Gene Gene information from NCBI Gene database.
Entrez ID 8739
Gene name Harakiri, BCL2 interacting protein
Gene symbol HRK
Synonyms (NCBI Gene)
DP5HARAKIRI
Chromosome 12
Chromosome location 12q24.22
Summary This gene encodes a member of the BCL-2 protein family. Members of this family are involved in activating or inhibiting apoptosis. The encoded protein localizes to intracellular membranes. This protein promotes apoptosis by interacting with the apoptotic
miRNA miRNA information provided by mirtarbase database.
893
miRTarBase ID miRNA Experiments Reference
MIRT608161 hsa-miR-8485 HITS-CLIP 22927820
MIRT678955 hsa-miR-377-3p HITS-CLIP 22927820
MIRT608161 hsa-miR-8485 HITS-CLIP 23313552
MIRT608160 hsa-miR-603 HITS-CLIP 23313552
MIRT608159 hsa-miR-3120-5p HITS-CLIP 23313552
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
ATF4 Activation 23090478
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
13
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 14596824, 15031724, 15694340
GO:0005739 Component Mitochondrion IBA
GO:0005739 Component Mitochondrion IDA 15031724
GO:0005739 Component Mitochondrion IEA
GO:0006915 Process Apoptotic process IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603447 5185 ENSG00000135116
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O00198
Protein name Activator of apoptosis harakiri (BH3-interacting domain-containing protein 3) (Neuronal death protein DP5)
Protein function Promotes apoptosis.
PDB 2L58 , 2L5B , 6XY4 , 7P0U
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15196 Harakiri 1 91 Activator of apoptosis harakiri Family
Sequence
Sequence length 91
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Apoptosis  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Astrocytoma Astrocytoma BEFREE 16155764
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 31825969 Associate
★☆☆☆☆
Found in Text Mining only
Cognition Disorders Cognition disorder Pubtator 22504421 Associate
★☆☆☆☆
Found in Text Mining only
Colorectal Carcinoma Colorectal Cancer BEFREE 14695142
★☆☆☆☆
Found in Text Mining only
Dementia Dementia Pubtator 22504421 Associate
★☆☆☆☆
Found in Text Mining only
Diabetes Gestational Gestational diabetes Pubtator 31923230 Inhibit
★☆☆☆☆
Found in Text Mining only
Diabetes Gestational Gestational diabetes Pubtator 38497391 Associate
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus Diabetes Mellitus BEFREE 31851028
★☆☆☆☆
Found in Text Mining only
Down Syndrome Down syndrome Pubtator 9758616 Associate
★☆☆☆☆
Found in Text Mining only
Glioblastoma Glioblastoma BEFREE 16155764
★☆☆☆☆
Found in Text Mining only