E1A-stimulated genes 1)
Protein function May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires inte
PDB 1XHN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13883 Pyrid_oxidase_2 50 216 Domain
Sequence
Sequence length 220
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Neutrophil degranulation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
APPENDICITIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ATROPHIC GASTRITIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CREG1-related disorder Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Ankylosing spondylitis Ankylosing Spondylitis BEFREE 6606463
★☆☆☆☆
Found in Text Mining only
Arteriosclerosis Arteriosclerosis BEFREE 21872252, 26163874, 27784214
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis BEFREE 21872252, 26163874, 27784214
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis Pubtator 27139506, 32067910 Inhibit
★☆☆☆☆
Found in Text Mining only
Cardiovascular Diseases Cardiovascular Diseases BEFREE 30076625
★☆☆☆☆
Found in Text Mining only
Coronary Arteriosclerosis Coronary Arteriosclerosis BEFREE 20951690
★☆☆☆☆
Found in Text Mining only
Coronary Artery Disease Coronary artery disease BEFREE 20951690
★☆☆☆☆
Found in Text Mining only
Coronary heart disease Coronary Heart Disease BEFREE 20951690
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus Type 2 Diabetes mellitus, type 2 Pubtator 27139506 Inhibit
★☆☆☆☆
Found in Text Mining only
Endometrial Carcinoma Endometrial carcinoma BEFREE 17451460
★☆☆☆☆
Found in Text Mining only