Gene Gene information from NCBI Gene database.
Entrez ID 8766
Gene name RAB11A, member RAS oncogene family
Gene symbol RAB11A
Synonyms (NCBI Gene)
YL8
Chromosome 15
Chromosome location 15q22.31
Summary The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isof
miRNA miRNA information provided by mirtarbase database.
1192
miRTarBase ID miRNA Experiments Reference
MIRT021133 hsa-miR-186-5p Sequencing 20371350
MIRT049348 hsa-miR-92a-3p CLASH 23622248
MIRT737848 hsa-miR-556-3p HITS-CLIP 33718276
MIRT1280877 hsa-miR-1224-3p CLIP-seq
MIRT1280878 hsa-miR-1260 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
120
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IDA 25673879
GO:0000166 Function Nucleotide binding IEA
GO:0000281 Process Mitotic cytokinesis IC 18511905
GO:0000922 Component Spindle pole IDA 24561039
GO:0003924 Function GTPase activity IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605570 9760 ENSG00000103769
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P62491
Protein name Ras-related protein Rab-11A (Rab-11) (EC 3.6.5.2) (YL8)
Protein function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to r
PDB 1OIV , 1OIW , 1OIX , 1YZK , 2D7C , 2GZD , 2GZH , 2HV8 , 4C4P , 4D0L , 4D0M , 4LWZ , 4LX0 , 4UJ3 , 4UJ4 , 4UJ5 , 5C46 , 5C4G , 5EUQ , 5EZ5 , 5FBL , 5FBQ , 5FBR , 5FBV , 5FBW , 5JCZ , 6DJL , 6IXV , 8VOF
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 13 174 Ras family Domain
Sequence
Sequence length 216
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Endocytosis
Endocrine and other factor-regulated calcium reabsorption
Vasopressin-regulated water reabsorption
Pancreatic secretion
Influenza A
  Vasopressin regulates renal water homeostasis via Aquaporins
Anchoring of the basal body to the plasma membrane
VxPx cargo-targeting to cilium
TBC/RABGAPs
RAB geranylgeranylation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
8
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ASTROCYTOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTOSOMAL DOMINANT NON-SYNDROMIC INTELLECTUAL DISABILITY Disgenet, Orphanet
Disgenet, Orphanet
Disgenet, Orphanet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHLORACNE CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CONGENITAL MICROCEPHALY Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Alzheimer Disease Alzheimer disease Pubtator 24373285 Associate
★☆☆☆☆
Found in Text Mining only
Amyloidosis Amyloidosis BEFREE 24373285
★☆☆☆☆
Found in Text Mining only
Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis BEFREE 25398946, 31196199
★☆☆☆☆
Found in Text Mining only
Amyotrophic Lateral Sclerosis Amyotrophic lateral sclerosis Pubtator 31196199 Inhibit
★☆☆☆☆
Found in Text Mining only
Atrophy Atrophy Pubtator 24413175 Associate
★☆☆☆☆
Found in Text Mining only
Autosomal dominant non-syndromic intellectual disability Non-Syndromic Intellectual Disability Orphanet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Barrett Esophagus Barrett esophagus Pubtator 10780572 Associate
★☆☆☆☆
Found in Text Mining only
Bladder Neoplasm Bladder Neoplasm BEFREE 30032159
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 19327867, 28781694, 29549047
★☆☆☆☆
Found in Text Mining only
Burkitt Lymphoma Burkitt`s Lymphoma BEFREE 27655016
★☆☆☆☆
Found in Text Mining only