Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	8801
Gene name	Succinate-CoA ligase GDP-forming subunit beta
Gene symbol	SUCLG2
Synonyms (NCBI Gene)	G-SCSGBETAGTPSCS
Chromosome	3
Chromosome location	3p14.1
Summary	This gene encodes a GTP-specific beta subunit of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the reversible reaction involving the formation of succinyl-CoA and succinate. Alternate splicing results in multiple transcript variants. Pseudoge

147

Show/Hide all (147)

miRTarBase ID	miRNA	Experiments	Reference
MIRT001830	hsa-miR-124-3p	MicroarrayqRT-PCR	16549876
MIRT001830	hsa-miR-124-3p	Microarray	16549876
MIRT001830	hsa-miR-124-3p	qRT-PCR;Other	16549876
MIRT049822	hsa-miR-92a-3p	CLASH	23622248
MIRT648151	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT648149	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT648150	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT648148	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT648147	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT648146	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT648145	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT648144	hsa-miR-4297	HITS-CLIP	23824327
MIRT648143	hsa-miR-5581-5p	HITS-CLIP	23824327
MIRT648142	hsa-miR-2355-5p	HITS-CLIP	23824327
MIRT648141	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT648140	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT648139	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT648138	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT648151	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT648149	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT648150	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT648148	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT648147	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT648146	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT648145	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT648144	hsa-miR-4297	HITS-CLIP	23824327
MIRT648143	hsa-miR-5581-5p	HITS-CLIP	23824327
MIRT648142	hsa-miR-2355-5p	HITS-CLIP	23824327
MIRT648141	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT648140	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT648139	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT648138	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT1402226	hsa-miR-587	CLIP-seq
MIRT1402227	hsa-miR-938	CLIP-seq
MIRT1402228	hsa-let-7a	CLIP-seq
MIRT1402229	hsa-let-7b	CLIP-seq
MIRT1402230	hsa-let-7c	CLIP-seq
MIRT1402231	hsa-let-7d	CLIP-seq
MIRT1402232	hsa-let-7e	CLIP-seq
MIRT1402233	hsa-let-7f	CLIP-seq
MIRT1402234	hsa-let-7g	CLIP-seq
MIRT1402235	hsa-let-7i	CLIP-seq
MIRT1402236	hsa-miR-1284	CLIP-seq
MIRT1402237	hsa-miR-1294	CLIP-seq
MIRT1402238	hsa-miR-144	CLIP-seq
MIRT1402239	hsa-miR-150	CLIP-seq
MIRT1402240	hsa-miR-202	CLIP-seq
MIRT1402241	hsa-miR-203	CLIP-seq
MIRT1402242	hsa-miR-2115	CLIP-seq
MIRT1402243	hsa-miR-30a	CLIP-seq
MIRT1402244	hsa-miR-30b	CLIP-seq
MIRT1402245	hsa-miR-30c	CLIP-seq
MIRT1402246	hsa-miR-30d	CLIP-seq
MIRT1402247	hsa-miR-30e	CLIP-seq
MIRT1402248	hsa-miR-3120-5p	CLIP-seq
MIRT1402249	hsa-miR-3159	CLIP-seq
MIRT1402250	hsa-miR-329	CLIP-seq
MIRT1402251	hsa-miR-338-5p	CLIP-seq
MIRT1402252	hsa-miR-3591-5p	CLIP-seq
MIRT1402253	hsa-miR-362-3p	CLIP-seq
MIRT1402254	hsa-miR-3671	CLIP-seq
MIRT1402255	hsa-miR-3941	CLIP-seq
MIRT1402256	hsa-miR-4272	CLIP-seq
MIRT1402257	hsa-miR-4276	CLIP-seq
MIRT1402258	hsa-miR-4316	CLIP-seq
MIRT1402259	hsa-miR-4436b-5p	CLIP-seq
MIRT1402260	hsa-miR-4458	CLIP-seq
MIRT1402261	hsa-miR-4500	CLIP-seq
MIRT1402262	hsa-miR-4517	CLIP-seq
MIRT1402263	hsa-miR-4635	CLIP-seq
MIRT1402264	hsa-miR-4694-3p	CLIP-seq
MIRT1402265	hsa-miR-4719	CLIP-seq
MIRT1402266	hsa-miR-4778-5p	CLIP-seq
MIRT1402267	hsa-miR-4789-5p	CLIP-seq
MIRT1402268	hsa-miR-4796-5p	CLIP-seq
MIRT1402269	hsa-miR-514	CLIP-seq
MIRT1402270	hsa-miR-514b-3p	CLIP-seq
MIRT1402271	hsa-miR-603	CLIP-seq
MIRT1402272	hsa-miR-607	CLIP-seq
MIRT1402273	hsa-miR-642b	CLIP-seq
MIRT1402274	hsa-miR-648	CLIP-seq
MIRT1402275	hsa-miR-671-5p	CLIP-seq
MIRT1402276	hsa-miR-98	CLIP-seq
MIRT2120553	hsa-miR-1272	CLIP-seq
MIRT2120554	hsa-miR-3658	CLIP-seq
MIRT2120555	hsa-miR-376c	CLIP-seq
MIRT2120556	hsa-miR-513b	CLIP-seq
MIRT2120557	hsa-miR-570	CLIP-seq
MIRT2342671	hsa-miR-3187-3p	CLIP-seq
MIRT2120554	hsa-miR-3658	CLIP-seq
MIRT2120555	hsa-miR-376c	CLIP-seq
MIRT2342672	hsa-miR-4435	CLIP-seq
MIRT2342673	hsa-miR-4701-5p	CLIP-seq
MIRT2342674	hsa-miR-4756-3p	CLIP-seq
MIRT2342675	hsa-miR-548s	CLIP-seq
MIRT1402226	hsa-miR-587	CLIP-seq
MIRT2342676	hsa-miR-588	CLIP-seq
MIRT1402274	hsa-miR-648	CLIP-seq
MIRT2636478	hsa-miR-340	CLIP-seq
MIRT1402228	hsa-let-7a	CLIP-seq
MIRT1402229	hsa-let-7b	CLIP-seq
MIRT1402230	hsa-let-7c	CLIP-seq
MIRT1402231	hsa-let-7d	CLIP-seq
MIRT1402232	hsa-let-7e	CLIP-seq
MIRT1402233	hsa-let-7f	CLIP-seq
MIRT1402234	hsa-let-7g	CLIP-seq
MIRT1402235	hsa-let-7i	CLIP-seq
MIRT2692396	hsa-miR-124	CLIP-seq
MIRT1402237	hsa-miR-1294	CLIP-seq
MIRT2692397	hsa-miR-142-5p	CLIP-seq
MIRT1402238	hsa-miR-144	CLIP-seq
MIRT2692398	hsa-miR-146a	CLIP-seq
MIRT2692399	hsa-miR-146b-5p	CLIP-seq
MIRT1402239	hsa-miR-150	CLIP-seq
MIRT1402240	hsa-miR-202	CLIP-seq
MIRT1402242	hsa-miR-2115	CLIP-seq
MIRT1402243	hsa-miR-30a	CLIP-seq
MIRT1402244	hsa-miR-30b	CLIP-seq
MIRT1402245	hsa-miR-30c	CLIP-seq
MIRT1402246	hsa-miR-30d	CLIP-seq
MIRT1402247	hsa-miR-30e	CLIP-seq
MIRT2636478	hsa-miR-340	CLIP-seq
MIRT1402252	hsa-miR-3591-5p	CLIP-seq
MIRT2692400	hsa-miR-3714	CLIP-seq
MIRT2692401	hsa-miR-3910	CLIP-seq
MIRT1402256	hsa-miR-4272	CLIP-seq
MIRT1402258	hsa-miR-4316	CLIP-seq
MIRT1402259	hsa-miR-4436b-5p	CLIP-seq
MIRT1402260	hsa-miR-4458	CLIP-seq
MIRT2692402	hsa-miR-4477a	CLIP-seq
MIRT1402261	hsa-miR-4500	CLIP-seq
MIRT1402264	hsa-miR-4694-3p	CLIP-seq
MIRT2692403	hsa-miR-4712-3p	CLIP-seq
MIRT1402265	hsa-miR-4719	CLIP-seq
MIRT2692404	hsa-miR-4731-3p	CLIP-seq
MIRT2692405	hsa-miR-4795-3p	CLIP-seq
MIRT2692406	hsa-miR-4801	CLIP-seq
MIRT2692407	hsa-miR-506	CLIP-seq
MIRT2692408	hsa-miR-548l	CLIP-seq
MIRT2692409	hsa-miR-548n	CLIP-seq
MIRT2692410	hsa-miR-548u	CLIP-seq
MIRT2692411	hsa-miR-589	CLIP-seq
MIRT1402273	hsa-miR-642b	CLIP-seq
MIRT1402274	hsa-miR-648	CLIP-seq
MIRT2692412	hsa-miR-656	CLIP-seq
MIRT1402275	hsa-miR-671-5p	CLIP-seq
MIRT1402276	hsa-miR-98	CLIP-seq

Show/Hide all (34)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000287	Function	Magnesium ion binding	IEA
GO:0003824	Function	Catalytic activity	IEA
GO:0004775	Function	Succinate-CoA ligase (ADP-forming) activity	IBA
GO:0004776	Function	Succinate-CoA ligase (GDP-forming) activity	IBA
GO:0004776	Function	Succinate-CoA ligase (GDP-forming) activity	IEA
GO:0004776	Function	Succinate-CoA ligase (GDP-forming) activity	NAS	9765291
GO:0005515	Function	Protein binding	IPI	24606901, 28380382, 28514442, 32627745, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005525	Function	GTP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005739	Component	Mitochondrion	NAS	32627745
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0006099	Process	Tricarboxylic acid cycle	IBA
GO:0006099	Process	Tricarboxylic acid cycle	IEA
GO:0006099	Process	Tricarboxylic acid cycle	NAS	32627745
GO:0006104	Process	Succinyl-CoA metabolic process	IBA
GO:0006104	Process	Succinyl-CoA metabolic process	IEA
GO:0006104	Process	Succinyl-CoA metabolic process	NAS	9765291
GO:0006105	Process	Succinate metabolic process	IEA
GO:0016874	Function	Ligase activity	IEA
GO:0019003	Function	GDP binding	IEA
GO:0032991	Component	Protein-containing complex	IEA
GO:0042709	Component	Succinate-CoA ligase complex	IBA
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045244	Component	Succinate-CoA ligase complex (GDP-forming)	IEA
GO:0045244	Component	Succinate-CoA ligase complex (GDP-forming)	IPI	32627745
GO:0046872	Function	Metal ion binding	IEA
GO:1901289	Process	Succinyl-CoA catabolic process	NAS	32627745

MIM	HGNC	e!Ensembl
603922	11450	ENSG00000172340

Q96I99

Protein name

Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial (EC 6.2.1.4) (GTP-specific succinyl-CoA synthetase subunit beta) (G-SCS) (GTPSCS) (Succinyl-CoA synthetase beta-G chain) (SCS-betaG)

Protein function

GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit prov

PDB

6WCV , 7MSR , 7MSS , 7MST , 8Z02 , 8Z03

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08442	ATP-grasp_2	39 → 247	ATP-grasp domain	Domain
PF00549	Ligase_CoA	306 → 426	CoA-ligase	Domain

Tissue specificity

TISSUE SPECIFICITY: Mainly expressed in liver, kidney, heart, spleen and skeletal muscle. Also found in intestine and colon, and in low amounts in lung, brain, prostate, testis and ovary. {ECO:0000269|PubMed:9765291}.

Sequence

MASPVAAQAGKLLRALALRPRFLAAGSQAVQLTSRRWLNLQEYQSKKLMSDNGVRVQRFF
VADTANEALEAAKRLNAKEIVLKAQILAGGRGKGVFNSGLKGGVHLTKDPNVVGQLAKQM
IGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRSCNGPVLVGSPQGGVDIEEV
AASNPELIFKEQIDIFEGIKDSQAQRMAENLGFVGPLKSQAADQITKLYNLFLKIDATQV
EVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSENEPIENEAAKYDLKYIGLD
GNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGVKEAQVYQAFKLLTADPKVEAILV
NIFGGIVNCAIIANGITKACRELELKVPLVVRLEGTNVQEAQKILNNSGLPITSAIDLED
AAKKAVASVAKK

Sequence length

432

Interactions

View interactions

	KEGG		Reactome
	Citrate cycle (TCA cycle) Propanoate metabolism Metabolic pathways Carbon metabolism		Citric acid cycle (TCA cycle)

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (16)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Cholangiocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Chronic lymphocytic leukemia/small lymphocytic lymphoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORNEAL ASTIGMATISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETIC NEPHROPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIOSIS	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METHYLMALONIC ACIDEMIA	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METHYLMALONIC ACIDURIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mitochondrial DNA depletion syndrome 9	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PELVIC ORGAN PROLAPSE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUCLG2-related disorder	Uncertain significance; Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uveal melanoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (28)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	CTD_human_DG	27602772		★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	25027320, 32711556	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer`s Disease	Alzheimer disease	GWASCAT_DG	25027320		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	36308411	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	33564363	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiomyopathies	Cardiomyopathy	Pubtator	33484326	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cognition Disorders	Cognition disorder	Pubtator	25027320	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cognitive Dysfunction	Cognition disorder	Pubtator	21295139	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic neoplasm	Pubtator	38186579	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	34174878, 38186579	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	33484326	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrioma	Endometrioma	CTD_human_DG	23284138		★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometriosis	Endometriosis	CTD_human_DG	23284138		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Epilepsy	Epilepsy	Pubtator	33484326	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glaucoma Open Angle	Open angle glaucoma	Pubtator	29847670	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertension	Hypertension	Pubtator	11688759	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	BEFREE	25027320		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leiomyoma	Leiomyoma	Pubtator	36948524	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	GWASCAT_DG	27903959		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mitochondrial Diseases	Mitochondrial disease	Pubtator	21295139, 32711556, 33484326, 37904651	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mitochondrial encephalopathy	Mitochondrial encephalopathy	Pubtator	33484326	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	37658588	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	8216227	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	CTD_human_DG	20882379		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pheochromocytoma	Pheochromocytoma	Pubtator	34415331	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	GWASCAT_DG	26307654		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Seizures	Seizures	Pubtator	27108799, 33484326	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	33934391	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

SUCLG2 (succinate-CoA ligase GDP-forming subunit beta)