Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	8732
Gene name	RNA guanylyltransferase and 5'-phosphatase
Gene symbol	RNGTT
Synonyms (NCBI Gene)	CAP1AHCEHCE1hCAP
Chromosome	6
Chromosome location	6q15

207

Show/Hide all (207)

miRTarBase ID	miRNA	Experiments	Reference
MIRT050539	hsa-miR-20a-5p	CLASH	23622248
MIRT050338	hsa-miR-25-3p	CLASH	23622248
MIRT1313927	hsa-miR-103a	CLIP-seq
MIRT1313928	hsa-miR-107	CLIP-seq
MIRT1313929	hsa-miR-1253	CLIP-seq
MIRT1313930	hsa-miR-128	CLIP-seq
MIRT1313931	hsa-miR-1292	CLIP-seq
MIRT1313932	hsa-miR-1297	CLIP-seq
MIRT1313933	hsa-miR-1301	CLIP-seq
MIRT1313934	hsa-miR-205	CLIP-seq
MIRT1313935	hsa-miR-219-1-3p	CLIP-seq
MIRT1313936	hsa-miR-25	CLIP-seq
MIRT1313937	hsa-miR-26a	CLIP-seq
MIRT1313938	hsa-miR-26b	CLIP-seq
MIRT1313939	hsa-miR-27a	CLIP-seq
MIRT1313940	hsa-miR-27b	CLIP-seq
MIRT1313941	hsa-miR-300	CLIP-seq
MIRT1313942	hsa-miR-3171	CLIP-seq
MIRT1313943	hsa-miR-3174	CLIP-seq
MIRT1313944	hsa-miR-32	CLIP-seq
MIRT1313945	hsa-miR-363	CLIP-seq
MIRT1313946	hsa-miR-3646	CLIP-seq
MIRT1313947	hsa-miR-3647-3p	CLIP-seq
MIRT1313948	hsa-miR-367	CLIP-seq
MIRT1313949	hsa-miR-381	CLIP-seq
MIRT1313950	hsa-miR-3915	CLIP-seq
MIRT1313951	hsa-miR-3928	CLIP-seq
MIRT1313952	hsa-miR-3941	CLIP-seq
MIRT1313953	hsa-miR-4282	CLIP-seq
MIRT1313954	hsa-miR-4438	CLIP-seq
MIRT1313955	hsa-miR-4465	CLIP-seq
MIRT1313956	hsa-miR-4471	CLIP-seq
MIRT1313957	hsa-miR-4496	CLIP-seq
MIRT1313958	hsa-miR-466	CLIP-seq
MIRT1313959	hsa-miR-4666-3p	CLIP-seq
MIRT1313960	hsa-miR-4668-3p	CLIP-seq
MIRT1313961	hsa-miR-4672	CLIP-seq
MIRT1313962	hsa-miR-4699-3p	CLIP-seq
MIRT1313963	hsa-miR-4711-5p	CLIP-seq
MIRT1313964	hsa-miR-4732-3p	CLIP-seq
MIRT1313965	hsa-miR-4799-5p	CLIP-seq
MIRT1313966	hsa-miR-5047	CLIP-seq
MIRT1313967	hsa-miR-5095	CLIP-seq
MIRT1313968	hsa-miR-513b	CLIP-seq
MIRT1313969	hsa-miR-571	CLIP-seq
MIRT1313970	hsa-miR-586	CLIP-seq
MIRT1313971	hsa-miR-591	CLIP-seq
MIRT1313972	hsa-miR-92a	CLIP-seq
MIRT1313973	hsa-miR-92b	CLIP-seq
MIRT2093398	hsa-miR-1	CLIP-seq
MIRT2093399	hsa-miR-1228	CLIP-seq
MIRT1313930	hsa-miR-128	CLIP-seq
MIRT2093400	hsa-miR-1305	CLIP-seq
MIRT2093401	hsa-miR-206	CLIP-seq
MIRT1313939	hsa-miR-27a	CLIP-seq
MIRT1313940	hsa-miR-27b	CLIP-seq
MIRT2093402	hsa-miR-3148	CLIP-seq
MIRT2093403	hsa-miR-3978	CLIP-seq
MIRT2093404	hsa-miR-4303	CLIP-seq
MIRT1313962	hsa-miR-4699-3p	CLIP-seq
MIRT2093405	hsa-miR-4762-3p	CLIP-seq
MIRT2093406	hsa-miR-613	CLIP-seq
MIRT2093407	hsa-miR-642b	CLIP-seq
MIRT2093408	hsa-miR-936	CLIP-seq
MIRT2093398	hsa-miR-1	CLIP-seq
MIRT2317952	hsa-miR-153	CLIP-seq
MIRT2093401	hsa-miR-206	CLIP-seq
MIRT2317953	hsa-miR-3065-5p	CLIP-seq
MIRT2093402	hsa-miR-3148	CLIP-seq
MIRT2317954	hsa-miR-3166	CLIP-seq
MIRT2317955	hsa-miR-3692	CLIP-seq
MIRT2093403	hsa-miR-3978	CLIP-seq
MIRT2317956	hsa-miR-4275	CLIP-seq
MIRT2317957	hsa-miR-448	CLIP-seq
MIRT2317958	hsa-miR-4789-5p	CLIP-seq
MIRT2317959	hsa-miR-606	CLIP-seq
MIRT2093406	hsa-miR-613	CLIP-seq
MIRT2093407	hsa-miR-642b	CLIP-seq
MIRT2317960	hsa-miR-659	CLIP-seq
MIRT2317961	hsa-miR-668	CLIP-seq
MIRT2093408	hsa-miR-936	CLIP-seq
MIRT2093398	hsa-miR-1	CLIP-seq
MIRT2093401	hsa-miR-206	CLIP-seq
MIRT2093402	hsa-miR-3148	CLIP-seq
MIRT2093403	hsa-miR-3978	CLIP-seq
MIRT2093404	hsa-miR-4303	CLIP-seq
MIRT2093405	hsa-miR-4762-3p	CLIP-seq
MIRT2093406	hsa-miR-613	CLIP-seq
MIRT2093407	hsa-miR-642b	CLIP-seq
MIRT2613649	hsa-let-7a	CLIP-seq
MIRT2613650	hsa-let-7b	CLIP-seq
MIRT2613651	hsa-let-7c	CLIP-seq
MIRT2613652	hsa-let-7d	CLIP-seq
MIRT2613653	hsa-let-7e	CLIP-seq
MIRT2613654	hsa-let-7f	CLIP-seq
MIRT2613655	hsa-let-7g	CLIP-seq
MIRT2613656	hsa-let-7i	CLIP-seq
MIRT2093398	hsa-miR-1	CLIP-seq
MIRT2613657	hsa-miR-1205	CLIP-seq
MIRT2093399	hsa-miR-1228	CLIP-seq
MIRT1313929	hsa-miR-1253	CLIP-seq
MIRT2613658	hsa-miR-1256	CLIP-seq
MIRT2613659	hsa-miR-1286	CLIP-seq
MIRT2613660	hsa-miR-129-3p	CLIP-seq
MIRT2613661	hsa-miR-186	CLIP-seq
MIRT2613662	hsa-miR-202	CLIP-seq
MIRT1313934	hsa-miR-205	CLIP-seq
MIRT2093401	hsa-miR-206	CLIP-seq
MIRT2613663	hsa-miR-298	CLIP-seq
MIRT1313941	hsa-miR-300	CLIP-seq
MIRT2093402	hsa-miR-3148	CLIP-seq
MIRT2613664	hsa-miR-3185	CLIP-seq
MIRT1313946	hsa-miR-3646	CLIP-seq
MIRT1313947	hsa-miR-3647-3p	CLIP-seq
MIRT2613665	hsa-miR-3653	CLIP-seq
MIRT2613666	hsa-miR-3658	CLIP-seq
MIRT2613667	hsa-miR-3662	CLIP-seq
MIRT2613668	hsa-miR-3685	CLIP-seq
MIRT2613669	hsa-miR-370	CLIP-seq
MIRT1313949	hsa-miR-381	CLIP-seq
MIRT2613670	hsa-miR-384	CLIP-seq
MIRT1313952	hsa-miR-3941	CLIP-seq
MIRT2093403	hsa-miR-3978	CLIP-seq
MIRT2093404	hsa-miR-4303	CLIP-seq
MIRT2613671	hsa-miR-4418	CLIP-seq
MIRT2613672	hsa-miR-4422	CLIP-seq
MIRT2613673	hsa-miR-4458	CLIP-seq
MIRT2613674	hsa-miR-4500	CLIP-seq
MIRT1313958	hsa-miR-466	CLIP-seq
MIRT1313959	hsa-miR-4666-3p	CLIP-seq
MIRT1313960	hsa-miR-4668-3p	CLIP-seq
MIRT1313961	hsa-miR-4672	CLIP-seq
MIRT2613675	hsa-miR-4687-5p	CLIP-seq
MIRT2613676	hsa-miR-4720-5p	CLIP-seq
MIRT2613677	hsa-miR-4722-3p	CLIP-seq
MIRT2613678	hsa-miR-4722-5p	CLIP-seq
MIRT1313964	hsa-miR-4732-3p	CLIP-seq
MIRT2093405	hsa-miR-4762-3p	CLIP-seq
MIRT2613679	hsa-miR-4768-3p	CLIP-seq
MIRT2613680	hsa-miR-4777-5p	CLIP-seq
MIRT2613681	hsa-miR-4799-3p	CLIP-seq
MIRT1313965	hsa-miR-4799-5p	CLIP-seq
MIRT2613682	hsa-miR-488	CLIP-seq
MIRT2613683	hsa-miR-495	CLIP-seq
MIRT2613684	hsa-miR-509-3-5p	CLIP-seq
MIRT2613685	hsa-miR-509-5p	CLIP-seq
MIRT1313968	hsa-miR-513b	CLIP-seq
MIRT2613686	hsa-miR-548ac	CLIP-seq
MIRT2613687	hsa-miR-548ae	CLIP-seq
MIRT2613688	hsa-miR-548aj	CLIP-seq
MIRT2613689	hsa-miR-548am	CLIP-seq
MIRT2613690	hsa-miR-548d-3p	CLIP-seq
MIRT2613691	hsa-miR-548p	CLIP-seq
MIRT2613692	hsa-miR-548u	CLIP-seq
MIRT2613693	hsa-miR-548x	CLIP-seq
MIRT2613694	hsa-miR-548z	CLIP-seq
MIRT2613695	hsa-miR-562	CLIP-seq
MIRT1313970	hsa-miR-586	CLIP-seq
MIRT1313971	hsa-miR-591	CLIP-seq
MIRT2093406	hsa-miR-613	CLIP-seq
MIRT2317961	hsa-miR-668	CLIP-seq
MIRT2093408	hsa-miR-936	CLIP-seq
MIRT2613696	hsa-miR-98	CLIP-seq
MIRT2613649	hsa-let-7a	CLIP-seq
MIRT2613650	hsa-let-7b	CLIP-seq
MIRT2613651	hsa-let-7c	CLIP-seq
MIRT2613652	hsa-let-7d	CLIP-seq
MIRT2613653	hsa-let-7e	CLIP-seq
MIRT2613654	hsa-let-7f	CLIP-seq
MIRT2613655	hsa-let-7g	CLIP-seq
MIRT2613656	hsa-let-7i	CLIP-seq
MIRT2093398	hsa-miR-1	CLIP-seq
MIRT1313929	hsa-miR-1253	CLIP-seq
MIRT2613658	hsa-miR-1256	CLIP-seq
MIRT2613660	hsa-miR-129-3p	CLIP-seq
MIRT2613661	hsa-miR-186	CLIP-seq
MIRT2613662	hsa-miR-202	CLIP-seq
MIRT1313934	hsa-miR-205	CLIP-seq
MIRT2093401	hsa-miR-206	CLIP-seq
MIRT2613663	hsa-miR-298	CLIP-seq
MIRT1313941	hsa-miR-300	CLIP-seq
MIRT2093402	hsa-miR-3148	CLIP-seq
MIRT1313949	hsa-miR-381	CLIP-seq
MIRT2093403	hsa-miR-3978	CLIP-seq
MIRT2093404	hsa-miR-4303	CLIP-seq
MIRT2613672	hsa-miR-4422	CLIP-seq
MIRT2613673	hsa-miR-4458	CLIP-seq
MIRT2613674	hsa-miR-4500	CLIP-seq
MIRT1313959	hsa-miR-4666-3p	CLIP-seq
MIRT1313960	hsa-miR-4668-3p	CLIP-seq
MIRT2613675	hsa-miR-4687-5p	CLIP-seq
MIRT2613676	hsa-miR-4720-5p	CLIP-seq
MIRT2613677	hsa-miR-4722-3p	CLIP-seq
MIRT2093405	hsa-miR-4762-3p	CLIP-seq
MIRT2613680	hsa-miR-4777-5p	CLIP-seq
MIRT2613681	hsa-miR-4799-3p	CLIP-seq
MIRT2613682	hsa-miR-488	CLIP-seq
MIRT2613683	hsa-miR-495	CLIP-seq
MIRT1313968	hsa-miR-513b	CLIP-seq
MIRT2613691	hsa-miR-548p	CLIP-seq
MIRT2613695	hsa-miR-562	CLIP-seq
MIRT1313970	hsa-miR-586	CLIP-seq
MIRT2093406	hsa-miR-613	CLIP-seq
MIRT2093407	hsa-miR-642b	CLIP-seq
MIRT2317961	hsa-miR-668	CLIP-seq
MIRT2093408	hsa-miR-936	CLIP-seq
MIRT2613696	hsa-miR-98	CLIP-seq

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003824	Function	Catalytic activity	IEA
GO:0004484	Function	MRNA guanylyltransferase activity	IBA
GO:0004484	Function	MRNA guanylyltransferase activity	IDA	9473487
GO:0004484	Function	MRNA guanylyltransferase activity	IEA
GO:0004651	Function	Polynucleotide 5'-phosphatase activity	IEA
GO:0004651	Function	Polynucleotide 5'-phosphatase activity	TAS
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0005515	Function	Protein binding	IPI	25137142, 32296183, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005525	Function	GTP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	9473487
GO:0005654	Component	Nucleoplasm	TAS
GO:0006139	Process	Nucleobase-containing compound metabolic process	IEA
GO:0006370	Process	7-methylguanosine mRNA capping	IBA
GO:0006370	Process	7-methylguanosine mRNA capping	IDA	9473487
GO:0006370	Process	7-methylguanosine mRNA capping	IEA
GO:0006370	Process	7-methylguanosine mRNA capping	TAS
GO:0006396	Process	RNA processing	IDA	21636784
GO:0006397	Process	MRNA processing	IEA
GO:0008192	Function	RNA guanylyltransferase activity	IDA	21636784
GO:0016740	Function	Transferase activity	IEA
GO:0016779	Function	Nucleotidyltransferase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0050355	Function	Inorganic triphosphate phosphatase activity	IDA	9473487
GO:0140818	Function	MRNA 5'-triphosphate monophosphatase activity	IEA

MIM	HGNC	e!Ensembl
603512	10073	ENSG00000111880

O60942

Protein name

mRNA-capping enzyme (HCAP1) (HCE) [Includes: mRNA 5'-triphosphate monophosphatase (EC 3.6.1.74) (mRNA 5'-phosphatase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)]

Protein function

Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-p

PDB

2C46 , 3S24 , 8P4A , 8P4B , 8P4C , 8P4D , 8P4E , 8W8E , 8W8F

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00782	DSPc	46 → 179	Dual specificity phosphatase, catalytic domain	Domain
PF01331	mRNA_cap_enzyme	272 → 460	mRNA capping enzyme, catalytic domain	Domain
PF03919	mRNA_cap_C	464 → 559	mRNA capping enzyme, C-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Isoform 1 and isoform 4 (at a lesser extent) are expressed in cerebrum, cerebellum, thyroid, lung, heart, liver, kidney, spleen, large intestine, testis, skin and muscle.

Sequence

MAHNKIPPRWLNCPRRGQPVAGRFLPLKTMLGPRYDSQVAEENRFHPSMLSNYLKSLKVK
MGLLVDLTNTSRFYDRNDIEKEGIKYIKLQCKGHGECPTTENTETFIRLCERFNERNPPE
LIGVHCTHGFNRTGFLICAFLVEKMDWSIEAAVATFAQARPPGIYKGDYLKELFRRYGDI
EEAPPPPLLPDWCFEDDEDEDEDEDGKKESEPGSSASFGKRRKERLKLGAIFLEGVTVKG
VTQVTTQPKLGEVQQKCHQFCGWEGSGFPGAQPVSMDKQNIKLLDLKPYKVSWKADGTRY
MMLIDGTNEVFMIDRDNSVFHVSNLEFPFRKDLRMHLSNTLLDGEMIIDRVNGQAVPRYL
IYDIIKFNSQPVGDCDFNVRLQCIEREIISPRHEKMKTGLIDKTQEPFSVRNKPFFDICT
SRKLLEGNFAKEVSHEMDGLIFQPTGKYKPGRCDDILKWKPPSLNSVDFRLKITRMGGEG
LLPQNVGLLYVGGYERPFAQIKVTKELKQYDNKIIECKFENNSWVFMRQRTDKSFPNAYN
TAMAVCNSISNPVTKEMLFEFIDRCTAASQGQKRKHHLDPDTELMPPPPPKRPRPLT

Sequence length

597

Interactions

View interactions

	KEGG		Reactome
	mRNA surveillance pathway		mRNA Capping RNA Pol II CTD phosphorylation and interaction with CE

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (11)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BIPOLAR DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIAL NEOPLASM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MENTAL OR BEHAVIOURAL DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-ALCOHOLIC FATTY LIVER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (20)

Disease Name	Disease (Merged)	Source	PMID	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma of large intestine	Colorectal Cancer	GWASCAT_DG	26621817	★★★★★ ★☆☆☆☆ Found in Text Mining only
alpha-Thalassemia	alpha Thalassemia	BEFREE	17900295	★★★★★ ★☆☆☆☆ Found in Text Mining only
alpha^+^ Thalassemia	alpha Thalassemia	BEFREE	17900295	★★★★★ ★☆☆☆☆ Found in Text Mining only
beta Thalassemia	beta Thalassemia	BEFREE	17900295	★★★★★ ★☆☆☆☆ Found in Text Mining only
beta^+^ Thalassemia	beta Thalassemia	BEFREE	17900295	★★★★★ ★☆☆☆☆ Found in Text Mining only
CATARACT, ANTERIOR POLAR	Cataract	BEFREE	31843272	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	BEFREE	27431006	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	GWASCAT_DG	26621817	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal Neoplasms	GWASCAT_DG	26621817	★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial Neoplasms	GWASCAT_DG	26621817	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	31268531	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	14603441	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of large intestine	Colorectal Neoplasms	GWASCAT_DG	26621817	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	14603441	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	28445145	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	14603441	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	GWASCAT_DG	26621817	★★★★★ ★☆☆☆☆ Found in Text Mining only
Narcolepsy	Narcolepsy	GWASDB_DG	19629137	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	28445145	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	28445145	★★★★★ ★☆☆☆☆ Found in Text Mining only

RNGTT (RNA guanylyltransferase and 5'-phosphatase)