PNPT1 (polyribonucleotide nucleotidyltransferase 1)

Gene

• Entrez ID: 87178
• Gene name: Polyribonucleotide nucleotidyltransferase 1
• Gene symbol: PNPT1
• Synonyms (NCBI Gene): COXPD13, DFNB70, OLD35, PNPASE, SCA25, old-35
• Chromosome: 2
• Chromosome location: 2p16.1
• Summary: The protein encoded by this gene belongs to the evolutionary conserved polynucleotide phosphorylase family comprised of phosphate dependent 3`-to-5` exoribonucleases implicated in RNA processing and degradation. This enzyme is predominantly localized in t

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs34928857	C>G	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Coding sequence variant, missense variant, non coding transcript variant
rs143712760	C>A	Uncertain-significance, likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs146571352	C>T	Likely-pathogenic, not-provided, uncertain-significance	Missense variant, coding sequence variant, non coding transcript variant
rs151166046	G>A	Conflicting-interpretations-of-pathogenicity	Non coding transcript variant, missense variant, coding sequence variant
rs200088200	G>C	Likely-pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs374698153	G>C	Likely-pathogenic, uncertain-significance	Non coding transcript variant, coding sequence variant, missense variant
rs397514598	T>C	Pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs397514599	T>C	Pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs746356243	C>G,T	Pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs752550279	C>A,G	Pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant
rs767310806	T>C,G	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs772153760	C>T	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs774425075	C>T	Likely-pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs778100619	G>A,C,T	Pathogenic	Missense variant, non coding transcript variant, coding sequence variant, stop gained
rs863225449	C>T	Pathogenic	Splice acceptor variant
rs879255657	C>G	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs1064793593	GT>-	Pathogenic	Coding sequence variant, frameshift variant, non coding transcript variant
rs1365308037	C>A,T	Likely-pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs1553493871	A>-	Likely-pathogenic	Non coding transcript variant, frameshift variant, coding sequence variant
rs1559094461	C>G	Pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs1559114055	A>G	Pathogenic	Coding sequence variant, intron variant, 5 prime UTR variant, non coding transcript variant, missense variant
rs1572834021	C>-	Likely-pathogenic	Coding sequence variant, non coding transcript variant, frameshift variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020848	hsa-miR-155-5p	Proteomics	18668040
MIRT706636	hsa-miR-6838-3p	HITS-CLIP	21572407
MIRT706635	hsa-miR-4781-3p	HITS-CLIP	21572407
MIRT706634	hsa-miR-370-3p	HITS-CLIP	21572407
MIRT706633	hsa-miR-6893-3p	HITS-CLIP	21572407
MIRT706632	hsa-miR-31-3p	HITS-CLIP	21572407
MIRT706631	hsa-miR-3135b	HITS-CLIP	21572407
MIRT706629	hsa-miR-3652	HITS-CLIP	21572407
MIRT706630	hsa-miR-4430	HITS-CLIP	21572407
MIRT706628	hsa-miR-6501-5p	HITS-CLIP	21572407
MIRT706627	hsa-miR-4423-5p	HITS-CLIP	21572407
MIRT706626	hsa-miR-744-3p	HITS-CLIP	21572407
MIRT625290	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT625289	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT625288	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT625287	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT625286	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT625285	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT625284	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT625283	hsa-miR-136-5p	HITS-CLIP	23824327
MIRT625282	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT625281	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT625280	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT625279	hsa-miR-4284	HITS-CLIP	23824327
MIRT625278	hsa-miR-7977	HITS-CLIP	23824327
MIRT654948	hsa-miR-652-3p	HITS-CLIP	23824327
MIRT625290	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT654947	hsa-miR-3155a	HITS-CLIP	23824327
MIRT654946	hsa-miR-3155b	HITS-CLIP	23824327
MIRT654945	hsa-miR-484	HITS-CLIP	23824327
MIRT625289	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT625288	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT625287	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT625286	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT625285	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT625284	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT625283	hsa-miR-136-5p	HITS-CLIP	23824327
MIRT625282	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT625281	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT625280	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT636935	hsa-miR-6722-5p	HITS-CLIP	23824327
MIRT625279	hsa-miR-4284	HITS-CLIP	23824327
MIRT625278	hsa-miR-7977	HITS-CLIP	23824327
MIRT625290	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT625285	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT625284	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT625283	hsa-miR-136-5p	HITS-CLIP	23824327
MIRT625282	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT625281	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT625280	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT636935	hsa-miR-6722-5p	HITS-CLIP	23824327
MIRT625279	hsa-miR-4284	HITS-CLIP	23824327
MIRT625278	hsa-miR-7977	HITS-CLIP	23824327
MIRT625290	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT625289	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT625288	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT625287	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT625286	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT625285	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT625284	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT625283	hsa-miR-136-5p	HITS-CLIP	23824327
MIRT625282	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT625281	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT625280	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT625279	hsa-miR-4284	HITS-CLIP	23824327
MIRT625278	hsa-miR-7977	HITS-CLIP	23824327
MIRT625290	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT625289	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT625288	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT625287	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT625286	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT625285	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT625284	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT625283	hsa-miR-136-5p	HITS-CLIP	23824327
MIRT625282	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT625281	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT625280	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT625279	hsa-miR-4284	HITS-CLIP	23824327
MIRT625278	hsa-miR-7977	HITS-CLIP	23824327
MIRT625290	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT625289	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT625288	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT625287	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT625286	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT625285	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT625284	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT625283	hsa-miR-136-5p	HITS-CLIP	23824327
MIRT625282	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT625281	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT625280	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT625279	hsa-miR-4284	HITS-CLIP	23824327
MIRT625278	hsa-miR-7977	HITS-CLIP	23824327
MIRT706636	hsa-miR-6838-3p	HITS-CLIP	21572407
MIRT706635	hsa-miR-4781-3p	HITS-CLIP	21572407
MIRT706634	hsa-miR-370-3p	HITS-CLIP	21572407
MIRT706633	hsa-miR-6893-3p	HITS-CLIP	21572407
MIRT706632	hsa-miR-31-3p	HITS-CLIP	21572407
MIRT706631	hsa-miR-3135b	HITS-CLIP	21572407
MIRT706629	hsa-miR-3652	HITS-CLIP	21572407
MIRT706630	hsa-miR-4430	HITS-CLIP	21572407
MIRT706628	hsa-miR-6501-5p	HITS-CLIP	21572407
MIRT706627	hsa-miR-4423-5p	HITS-CLIP	21572407
MIRT706626	hsa-miR-744-3p	HITS-CLIP	21572407
MIRT625290	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT625289	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT625288	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT625287	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT625286	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT625285	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT625284	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT625283	hsa-miR-136-5p	HITS-CLIP	23824327
MIRT625282	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT625281	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT625280	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT625279	hsa-miR-4284	HITS-CLIP	23824327
MIRT625278	hsa-miR-7977	HITS-CLIP	23824327
MIRT654948	hsa-miR-652-3p	HITS-CLIP	23824327
MIRT625290	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT654947	hsa-miR-3155a	HITS-CLIP	23824327
MIRT654946	hsa-miR-3155b	HITS-CLIP	23824327
MIRT654945	hsa-miR-484	HITS-CLIP	23824327
MIRT625289	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT625288	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT625287	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT625286	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT625285	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT625284	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT625283	hsa-miR-136-5p	HITS-CLIP	23824327
MIRT625282	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT625281	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT625280	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT636935	hsa-miR-6722-5p	HITS-CLIP	23824327
MIRT625279	hsa-miR-4284	HITS-CLIP	23824327
MIRT625278	hsa-miR-7977	HITS-CLIP	23824327
MIRT625290	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT625285	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT625284	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT625283	hsa-miR-136-5p	HITS-CLIP	23824327
MIRT625282	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT625281	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT625280	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT636935	hsa-miR-6722-5p	HITS-CLIP	23824327
MIRT625279	hsa-miR-4284	HITS-CLIP	23824327
MIRT625278	hsa-miR-7977	HITS-CLIP	23824327
MIRT625290	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT625289	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT625288	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT625287	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT625286	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT625285	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT625284	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT625283	hsa-miR-136-5p	HITS-CLIP	23824327
MIRT625282	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT625281	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT625280	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT625279	hsa-miR-4284	HITS-CLIP	23824327
MIRT625278	hsa-miR-7977	HITS-CLIP	23824327
MIRT625290	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT625289	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT625288	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT625287	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT625286	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT625285	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT625284	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT625283	hsa-miR-136-5p	HITS-CLIP	23824327
MIRT625282	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT625281	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT625280	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT625279	hsa-miR-4284	HITS-CLIP	23824327
MIRT625278	hsa-miR-7977	HITS-CLIP	23824327
MIRT625290	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT625289	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT625288	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT625287	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT625286	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT625285	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT625284	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT625283	hsa-miR-136-5p	HITS-CLIP	23824327
MIRT625282	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT625281	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT625280	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT625279	hsa-miR-4284	HITS-CLIP	23824327
MIRT625278	hsa-miR-7977	HITS-CLIP	23824327
MIRT1245788	hsa-miR-101	CLIP-seq
MIRT1245789	hsa-miR-1183	CLIP-seq
MIRT1245790	hsa-miR-1200	CLIP-seq
MIRT1245791	hsa-miR-122	CLIP-seq
MIRT1245792	hsa-miR-125a-3p	CLIP-seq
MIRT1245793	hsa-miR-1273f	CLIP-seq
MIRT1245794	hsa-miR-1299	CLIP-seq
MIRT1245795	hsa-miR-130a	CLIP-seq
MIRT1245796	hsa-miR-130b	CLIP-seq
MIRT1245797	hsa-miR-1343	CLIP-seq
MIRT1245798	hsa-miR-144	CLIP-seq
MIRT1245799	hsa-miR-1915	CLIP-seq
MIRT1245800	hsa-miR-197	CLIP-seq
MIRT1245801	hsa-miR-1976	CLIP-seq
MIRT1245802	hsa-miR-205	CLIP-seq
MIRT1245803	hsa-miR-2054	CLIP-seq
MIRT1245804	hsa-miR-299-5p	CLIP-seq
MIRT1245805	hsa-miR-300	CLIP-seq
MIRT1245806	hsa-miR-301a	CLIP-seq
MIRT1245807	hsa-miR-301b	CLIP-seq
MIRT1245808	hsa-miR-3147	CLIP-seq
MIRT1245809	hsa-miR-3149	CLIP-seq
MIRT1245810	hsa-miR-3170	CLIP-seq
MIRT1245811	hsa-miR-3187-3p	CLIP-seq
MIRT1245812	hsa-miR-3194-3p	CLIP-seq
MIRT1245813	hsa-miR-3199	CLIP-seq
MIRT1245814	hsa-miR-331-5p	CLIP-seq
MIRT1245815	hsa-miR-335	CLIP-seq
MIRT1245816	hsa-miR-3616-5p	CLIP-seq
MIRT1245817	hsa-miR-3622a-5p	CLIP-seq
MIRT1245818	hsa-miR-3647-5p	CLIP-seq
MIRT1245819	hsa-miR-3662	CLIP-seq
MIRT1245820	hsa-miR-3663-5p	CLIP-seq
MIRT1245821	hsa-miR-3666	CLIP-seq
MIRT1245822	hsa-miR-370	CLIP-seq
MIRT1245823	hsa-miR-381	CLIP-seq
MIRT1245824	hsa-miR-382	CLIP-seq
MIRT1245825	hsa-miR-3934	CLIP-seq
MIRT1245826	hsa-miR-3940-5p	CLIP-seq
MIRT1245827	hsa-miR-410	CLIP-seq
MIRT1245828	hsa-miR-411	CLIP-seq
MIRT1245829	hsa-miR-4269	CLIP-seq
MIRT1245830	hsa-miR-4279	CLIP-seq
MIRT1245831	hsa-miR-4294	CLIP-seq
MIRT1245832	hsa-miR-4295	CLIP-seq
MIRT1245833	hsa-miR-431	CLIP-seq
MIRT1245834	hsa-miR-4324	CLIP-seq
MIRT1245835	hsa-miR-433	CLIP-seq
MIRT1245836	hsa-miR-4425	CLIP-seq
MIRT1245837	hsa-miR-4426	CLIP-seq
MIRT1245838	hsa-miR-4435	CLIP-seq
MIRT1245839	hsa-miR-4438	CLIP-seq
MIRT1245840	hsa-miR-4507	CLIP-seq
MIRT1245841	hsa-miR-454	CLIP-seq
MIRT1245842	hsa-miR-4647	CLIP-seq
MIRT1245843	hsa-miR-4652-3p	CLIP-seq
MIRT1245844	hsa-miR-4662a-5p	CLIP-seq
MIRT1245845	hsa-miR-4662b	CLIP-seq
MIRT1245846	hsa-miR-4666-3p	CLIP-seq
MIRT1245847	hsa-miR-4676-5p	CLIP-seq
MIRT1245848	hsa-miR-4701-5p	CLIP-seq
MIRT1245849	hsa-miR-4715-3p	CLIP-seq
MIRT1245850	hsa-miR-4716-5p	CLIP-seq
MIRT1245851	hsa-miR-4722-3p	CLIP-seq
MIRT1245852	hsa-miR-4724-3p	CLIP-seq
MIRT1245853	hsa-miR-4735-5p	CLIP-seq
MIRT1245854	hsa-miR-4755-3p	CLIP-seq
MIRT1245855	hsa-miR-4763-5p	CLIP-seq
MIRT1245856	hsa-miR-4775	CLIP-seq
MIRT1245857	hsa-miR-4782-5p	CLIP-seq
MIRT1245858	hsa-miR-4795-5p	CLIP-seq
MIRT1245859	hsa-miR-489	CLIP-seq
MIRT1245860	hsa-miR-493	CLIP-seq
MIRT1245861	hsa-miR-5095	CLIP-seq
MIRT1245862	hsa-miR-5096	CLIP-seq
MIRT1245863	hsa-miR-513a-3p	CLIP-seq
MIRT1245864	hsa-miR-516b	CLIP-seq
MIRT1245865	hsa-miR-520d-5p	CLIP-seq
MIRT1245866	hsa-miR-524-5p	CLIP-seq
MIRT1245867	hsa-miR-544b	CLIP-seq
MIRT1245868	hsa-miR-548ag	CLIP-seq
MIRT1245869	hsa-miR-548ai	CLIP-seq
MIRT1245870	hsa-miR-548g	CLIP-seq
MIRT1245871	hsa-miR-548s	CLIP-seq
MIRT1245872	hsa-miR-550a	CLIP-seq
MIRT1245873	hsa-miR-552	CLIP-seq
MIRT1245874	hsa-miR-561	CLIP-seq
MIRT1245875	hsa-miR-573	CLIP-seq
MIRT1245876	hsa-miR-575	CLIP-seq
MIRT1245877	hsa-miR-577	CLIP-seq
MIRT1245878	hsa-miR-588	CLIP-seq
MIRT1245879	hsa-miR-590-3p	CLIP-seq
MIRT1245880	hsa-miR-652	CLIP-seq
MIRT1245881	hsa-miR-656	CLIP-seq
MIRT1245882	hsa-miR-659	CLIP-seq
MIRT1245883	hsa-miR-668	CLIP-seq
MIRT1245884	hsa-miR-764	CLIP-seq
MIRT1245885	hsa-miR-9	CLIP-seq
MIRT1245886	hsa-miR-924	CLIP-seq
MIRT1245884	hsa-miR-764	CLIP-seq
MIRT2072659	hsa-miR-106a	CLIP-seq
MIRT2072660	hsa-miR-106b	CLIP-seq
MIRT1245790	hsa-miR-1200	CLIP-seq
MIRT2072661	hsa-miR-1234	CLIP-seq
MIRT1245792	hsa-miR-125a-3p	CLIP-seq
MIRT1245793	hsa-miR-1273f	CLIP-seq
MIRT2072662	hsa-miR-1287	CLIP-seq
MIRT2072663	hsa-miR-129-5p	CLIP-seq
MIRT2072664	hsa-miR-1307	CLIP-seq
MIRT1245797	hsa-miR-1343	CLIP-seq
MIRT2072665	hsa-miR-150	CLIP-seq
MIRT2072666	hsa-miR-17	CLIP-seq
MIRT1245799	hsa-miR-1915	CLIP-seq
MIRT1245800	hsa-miR-197	CLIP-seq
MIRT1245801	hsa-miR-1976	CLIP-seq
MIRT2072667	hsa-miR-20a	CLIP-seq
MIRT2072668	hsa-miR-20b	CLIP-seq
MIRT2072669	hsa-miR-302a	CLIP-seq
MIRT2072670	hsa-miR-302b	CLIP-seq
MIRT2072671	hsa-miR-302c	CLIP-seq
MIRT2072672	hsa-miR-302d	CLIP-seq
MIRT2072673	hsa-miR-302e	CLIP-seq
MIRT1245809	hsa-miR-3149	CLIP-seq
MIRT2072674	hsa-miR-3159	CLIP-seq
MIRT1245810	hsa-miR-3170	CLIP-seq
MIRT1245811	hsa-miR-3187-3p	CLIP-seq
MIRT1245815	hsa-miR-335	CLIP-seq
MIRT1245816	hsa-miR-3616-5p	CLIP-seq
MIRT1245818	hsa-miR-3647-5p	CLIP-seq
MIRT1245820	hsa-miR-3663-5p	CLIP-seq
MIRT2072675	hsa-miR-372	CLIP-seq
MIRT2072676	hsa-miR-373	CLIP-seq
MIRT1245825	hsa-miR-3934	CLIP-seq
MIRT1245826	hsa-miR-3940-5p	CLIP-seq
MIRT1245828	hsa-miR-411	CLIP-seq
MIRT2072677	hsa-miR-4258	CLIP-seq
MIRT1245830	hsa-miR-4279	CLIP-seq
MIRT1245834	hsa-miR-4324	CLIP-seq
MIRT2072678	hsa-miR-4325	CLIP-seq
MIRT1245838	hsa-miR-4435	CLIP-seq
MIRT1245839	hsa-miR-4438	CLIP-seq
MIRT2072679	hsa-miR-4476	CLIP-seq
MIRT1245840	hsa-miR-4507	CLIP-seq
MIRT2072680	hsa-miR-450b-5p	CLIP-seq
MIRT2072681	hsa-miR-4695-3p	CLIP-seq
MIRT1245848	hsa-miR-4701-5p	CLIP-seq
MIRT2072682	hsa-miR-4707-3p	CLIP-seq
MIRT1245849	hsa-miR-4715-3p	CLIP-seq
MIRT1245850	hsa-miR-4716-5p	CLIP-seq
MIRT1245851	hsa-miR-4722-3p	CLIP-seq
MIRT1245853	hsa-miR-4735-5p	CLIP-seq
MIRT2072683	hsa-miR-4740-3p	CLIP-seq
MIRT1245854	hsa-miR-4755-3p	CLIP-seq
MIRT1245856	hsa-miR-4775	CLIP-seq
MIRT2072684	hsa-miR-4787-3p	CLIP-seq
MIRT1245858	hsa-miR-4795-5p	CLIP-seq
MIRT2072685	hsa-miR-499-3p	CLIP-seq
MIRT2072686	hsa-miR-499a-3p	CLIP-seq
MIRT2072687	hsa-miR-507	CLIP-seq
MIRT1245861	hsa-miR-5095	CLIP-seq
MIRT1245862	hsa-miR-5096	CLIP-seq
MIRT2072688	hsa-miR-512-3p	CLIP-seq
MIRT2072689	hsa-miR-519d	CLIP-seq
MIRT2072690	hsa-miR-520a-3p	CLIP-seq
MIRT2072691	hsa-miR-520b	CLIP-seq
MIRT2072692	hsa-miR-520c-3p	CLIP-seq
MIRT2072693	hsa-miR-520d-3p	CLIP-seq
MIRT2072694	hsa-miR-520e	CLIP-seq
MIRT2072695	hsa-miR-520g	CLIP-seq
MIRT2072696	hsa-miR-520h	CLIP-seq
MIRT1245867	hsa-miR-544b	CLIP-seq
MIRT1245871	hsa-miR-548s	CLIP-seq
MIRT1245873	hsa-miR-552	CLIP-seq
MIRT2072697	hsa-miR-557	CLIP-seq
MIRT1245875	hsa-miR-573	CLIP-seq
MIRT1245878	hsa-miR-588	CLIP-seq
MIRT1245879	hsa-miR-590-3p	CLIP-seq
MIRT1245884	hsa-miR-764	CLIP-seq
MIRT2072698	hsa-miR-93	CLIP-seq
MIRT1245788	hsa-miR-101	CLIP-seq
MIRT1245790	hsa-miR-1200	CLIP-seq
MIRT1245791	hsa-miR-122	CLIP-seq
MIRT2299862	hsa-miR-1254	CLIP-seq
MIRT1245793	hsa-miR-1273f	CLIP-seq
MIRT2072663	hsa-miR-129-5p	CLIP-seq
MIRT2072664	hsa-miR-1307	CLIP-seq
MIRT1245795	hsa-miR-130a	CLIP-seq
MIRT1245796	hsa-miR-130b	CLIP-seq
MIRT1245797	hsa-miR-1343	CLIP-seq
MIRT1245798	hsa-miR-144	CLIP-seq
MIRT2072665	hsa-miR-150	CLIP-seq
MIRT1245799	hsa-miR-1915	CLIP-seq
MIRT1245800	hsa-miR-197	CLIP-seq
MIRT1245801	hsa-miR-1976	CLIP-seq
MIRT1245806	hsa-miR-301a	CLIP-seq
MIRT1245807	hsa-miR-301b	CLIP-seq
MIRT2299863	hsa-miR-3116	CLIP-seq
MIRT1245808	hsa-miR-3147	CLIP-seq
MIRT1245809	hsa-miR-3149	CLIP-seq
MIRT2299864	hsa-miR-3155	CLIP-seq
MIRT2072674	hsa-miR-3159	CLIP-seq
MIRT1245810	hsa-miR-3170	CLIP-seq
MIRT1245811	hsa-miR-3187-3p	CLIP-seq
MIRT1245812	hsa-miR-3194-3p	CLIP-seq
MIRT1245816	hsa-miR-3616-5p	CLIP-seq
MIRT1245818	hsa-miR-3647-5p	CLIP-seq
MIRT1245820	hsa-miR-3663-5p	CLIP-seq
MIRT1245821	hsa-miR-3666	CLIP-seq
MIRT1245825	hsa-miR-3934	CLIP-seq
MIRT1245826	hsa-miR-3940-5p	CLIP-seq
MIRT1245828	hsa-miR-411	CLIP-seq
MIRT2072677	hsa-miR-4258	CLIP-seq
MIRT1245830	hsa-miR-4279	CLIP-seq
MIRT1245831	hsa-miR-4294	CLIP-seq
MIRT1245832	hsa-miR-4295	CLIP-seq
MIRT1245833	hsa-miR-431	CLIP-seq
MIRT1245834	hsa-miR-4324	CLIP-seq
MIRT2072678	hsa-miR-4325	CLIP-seq
MIRT1245836	hsa-miR-4425	CLIP-seq
MIRT1245837	hsa-miR-4426	CLIP-seq
MIRT1245838	hsa-miR-4435	CLIP-seq
MIRT1245839	hsa-miR-4438	CLIP-seq
MIRT1245840	hsa-miR-4507	CLIP-seq
MIRT2299865	hsa-miR-450b-3p	CLIP-seq
MIRT1245841	hsa-miR-454	CLIP-seq
MIRT2299866	hsa-miR-4643	CLIP-seq
MIRT1245842	hsa-miR-4647	CLIP-seq
MIRT2299867	hsa-miR-466	CLIP-seq
MIRT1245845	hsa-miR-4662b	CLIP-seq
MIRT2072681	hsa-miR-4695-3p	CLIP-seq
MIRT1245848	hsa-miR-4701-5p	CLIP-seq
MIRT2072682	hsa-miR-4707-3p	CLIP-seq
MIRT1245849	hsa-miR-4715-3p	CLIP-seq
MIRT1245850	hsa-miR-4716-5p	CLIP-seq
MIRT1245851	hsa-miR-4722-3p	CLIP-seq
MIRT2299868	hsa-miR-4727-5p	CLIP-seq
MIRT1245853	hsa-miR-4735-5p	CLIP-seq
MIRT2072683	hsa-miR-4740-3p	CLIP-seq
MIRT1245854	hsa-miR-4755-3p	CLIP-seq
MIRT1245856	hsa-miR-4775	CLIP-seq
MIRT2072684	hsa-miR-4787-3p	CLIP-seq
MIRT2299869	hsa-miR-4789-3p	CLIP-seq
MIRT1245858	hsa-miR-4795-5p	CLIP-seq
MIRT2072687	hsa-miR-507	CLIP-seq
MIRT1245861	hsa-miR-5095	CLIP-seq
MIRT1245862	hsa-miR-5096	CLIP-seq
MIRT2072695	hsa-miR-520g	CLIP-seq
MIRT2072696	hsa-miR-520h	CLIP-seq
MIRT1245867	hsa-miR-544b	CLIP-seq
MIRT1245871	hsa-miR-548s	CLIP-seq
MIRT1245873	hsa-miR-552	CLIP-seq
MIRT2072697	hsa-miR-557	CLIP-seq
MIRT1245875	hsa-miR-573	CLIP-seq
MIRT1245878	hsa-miR-588	CLIP-seq
MIRT1245879	hsa-miR-590-3p	CLIP-seq
MIRT1245880	hsa-miR-652	CLIP-seq
MIRT2299870	hsa-miR-661	CLIP-seq
MIRT2299871	hsa-miR-769-3p	CLIP-seq
MIRT1245886	hsa-miR-924	CLIP-seq
MIRT1245788	hsa-miR-101	CLIP-seq
MIRT1245791	hsa-miR-122	CLIP-seq
MIRT2072664	hsa-miR-1307	CLIP-seq
MIRT1245795	hsa-miR-130a	CLIP-seq
MIRT1245796	hsa-miR-130b	CLIP-seq
MIRT1245797	hsa-miR-1343	CLIP-seq
MIRT1245798	hsa-miR-144	CLIP-seq
MIRT1245806	hsa-miR-301a	CLIP-seq
MIRT1245807	hsa-miR-301b	CLIP-seq
MIRT2392778	hsa-miR-3160-3p	CLIP-seq
MIRT2392779	hsa-miR-3182	CLIP-seq
MIRT1245816	hsa-miR-3616-5p	CLIP-seq
MIRT1245818	hsa-miR-3647-5p	CLIP-seq
MIRT1245821	hsa-miR-3666	CLIP-seq
MIRT1245826	hsa-miR-3940-5p	CLIP-seq
MIRT1245832	hsa-miR-4295	CLIP-seq
MIRT2392780	hsa-miR-4487	CLIP-seq
MIRT1245840	hsa-miR-4507	CLIP-seq
MIRT1245841	hsa-miR-454	CLIP-seq
MIRT1245858	hsa-miR-4795-5p	CLIP-seq
MIRT2392781	hsa-miR-558	CLIP-seq
MIRT1245875	hsa-miR-573	CLIP-seq
MIRT1245880	hsa-miR-652	CLIP-seq
MIRT1245790	hsa-miR-1200	CLIP-seq
MIRT1245793	hsa-miR-1273f	CLIP-seq
MIRT1245799	hsa-miR-1915	CLIP-seq
MIRT1245801	hsa-miR-1976	CLIP-seq
MIRT1245809	hsa-miR-3149	CLIP-seq
MIRT1245810	hsa-miR-3170	CLIP-seq
MIRT1245815	hsa-miR-335	CLIP-seq
MIRT1245828	hsa-miR-411	CLIP-seq
MIRT2072677	hsa-miR-4258	CLIP-seq
MIRT1245830	hsa-miR-4279	CLIP-seq
MIRT1245834	hsa-miR-4324	CLIP-seq
MIRT1245839	hsa-miR-4438	CLIP-seq
MIRT2072682	hsa-miR-4707-3p	CLIP-seq
MIRT1245849	hsa-miR-4715-3p	CLIP-seq
MIRT1245851	hsa-miR-4722-3p	CLIP-seq
MIRT1245853	hsa-miR-4735-5p	CLIP-seq
MIRT1245856	hsa-miR-4775	CLIP-seq
MIRT1245861	hsa-miR-5095	CLIP-seq
MIRT1245867	hsa-miR-544b	CLIP-seq
MIRT1245879	hsa-miR-590-3p	CLIP-seq
MIRT1245793	hsa-miR-1273f	CLIP-seq
MIRT1245799	hsa-miR-1915	CLIP-seq
MIRT1245801	hsa-miR-1976	CLIP-seq
MIRT1245809	hsa-miR-3149	CLIP-seq
MIRT1245810	hsa-miR-3170	CLIP-seq
MIRT1245815	hsa-miR-335	CLIP-seq
MIRT1245828	hsa-miR-411	CLIP-seq
MIRT2072677	hsa-miR-4258	CLIP-seq
MIRT1245830	hsa-miR-4279	CLIP-seq
MIRT2072682	hsa-miR-4707-3p	CLIP-seq
MIRT1245849	hsa-miR-4715-3p	CLIP-seq
MIRT1245851	hsa-miR-4722-3p	CLIP-seq
MIRT1245853	hsa-miR-4735-5p	CLIP-seq
MIRT1245856	hsa-miR-4775	CLIP-seq
MIRT1245879	hsa-miR-590-3p	CLIP-seq
MIRT1245789	hsa-miR-1183	CLIP-seq
MIRT1245790	hsa-miR-1200	CLIP-seq
MIRT1245791	hsa-miR-122	CLIP-seq
MIRT1245793	hsa-miR-1273f	CLIP-seq
MIRT2072663	hsa-miR-129-5p	CLIP-seq
MIRT2072664	hsa-miR-1307	CLIP-seq
MIRT1245795	hsa-miR-130a	CLIP-seq
MIRT1245796	hsa-miR-130b	CLIP-seq
MIRT1245799	hsa-miR-1915	CLIP-seq
MIRT1245800	hsa-miR-197	CLIP-seq
MIRT1245801	hsa-miR-1976	CLIP-seq
MIRT1245805	hsa-miR-300	CLIP-seq
MIRT1245806	hsa-miR-301a	CLIP-seq
MIRT1245807	hsa-miR-301b	CLIP-seq
MIRT1245809	hsa-miR-3149	CLIP-seq
MIRT1245810	hsa-miR-3170	CLIP-seq
MIRT1245811	hsa-miR-3187-3p	CLIP-seq
MIRT1245815	hsa-miR-335	CLIP-seq
MIRT1245821	hsa-miR-3666	CLIP-seq
MIRT2596573	hsa-miR-369-3p	CLIP-seq
MIRT2596574	hsa-miR-374a	CLIP-seq
MIRT2596575	hsa-miR-374b	CLIP-seq
MIRT1245823	hsa-miR-381	CLIP-seq
MIRT1245828	hsa-miR-411	CLIP-seq
MIRT2596576	hsa-miR-425	CLIP-seq
MIRT2072677	hsa-miR-4258	CLIP-seq
MIRT1245830	hsa-miR-4279	CLIP-seq
MIRT1245832	hsa-miR-4295	CLIP-seq
MIRT1245834	hsa-miR-4324	CLIP-seq
MIRT2072678	hsa-miR-4325	CLIP-seq
MIRT1245837	hsa-miR-4426	CLIP-seq
MIRT1245838	hsa-miR-4435	CLIP-seq
MIRT1245839	hsa-miR-4438	CLIP-seq
MIRT2072679	hsa-miR-4476	CLIP-seq
MIRT2072680	hsa-miR-450b-5p	CLIP-seq
MIRT1245841	hsa-miR-454	CLIP-seq
MIRT1245842	hsa-miR-4647	CLIP-seq
MIRT1245845	hsa-miR-4662b	CLIP-seq
MIRT1245846	hsa-miR-4666-3p	CLIP-seq
MIRT1245848	hsa-miR-4701-5p	CLIP-seq
MIRT2072682	hsa-miR-4707-3p	CLIP-seq
MIRT1245849	hsa-miR-4715-3p	CLIP-seq
MIRT1245850	hsa-miR-4716-5p	CLIP-seq
MIRT1245851	hsa-miR-4722-3p	CLIP-seq
MIRT1245853	hsa-miR-4735-5p	CLIP-seq
MIRT1245854	hsa-miR-4755-3p	CLIP-seq
MIRT1245855	hsa-miR-4763-5p	CLIP-seq
MIRT1245856	hsa-miR-4775	CLIP-seq
MIRT2072684	hsa-miR-4787-3p	CLIP-seq
MIRT2596577	hsa-miR-4803	CLIP-seq
MIRT2072687	hsa-miR-507	CLIP-seq
MIRT1245861	hsa-miR-5095	CLIP-seq
MIRT1245862	hsa-miR-5096	CLIP-seq
MIRT1245865	hsa-miR-520d-5p	CLIP-seq
MIRT1245866	hsa-miR-524-5p	CLIP-seq
MIRT1245867	hsa-miR-544b	CLIP-seq
MIRT1245871	hsa-miR-548s	CLIP-seq
MIRT1245872	hsa-miR-550a	CLIP-seq
MIRT2072697	hsa-miR-557	CLIP-seq
MIRT1245878	hsa-miR-588	CLIP-seq
MIRT1245879	hsa-miR-590-3p	CLIP-seq
MIRT1245880	hsa-miR-652	CLIP-seq
MIRT1245883	hsa-miR-668	CLIP-seq
MIRT1245789	hsa-miR-1183	CLIP-seq
MIRT1245790	hsa-miR-1200	CLIP-seq
MIRT1245791	hsa-miR-122	CLIP-seq
MIRT1245793	hsa-miR-1273f	CLIP-seq
MIRT2072664	hsa-miR-1307	CLIP-seq
MIRT1245795	hsa-miR-130a	CLIP-seq
MIRT1245796	hsa-miR-130b	CLIP-seq
MIRT1245799	hsa-miR-1915	CLIP-seq
MIRT1245800	hsa-miR-197	CLIP-seq
MIRT1245801	hsa-miR-1976	CLIP-seq
MIRT1245805	hsa-miR-300	CLIP-seq
MIRT1245806	hsa-miR-301a	CLIP-seq
MIRT1245807	hsa-miR-301b	CLIP-seq
MIRT1245809	hsa-miR-3149	CLIP-seq
MIRT1245810	hsa-miR-3170	CLIP-seq
MIRT1245811	hsa-miR-3187-3p	CLIP-seq
MIRT1245815	hsa-miR-335	CLIP-seq
MIRT1245821	hsa-miR-3666	CLIP-seq
MIRT1245823	hsa-miR-381	CLIP-seq
MIRT1245828	hsa-miR-411	CLIP-seq
MIRT2072677	hsa-miR-4258	CLIP-seq
MIRT1245830	hsa-miR-4279	CLIP-seq
MIRT1245832	hsa-miR-4295	CLIP-seq
MIRT1245834	hsa-miR-4324	CLIP-seq
MIRT1245837	hsa-miR-4426	CLIP-seq
MIRT1245838	hsa-miR-4435	CLIP-seq
MIRT1245839	hsa-miR-4438	CLIP-seq
MIRT2072679	hsa-miR-4476	CLIP-seq
MIRT1245841	hsa-miR-454	CLIP-seq
MIRT1245842	hsa-miR-4647	CLIP-seq
MIRT1245845	hsa-miR-4662b	CLIP-seq
MIRT1245846	hsa-miR-4666-3p	CLIP-seq
MIRT1245848	hsa-miR-4701-5p	CLIP-seq
MIRT2072682	hsa-miR-4707-3p	CLIP-seq
MIRT1245849	hsa-miR-4715-3p	CLIP-seq
MIRT1245850	hsa-miR-4716-5p	CLIP-seq
MIRT1245851	hsa-miR-4722-3p	CLIP-seq
MIRT1245853	hsa-miR-4735-5p	CLIP-seq
MIRT1245854	hsa-miR-4755-3p	CLIP-seq
MIRT1245855	hsa-miR-4763-5p	CLIP-seq
MIRT1245856	hsa-miR-4775	CLIP-seq
MIRT1245861	hsa-miR-5095	CLIP-seq
MIRT1245862	hsa-miR-5096	CLIP-seq
MIRT1245865	hsa-miR-520d-5p	CLIP-seq
MIRT1245866	hsa-miR-524-5p	CLIP-seq
MIRT1245867	hsa-miR-544b	CLIP-seq
MIRT1245871	hsa-miR-548s	CLIP-seq
MIRT1245872	hsa-miR-550a	CLIP-seq
MIRT1245878	hsa-miR-588	CLIP-seq
MIRT1245879	hsa-miR-590-3p	CLIP-seq
MIRT1245880	hsa-miR-652	CLIP-seq
MIRT1245883	hsa-miR-668	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000175	Function	3'-5'-RNA exonuclease activity	IBA
GO:0000175	Function	3'-5'-RNA exonuclease activity	IDA	19509288
GO:0000175	Function	3'-5'-RNA exonuclease activity	TAS
GO:0000957	Process	Mitochondrial RNA catabolic process	IDA	18501193, 29967381, 39019044
GO:0000957	Process	Mitochondrial RNA catabolic process	TAS
GO:0000958	Process	Mitochondrial mRNA catabolic process	IBA
GO:0000958	Process	Mitochondrial mRNA catabolic process	IDA	20691904
GO:0000958	Process	Mitochondrial mRNA catabolic process	IEA
GO:0000958	Process	Mitochondrial mRNA catabolic process	IMP	22661577
GO:0000962	Process	Positive regulation of mitochondrial RNA catabolic process	IDA	19509288
GO:0000964	Process	Mitochondrial RNA 5'-end processing	IMP	18083837
GO:0000965	Process	Mitochondrial RNA 3'-end processing	IBA
GO:0000965	Process	Mitochondrial RNA 3'-end processing	IMP	18083837
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003723	Function	RNA binding	IEA
GO:0004518	Function	Nuclease activity	IEA
GO:0004527	Function	Exonuclease activity	IEA
GO:0004654	Function	Polyribonucleotide nucleotidyltransferase activity	IBA
GO:0004654	Function	Polyribonucleotide nucleotidyltransferase activity	IDA	18083836
GO:0004654	Function	Polyribonucleotide nucleotidyltransferase activity	IEA
GO:0005515	Function	Protein binding	IPI	16934922, 19509288, 28514442, 29967381, 32296183, 33961781, 39251607
GO:0005737	Component	Cytoplasm	IDA	16055741
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	16055741, 19864255, 20691904
GO:0005739	Component	Mitochondrion	IEA
GO:0005758	Component	Mitochondrial intermembrane space	IDA	16966381
GO:0005758	Component	Mitochondrial intermembrane space	IEA
GO:0005759	Component	Mitochondrial matrix	IDA	39019044
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005840	Component	Ribosome	IEA
GO:0006396	Process	RNA processing	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0006401	Process	RNA catabolic process	IDA	18083836
GO:0006402	Process	MRNA catabolic process	IDA	12721301, 16055741
GO:0006402	Process	MRNA catabolic process	IEA
GO:0007005	Process	Mitochondrion organization	IEA
GO:0007005	Process	Mitochondrion organization	ISS
GO:0008266	Function	Poly(U) RNA binding	IDA	18083836
GO:0016020	Component	Membrane	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016779	Function	Nucleotidyltransferase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0034046	Function	Poly(G) binding	IDA	18083836
GO:0034599	Process	Cellular response to oxidative stress	IDA	18501193
GO:0035198	Function	MiRNA binding	IDA	20547861
GO:0035458	Process	Cellular response to interferon-beta	IDA	16410805
GO:0035927	Process	RNA import into mitochondrion	IDA	20691904
GO:0035928	Process	RRNA import into mitochondrion	IDA	20691904
GO:0042802	Function	Identical protein binding	IPI	19509288
GO:0043457	Process	Regulation of cellular respiration	IEA
GO:0043457	Process	Regulation of cellular respiration	ISS
GO:0045025	Component	Mitochondrial degradosome	IDA	19509288, 29967381
GO:0051260	Process	Protein homooligomerization	IDA	20691904
GO:0051591	Process	Response to cAMP	IEA
GO:0060416	Process	Response to growth hormone	IEA
GO:0061014	Process	Positive regulation of mRNA catabolic process	IEA
GO:0061014	Process	Positive regulation of mRNA catabolic process	IMP	16410805
GO:0070207	Process	Protein homotrimerization	IDA	19509288, 20691904
GO:0071042	Process	Nuclear polyadenylation-dependent mRNA catabolic process	IDA	16934922
GO:0097222	Process	Mitochondrial mRNA polyadenylation	IMP	18083837
GO:0097421	Process	Liver regeneration	IEA
GO:1905354	Component	Exoribonuclease complex	IEA
GO:2000627	Process	Positive regulation of miRNA catabolic process	IDA	20547861
GO:2000772	Process	Regulation of cellular senescence	IDA	16055741

Other IDs

• MIM: 610316
• HGNC: 23166
• e!Ensembl: ENSG00000138035

Protein

• UniProt ID: Q8TCS8
• Protein name: Polyribonucleotide nucleotidyltransferase 1, mitochondrial (EC 2.7.7.8) (3'-5' RNA exonuclease OLD35) (PNPase old-35) (Polynucleotide phosphorylase 1) (PNPase 1) (Polynucleotide phosphorylase-like protein)
• Protein function: RNA-binding protein implicated in numerous RNA metabolic processes (PubMed:29967381, PubMed:39019044). Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction (PubMed:29967381, PubMed:39019044).
• PDB: 3U1K, 5ZF6, 9KJR, 9KJT
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01138	RNase_PH	52 → 183		Domain
  PF03725	RNase_PH_C	186 → 251		Domain
  PF03726	PNPase	282 → 363	Polyribonucleotide nucleotidyltransferase, RNA binding domain	Domain
  PF01138	RNase_PH	366 → 501		Domain
  PF00013	KH_1	607 → 666	KH domain	Domain
  PF00575	S1	675 → 750	S1 RNA binding domain	Domain

• Sequence:

  MAACRYCCSCLRLRPLSDGPFLLPRRDRALTQLQVRALWSSAGSRAVAVDLGNRKLEISS
  GKLARFADGSAVVQSGDTAVMVTAVSKTKPSPSQFMPLVVDYRQKAAAAGRIPTNYLRRE
  IGTSDKEILTSRIIDRSIRPLFPAGYFYDTQVLCNLLAVDGVNEPDVLAINGASVALSLS
  DIPWNGPVGAVRIGIIDGEYVVNPTRKEMSSSTLNLVVAGAPKSQIVMLEASAENILQQD
  FCHAIKVGVKYTQQIIQGIQQLVKETGVTKRTPQKLFTPSPEIVKYTHKLAMERLYAVFT
  DYEHDKVSRDEAVNKIRLDTEEQLKEKFPEADPYEIIESFNVVAKEVFRSIVLNEYKRCD
  GRDLTSLRNVSCEVDMFKTLHGSALFQRGQTQVLCTVTFDSLESGIKSDQVITAINGIKD
  KNFMLHYEFPPYATNEIGKVTGLNRRELGHGALAEKALYPVIPRDFPFTIRVTSEVLESN
  GSSSMASACGGSLALMDSGVPISSAVAGVAIGLVTKTDPEKGEIEDYRLLTDILGIEDYN
  GDMDFKIAGTNKGITALQADIKLPGIPIKIVMEAIQQASVAKKEILQIMNKTISKPRASR
  KENGPVVETVQVPLSKRAKFVGPGGYNLKKLQAETGVTISQVDEETFSVFAPTPSAMHEA
  RDFITEICKDDQEQQLEFGAVYTATITEIRDTGVMVKLYPNMTAVLLHNTQLDQRKIKHP
  TALGLEVGQEIQVKYFGRDPADGRMRLSRKVLQSPATTVVRTLNDRSSIVMGEPISQSSS
  NSQ

• Sequence length: 783

Pathways

KEGG:

RNA degradation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Autosomal recessive nonsyndromic hearing loss 70	Pathogenic; Likely pathogenic	rs1696930196, rs1478363532, rs35239216, rs991366882, rs143712760, rs397514599, rs1049082567	RCV001336838 RCV001336835 RCV002265053 RCV002283958 RCV001089488 RCV000033023 RCV001089489	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Combined oxidative phosphorylation defect type 13	Likely pathogenic; Pathogenic	rs1695931094, rs2104038061, rs1329170892, rs775717775, rs143712760, rs780383722, rs863225449, rs879255657, rs778100619, rs755065532, rs397514598, rs746356243, rs1559114055, rs752550279, rs1559094461, rs1365308037, rs1049082567	RCV001332754 RCV002274863 RCV002472030 RCV002472072 RCV000680151 RCV003314052 RCV000202393 RCV000239707 RCV000239625 RCV003991950 RCV000033022 RCV000714514 RCV000714515 RCV000714516 RCV000714517 RCV000986759 RCV001089489	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Global developmental delay	Likely pathogenic; Pathogenic	rs992877769	RCV002463864	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Neurodevelopmental disorder	Likely pathogenic; Pathogenic	rs143712760, rs1572834021	RCV000787360 RCV000787359	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Ovarian serous cystadenocarcinoma	Likely pathogenic	rs755065532	RCV005937397	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
PNPT1-related disorder	Pathogenic; Likely pathogenic	rs1696930196, rs572684828, rs2529522692, rs2529577004, rs1448753696, rs2529560640	RCV004531125 RCV003155418 RCV003226870 RCV003335859 RCV004542643 RCV004579635	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Spinocerebellar ataxia type 25	Pathogenic; Likely pathogenic	rs2104026165, rs748445058, rs143712760, rs2529627773	RCV002265066 RCV002265067 RCV003152598 RCV004515752	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Adrenocortical carcinoma, hereditary	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AMYOTROPHIC LATERAL SCLEROSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANDROGENETIC ALOPECIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTOIMMUNE THYROID DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTOSOMAL RECESSIVE ISOLATED SENSORINEURAL DEAFNESS TYPE DFNB	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, HEPATOCELLULAR	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cholangiocarcinoma	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Chronic lymphocytic leukemia/small lymphocytic lymphoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 13	—	CTD, HPO CTD, HPO	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEAFNESS, AUTOSOMAL RECESSIVE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEAFNESS, AUTOSOMAL RECESSIVE 70	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEAFNESS, AUTOSOMAL RECESSIVE 70, WITH OR WITHOUT ADULT-ONSET NEURODEGENERATION	—	CTD, HPO CTD, HPO	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DISORDER OF VISUAL SYSTEM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIVERTICULAR DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EYE DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EYELID DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Benign; Likely benign; Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial pancreatic carcinoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Germ cell tumor of testis	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLAUCOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Glioma susceptibility 1	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEARING IMPAIRMENT	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEARING LOSS DISORDER	—	GenCC	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hereditary ataxia	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPOTHYROIDISM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LEIGH SYNDROME	—	ClinGen, GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lymphoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign; Likely benign; Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROPATHY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OPEN-ANGLE GLAUCOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OPTIC NEURITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian cancer	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PELVIC ORGAN PROLAPSE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Uncertain significance	ClinVar Disgenet	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
SENSORINEURAL HEARING LOSS OF BILATERAL EARS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SPINOCEREBELLAR ATAXIA 25	—	CTD, Disgenet, HPO CTD, Disgenet, HPO CTD, Disgenet, HPO	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE PROLAPSE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uveal melanoma	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VISUAL PATHWAY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenocarcinoma of colon	Adenocarcinoma Of Colon	BEFREE	24729470		★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of prostate	Prostate adenocarcinoma	BEFREE	24729470		★☆☆☆☆ Found in Text Mining only
Anemia Pernicious	Pernicious anemia	Pubtator	34145262	Associate	★☆☆☆☆ Found in Text Mining only
Ataxia	Ataxia	Pubtator	35411967	Associate	★☆☆☆☆ Found in Text Mining only
Autosomal recessive non-syndromic sensorineural deafness type DFNB	Non-Syndromic Sensorineural Deafness	Orphanet			★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	36232701, 37400627, 39522317	Associate	★☆☆☆☆ Found in Text Mining only
Cataract	Cataract	HPO_DG			★☆☆☆☆ Found in Text Mining only
Cerebellar Ataxia	Cerebellar ataxia	Pubtator	35411967	Associate	★☆☆☆☆ Found in Text Mining only
Choreoathetosis	Choreoathetosis	HPO_DG			★☆☆☆☆ Found in Text Mining only
Chronic Obstructive Airway Disease	Chronic Obstructive Pulmonary Disease	BEFREE	24729470		★☆☆☆☆ Found in Text Mining only
Combined oxidative phosphorylation defect type 13	Combined Oxidative Phosphorylation Deficiency	Orphanet			★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 13	Combined Oxidative Phosphorylation Deficiency	CLINVAR_DG	23084291, 26633545, 27759031		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 13	Combined Oxidative Phosphorylation Deficiency	ORPHANET_DG	23084291		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 13	Combined Oxidative Phosphorylation Deficiency	GENOMICS_ENGLAND_DG	23084291, 25457163, 27604308, 31752325		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 13	Combined Oxidative Phosphorylation Deficiency	UNIPROT_DG	23084291		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 13	Combined Oxidative Phosphorylation Deficiency	CTD_human_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Congenital sensorineural hearing loss	Congenital Sensorineural Hearing Loss	BEFREE	30244537		★☆☆☆☆ Found in Text Mining only
DEAFNESS, AUTOSOMAL RECESSIVE (disorder)	Deafness	CLINGEN_DG	23084290		★☆☆☆☆ Found in Text Mining only
DEAFNESS, AUTOSOMAL RECESSIVE 70	Deafness	UNIPROT_DG	23084290		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEAFNESS, AUTOSOMAL RECESSIVE 70	Deafness	GENOMICS_ENGLAND_DG	25457163, 27604308, 31752325		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEAFNESS, AUTOSOMAL RECESSIVE 70	Deafness	CTD_human_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Dyskinetic syndrome	Dyskinetic Syndrome	HPO_DG			★☆☆☆☆ Found in Text Mining only
Eye Abnormalities	Eye abnormalities	Pubtator	25457163	Associate	★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	GENOMICS_ENGLAND_DG	31752325		★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Hearing Loss	Hearing loss	Pubtator	34194829	Associate	★☆☆☆☆ Found in Text Mining only
Hearing Loss Sensorineural	Hearing loss	Pubtator	25457163	Associate	★☆☆☆☆ Found in Text Mining only
Hip Contracture	Hip Contracture	HPO_DG			★☆☆☆☆ Found in Text Mining only
Hypothyroidism	Hypothyroidism	GWASCAT_DG	30595370		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Intellectual Disability	Mental retardation	GENOMICS_ENGLAND_DG	31752325		★☆☆☆☆ Found in Text Mining only
Intervertebral Disc Degeneration	Intervertebral disc disease	Pubtator	33174041	Associate	★☆☆☆☆ Found in Text Mining only
Leigh Disease	Leigh Syndrome	BEFREE	28645153		★☆☆☆☆ Found in Text Mining only
Leukodystrophy	Leukodystrophy	HPO_DG			★☆☆☆☆ Found in Text Mining only
Lingual-Facial-Buccal Dyskinesia	Orofacial dyskinesia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	CTD_human_DG	21472284		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	17960560		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	17960560		★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	16055741, 20547861, 24729470	Associate	★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	16410805, 20547861, 24143183		★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	LHGDN	16410805, 16505900		★☆☆☆☆ Found in Text Mining only
Microcephaly	Microcephaly	Pubtator	25457163	Associate	★☆☆☆☆ Found in Text Mining only
Mitochondrial Diseases	Mitochondrial disease	Pubtator	22411789, 23084291, 24143183, 27759031, 30020492	Associate	★☆☆☆☆ Found in Text Mining only
Mitochondrial Encephalomyopathies	Mitochondrial encephalomyopathy	Pubtator	23084291	Associate	★☆☆☆☆ Found in Text Mining only
Mitochondrial Respiratory Chain Deficiencies	Mitochondrial Respiratory Chain Deficiencies	BEFREE	23084291		★☆☆☆☆ Found in Text Mining only
Movement Disorders	Movement disorder	Pubtator	23084291	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	19580345, 20547861		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	19202553		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	19202553	Associate	★☆☆☆☆ Found in Text Mining only
Nonsyndromic Deafness	Nonsyndromic Deafness	BEFREE	23084290		★☆☆☆☆ Found in Text Mining only
Nystagmus	Nystagmus	HPO_DG			★☆☆☆☆ Found in Text Mining only
Oxidative Phosphorylation Deficiencies	Oxidative Phosphorylation Deficiency	BEFREE	30244537		★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	17960560		★☆☆☆☆ Found in Text Mining only
Profound static encephalopathy	Encephalopathy	HPO_DG			★☆☆☆☆ Found in Text Mining only
Seizures	Seizures	Pubtator	25457163	Associate	★☆☆☆☆ Found in Text Mining only
Sensorineural Hearing Loss (disorder)	Hearing Loss	BEFREE	30244537		★☆☆☆☆ Found in Text Mining only
Sensorineural Hearing Loss (disorder)	Hearing Loss	HPO_DG			★☆☆☆☆ Found in Text Mining only
Sensory neuropathy	Sensory neuropathy	HPO_DG			★☆☆☆☆ Found in Text Mining only
Spinocerebellar ataxia 25	Spinocerebellar Ataxia	BEFREE	15895562		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Spinocerebellar ataxia 25	Spinocerebellar ataxia	Pubtator	35411967	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Spinocerebellar ataxia 25	Spinocerebellar Ataxia	ORPHANET_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Spinocerebellar ataxia type 25	Spinocerebellar Ataxia	Orphanet			★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Spinocerebellar Ataxias	Spinocerebellar ataxia	Pubtator	35411967	Associate	★☆☆☆☆ Found in Text Mining only