Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	8790
Gene name	Fucose-1-phosphate guanylyltransferase
Gene symbol	FPGT
Synonyms (NCBI Gene)	GFPP
Chromosome	1
Chromosome location	1p31.1
Summary	L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell-cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-be

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018371	hsa-miR-335-5p	Microarray	18185580
MIRT445849	hsa-miR-186-5p	PAR-CLIP	22100165
MIRT445848	hsa-miR-4635	PAR-CLIP	22100165
MIRT445847	hsa-miR-302b-5p	PAR-CLIP	22100165
MIRT445846	hsa-miR-302d-5p	PAR-CLIP	22100165
MIRT445849	hsa-miR-186-5p	PAR-CLIP	22100165
MIRT445848	hsa-miR-4635	PAR-CLIP	22100165
MIRT445847	hsa-miR-302b-5p	PAR-CLIP	22100165
MIRT445846	hsa-miR-302d-5p	PAR-CLIP	22100165
MIRT445849	hsa-miR-186-5p	PAR-CLIP	22100165
MIRT445848	hsa-miR-4635	PAR-CLIP	22100165
MIRT445847	hsa-miR-302b-5p	PAR-CLIP	22100165
MIRT445846	hsa-miR-302d-5p	PAR-CLIP	22100165
MIRT445849	hsa-miR-186-5p	PAR-CLIP	22100165
MIRT445848	hsa-miR-4635	PAR-CLIP	22100165
MIRT445847	hsa-miR-302b-5p	PAR-CLIP	22100165
MIRT445846	hsa-miR-302d-5p	PAR-CLIP	22100165
MIRT1003900	hsa-miR-1	CLIP-seq
MIRT1003901	hsa-miR-1226	CLIP-seq
MIRT1003902	hsa-miR-1297	CLIP-seq
MIRT1003903	hsa-miR-186	CLIP-seq
MIRT1003904	hsa-miR-206	CLIP-seq
MIRT1003905	hsa-miR-26a	CLIP-seq
MIRT1003906	hsa-miR-26b	CLIP-seq
MIRT1003907	hsa-miR-3138	CLIP-seq
MIRT1003908	hsa-miR-337-3p	CLIP-seq
MIRT1003909	hsa-miR-338-3p	CLIP-seq
MIRT1003910	hsa-miR-3609	CLIP-seq
MIRT1003911	hsa-miR-3613-3p	CLIP-seq
MIRT1003912	hsa-miR-3617	CLIP-seq
MIRT1003913	hsa-miR-3647-3p	CLIP-seq
MIRT1003914	hsa-miR-3673	CLIP-seq
MIRT1003915	hsa-miR-3685	CLIP-seq
MIRT1003916	hsa-miR-3688-3p	CLIP-seq
MIRT1003917	hsa-miR-384	CLIP-seq
MIRT1003918	hsa-miR-4282	CLIP-seq
MIRT1003919	hsa-miR-4310	CLIP-seq
MIRT1003920	hsa-miR-4465	CLIP-seq
MIRT1003921	hsa-miR-4491	CLIP-seq
MIRT1003922	hsa-miR-4657	CLIP-seq
MIRT1003923	hsa-miR-4733-3p	CLIP-seq
MIRT1003924	hsa-miR-4738-3p	CLIP-seq
MIRT1003925	hsa-miR-4766-5p	CLIP-seq
MIRT1003926	hsa-miR-4800-5p	CLIP-seq
MIRT1003927	hsa-miR-495	CLIP-seq
MIRT1003928	hsa-miR-498	CLIP-seq
MIRT1003929	hsa-miR-513a-3p	CLIP-seq
MIRT1003930	hsa-miR-548ah	CLIP-seq
MIRT1003931	hsa-miR-548g	CLIP-seq
MIRT1003932	hsa-miR-548t	CLIP-seq
MIRT1003933	hsa-miR-613	CLIP-seq
MIRT1003934	hsa-miR-634	CLIP-seq
MIRT1003935	hsa-miR-641	CLIP-seq
MIRT1003936	hsa-miR-802	CLIP-seq
MIRT1003937	hsa-miR-1324	CLIP-seq
MIRT1003938	hsa-miR-3148	CLIP-seq
MIRT1003939	hsa-miR-3153	CLIP-seq
MIRT1003940	hsa-miR-3158-3p	CLIP-seq
MIRT1003941	hsa-miR-3189-3p	CLIP-seq
MIRT1003942	hsa-miR-3662	CLIP-seq
MIRT1003943	hsa-miR-4279	CLIP-seq
MIRT1003944	hsa-miR-4668-5p	CLIP-seq
MIRT1003945	hsa-miR-4698	CLIP-seq
MIRT1003946	hsa-miR-4721	CLIP-seq
MIRT1003947	hsa-miR-548ae	CLIP-seq
MIRT1003948	hsa-miR-548aj	CLIP-seq
MIRT1003949	hsa-miR-548am	CLIP-seq
MIRT1003950	hsa-miR-548x	CLIP-seq
MIRT1003951	hsa-miR-942	CLIP-seq
MIRT1548901	hsa-miR-345	CLIP-seq
MIRT1548902	hsa-miR-4256	CLIP-seq
MIRT1548903	hsa-miR-4762-3p	CLIP-seq
MIRT1997574	hsa-miR-144	CLIP-seq
MIRT1997575	hsa-miR-4682	CLIP-seq
MIRT2449888	hsa-miR-1276	CLIP-seq
MIRT2449889	hsa-miR-330-3p	CLIP-seq
MIRT2449890	hsa-miR-371-5p	CLIP-seq
MIRT2449891	hsa-miR-371b-5p	CLIP-seq
MIRT2449892	hsa-miR-451b	CLIP-seq
MIRT2449893	hsa-miR-548ac	CLIP-seq
MIRT1003947	hsa-miR-548ae	CLIP-seq
MIRT1003948	hsa-miR-548aj	CLIP-seq
MIRT1003949	hsa-miR-548am	CLIP-seq
MIRT2449894	hsa-miR-548d-3p	CLIP-seq
MIRT1003950	hsa-miR-548x	CLIP-seq
MIRT2449895	hsa-miR-548z	CLIP-seq
MIRT1003900	hsa-miR-1	CLIP-seq
MIRT1003901	hsa-miR-1226	CLIP-seq
MIRT2535165	hsa-miR-147	CLIP-seq
MIRT1003904	hsa-miR-206	CLIP-seq
MIRT2535166	hsa-miR-2113	CLIP-seq
MIRT2535167	hsa-miR-216a	CLIP-seq
MIRT2535168	hsa-miR-218	CLIP-seq
MIRT2535169	hsa-miR-2276	CLIP-seq
MIRT2535170	hsa-miR-2355-5p	CLIP-seq
MIRT2535171	hsa-miR-3149	CLIP-seq
MIRT2535172	hsa-miR-323-3p	CLIP-seq
MIRT2535173	hsa-miR-323-5p	CLIP-seq
MIRT2535174	hsa-miR-329	CLIP-seq
MIRT2535175	hsa-miR-331-5p	CLIP-seq
MIRT1003909	hsa-miR-338-3p	CLIP-seq
MIRT2535176	hsa-miR-3606	CLIP-seq
MIRT1003912	hsa-miR-3617	CLIP-seq
MIRT2535177	hsa-miR-362-3p	CLIP-seq
MIRT1003914	hsa-miR-3673	CLIP-seq
MIRT2535178	hsa-miR-3679-3p	CLIP-seq
MIRT1003915	hsa-miR-3685	CLIP-seq
MIRT1003916	hsa-miR-3688-3p	CLIP-seq
MIRT1003917	hsa-miR-384	CLIP-seq
MIRT2535179	hsa-miR-3941	CLIP-seq
MIRT2535180	hsa-miR-4275	CLIP-seq
MIRT2535181	hsa-miR-4286	CLIP-seq
MIRT1003919	hsa-miR-4310	CLIP-seq
MIRT2535182	hsa-miR-4452	CLIP-seq
MIRT2535183	hsa-miR-448	CLIP-seq
MIRT1997575	hsa-miR-4682	CLIP-seq
MIRT2535184	hsa-miR-4705	CLIP-seq
MIRT1003923	hsa-miR-4733-3p	CLIP-seq
MIRT1003925	hsa-miR-4766-5p	CLIP-seq
MIRT2535185	hsa-miR-4772-3p	CLIP-seq
MIRT2535186	hsa-miR-4796-5p	CLIP-seq
MIRT2535187	hsa-miR-4803	CLIP-seq
MIRT2535188	hsa-miR-548c-3p	CLIP-seq
MIRT2535189	hsa-miR-556-3p	CLIP-seq
MIRT2535190	hsa-miR-599	CLIP-seq
MIRT2535191	hsa-miR-603	CLIP-seq
MIRT1003933	hsa-miR-613	CLIP-seq
MIRT1003934	hsa-miR-634	CLIP-seq
MIRT1003935	hsa-miR-641	CLIP-seq
MIRT2535192	hsa-miR-668	CLIP-seq
MIRT2535193	hsa-miR-876-3p	CLIP-seq
MIRT2535194	hsa-miR-944	CLIP-seq
MIRT1003901	hsa-miR-1226	CLIP-seq
MIRT2535166	hsa-miR-2113	CLIP-seq
MIRT2535168	hsa-miR-218	CLIP-seq
MIRT2535170	hsa-miR-2355-5p	CLIP-seq
MIRT2535172	hsa-miR-323-3p	CLIP-seq
MIRT2535173	hsa-miR-323-5p	CLIP-seq
MIRT2535174	hsa-miR-329	CLIP-seq
MIRT2535175	hsa-miR-331-5p	CLIP-seq
MIRT1003909	hsa-miR-338-3p	CLIP-seq
MIRT2535176	hsa-miR-3606	CLIP-seq
MIRT2535177	hsa-miR-362-3p	CLIP-seq
MIRT2535178	hsa-miR-3679-3p	CLIP-seq
MIRT2535179	hsa-miR-3941	CLIP-seq
MIRT2535181	hsa-miR-4286	CLIP-seq
MIRT1003919	hsa-miR-4310	CLIP-seq
MIRT2535182	hsa-miR-4452	CLIP-seq
MIRT1997575	hsa-miR-4682	CLIP-seq
MIRT2681170	hsa-miR-4684-5p	CLIP-seq
MIRT1003923	hsa-miR-4733-3p	CLIP-seq
MIRT2681171	hsa-miR-4762-5p	CLIP-seq
MIRT2681172	hsa-miR-4768-5p	CLIP-seq
MIRT2681173	hsa-miR-4789-3p	CLIP-seq
MIRT2535186	hsa-miR-4796-5p	CLIP-seq
MIRT2535190	hsa-miR-599	CLIP-seq
MIRT2535191	hsa-miR-603	CLIP-seq
MIRT1003934	hsa-miR-634	CLIP-seq
MIRT2535192	hsa-miR-668	CLIP-seq
MIRT2535193	hsa-miR-876-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0005525	Function	GTP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	9804772
GO:0005829	Component	Cytosol	TAS
GO:0006004	Process	Fucose metabolic process	TAS	9804772
GO:0016740	Function	Transferase activity	IEA
GO:0016772	Function	Transferase activity, transferring phosphorus-containing groups	IEA
GO:0016779	Function	Nucleotidyltransferase activity	IEA
GO:0042350	Process	GDP-L-fucose biosynthetic process	IEA
GO:0042350	Process	GDP-L-fucose biosynthetic process	TAS
GO:0047341	Function	Fucose-1-phosphate guanylyltransferase activity	IDA	9804772
GO:0047341	Function	Fucose-1-phosphate guanylyltransferase activity	IEA
GO:0047341	Function	Fucose-1-phosphate guanylyltransferase activity	TAS

MIM	HGNC	e!Ensembl
603609	3825	ENSG00000254685

O14772

Protein name

Fucose-1-phosphate guanylyltransferase (EC 2.7.7.30) (GDP-L-fucose diphosphorylase) (GDP-L-fucose pyrophosphorylase)

Protein function

Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate (PubMed:9804772). Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids (PubMed:9804772). {ECO:0000269|PubMed:980

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07959	Fucokinase	127 → 546	L-fucokinase	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in many tissues.

Sequence

MRAVRRGLREGGAMAAARDPPEVSLREATQRKLRRFSELRGKLVARGEFWDIVAITAADE
KQELAYNQQLSEKLKRKELPLGVQYHVFVDPAGAKIGNGGSTLCALQCLEKLYGDKWNSF
TILLIHSGGYSQRLPNASALGKIFTALPLGNPIYQMLELKLAMYIDFPLNMNPGILVTCA
DDIELYSIGEFEFIRFDKPGFTALAHPSSLTIGTTHGVFVLDPFDDLKHRDLEYRSCHRF
LHKPSIEKMYQFNAVCRPGNFCQQDFAGGDIADLKLDSDYVYTDSLFYMDHKSAKMLLAF
YEKIGTLSCEIDAYGDFLQALGPGATVEYTRNTSNVIKEESELVEMRQRIFHLLKGTSLN
VVVLNNSKFYHIGTTEEYLFYFTSDNSLKSELGLQSITFSIFPDIPECSGKTSCIIQSIL
DSRCSVAPGSVVEYSRLGPDVSVGENCIISGSYILTKAALPAHSFVCSLSLKMNRCLKYA
TMAFGVQDNLKKSVKTLSDIKLLQFFGVCFLSCLDVWNLKVTEELFSGNKTCLSLWTARI
FPVCSSLSDSVITSLKMLNAVKNKSAFSLNSYKLLSIEEMLIYKDVEDMITYREQIFLEI
SLKSSLM

Sequence length

607

Interactions

View interactions

	KEGG		Reactome
	Fructose and mannose metabolism Amino sugar and nucleotide sugar metabolism Metabolic pathways Biosynthesis of nucleotide sugars		GDP-fucose biosynthesis

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CARCINOMA, RENAL CELL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Disease (Merged)	Source	PMID	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Chromophobe Renal Cell Carcinoma	Chromophobe Carcinoma	CTD_human_DG	23797736	★★★★★ ★☆☆☆☆ Found in Text Mining only
Collecting Duct Carcinoma of the Kidney	Renal Carcinoma	CTD_human_DG	23797736	★★★★★ ★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	CTD_human_DG	23797736	★★★★★ ★☆☆☆☆ Found in Text Mining only
Papillary Renal Cell Carcinoma	Papillary Renal Carcinoma	CTD_human_DG	23797736	★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal Cell Carcinoma	Renal Carcinoma	CTD_human_DG	23797736	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcomatoid Renal Cell Carcinoma	Renal Carcinoma	CTD_human_DG	23797736	★★★★★ ★☆☆☆☆ Found in Text Mining only

FPGT (fucose-1-phosphate guanylyltransferase)