Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	8728
Gene name	ADAM metallopeptidase domain 19
Gene symbol	ADAM19
Synonyms (NCBI Gene)	FKSG34MADDAMMLTNB
Chromosome	5
Chromosome location	5q33.3
Summary	This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes

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miRTarBase ID	miRNA	Experiments	Reference
MIRT660931	hsa-miR-4753-5p	HITS-CLIP	23824327
MIRT660930	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT660929	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT660928	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT660927	hsa-miR-3183	HITS-CLIP	23824327
MIRT660926	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT660925	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT660924	hsa-miR-4469	HITS-CLIP	23824327
MIRT660923	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT660922	hsa-miR-4287	HITS-CLIP	23824327
MIRT660920	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT660921	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT660919	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT660918	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT660917	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT660916	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT660915	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT660914	hsa-miR-507	HITS-CLIP	23824327
MIRT660913	hsa-miR-557	HITS-CLIP	23824327
MIRT660912	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT733905	hsa-miR-7973	Luciferase reporter assayMicroarrayqRT-PCR	32042028
MIRT736303	hsa-miR-206	Luciferase reporter assayRNA-seqqRT-PCR	32129700
MIRT660931	hsa-miR-4753-5p	HITS-CLIP	23824327
MIRT660930	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT660929	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT660928	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT660927	hsa-miR-3183	HITS-CLIP	23824327
MIRT660926	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT660925	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT660924	hsa-miR-4469	HITS-CLIP	23824327
MIRT660923	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT660922	hsa-miR-4287	HITS-CLIP	23824327
MIRT660920	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT660921	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT660919	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT660918	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT660917	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT660916	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT660915	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT660914	hsa-miR-507	HITS-CLIP	23824327
MIRT660913	hsa-miR-557	HITS-CLIP	23824327
MIRT660912	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT766002	hsa-miR-1178	CLIP-seq
MIRT766003	hsa-miR-1207-5p	CLIP-seq
MIRT766004	hsa-miR-124	CLIP-seq
MIRT766005	hsa-miR-1257	CLIP-seq
MIRT766006	hsa-miR-1273g	CLIP-seq
MIRT766007	hsa-miR-1286	CLIP-seq
MIRT766008	hsa-miR-1288	CLIP-seq
MIRT766009	hsa-miR-1294	CLIP-seq
MIRT766010	hsa-miR-1321	CLIP-seq
MIRT766011	hsa-miR-137	CLIP-seq
MIRT766012	hsa-miR-183	CLIP-seq
MIRT766013	hsa-miR-22	CLIP-seq
MIRT766014	hsa-miR-2392	CLIP-seq
MIRT766015	hsa-miR-2467-5p	CLIP-seq
MIRT766016	hsa-miR-302f	CLIP-seq
MIRT766017	hsa-miR-3126-5p	CLIP-seq
MIRT766018	hsa-miR-3136-3p	CLIP-seq
MIRT766019	hsa-miR-3148	CLIP-seq
MIRT766020	hsa-miR-3150a-3p	CLIP-seq
MIRT766021	hsa-miR-3150b-3p	CLIP-seq
MIRT766022	hsa-miR-3151	CLIP-seq
MIRT766023	hsa-miR-3169	CLIP-seq
MIRT766024	hsa-miR-3175	CLIP-seq
MIRT766025	hsa-miR-3184	CLIP-seq
MIRT766026	hsa-miR-3194-3p	CLIP-seq
MIRT766027	hsa-miR-345	CLIP-seq
MIRT766028	hsa-miR-3613-3p	CLIP-seq
MIRT766029	hsa-miR-3620	CLIP-seq
MIRT766030	hsa-miR-3650	CLIP-seq
MIRT766031	hsa-miR-3689d	CLIP-seq
MIRT766032	hsa-miR-3974	CLIP-seq
MIRT766033	hsa-miR-423-5p	CLIP-seq
MIRT766034	hsa-miR-4270	CLIP-seq
MIRT766035	hsa-miR-4299	CLIP-seq
MIRT766036	hsa-miR-4316	CLIP-seq
MIRT766037	hsa-miR-4419a	CLIP-seq
MIRT766038	hsa-miR-4434	CLIP-seq
MIRT766039	hsa-miR-4436a	CLIP-seq
MIRT766040	hsa-miR-4441	CLIP-seq
MIRT766041	hsa-miR-4456	CLIP-seq
MIRT766042	hsa-miR-4459	CLIP-seq
MIRT766043	hsa-miR-4489	CLIP-seq
MIRT766044	hsa-miR-4510	CLIP-seq
MIRT766045	hsa-miR-4516	CLIP-seq
MIRT766046	hsa-miR-4652-3p	CLIP-seq
MIRT766047	hsa-miR-4663	CLIP-seq
MIRT766048	hsa-miR-4667-3p	CLIP-seq
MIRT766049	hsa-miR-4677-3p	CLIP-seq
MIRT766050	hsa-miR-4679	CLIP-seq
MIRT766051	hsa-miR-4685-5p	CLIP-seq
MIRT766052	hsa-miR-4704-3p	CLIP-seq
MIRT766053	hsa-miR-4712-3p	CLIP-seq
MIRT766054	hsa-miR-4722-5p	CLIP-seq
MIRT766055	hsa-miR-4728-5p	CLIP-seq
MIRT766056	hsa-miR-4733-3p	CLIP-seq
MIRT766057	hsa-miR-4736	CLIP-seq
MIRT766058	hsa-miR-4739	CLIP-seq
MIRT766059	hsa-miR-4756-5p	CLIP-seq
MIRT766060	hsa-miR-4763-3p	CLIP-seq
MIRT766061	hsa-miR-4784	CLIP-seq
MIRT766062	hsa-miR-486-3p	CLIP-seq
MIRT766063	hsa-miR-491-5p	CLIP-seq
MIRT766064	hsa-miR-493	CLIP-seq
MIRT766065	hsa-miR-506	CLIP-seq
MIRT766066	hsa-miR-516b	CLIP-seq
MIRT766067	hsa-miR-548an	CLIP-seq
MIRT766068	hsa-miR-548q	CLIP-seq
MIRT766069	hsa-miR-765	CLIP-seq
MIRT766070	hsa-miR-767-5p	CLIP-seq
MIRT766071	hsa-miR-877	CLIP-seq
MIRT766072	hsa-miR-939	CLIP-seq
MIRT766073	hsa-miR-943	CLIP-seq
MIRT766005	hsa-miR-1257	CLIP-seq
MIRT766005	hsa-miR-1257	CLIP-seq
MIRT766005	hsa-miR-1257	CLIP-seq
MIRT1925709	hsa-miR-1200	CLIP-seq
MIRT766005	hsa-miR-1257	CLIP-seq
MIRT1925710	hsa-miR-1297	CLIP-seq
MIRT1925711	hsa-miR-2052	CLIP-seq
MIRT1925712	hsa-miR-2110	CLIP-seq
MIRT1925713	hsa-miR-2467-3p	CLIP-seq
MIRT1925714	hsa-miR-26a	CLIP-seq
MIRT1925715	hsa-miR-26b	CLIP-seq
MIRT1925716	hsa-miR-29a	CLIP-seq
MIRT1925717	hsa-miR-29b	CLIP-seq
MIRT1925718	hsa-miR-29c	CLIP-seq
MIRT766018	hsa-miR-3136-3p	CLIP-seq
MIRT1925719	hsa-miR-3176	CLIP-seq
MIRT1925720	hsa-miR-330-3p	CLIP-seq
MIRT1925721	hsa-miR-3649	CLIP-seq
MIRT1925722	hsa-miR-3663-5p	CLIP-seq
MIRT1925723	hsa-miR-3664-5p	CLIP-seq
MIRT1925724	hsa-miR-3678-3p	CLIP-seq
MIRT1925725	hsa-miR-3922-3p	CLIP-seq
MIRT1925726	hsa-miR-4271	CLIP-seq
MIRT1925727	hsa-miR-4307	CLIP-seq
MIRT1925728	hsa-miR-4324	CLIP-seq
MIRT1925729	hsa-miR-4433	CLIP-seq
MIRT1925730	hsa-miR-4465	CLIP-seq
MIRT766053	hsa-miR-4712-3p	CLIP-seq
MIRT1925731	hsa-miR-4714-5p	CLIP-seq
MIRT1925732	hsa-miR-4725-3p	CLIP-seq
MIRT1925733	hsa-miR-4747-5p	CLIP-seq
MIRT1925734	hsa-miR-483-3p	CLIP-seq
MIRT1925735	hsa-miR-488	CLIP-seq
MIRT1925736	hsa-miR-5096	CLIP-seq
MIRT1925737	hsa-miR-544b	CLIP-seq
MIRT1925738	hsa-miR-665	CLIP-seq
MIRT1925739	hsa-miR-934	CLIP-seq
MIRT2167099	hsa-miR-122	CLIP-seq
MIRT766005	hsa-miR-1257	CLIP-seq
MIRT2167100	hsa-miR-1285	CLIP-seq
MIRT2167101	hsa-miR-1304	CLIP-seq
MIRT2167102	hsa-miR-1343	CLIP-seq
MIRT2167103	hsa-miR-1909	CLIP-seq
MIRT1925711	hsa-miR-2052	CLIP-seq
MIRT2167104	hsa-miR-3065-3p	CLIP-seq
MIRT2167105	hsa-miR-3187-5p	CLIP-seq
MIRT1925727	hsa-miR-4307	CLIP-seq
MIRT2167106	hsa-miR-4481	CLIP-seq
MIRT766055	hsa-miR-4728-5p	CLIP-seq
MIRT2167107	hsa-miR-4745-5p	CLIP-seq
MIRT2167108	hsa-miR-4752	CLIP-seq
MIRT1925735	hsa-miR-488	CLIP-seq
MIRT1925736	hsa-miR-5096	CLIP-seq
MIRT2167109	hsa-miR-612	CLIP-seq
MIRT2167110	hsa-miR-642a	CLIP-seq
MIRT766005	hsa-miR-1257	CLIP-seq
MIRT2383883	hsa-miR-370	CLIP-seq
MIRT1925737	hsa-miR-544b	CLIP-seq
MIRT766069	hsa-miR-765	CLIP-seq
MIRT2167100	hsa-miR-1285	CLIP-seq
MIRT2167102	hsa-miR-1343	CLIP-seq
MIRT2443140	hsa-miR-1976	CLIP-seq
MIRT2167105	hsa-miR-3187-5p	CLIP-seq
MIRT2443141	hsa-miR-3618	CLIP-seq
MIRT2383883	hsa-miR-370	CLIP-seq
MIRT2443142	hsa-miR-4435	CLIP-seq
MIRT2443143	hsa-miR-4691-5p	CLIP-seq
MIRT2167109	hsa-miR-612	CLIP-seq
MIRT2443144	hsa-miR-626	CLIP-seq
MIRT1925739	hsa-miR-934	CLIP-seq
MIRT1925709	hsa-miR-1200	CLIP-seq
MIRT2469623	hsa-miR-1224-5p	CLIP-seq
MIRT766004	hsa-miR-124	CLIP-seq
MIRT2469624	hsa-miR-1253	CLIP-seq
MIRT766005	hsa-miR-1257	CLIP-seq
MIRT2469625	hsa-miR-125a-5p	CLIP-seq
MIRT2469626	hsa-miR-125b	CLIP-seq
MIRT1925710	hsa-miR-1297	CLIP-seq
MIRT2469627	hsa-miR-1301	CLIP-seq
MIRT2469628	hsa-miR-145	CLIP-seq
MIRT2469629	hsa-miR-148a	CLIP-seq
MIRT2469630	hsa-miR-148b	CLIP-seq
MIRT2469631	hsa-miR-150	CLIP-seq
MIRT2469632	hsa-miR-152	CLIP-seq
MIRT2469633	hsa-miR-153	CLIP-seq
MIRT2469634	hsa-miR-1825	CLIP-seq
MIRT2167103	hsa-miR-1909	CLIP-seq
MIRT2469635	hsa-miR-199a-5p	CLIP-seq
MIRT2469636	hsa-miR-199b-5p	CLIP-seq
MIRT766015	hsa-miR-2467-5p	CLIP-seq
MIRT1925714	hsa-miR-26a	CLIP-seq
MIRT1925715	hsa-miR-26b	CLIP-seq
MIRT2469637	hsa-miR-3064-5p	CLIP-seq
MIRT2469638	hsa-miR-3074-5p	CLIP-seq
MIRT2469639	hsa-miR-30a	CLIP-seq
MIRT2469640	hsa-miR-30b	CLIP-seq
MIRT2469641	hsa-miR-30c	CLIP-seq
MIRT2469642	hsa-miR-30d	CLIP-seq
MIRT2469643	hsa-miR-30e	CLIP-seq
MIRT766017	hsa-miR-3126-5p	CLIP-seq
MIRT766018	hsa-miR-3136-3p	CLIP-seq
MIRT2469644	hsa-miR-3138	CLIP-seq
MIRT2469645	hsa-miR-3145-5p	CLIP-seq
MIRT766019	hsa-miR-3148	CLIP-seq
MIRT2469646	hsa-miR-3156-5p	CLIP-seq
MIRT2469647	hsa-miR-3185	CLIP-seq
MIRT766026	hsa-miR-3194-3p	CLIP-seq
MIRT2469648	hsa-miR-320a	CLIP-seq
MIRT2469649	hsa-miR-320b	CLIP-seq
MIRT2469650	hsa-miR-320c	CLIP-seq
MIRT2469651	hsa-miR-320d	CLIP-seq
MIRT2469652	hsa-miR-320e	CLIP-seq
MIRT766027	hsa-miR-345	CLIP-seq
MIRT766029	hsa-miR-3620	CLIP-seq
MIRT2469653	hsa-miR-3915	CLIP-seq
MIRT2469654	hsa-miR-3925-3p	CLIP-seq
MIRT2469655	hsa-miR-3928	CLIP-seq
MIRT2469656	hsa-miR-3940-5p	CLIP-seq
MIRT2469657	hsa-miR-3944-5p	CLIP-seq
MIRT2469658	hsa-miR-3978	CLIP-seq
MIRT2469659	hsa-miR-4263	CLIP-seq
MIRT2469660	hsa-miR-4297	CLIP-seq
MIRT2469661	hsa-miR-4319	CLIP-seq
MIRT1925728	hsa-miR-4324	CLIP-seq
MIRT766037	hsa-miR-4419a	CLIP-seq
MIRT2469662	hsa-miR-4429	CLIP-seq
MIRT1925730	hsa-miR-4465	CLIP-seq
MIRT2469663	hsa-miR-448	CLIP-seq
MIRT2469664	hsa-miR-4507	CLIP-seq
MIRT766044	hsa-miR-4510	CLIP-seq
MIRT2469665	hsa-miR-4660	CLIP-seq
MIRT2469666	hsa-miR-4689	CLIP-seq
MIRT2469667	hsa-miR-4713-5p	CLIP-seq
MIRT2469668	hsa-miR-4799-5p	CLIP-seq
MIRT2469669	hsa-miR-5047	CLIP-seq
MIRT766065	hsa-miR-506	CLIP-seq
MIRT2469670	hsa-miR-515-5p	CLIP-seq
MIRT2469671	hsa-miR-532-3p	CLIP-seq
MIRT1925737	hsa-miR-544b	CLIP-seq
MIRT766067	hsa-miR-548an	CLIP-seq
MIRT2469672	hsa-miR-576-3p	CLIP-seq
MIRT2469673	hsa-miR-576-5p	CLIP-seq
MIRT2469674	hsa-miR-604	CLIP-seq
MIRT2469675	hsa-miR-633	CLIP-seq
MIRT2469676	hsa-miR-647	CLIP-seq
MIRT2469677	hsa-miR-766	CLIP-seq
MIRT766070	hsa-miR-767-5p	CLIP-seq
MIRT766073	hsa-miR-943	CLIP-seq
MIRT1925709	hsa-miR-1200	CLIP-seq
MIRT2469623	hsa-miR-1224-5p	CLIP-seq
MIRT766004	hsa-miR-124	CLIP-seq
MIRT2469624	hsa-miR-1253	CLIP-seq
MIRT2469625	hsa-miR-125a-5p	CLIP-seq
MIRT2469626	hsa-miR-125b	CLIP-seq
MIRT2167100	hsa-miR-1285	CLIP-seq
MIRT1925710	hsa-miR-1297	CLIP-seq
MIRT2469627	hsa-miR-1301	CLIP-seq
MIRT2674397	hsa-miR-1323	CLIP-seq
MIRT2469628	hsa-miR-145	CLIP-seq
MIRT2469629	hsa-miR-148a	CLIP-seq
MIRT2469630	hsa-miR-148b	CLIP-seq
MIRT2469631	hsa-miR-150	CLIP-seq
MIRT2469632	hsa-miR-152	CLIP-seq
MIRT2469633	hsa-miR-153	CLIP-seq
MIRT2469634	hsa-miR-1825	CLIP-seq
MIRT2469635	hsa-miR-199a-5p	CLIP-seq
MIRT2469636	hsa-miR-199b-5p	CLIP-seq
MIRT766015	hsa-miR-2467-5p	CLIP-seq
MIRT1925714	hsa-miR-26a	CLIP-seq
MIRT1925715	hsa-miR-26b	CLIP-seq
MIRT2469638	hsa-miR-3074-5p	CLIP-seq
MIRT2469639	hsa-miR-30a	CLIP-seq
MIRT2469640	hsa-miR-30b	CLIP-seq
MIRT2469641	hsa-miR-30c	CLIP-seq
MIRT2469642	hsa-miR-30d	CLIP-seq
MIRT2469643	hsa-miR-30e	CLIP-seq
MIRT766017	hsa-miR-3126-5p	CLIP-seq
MIRT766018	hsa-miR-3136-3p	CLIP-seq
MIRT2469644	hsa-miR-3138	CLIP-seq
MIRT2469645	hsa-miR-3145-5p	CLIP-seq
MIRT766019	hsa-miR-3148	CLIP-seq
MIRT2469646	hsa-miR-3156-5p	CLIP-seq
MIRT2469647	hsa-miR-3185	CLIP-seq
MIRT2167105	hsa-miR-3187-5p	CLIP-seq
MIRT766026	hsa-miR-3194-3p	CLIP-seq
MIRT2469648	hsa-miR-320a	CLIP-seq
MIRT2469649	hsa-miR-320b	CLIP-seq
MIRT2469650	hsa-miR-320c	CLIP-seq
MIRT2469651	hsa-miR-320d	CLIP-seq
MIRT2469652	hsa-miR-320e	CLIP-seq
MIRT766027	hsa-miR-345	CLIP-seq
MIRT766029	hsa-miR-3620	CLIP-seq
MIRT2674398	hsa-miR-3647-3p	CLIP-seq
MIRT2674399	hsa-miR-371b-5p	CLIP-seq
MIRT2469653	hsa-miR-3915	CLIP-seq
MIRT2469655	hsa-miR-3928	CLIP-seq
MIRT2469656	hsa-miR-3940-5p	CLIP-seq
MIRT2469657	hsa-miR-3944-5p	CLIP-seq
MIRT2469658	hsa-miR-3978	CLIP-seq
MIRT2469661	hsa-miR-4319	CLIP-seq
MIRT1925728	hsa-miR-4324	CLIP-seq
MIRT766037	hsa-miR-4419a	CLIP-seq
MIRT2469662	hsa-miR-4429	CLIP-seq
MIRT1925730	hsa-miR-4465	CLIP-seq
MIRT2469663	hsa-miR-448	CLIP-seq
MIRT2469664	hsa-miR-4507	CLIP-seq
MIRT766044	hsa-miR-4510	CLIP-seq
MIRT2469665	hsa-miR-4660	CLIP-seq
MIRT2469666	hsa-miR-4689	CLIP-seq
MIRT2469667	hsa-miR-4713-5p	CLIP-seq
MIRT2469669	hsa-miR-5047	CLIP-seq
MIRT766065	hsa-miR-506	CLIP-seq
MIRT2469671	hsa-miR-532-3p	CLIP-seq
MIRT1925737	hsa-miR-544b	CLIP-seq
MIRT766067	hsa-miR-548an	CLIP-seq
MIRT2674400	hsa-miR-548o	CLIP-seq
MIRT2469672	hsa-miR-576-3p	CLIP-seq
MIRT2167109	hsa-miR-612	CLIP-seq
MIRT2469675	hsa-miR-633	CLIP-seq
MIRT766069	hsa-miR-765	CLIP-seq
MIRT766070	hsa-miR-767-5p	CLIP-seq
MIRT2674401	hsa-miR-875-3p	CLIP-seq
MIRT766073	hsa-miR-943	CLIP-seq

Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001890	Process	Placenta development	IEP	19727588
GO:0004222	Function	Metalloendopeptidase activity	IBA
GO:0004222	Function	Metalloendopeptidase activity	IEA
GO:0004222	Function	Metalloendopeptidase activity	IMP	11162584, 17112471
GO:0005515	Function	Protein binding	IPI	11162584, 17112471, 25825872, 33961781
GO:0005634	Component	Nucleus	IDA	19727588
GO:0005886	Component	Plasma membrane	TAS
GO:0006508	Process	Proteolysis	IEA
GO:0006509	Process	Membrane protein ectodomain proteolysis	IBA
GO:0008233	Function	Peptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0010628	Process	Positive regulation of gene expression	IDA	19727588
GO:0016020	Component	Membrane	IEA
GO:0016485	Process	Protein processing	IMP	17112471
GO:0016787	Function	Hydrolase activity	IEA
GO:0017124	Function	SH3 domain binding	IEA
GO:0031012	Component	Extracellular matrix	HDA	28344315
GO:0042987	Process	Amyloid precursor protein catabolic process	IMP	17112471
GO:0046872	Function	Metal ion binding	IEA
GO:1902945	Function	Metalloendopeptidase activity involved in amyloid precursor protein catabolic process	IMP	17112471
GO:2000049	Process	Positive regulation of cell-cell adhesion mediated by cadherin	IDA	19727588

MIM	HGNC	e!Ensembl
603640	197	ENSG00000135074

Q9H013

Protein name

Disintegrin and metalloproteinase domain-containing protein 19 (ADAM 19) (EC 3.4.24.-) (Meltrin-beta) (Metalloprotease and disintegrin dendritic antigen marker) (MADDAM)

Protein function

Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast diff

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01562	Pep_M12B_propep	34 → 162	Reprolysin family propeptide	Family
PF01421	Reprolysin	210 → 408	Reprolysin (M12B) family zinc metalloprotease	Domain
PF00200	Disintegrin	425 → 497	Disintegrin	Domain
PF08516	ADAM_CR	502 → 624	ADAM cysteine-rich	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in many normal organ tissues and several cancer cell lines.

Sequence

MPGGAGAARLCLLAFALQPLRPRAAREPGWTRGSEEGSPKLQHELIIPQWKTSESPVREK
HPLKAELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVR
ETELSSVTLSTCRGIRGLITVSSNLSYVIEPLPDSKGQHLIYRSEHLKPPPGNCGFEHSK
PTTRDWALQFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHKLIEI
ANYVDKFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKLLAQKYHDNAQL
ITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHDSADC
CSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRMLYGGRRCG
NGYLEDGEECDCGEEEECNNPCCNASNCTLRPGAECAHGSCCHQCKLLAPGTLCREQARQ
CDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLC
FEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVPIDTTIIMNG
RQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGCGKKCNG
HGVCNNNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVAILVLAVLMLM
YYCCRQNNKLGQLKPSALPSKLRQQFSCPFRVSQNSGTGHANPTFKLQTPQGKRKVINTP
EILRKPSQPPPRPPPDYLRGGSPPAPLPAHLSRAARNSPGPGSQIERTESSRRPPPSRPI
PPAPNCIVSQDFSRPRPPQKALPANPVPGRRSLPRPGGASPLRPPGAGPQQSRPLAALAP
KVSPREALKVKAGTRGLQGGRCRVEKTKQFMLLVVWTELPEQKPRAKHSCFLVPA

Sequence length

955

Interactions

View interactions

	Reactome
			Invadopodia formation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (22)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Abnormality of neuronal migration	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATOPIC ECZEMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHOLECYSTITIS, ACUTE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHOLELITHIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTROESOPHAGEAL REFLUX DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY SKIN DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung adenocarcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MENTAL OR BEHAVIOURAL DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSYCHIATRIC DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Squamous cell carcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (52)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alzheimer Disease	Alzheimer disease	Pubtator	25114068	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	Pubtator	29692868	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Asthma	Asthma	Pubtator	37809092	Inhibit	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar disorder	Pubtator	19319892	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Brain Tumor, Primary	Brain Neoplasms	BEFREE	16772875		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	33548228	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	30814494		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	38149560	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	18714391, 20065949		★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Obstructive Airway Disease	Chronic Obstructive Pulmonary Disease	GWASCAT_DG	28166215, 30804561		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	25799050		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Depressive Disorder	Major depressive disorder	Pubtator	22590542	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Dermatitis Herpetiformis	Dermatitis herpetiformis	Pubtator	22991566	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	28265178		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	29190936		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	29190936		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glomerulonephritis	Glomerulonephritis	Pubtator	16900093	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glycogen Storage Disease Type IV	Glycogen storage disease	Pubtator	31675985	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hemangiosarcoma	Hemangiosarcoma	BEFREE	28916654		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypotension	Hypotension	Pubtator	19319892	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 6	Ichthyosis with hypotrichosis	CLINVAR_DG	15317751, 17557927, 20016120, 22622417, 24397709, 25458912, 26762237		★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Diseases	Kidney Disease	BEFREE	16827870, 16900093		★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Diseases	Kidney disease	Pubtator	16900093	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Diseases	Lung disease	Pubtator	20010835	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	BEFREE	21239057		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	Pubtator	21239057	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	Pubtator	21239057	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	18714391, 20065949		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	26912236		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	31675985		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mental disorders	Mental Disorders	GWASCAT_DG	20889312		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mental disorders	Mental Disorders	GWASDB_DG	20889312		★★★★★ ★☆☆☆☆ Found in Text Mining only
Metabolic Syndrome X	Metabolic Syndrome	BEFREE	28265178		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	16772875, 26912236		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	31298334		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	28265178		★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	18714391, 20065949		★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	LHGDN	18714391		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	18714391	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Ductal Adenocarcinoma	Pancreatic adenocarcinoma	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Polymyositis	Polymyositis	BEFREE	17207628		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	26912236		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	26912236	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Psychotic Disorders	Psychosis	GWASDB_DG	20889312		★★★★★ ★☆☆☆☆ Found in Text Mining only
Psychotic Disorders	Psychosis	GWASCAT_DG	20889312		★★★★★ ★☆☆☆☆ Found in Text Mining only
Psychotic Disorders	Psychotic disorders	Pubtator	22590542	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	21659657, 27078193	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Retinoblastoma	Retinoblastoma	BEFREE	26823772		★★★★★ ★☆☆☆☆ Found in Text Mining only
Retinoblastoma	Retinoblastoma	Pubtator	26823772	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	31675985		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	31675985	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

ADAM19 (ADAM metallopeptidase domain 19)