Gene Gene information from NCBI Gene database.
Entrez ID 8675
Gene name Syntaxin 16
Gene symbol STX16
Synonyms (NCBI Gene)
SYN-16SYN16
Chromosome 20
Chromosome location 20q13.32
Summary This gene encodes a protein that is a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for V-SNARES (vesicle-SNAP receptors) permitting specific synaptic vesicle docking a
miRNA miRNA information provided by mirtarbase database.
827
miRTarBase ID miRNA Experiments Reference
MIRT028613 hsa-miR-30a-5p Proteomics 18668040
MIRT030553 hsa-miR-24-3p Western blot;Other 17150773
MIRT048767 hsa-miR-93-5p CLASH 23622248
MIRT043405 hsa-miR-331-3p CLASH 23622248
MIRT042882 hsa-miR-324-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
37
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0000139 Component Golgi membrane TAS
GO:0000149 Function SNARE binding IBA
GO:0005484 Function SNAP receptor activity IBA
GO:0005484 Function SNAP receptor activity IDA 15215310
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603666 11431 ENSG00000124222
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O14662
Protein name Syntaxin-16 (Syn16)
Protein function SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.
PDB 8QQF
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00804 Syntaxin 78 265 Syntaxin Domain
PF05739 SNARE 266 318 SNARE domain Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous.
Sequence
Sequence length 325
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  SNARE interactions in vesicular transport   Intra-Golgi traffic
Retrograde transport at the Trans-Golgi-Network
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Autosomal dominant pseudohypoaldosteronism type 1 Uncertain significance; Benign; Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PSEUDOHYPOALDOSTERONISM CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PSEUDOHYPOALDOSTERONISM, TYPE I, AUTOSOMAL DOMINANT Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Pseudohypoparathyroidism type 1B Uncertain significance; Conflicting classifications of pathogenicity; Benign; Likely benign ClinVar
ClinVar, GWAS catalog, Orphanet
ClinVar, GWAS catalog, Orphanet
★★★☆☆
Reported in Unknown/Other Associations (≥2 sources)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Alzheimer Disease Alzheimer disease Pubtator 28084650, 28711660 Associate
★☆☆☆☆
Found in Text Mining only
Anxiety Anxiety Disorder HPO_DG
★☆☆☆☆
Found in Text Mining only
Autism Spectrum Disorder Autism Pubtator 27404287 Associate
★☆☆☆☆
Found in Text Mining only
Autism Spectrum Disorders Autism Spectrum Disorder BEFREE 27404287
★☆☆☆☆
Found in Text Mining only
Calcium Metabolism Disorders Calcium metabolism disorders Pubtator 34477200 Associate
★☆☆☆☆
Found in Text Mining only
Camurati-Engelmann Syndrome Diaphyseal dysplasia HPO_DG
★☆☆☆☆
Found in Text Mining only
Cataract Cataract HPO_DG
★☆☆☆☆
Found in Text Mining only
Conjunctivitis Conjunctivitis HPO_DG
★☆☆☆☆
Found in Text Mining only
Dental Enamel Hypoplasia Dental Enamel Hypoplasia HPO_DG
★☆☆☆☆
Found in Text Mining only
Depressive disorder Mental Depression HPO_DG
★☆☆☆☆
Found in Text Mining only