Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	8723
Gene name	Sorting nexin 4
Gene symbol	SNX4
Synonyms (NCBI Gene)	ATG24B
Chromosome	3
Chromosome location	3q21.2
Summary	This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the lept

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miRTarBase ID	miRNA	Experiments	Reference
MIRT021294	hsa-miR-125a-5p	Sequencing	20371350
MIRT025597	hsa-miR-10a-5p	Sequencing	20371350
MIRT048486	hsa-miR-100-5p	CLASH	23622248
MIRT699069	hsa-miR-3606-3p	HITS-CLIP	23313552
MIRT699068	hsa-miR-513a-3p	HITS-CLIP	23313552
MIRT699067	hsa-miR-513c-3p	HITS-CLIP	23313552
MIRT699066	hsa-miR-6507-5p	HITS-CLIP	23313552
MIRT699065	hsa-miR-944	HITS-CLIP	23313552
MIRT699064	hsa-miR-32-3p	HITS-CLIP	23313552
MIRT699063	hsa-miR-7162-3p	HITS-CLIP	23313552
MIRT699062	hsa-miR-655-5p	HITS-CLIP	23313552
MIRT699061	hsa-miR-377-5p	HITS-CLIP	23313552
MIRT699060	hsa-miR-6086	HITS-CLIP	23313552
MIRT699059	hsa-miR-3653-3p	HITS-CLIP	23313552
MIRT699058	hsa-miR-580-3p	HITS-CLIP	23313552
MIRT699057	hsa-miR-3658	HITS-CLIP	23313552
MIRT554084	hsa-miR-504-5p	PAR-CLIP	20371350
MIRT025597	hsa-miR-10a-5p	PAR-CLIP	20371350
MIRT554083	hsa-miR-10b-5p	PAR-CLIP	20371350
MIRT554082	hsa-miR-6758-5p	PAR-CLIP	20371350
MIRT554081	hsa-miR-6856-5p	PAR-CLIP	20371350
MIRT554080	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT554079	hsa-miR-345-3p	PAR-CLIP	20371350
MIRT554078	hsa-miR-203a-3p	PAR-CLIP	20371350
MIRT554075	hsa-miR-6832-5p	PAR-CLIP	20371350
MIRT554074	hsa-miR-4732-5p	PAR-CLIP	20371350
MIRT554073	hsa-miR-3144-3p	PAR-CLIP	20371350
MIRT554072	hsa-miR-4659a-5p	PAR-CLIP	20371350
MIRT554071	hsa-miR-4659b-5p	PAR-CLIP	20371350
MIRT554086	hsa-miR-221-3p	PAR-CLIP	21572407
MIRT554085	hsa-miR-222-3p	PAR-CLIP	21572407
MIRT554084	hsa-miR-504-5p	PAR-CLIP	21572407
MIRT025597	hsa-miR-10a-5p	PAR-CLIP	21572407
MIRT554083	hsa-miR-10b-5p	PAR-CLIP	21572407
MIRT554082	hsa-miR-6758-5p	PAR-CLIP	21572407
MIRT554081	hsa-miR-6856-5p	PAR-CLIP	21572407
MIRT554080	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT554079	hsa-miR-345-3p	PAR-CLIP	21572407
MIRT554078	hsa-miR-203a-3p	PAR-CLIP	21572407
MIRT554077	hsa-miR-187-5p	PAR-CLIP	21572407
MIRT554076	hsa-miR-548v	PAR-CLIP	21572407
MIRT554075	hsa-miR-6832-5p	PAR-CLIP	21572407
MIRT554074	hsa-miR-4732-5p	PAR-CLIP	21572407
MIRT554073	hsa-miR-3144-3p	PAR-CLIP	21572407
MIRT554072	hsa-miR-4659a-5p	PAR-CLIP	21572407
MIRT554071	hsa-miR-4659b-5p	PAR-CLIP	21572407
MIRT439571	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439571	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT699069	hsa-miR-3606-3p	HITS-CLIP	23313552
MIRT699068	hsa-miR-513a-3p	HITS-CLIP	23313552
MIRT699067	hsa-miR-513c-3p	HITS-CLIP	23313552
MIRT699066	hsa-miR-6507-5p	HITS-CLIP	23313552
MIRT699065	hsa-miR-944	HITS-CLIP	23313552
MIRT699064	hsa-miR-32-3p	HITS-CLIP	23313552
MIRT699063	hsa-miR-7162-3p	HITS-CLIP	23313552
MIRT699062	hsa-miR-655-5p	HITS-CLIP	23313552
MIRT699061	hsa-miR-377-5p	HITS-CLIP	23313552
MIRT699060	hsa-miR-6086	HITS-CLIP	23313552
MIRT699059	hsa-miR-3653-3p	HITS-CLIP	23313552
MIRT699058	hsa-miR-580-3p	HITS-CLIP	23313552
MIRT699057	hsa-miR-3658	HITS-CLIP	23313552
MIRT554084	hsa-miR-504-5p	PAR-CLIP	20371350
MIRT025597	hsa-miR-10a-5p	PAR-CLIP	20371350
MIRT554083	hsa-miR-10b-5p	PAR-CLIP	20371350
MIRT554082	hsa-miR-6758-5p	PAR-CLIP	20371350
MIRT554081	hsa-miR-6856-5p	PAR-CLIP	20371350
MIRT554080	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT554079	hsa-miR-345-3p	PAR-CLIP	20371350
MIRT554078	hsa-miR-203a-3p	PAR-CLIP	20371350
MIRT554075	hsa-miR-6832-5p	PAR-CLIP	20371350
MIRT554074	hsa-miR-4732-5p	PAR-CLIP	20371350
MIRT554073	hsa-miR-3144-3p	PAR-CLIP	20371350
MIRT554072	hsa-miR-4659a-5p	PAR-CLIP	20371350
MIRT554071	hsa-miR-4659b-5p	PAR-CLIP	20371350
MIRT554086	hsa-miR-221-3p	PAR-CLIP	21572407
MIRT554085	hsa-miR-222-3p	PAR-CLIP	21572407
MIRT554084	hsa-miR-504-5p	PAR-CLIP	21572407
MIRT025597	hsa-miR-10a-5p	PAR-CLIP	21572407
MIRT554083	hsa-miR-10b-5p	PAR-CLIP	21572407
MIRT554082	hsa-miR-6758-5p	PAR-CLIP	21572407
MIRT554081	hsa-miR-6856-5p	PAR-CLIP	21572407
MIRT554080	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT554079	hsa-miR-345-3p	PAR-CLIP	21572407
MIRT554078	hsa-miR-203a-3p	PAR-CLIP	21572407
MIRT554077	hsa-miR-187-5p	PAR-CLIP	21572407
MIRT554076	hsa-miR-548v	PAR-CLIP	21572407
MIRT554075	hsa-miR-6832-5p	PAR-CLIP	21572407
MIRT554074	hsa-miR-4732-5p	PAR-CLIP	21572407
MIRT554073	hsa-miR-3144-3p	PAR-CLIP	21572407
MIRT554072	hsa-miR-4659a-5p	PAR-CLIP	21572407
MIRT554071	hsa-miR-4659b-5p	PAR-CLIP	21572407
MIRT1378194	hsa-miR-105	CLIP-seq
MIRT1378195	hsa-miR-10a	CLIP-seq
MIRT1378196	hsa-miR-10b	CLIP-seq
MIRT1378197	hsa-miR-124	CLIP-seq
MIRT1378198	hsa-miR-1290	CLIP-seq
MIRT1378199	hsa-miR-196a	CLIP-seq
MIRT1378200	hsa-miR-196b	CLIP-seq
MIRT1378201	hsa-miR-203	CLIP-seq
MIRT1378202	hsa-miR-221	CLIP-seq
MIRT1378203	hsa-miR-222	CLIP-seq
MIRT1378204	hsa-miR-23a	CLIP-seq
MIRT1378205	hsa-miR-23b	CLIP-seq
MIRT1378206	hsa-miR-23c	CLIP-seq
MIRT1378207	hsa-miR-31	CLIP-seq
MIRT1378208	hsa-miR-3164	CLIP-seq
MIRT1378209	hsa-miR-3714	CLIP-seq
MIRT1378210	hsa-miR-3910	CLIP-seq
MIRT1378211	hsa-miR-3927	CLIP-seq
MIRT1378212	hsa-miR-4643	CLIP-seq
MIRT1378213	hsa-miR-466	CLIP-seq
MIRT1378214	hsa-miR-4700-3p	CLIP-seq
MIRT1378215	hsa-miR-4759	CLIP-seq
MIRT1378216	hsa-miR-4789-3p	CLIP-seq
MIRT1378217	hsa-miR-506	CLIP-seq
MIRT1378218	hsa-miR-5096	CLIP-seq
MIRT1378219	hsa-miR-544	CLIP-seq
MIRT1378220	hsa-miR-570	CLIP-seq
MIRT1920924	hsa-miR-499-3p	CLIP-seq
MIRT1920925	hsa-miR-499a-3p	CLIP-seq
MIRT1378195	hsa-miR-10a	CLIP-seq
MIRT1378196	hsa-miR-10b	CLIP-seq
MIRT2112783	hsa-miR-1265	CLIP-seq
MIRT1378201	hsa-miR-203	CLIP-seq
MIRT2112784	hsa-miR-2053	CLIP-seq
MIRT2112785	hsa-miR-3163	CLIP-seq
MIRT2112786	hsa-miR-338-5p	CLIP-seq
MIRT2112787	hsa-miR-4709-3p	CLIP-seq
MIRT1378216	hsa-miR-4789-3p	CLIP-seq
MIRT2112788	hsa-miR-569	CLIP-seq
MIRT2335720	hsa-miR-1237	CLIP-seq
MIRT2335721	hsa-miR-1271	CLIP-seq
MIRT2335722	hsa-miR-181a	CLIP-seq
MIRT2335723	hsa-miR-181b	CLIP-seq
MIRT2335724	hsa-miR-181c	CLIP-seq
MIRT2335725	hsa-miR-181d	CLIP-seq
MIRT2335726	hsa-miR-182	CLIP-seq
MIRT2335727	hsa-miR-186	CLIP-seq
MIRT1378201	hsa-miR-203	CLIP-seq
MIRT1378202	hsa-miR-221	CLIP-seq
MIRT1378203	hsa-miR-222	CLIP-seq
MIRT1378204	hsa-miR-23a	CLIP-seq
MIRT1378205	hsa-miR-23b	CLIP-seq
MIRT1378206	hsa-miR-23c	CLIP-seq
MIRT2335728	hsa-miR-27a	CLIP-seq
MIRT2335729	hsa-miR-27b	CLIP-seq
MIRT2335730	hsa-miR-3065-3p	CLIP-seq
MIRT2335731	hsa-miR-3133	CLIP-seq
MIRT2335732	hsa-miR-320a	CLIP-seq
MIRT2335733	hsa-miR-320b	CLIP-seq
MIRT2335734	hsa-miR-320c	CLIP-seq
MIRT2335735	hsa-miR-320d	CLIP-seq
MIRT2335736	hsa-miR-323-3p	CLIP-seq
MIRT2335737	hsa-miR-4262	CLIP-seq
MIRT2335738	hsa-miR-4280	CLIP-seq
MIRT2335739	hsa-miR-4297	CLIP-seq
MIRT2335740	hsa-miR-4327	CLIP-seq
MIRT2335741	hsa-miR-4429	CLIP-seq
MIRT2335742	hsa-miR-4470	CLIP-seq
MIRT2335743	hsa-miR-4504	CLIP-seq
MIRT2335744	hsa-miR-4539	CLIP-seq
MIRT1378212	hsa-miR-4643	CLIP-seq
MIRT1378213	hsa-miR-466	CLIP-seq
MIRT2335745	hsa-miR-4680-3p	CLIP-seq
MIRT2335746	hsa-miR-4704-3p	CLIP-seq
MIRT2112787	hsa-miR-4709-3p	CLIP-seq
MIRT1378216	hsa-miR-4789-3p	CLIP-seq
MIRT2335747	hsa-miR-489	CLIP-seq
MIRT1920924	hsa-miR-499-3p	CLIP-seq
MIRT1920925	hsa-miR-499a-3p	CLIP-seq
MIRT1378218	hsa-miR-5096	CLIP-seq
MIRT2335748	hsa-miR-513a-5p	CLIP-seq
MIRT2335749	hsa-miR-539	CLIP-seq
MIRT2335750	hsa-miR-548c-3p	CLIP-seq
MIRT2335751	hsa-miR-616	CLIP-seq
MIRT2335752	hsa-miR-624	CLIP-seq
MIRT2335753	hsa-miR-659	CLIP-seq
MIRT2335754	hsa-miR-96	CLIP-seq
MIRT1378197	hsa-miR-124	CLIP-seq
MIRT1378207	hsa-miR-31	CLIP-seq
MIRT1378209	hsa-miR-3714	CLIP-seq
MIRT1378210	hsa-miR-3910	CLIP-seq
MIRT1378217	hsa-miR-506	CLIP-seq
MIRT1378220	hsa-miR-570	CLIP-seq
MIRT1378195	hsa-miR-10a	CLIP-seq
MIRT1378196	hsa-miR-10b	CLIP-seq
MIRT1378197	hsa-miR-124	CLIP-seq
MIRT1378201	hsa-miR-203	CLIP-seq
MIRT1378202	hsa-miR-221	CLIP-seq
MIRT1378203	hsa-miR-222	CLIP-seq
MIRT1378207	hsa-miR-31	CLIP-seq
MIRT1378209	hsa-miR-3714	CLIP-seq
MIRT1378210	hsa-miR-3910	CLIP-seq
MIRT2440623	hsa-miR-3941	CLIP-seq
MIRT1378212	hsa-miR-4643	CLIP-seq
MIRT1378213	hsa-miR-466	CLIP-seq
MIRT2440624	hsa-miR-4672	CLIP-seq
MIRT1378216	hsa-miR-4789-3p	CLIP-seq
MIRT1378217	hsa-miR-506	CLIP-seq
MIRT1378220	hsa-miR-570	CLIP-seq
MIRT1378197	hsa-miR-124	CLIP-seq
MIRT1378207	hsa-miR-31	CLIP-seq
MIRT1378209	hsa-miR-3714	CLIP-seq
MIRT1378210	hsa-miR-3910	CLIP-seq
MIRT1378217	hsa-miR-506	CLIP-seq
MIRT1378220	hsa-miR-570	CLIP-seq
MIRT1378195	hsa-miR-10a	CLIP-seq
MIRT1378196	hsa-miR-10b	CLIP-seq
MIRT2629888	hsa-miR-1207-3p	CLIP-seq
MIRT1378197	hsa-miR-124	CLIP-seq
MIRT2629889	hsa-miR-1253	CLIP-seq
MIRT1378201	hsa-miR-203	CLIP-seq
MIRT1378202	hsa-miR-221	CLIP-seq
MIRT1378203	hsa-miR-222	CLIP-seq
MIRT1378207	hsa-miR-31	CLIP-seq
MIRT2629890	hsa-miR-3200-5p	CLIP-seq
MIRT2629891	hsa-miR-3653	CLIP-seq
MIRT2629892	hsa-miR-3663-5p	CLIP-seq
MIRT2629893	hsa-miR-3713	CLIP-seq
MIRT1378209	hsa-miR-3714	CLIP-seq
MIRT2629894	hsa-miR-380	CLIP-seq
MIRT1378210	hsa-miR-3910	CLIP-seq
MIRT2440623	hsa-miR-3941	CLIP-seq
MIRT2629895	hsa-miR-4495	CLIP-seq
MIRT2629896	hsa-miR-4528	CLIP-seq
MIRT2629897	hsa-miR-4635	CLIP-seq
MIRT1378212	hsa-miR-4643	CLIP-seq
MIRT1378213	hsa-miR-466	CLIP-seq
MIRT2440624	hsa-miR-4672	CLIP-seq
MIRT2629898	hsa-miR-4733-5p	CLIP-seq
MIRT2629899	hsa-miR-4778-3p	CLIP-seq
MIRT1378216	hsa-miR-4789-3p	CLIP-seq
MIRT2335747	hsa-miR-489	CLIP-seq
MIRT2629900	hsa-miR-494	CLIP-seq
MIRT2629901	hsa-miR-495	CLIP-seq
MIRT1920924	hsa-miR-499-3p	CLIP-seq
MIRT1920925	hsa-miR-499a-3p	CLIP-seq
MIRT1378217	hsa-miR-506	CLIP-seq
MIRT1378220	hsa-miR-570	CLIP-seq
MIRT2629902	hsa-miR-580	CLIP-seq
MIRT1378195	hsa-miR-10a	CLIP-seq
MIRT1378196	hsa-miR-10b	CLIP-seq
MIRT2629888	hsa-miR-1207-3p	CLIP-seq
MIRT1378197	hsa-miR-124	CLIP-seq
MIRT2629889	hsa-miR-1253	CLIP-seq
MIRT1378201	hsa-miR-203	CLIP-seq
MIRT1378202	hsa-miR-221	CLIP-seq
MIRT1378203	hsa-miR-222	CLIP-seq
MIRT1378207	hsa-miR-31	CLIP-seq
MIRT2629891	hsa-miR-3653	CLIP-seq
MIRT2629892	hsa-miR-3663-5p	CLIP-seq
MIRT1378209	hsa-miR-3714	CLIP-seq
MIRT1378210	hsa-miR-3910	CLIP-seq
MIRT2440623	hsa-miR-3941	CLIP-seq
MIRT2629897	hsa-miR-4635	CLIP-seq
MIRT1378212	hsa-miR-4643	CLIP-seq
MIRT1378213	hsa-miR-466	CLIP-seq
MIRT2440624	hsa-miR-4672	CLIP-seq
MIRT1378216	hsa-miR-4789-3p	CLIP-seq
MIRT2629900	hsa-miR-494	CLIP-seq
MIRT2629901	hsa-miR-495	CLIP-seq
MIRT1920924	hsa-miR-499-3p	CLIP-seq
MIRT1920925	hsa-miR-499a-3p	CLIP-seq
MIRT1378217	hsa-miR-506	CLIP-seq
MIRT1378220	hsa-miR-570	CLIP-seq
MIRT2629902	hsa-miR-580	CLIP-seq

Show/Hide all (33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005154	Function	Epidermal growth factor receptor binding	IDA	9819414
GO:0005158	Function	Insulin receptor binding	IDA	9819414
GO:0005515	Function	Protein binding	IPI	9819414, 11278302, 11279102, 12668730, 17994011, 23085988, 25416956, 28514442, 31413325, 32296183, 32513819, 33961781, 35271311, 37158588
GO:0005737	Component	Cytoplasm	IDA	11279102
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IDA	32513819
GO:0005868	Component	Cytoplasmic dynein complex	IDA	17994011
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	18253931
GO:0008289	Function	Lipid binding	IEA
GO:0015031	Process	Protein transport	IBA
GO:0015031	Process	Protein transport	IEA
GO:0015031	Process	Protein transport	IMP	17994011, 32513819, 33468622
GO:0016020	Component	Membrane	IDA	9819414
GO:0016020	Component	Membrane	IEA
GO:0031201	Component	SNARE complex	IBA
GO:0031201	Component	SNARE complex	IDA	18253931
GO:0031901	Component	Early endosome membrane	IBA
GO:0031901	Component	Early endosome membrane	IDA	33468622
GO:0031901	Component	Early endosome membrane	IDA	17994011
GO:0031901	Component	Early endosome membrane	IEA
GO:0032266	Function	Phosphatidylinositol-3-phosphate binding	IBA
GO:0032266	Function	Phosphatidylinositol-3-phosphate binding	IMP	33468622
GO:0032456	Process	Endocytic recycling	IMP	17994011
GO:0032991	Component	Protein-containing complex	IDA	9819414
GO:0035091	Function	Phosphatidylinositol binding	IEA
GO:0035091	Function	Phosphatidylinositol binding	IMP	17994011
GO:0098830	Component	Presynaptic endosome	IEA
GO:1903595	Process	Positive regulation of histamine secretion by mast cell	IMP	18253931
GO:1990459	Function	Transferrin receptor binding	IDA	9819414
GO:1990460	Function	Leptin receptor binding	IDA	9819414
GO:2000786	Process	Positive regulation of autophagosome assembly	IBA
GO:2000786	Process	Positive regulation of autophagosome assembly	IMP	32513819, 33468622

MIM	HGNC	e!Ensembl
605931	11175	ENSG00000114520

O95219

Protein name

Sorting nexin-4

Protein function

Involved in the regulation of endocytosis and in several stages of intracellular trafficking (PubMed:12668730, PubMed:17994011, PubMed:32513819, PubMed:33468622). Plays a role in recycling endocytosed transferrin receptor and prevent its degrada

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00787	PX	93 → 184	PX domain	Domain

Sequence

MEQAPPDPERQLQPAPLEPLGSPDAGLGAAVGKEAEGAGEESSGVDTMTHNNFWLKKIEI
SVSEAEKRTGRNAMNMQETYTAYLIETRSVEHTDGQSVLTDSLWRRYSEFELLRSYLLVY
YPHIVVPPLPEKRAEFVWHKLSADNMDPDFVERRRIGLENFLLRIASHPILCRDKIFYLF
LTQEGNWKETVNETGFQLKADSRLKALNATFRVKNPDKRFTDLKHYSDELQSVISHLLRV
RARVADRLYGVYKVHGNYGRVFSEWSAIEKEMGDGLQSAGHHMDVYASSIDDILEDEEHY
ADQLKEYLFYAEALRAVCRKHELMQYDLEMAAQDLASKKQQCEELVTGTVRTFSLKGMTT
KLFGQETPEQREARIKVLEEQINEGEQQLKSKNLEGREFVKNAWADIERFKEQKNRDLKE
ALISYAVMQISMCKKGIQVWTNAKECFSKM

Sequence length

450

Interactions

View interactions

	KEGG
	Endocytosis

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
GOUT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Stomach Neoplasms	Stomach neoplasms	Pubtator	35715463	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only

SNX4 (sorting nexin 4)