Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	8650
Gene name	NUMB endocytic adaptor protein
Gene symbol	NUMB
Synonyms (NCBI Gene)	C14orf41S171c14_5527
Chromosome	14
Chromosome location	14q24.2-q24.3
Summary	The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate w

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miRTarBase ID	miRNA	Experiments	Reference
MIRT004970	hsa-miR-31-5p	Luciferase reporter assayqRT-PCR	19524507
MIRT019211	hsa-miR-335-5p	Microarray	18185580
MIRT020047	hsa-miR-375	Microarray	20215506
MIRT020360	hsa-miR-29c-3p	Sequencing	20371350
MIRT027189	hsa-miR-103a-3p	Sequencing	20371350
MIRT054669	hsa-miR-146a-5p	Luciferase reporter assay	24092752
MIRT054669	hsa-miR-146a-5p	Luciferase reporter assay	24092752
MIRT547268	hsa-miR-548av-3p	PAR-CLIP	21572407
MIRT547266	hsa-miR-4418	PAR-CLIP	21572407
MIRT547267	hsa-miR-509-3-5p	PAR-CLIP	21572407
MIRT547265	hsa-miR-509-5p	PAR-CLIP	21572407
MIRT547264	hsa-miR-3942-5p	PAR-CLIP	21572407
MIRT547263	hsa-miR-4703-5p	PAR-CLIP	21572407
MIRT547261	hsa-miR-4496	PAR-CLIP	21572407
MIRT547262	hsa-miR-3163	PAR-CLIP	21572407
MIRT547260	hsa-miR-6074	PAR-CLIP	21572407
MIRT547259	hsa-miR-1184	PAR-CLIP	21572407
MIRT547258	hsa-miR-4738-3p	PAR-CLIP	21572407
MIRT027189	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT547257	hsa-miR-107	PAR-CLIP	21572407
MIRT547256	hsa-miR-4684-5p	PAR-CLIP	21572407
MIRT547268	hsa-miR-548av-3p	PAR-CLIP	21572407
MIRT071145	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT547266	hsa-miR-4418	PAR-CLIP	21572407
MIRT547267	hsa-miR-509-3-5p	PAR-CLIP	21572407
MIRT547265	hsa-miR-509-5p	PAR-CLIP	21572407
MIRT547264	hsa-miR-3942-5p	PAR-CLIP	21572407
MIRT547263	hsa-miR-4703-5p	PAR-CLIP	21572407
MIRT547261	hsa-miR-4496	PAR-CLIP	21572407
MIRT547262	hsa-miR-3163	PAR-CLIP	21572407
MIRT547260	hsa-miR-6074	PAR-CLIP	21572407
MIRT547259	hsa-miR-1184	PAR-CLIP	21572407
MIRT547258	hsa-miR-4738-3p	PAR-CLIP	21572407
MIRT027189	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT547257	hsa-miR-107	PAR-CLIP	21572407
MIRT547256	hsa-miR-4684-5p	PAR-CLIP	21572407
MIRT731260	hsa-let-7c-5p	ASANPaCa"	27521217
MIRT731260	hsa-let-7c-5p	ASANPaCa"	27521217
MIRT731352	hsa-miR-34a-5p	Luciferase reporter assay	26849305
MIRT731352	hsa-miR-34a-5p	Luciferase reporter assay	26849305
MIRT734470	hsa-miR-146b-5p	Luciferase reporter assayWestern blotting	32346414
MIRT547268	hsa-miR-548av-3p	PAR-CLIP	21572407
MIRT547266	hsa-miR-4418	PAR-CLIP	21572407
MIRT547267	hsa-miR-509-3-5p	PAR-CLIP	21572407
MIRT547265	hsa-miR-509-5p	PAR-CLIP	21572407
MIRT547264	hsa-miR-3942-5p	PAR-CLIP	21572407
MIRT547263	hsa-miR-4703-5p	PAR-CLIP	21572407
MIRT547261	hsa-miR-4496	PAR-CLIP	21572407
MIRT547262	hsa-miR-3163	PAR-CLIP	21572407
MIRT547260	hsa-miR-6074	PAR-CLIP	21572407
MIRT547259	hsa-miR-1184	PAR-CLIP	21572407
MIRT547258	hsa-miR-4738-3p	PAR-CLIP	21572407
MIRT027189	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT547257	hsa-miR-107	PAR-CLIP	21572407
MIRT547256	hsa-miR-4684-5p	PAR-CLIP	21572407
MIRT547268	hsa-miR-548av-3p	PAR-CLIP	21572407
MIRT071145	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT547266	hsa-miR-4418	PAR-CLIP	21572407
MIRT547267	hsa-miR-509-3-5p	PAR-CLIP	21572407
MIRT547265	hsa-miR-509-5p	PAR-CLIP	21572407
MIRT547264	hsa-miR-3942-5p	PAR-CLIP	21572407
MIRT547263	hsa-miR-4703-5p	PAR-CLIP	21572407
MIRT547261	hsa-miR-4496	PAR-CLIP	21572407
MIRT547262	hsa-miR-3163	PAR-CLIP	21572407
MIRT547260	hsa-miR-6074	PAR-CLIP	21572407
MIRT547259	hsa-miR-1184	PAR-CLIP	21572407
MIRT547258	hsa-miR-4738-3p	PAR-CLIP	21572407
MIRT027189	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT547257	hsa-miR-107	PAR-CLIP	21572407
MIRT547256	hsa-miR-4684-5p	PAR-CLIP	21572407
MIRT755451	hsa-miR-222-5p	Luciferase reporter assayWestern blottingqRT-PCR	37566749
MIRT1198830	hsa-miR-1205	CLIP-seq
MIRT1198831	hsa-miR-1301	CLIP-seq
MIRT1198832	hsa-miR-2052	CLIP-seq
MIRT1198833	hsa-miR-2115	CLIP-seq
MIRT1198834	hsa-miR-219-5p	CLIP-seq
MIRT1198835	hsa-miR-3120-5p	CLIP-seq
MIRT1198836	hsa-miR-3122	CLIP-seq
MIRT1198837	hsa-miR-3158-5p	CLIP-seq
MIRT1198838	hsa-miR-335	CLIP-seq
MIRT1198839	hsa-miR-346	CLIP-seq
MIRT1198840	hsa-miR-3606	CLIP-seq
MIRT1198841	hsa-miR-3670	CLIP-seq
MIRT1198842	hsa-miR-369-3p	CLIP-seq
MIRT1198843	hsa-miR-374a	CLIP-seq
MIRT1198844	hsa-miR-374b	CLIP-seq
MIRT1198845	hsa-miR-3913-5p	CLIP-seq
MIRT1198846	hsa-miR-410	CLIP-seq
MIRT1198847	hsa-miR-4288	CLIP-seq
MIRT1198848	hsa-miR-4421	CLIP-seq
MIRT1198849	hsa-miR-4433	CLIP-seq
MIRT1198850	hsa-miR-4445	CLIP-seq
MIRT1198851	hsa-miR-4459	CLIP-seq
MIRT1198852	hsa-miR-450b-3p	CLIP-seq
MIRT1198853	hsa-miR-4660	CLIP-seq
MIRT1198854	hsa-miR-4713-3p	CLIP-seq
MIRT1198855	hsa-miR-4753-5p	CLIP-seq
MIRT1198856	hsa-miR-4768-3p	CLIP-seq
MIRT1198857	hsa-miR-4772-3p	CLIP-seq
MIRT1198858	hsa-miR-4778-5p	CLIP-seq
MIRT1198859	hsa-miR-4782-3p	CLIP-seq
MIRT1198860	hsa-miR-485-5p	CLIP-seq
MIRT1198861	hsa-miR-5047	CLIP-seq
MIRT1198862	hsa-miR-508-3p	CLIP-seq
MIRT1198863	hsa-miR-570	CLIP-seq
MIRT1198864	hsa-miR-632	CLIP-seq
MIRT1198865	hsa-miR-769-3p	CLIP-seq
MIRT1198866	hsa-miR-891b	CLIP-seq
MIRT1198867	hsa-miR-921	CLIP-seq
MIRT1198868	hsa-miR-101	CLIP-seq
MIRT1198869	hsa-miR-103a	CLIP-seq
MIRT1198870	hsa-miR-1197	CLIP-seq
MIRT1198830	hsa-miR-1205	CLIP-seq
MIRT1198871	hsa-miR-1231	CLIP-seq
MIRT1198872	hsa-miR-1238	CLIP-seq
MIRT1198873	hsa-miR-1254	CLIP-seq
MIRT1198874	hsa-miR-1271	CLIP-seq
MIRT1198875	hsa-miR-128	CLIP-seq
MIRT1198876	hsa-miR-1285	CLIP-seq
MIRT1198831	hsa-miR-1301	CLIP-seq
MIRT1198877	hsa-miR-1323	CLIP-seq
MIRT1198878	hsa-miR-134	CLIP-seq
MIRT1198879	hsa-miR-182	CLIP-seq
MIRT1198880	hsa-miR-199a-3p	CLIP-seq
MIRT1198881	hsa-miR-199b-3p	CLIP-seq
MIRT1198882	hsa-miR-200b	CLIP-seq
MIRT1198883	hsa-miR-200c	CLIP-seq
MIRT1198832	hsa-miR-2052	CLIP-seq
MIRT1198833	hsa-miR-2115	CLIP-seq
MIRT1198884	hsa-miR-2117	CLIP-seq
MIRT1198834	hsa-miR-219-5p	CLIP-seq
MIRT1198885	hsa-miR-27a	CLIP-seq
MIRT1198886	hsa-miR-27b	CLIP-seq
MIRT1198887	hsa-miR-2861	CLIP-seq
MIRT1198888	hsa-miR-31	CLIP-seq
MIRT1198889	hsa-miR-3116	CLIP-seq
MIRT1198890	hsa-miR-3118	CLIP-seq
MIRT1198835	hsa-miR-3120-5p	CLIP-seq
MIRT1198891	hsa-miR-3121-5p	CLIP-seq
MIRT1198892	hsa-miR-3124-3p	CLIP-seq
MIRT1198893	hsa-miR-3129-5p	CLIP-seq
MIRT1198894	hsa-miR-3140-3p	CLIP-seq
MIRT1198895	hsa-miR-3143	CLIP-seq
MIRT1198837	hsa-miR-3158-5p	CLIP-seq
MIRT1198896	hsa-miR-3159	CLIP-seq
MIRT1198897	hsa-miR-3187-5p	CLIP-seq
MIRT1198898	hsa-miR-326	CLIP-seq
MIRT1198899	hsa-miR-330-5p	CLIP-seq
MIRT1198838	hsa-miR-335	CLIP-seq
MIRT1198900	hsa-miR-339-5p	CLIP-seq
MIRT1198839	hsa-miR-346	CLIP-seq
MIRT1198901	hsa-miR-3591-5p	CLIP-seq
MIRT1198902	hsa-miR-3660	CLIP-seq
MIRT1198903	hsa-miR-3664-5p	CLIP-seq
MIRT1198904	hsa-miR-3690	CLIP-seq
MIRT1198905	hsa-miR-378	CLIP-seq
MIRT1198906	hsa-miR-378b	CLIP-seq
MIRT1198907	hsa-miR-378c	CLIP-seq
MIRT1198908	hsa-miR-378d	CLIP-seq
MIRT1198909	hsa-miR-378e	CLIP-seq
MIRT1198910	hsa-miR-378f	CLIP-seq
MIRT1198911	hsa-miR-378g	CLIP-seq
MIRT1198912	hsa-miR-378h	CLIP-seq
MIRT1198913	hsa-miR-378i	CLIP-seq
MIRT1198914	hsa-miR-3924	CLIP-seq
MIRT1198915	hsa-miR-3943	CLIP-seq
MIRT1198846	hsa-miR-410	CLIP-seq
MIRT1198916	hsa-miR-422a	CLIP-seq
MIRT1198917	hsa-miR-4255	CLIP-seq
MIRT1198918	hsa-miR-4268	CLIP-seq
MIRT1198919	hsa-miR-4273	CLIP-seq
MIRT1198920	hsa-miR-4286	CLIP-seq
MIRT1198847	hsa-miR-4288	CLIP-seq
MIRT1198921	hsa-miR-429	CLIP-seq
MIRT1198922	hsa-miR-4323	CLIP-seq
MIRT1198923	hsa-miR-4326	CLIP-seq
MIRT1198848	hsa-miR-4421	CLIP-seq
MIRT1198849	hsa-miR-4433	CLIP-seq
MIRT1198924	hsa-miR-4436a	CLIP-seq
MIRT1198850	hsa-miR-4445	CLIP-seq
MIRT1198925	hsa-miR-4448	CLIP-seq
MIRT1198851	hsa-miR-4459	CLIP-seq
MIRT1198926	hsa-miR-4486	CLIP-seq
MIRT1198927	hsa-miR-4526	CLIP-seq
MIRT1198928	hsa-miR-4640-3p	CLIP-seq
MIRT1198853	hsa-miR-4660	CLIP-seq
MIRT1198854	hsa-miR-4713-3p	CLIP-seq
MIRT1198929	hsa-miR-4714-3p	CLIP-seq
MIRT1198930	hsa-miR-4714-5p	CLIP-seq
MIRT1198931	hsa-miR-4724-3p	CLIP-seq
MIRT1198932	hsa-miR-4742-3p	CLIP-seq
MIRT1198856	hsa-miR-4768-3p	CLIP-seq
MIRT1198857	hsa-miR-4772-3p	CLIP-seq
MIRT1198859	hsa-miR-4782-3p	CLIP-seq
MIRT1198933	hsa-miR-4803	CLIP-seq
MIRT1198860	hsa-miR-485-5p	CLIP-seq
MIRT1198934	hsa-miR-502-5p	CLIP-seq
MIRT1198861	hsa-miR-5047	CLIP-seq
MIRT1198862	hsa-miR-508-3p	CLIP-seq
MIRT1198935	hsa-miR-548aa	CLIP-seq
MIRT1198936	hsa-miR-548ae	CLIP-seq
MIRT1198937	hsa-miR-548aj	CLIP-seq
MIRT1198938	hsa-miR-548am	CLIP-seq
MIRT1198939	hsa-miR-548o	CLIP-seq
MIRT1198940	hsa-miR-548x	CLIP-seq
MIRT1198863	hsa-miR-570	CLIP-seq
MIRT1198941	hsa-miR-612	CLIP-seq
MIRT1198864	hsa-miR-632	CLIP-seq
MIRT1198866	hsa-miR-891b	CLIP-seq
MIRT1198942	hsa-miR-936	CLIP-seq
MIRT1198943	hsa-miR-943	CLIP-seq
MIRT1198944	hsa-miR-96	CLIP-seq
MIRT1198830	hsa-miR-1205	CLIP-seq
MIRT1198872	hsa-miR-1238	CLIP-seq
MIRT2057626	hsa-miR-1273f	CLIP-seq
MIRT1198831	hsa-miR-1301	CLIP-seq
MIRT2057627	hsa-miR-143	CLIP-seq
MIRT1198880	hsa-miR-199a-3p	CLIP-seq
MIRT1198881	hsa-miR-199b-3p	CLIP-seq
MIRT1198833	hsa-miR-2115	CLIP-seq
MIRT1198834	hsa-miR-219-5p	CLIP-seq
MIRT1198835	hsa-miR-3120-5p	CLIP-seq
MIRT1198892	hsa-miR-3124-3p	CLIP-seq
MIRT1198893	hsa-miR-3129-5p	CLIP-seq
MIRT1198894	hsa-miR-3140-3p	CLIP-seq
MIRT1198837	hsa-miR-3158-5p	CLIP-seq
MIRT2057628	hsa-miR-340	CLIP-seq
MIRT1198839	hsa-miR-346	CLIP-seq
MIRT1198902	hsa-miR-3660	CLIP-seq
MIRT2057629	hsa-miR-3662	CLIP-seq
MIRT2057630	hsa-miR-3663-3p	CLIP-seq
MIRT1198841	hsa-miR-3670	CLIP-seq
MIRT1198914	hsa-miR-3924	CLIP-seq
MIRT1198846	hsa-miR-410	CLIP-seq
MIRT1198847	hsa-miR-4288	CLIP-seq
MIRT2057631	hsa-miR-4293	CLIP-seq
MIRT1198848	hsa-miR-4421	CLIP-seq
MIRT1198850	hsa-miR-4445	CLIP-seq
MIRT2057632	hsa-miR-4446-5p	CLIP-seq
MIRT1198927	hsa-miR-4526	CLIP-seq
MIRT1198853	hsa-miR-4660	CLIP-seq
MIRT2057633	hsa-miR-4708-5p	CLIP-seq
MIRT1198854	hsa-miR-4713-3p	CLIP-seq
MIRT1198855	hsa-miR-4753-5p	CLIP-seq
MIRT2057634	hsa-miR-4770	CLIP-seq
MIRT1198859	hsa-miR-4782-3p	CLIP-seq
MIRT2057635	hsa-miR-485-3p	CLIP-seq
MIRT1198861	hsa-miR-5047	CLIP-seq
MIRT2057636	hsa-miR-513a-3p	CLIP-seq
MIRT2057637	hsa-miR-548a-5p	CLIP-seq
MIRT2057638	hsa-miR-548ab	CLIP-seq
MIRT2057639	hsa-miR-548ak	CLIP-seq
MIRT2057640	hsa-miR-548b-5p	CLIP-seq
MIRT2057641	hsa-miR-548c-3p	CLIP-seq
MIRT2057642	hsa-miR-548c-5p	CLIP-seq
MIRT2057643	hsa-miR-548d-5p	CLIP-seq
MIRT2057644	hsa-miR-548h	CLIP-seq
MIRT2057645	hsa-miR-548i	CLIP-seq
MIRT2057646	hsa-miR-548j	CLIP-seq
MIRT2057647	hsa-miR-548n	CLIP-seq
MIRT2057648	hsa-miR-548w	CLIP-seq
MIRT2057649	hsa-miR-548y	CLIP-seq
MIRT2057650	hsa-miR-556-5p	CLIP-seq
MIRT2057651	hsa-miR-559	CLIP-seq
MIRT1198864	hsa-miR-632	CLIP-seq
MIRT1198942	hsa-miR-936	CLIP-seq
MIRT1198834	hsa-miR-219-5p	CLIP-seq
MIRT2286000	hsa-miR-2355-5p	CLIP-seq
MIRT1198846	hsa-miR-410	CLIP-seq
MIRT1198850	hsa-miR-4445	CLIP-seq
MIRT1198859	hsa-miR-4782-3p	CLIP-seq
MIRT2057641	hsa-miR-548c-3p	CLIP-seq
MIRT1198870	hsa-miR-1197	CLIP-seq
MIRT2286001	hsa-miR-1275	CLIP-seq
MIRT1198835	hsa-miR-3120-5p	CLIP-seq
MIRT2286002	hsa-miR-4260	CLIP-seq
MIRT2286003	hsa-miR-4271	CLIP-seq
MIRT1198848	hsa-miR-4421	CLIP-seq
MIRT2286004	hsa-miR-4525	CLIP-seq
MIRT2286005	hsa-miR-4665-5p	CLIP-seq
MIRT2286006	hsa-miR-4723-5p	CLIP-seq
MIRT2286007	hsa-miR-4725-3p	CLIP-seq
MIRT2286008	hsa-miR-625	CLIP-seq
MIRT2583935	hsa-miR-1202	CLIP-seq
MIRT1198830	hsa-miR-1205	CLIP-seq
MIRT1198872	hsa-miR-1238	CLIP-seq
MIRT2583936	hsa-miR-1257	CLIP-seq
MIRT2583937	hsa-miR-125a-3p	CLIP-seq
MIRT2583938	hsa-miR-1267	CLIP-seq
MIRT1198874	hsa-miR-1271	CLIP-seq
MIRT1198831	hsa-miR-1301	CLIP-seq
MIRT2583939	hsa-miR-146a	CLIP-seq
MIRT1198879	hsa-miR-182	CLIP-seq
MIRT2583940	hsa-miR-1827	CLIP-seq
MIRT1198880	hsa-miR-199a-3p	CLIP-seq
MIRT1198881	hsa-miR-199b-3p	CLIP-seq
MIRT1198882	hsa-miR-200b	CLIP-seq
MIRT1198883	hsa-miR-200c	CLIP-seq
MIRT1198833	hsa-miR-2115	CLIP-seq
MIRT2583941	hsa-miR-218	CLIP-seq
MIRT1198834	hsa-miR-219-5p	CLIP-seq
MIRT2583942	hsa-miR-3119	CLIP-seq
MIRT1198835	hsa-miR-3120-5p	CLIP-seq
MIRT1198892	hsa-miR-3124-3p	CLIP-seq
MIRT1198893	hsa-miR-3129-5p	CLIP-seq
MIRT1198894	hsa-miR-3140-3p	CLIP-seq
MIRT2583943	hsa-miR-3152-5p	CLIP-seq
MIRT1198837	hsa-miR-3158-5p	CLIP-seq
MIRT2583944	hsa-miR-3183	CLIP-seq
MIRT2583945	hsa-miR-3200-5p	CLIP-seq
MIRT1198839	hsa-miR-346	CLIP-seq
MIRT2583946	hsa-miR-3612	CLIP-seq
MIRT2583947	hsa-miR-3665	CLIP-seq
MIRT2583948	hsa-miR-3673	CLIP-seq
MIRT1198914	hsa-miR-3924	CLIP-seq
MIRT2583949	hsa-miR-3942-3p	CLIP-seq
MIRT1198915	hsa-miR-3943	CLIP-seq
MIRT2583950	hsa-miR-3972	CLIP-seq
MIRT2583951	hsa-miR-3977	CLIP-seq
MIRT2583952	hsa-miR-4251	CLIP-seq
MIRT1198847	hsa-miR-4288	CLIP-seq
MIRT1198921	hsa-miR-429	CLIP-seq
MIRT1198922	hsa-miR-4323	CLIP-seq
MIRT2583953	hsa-miR-4329	CLIP-seq
MIRT1198848	hsa-miR-4421	CLIP-seq
MIRT2583954	hsa-miR-4423-5p	CLIP-seq
MIRT1198924	hsa-miR-4436a	CLIP-seq
MIRT1198850	hsa-miR-4445	CLIP-seq
MIRT1198851	hsa-miR-4459	CLIP-seq
MIRT2583955	hsa-miR-4464	CLIP-seq
MIRT1198853	hsa-miR-4660	CLIP-seq
MIRT2583956	hsa-miR-4695-5p	CLIP-seq
MIRT1198854	hsa-miR-4713-3p	CLIP-seq
MIRT2583957	hsa-miR-4723-3p	CLIP-seq
MIRT1198931	hsa-miR-4724-3p	CLIP-seq
MIRT2583958	hsa-miR-4736	CLIP-seq
MIRT2583959	hsa-miR-4748	CLIP-seq
MIRT1198855	hsa-miR-4753-5p	CLIP-seq
MIRT2583960	hsa-miR-4756-3p	CLIP-seq
MIRT2583961	hsa-miR-4774-3p	CLIP-seq
MIRT1198859	hsa-miR-4782-3p	CLIP-seq
MIRT2583962	hsa-miR-4790-3p	CLIP-seq
MIRT2583963	hsa-miR-4799-5p	CLIP-seq
MIRT2057635	hsa-miR-485-3p	CLIP-seq
MIRT1198861	hsa-miR-5047	CLIP-seq
MIRT1198862	hsa-miR-508-3p	CLIP-seq
MIRT2583964	hsa-miR-516a-3p	CLIP-seq
MIRT1198935	hsa-miR-548aa	CLIP-seq
MIRT2057641	hsa-miR-548c-3p	CLIP-seq
MIRT1198863	hsa-miR-570	CLIP-seq
MIRT2583965	hsa-miR-578	CLIP-seq
MIRT2583966	hsa-miR-589	CLIP-seq
MIRT2583967	hsa-miR-600	CLIP-seq
MIRT1198864	hsa-miR-632	CLIP-seq
MIRT2583968	hsa-miR-636	CLIP-seq
MIRT2583969	hsa-miR-650	CLIP-seq
MIRT2583970	hsa-miR-889	CLIP-seq
MIRT1198942	hsa-miR-936	CLIP-seq
MIRT2583971	hsa-miR-940	CLIP-seq
MIRT1198944	hsa-miR-96	CLIP-seq
MIRT2583935	hsa-miR-1202	CLIP-seq
MIRT1198830	hsa-miR-1205	CLIP-seq
MIRT1198872	hsa-miR-1238	CLIP-seq
MIRT2583936	hsa-miR-1257	CLIP-seq
MIRT2583937	hsa-miR-125a-3p	CLIP-seq
MIRT2583938	hsa-miR-1267	CLIP-seq
MIRT1198874	hsa-miR-1271	CLIP-seq
MIRT1198831	hsa-miR-1301	CLIP-seq
MIRT2583939	hsa-miR-146a	CLIP-seq
MIRT1198879	hsa-miR-182	CLIP-seq
MIRT2583940	hsa-miR-1827	CLIP-seq
MIRT1198880	hsa-miR-199a-3p	CLIP-seq
MIRT1198881	hsa-miR-199b-3p	CLIP-seq
MIRT1198833	hsa-miR-2115	CLIP-seq
MIRT2583941	hsa-miR-218	CLIP-seq
MIRT1198888	hsa-miR-31	CLIP-seq
MIRT1198835	hsa-miR-3120-5p	CLIP-seq
MIRT1198892	hsa-miR-3124-3p	CLIP-seq
MIRT1198893	hsa-miR-3129-5p	CLIP-seq
MIRT2583943	hsa-miR-3152-5p	CLIP-seq
MIRT1198837	hsa-miR-3158-5p	CLIP-seq
MIRT2583944	hsa-miR-3183	CLIP-seq
MIRT2583945	hsa-miR-3200-5p	CLIP-seq
MIRT1198839	hsa-miR-346	CLIP-seq
MIRT2583946	hsa-miR-3612	CLIP-seq
MIRT2583947	hsa-miR-3665	CLIP-seq
MIRT2583948	hsa-miR-3673	CLIP-seq
MIRT1198914	hsa-miR-3924	CLIP-seq
MIRT2583949	hsa-miR-3942-3p	CLIP-seq
MIRT1198915	hsa-miR-3943	CLIP-seq
MIRT2583950	hsa-miR-3972	CLIP-seq
MIRT2583951	hsa-miR-3977	CLIP-seq
MIRT2583952	hsa-miR-4251	CLIP-seq
MIRT1198847	hsa-miR-4288	CLIP-seq
MIRT1198922	hsa-miR-4323	CLIP-seq
MIRT2583953	hsa-miR-4329	CLIP-seq
MIRT1198848	hsa-miR-4421	CLIP-seq
MIRT2583954	hsa-miR-4423-5p	CLIP-seq
MIRT1198851	hsa-miR-4459	CLIP-seq
MIRT2583955	hsa-miR-4464	CLIP-seq
MIRT1198853	hsa-miR-4660	CLIP-seq
MIRT2583956	hsa-miR-4695-5p	CLIP-seq
MIRT1198854	hsa-miR-4713-3p	CLIP-seq
MIRT2583957	hsa-miR-4723-3p	CLIP-seq
MIRT1198931	hsa-miR-4724-3p	CLIP-seq
MIRT2583958	hsa-miR-4736	CLIP-seq
MIRT2583959	hsa-miR-4748	CLIP-seq
MIRT2583961	hsa-miR-4774-3p	CLIP-seq
MIRT2583962	hsa-miR-4790-3p	CLIP-seq
MIRT2057635	hsa-miR-485-3p	CLIP-seq
MIRT1198861	hsa-miR-5047	CLIP-seq
MIRT2583964	hsa-miR-516a-3p	CLIP-seq
MIRT1198935	hsa-miR-548aa	CLIP-seq
MIRT1198863	hsa-miR-570	CLIP-seq
MIRT2583965	hsa-miR-578	CLIP-seq
MIRT2583966	hsa-miR-589	CLIP-seq
MIRT2583967	hsa-miR-600	CLIP-seq
MIRT1198864	hsa-miR-632	CLIP-seq
MIRT2583968	hsa-miR-636	CLIP-seq
MIRT2583969	hsa-miR-650	CLIP-seq
MIRT2583970	hsa-miR-889	CLIP-seq
MIRT1198942	hsa-miR-936	CLIP-seq
MIRT2583971	hsa-miR-940	CLIP-seq
MIRT1198944	hsa-miR-96	CLIP-seq
MIRT2057641	hsa-miR-548c-3p	CLIP-seq

Show/Hide all (38)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16273093, 17203073, 18172499, 23211419, 24336247, 24561623, 32814053, 35044719, 35384245, 37219487
GO:0005737	Component	Cytoplasm	IBA
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005905	Component	Clathrin-coated pit	IEA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0007399	Process	Nervous system development	IEA
GO:0007399	Process	Nervous system development	IEA
GO:0007405	Process	Neuroblast proliferation	IEA
GO:0007409	Process	Axonogenesis	IEA
GO:0008013	Function	Beta-catenin binding	IEA
GO:0010008	Component	Endosome membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	IBA
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0021670	Process	Lateral ventricle development	IEA
GO:0021670	Process	Lateral ventricle development	ISS
GO:0021849	Process	Neuroblast division in subventricular zone	IEA
GO:0021849	Process	Neuroblast division in subventricular zone	ISS
GO:0030136	Component	Clathrin-coated vesicle	IDA	19581412
GO:0030335	Process	Positive regulation of cell migration	IGI	19581412
GO:0030335	Process	Positive regulation of cell migration	IMP	19581412
GO:0030900	Process	Forebrain development	IEA
GO:0031410	Component	Cytoplasmic vesicle	IBA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0034332	Process	Adherens junction organization	IEA
GO:0045177	Component	Apical part of cell	IEA
GO:0045294	Function	Alpha-catenin binding	IEA
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0045296	Function	Cadherin binding	IEA
GO:0050769	Process	Positive regulation of neurogenesis	IBA
GO:0050769	Process	Positive regulation of neurogenesis	IEA
GO:0050769	Process	Positive regulation of neurogenesis	ISS
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099149	Process	Regulation of postsynaptic neurotransmitter receptor internalization	IEA
GO:1903077	Process	Negative regulation of protein localization to plasma membrane	IMP	19581412

MIM	HGNC	e!Ensembl
603728	8060	ENSG00000133961

P49757

Protein name

Protein numb homolog (h-Numb) (Protein S171)

Protein function

Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs

PDB

5NJJ , 5NJK

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00640	PID	39 → 172	Phosphotyrosine interaction domain (PTB/PID)	Domain
PF06311	NumbF	258 → 338	NUMB domain	Family

Sequence

MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICED
AVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPD
RNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTA
TFDASRTTFTREGSFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPS
SPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPFKRQLSLRINE
LPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPEDPFSSAPMTKPVTVVAPQ
SPTFQANGTDSAFHVLAKPAHTALAPVAMPVRETNPWAHAPDAANKEIAATCSGTEWGQS
SGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPTAISQPAS
PFQGNAFLTSQPVPVGVVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITPSQMVANVFG
TAGHPQAAHPHQSPSLVRQQTFPHYEASSATTSPFFKPPAQHLNGSAAFNGVDDGRLASA
DRHTEVPTGTCPVDPFEAQWAALENKSKQRTNPSPTNPFSSDLQKTFEIEL

Sequence length

651

Interactions

View interactions

	KEGG		Reactome
	Notch signaling pathway		Recycling pathway of L1 Degradation of GLI1 by the proteasome Hedgehog 'on' state

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BIPOLAR DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
KIDNEY CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (83)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Aneuploidy	Aneuploidy	Pubtator	22593191	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar Disorder	GWASCAT_DG	23092984		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Brain Neoplasms	Brain neoplasms	Pubtator	33120728	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	16865239, 18172499, 27345400, 29747452		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	15492044, 23140583, 23706821, 29269425, 29339436, 29747452, 32501652, 36200956	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	35478938	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	15492044, 25480416, 26860615, 27449031	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	21041478	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Adenoid Cystic	Adenoid cystic carcinoma	Pubtator	18179751	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	24770339, 26058814, 26165304	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Mucoepidermoid	Mucoepidermoid carcinoma	Pubtator	18179751	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	21939656, 24332178		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	26261495, 35197444	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	25480416	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	25994834	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebral Hemorrhage	Cerebral hemorrhage	Pubtator	30836997	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	16865239		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cervical Intraepithelial Neoplasia	Cervical Intraepithelial Neoplasia	BEFREE	29721172		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	16865239		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic Neoplasms	BEFREE	21041478		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic neoplasm	Pubtator	21041478	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	26074693, 27824903, 29190716		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	26074693, 27824903, 30396078, 31898732, 32774060	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cone-Rod Dystrophies	Cone-rod dystrophy	GENOMICS_ENGLAND_DG	28041643		★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	BEFREE	26415596		★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	Pubtator	26415596	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Emphysema	Emphysema	Pubtator	27104832	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	37657045	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	28095111	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	22553175, 31116627		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	31116627	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	31116627		★★★★★ ★☆☆☆☆ Found in Text Mining only
Graves Ophthalmopathy	Graves ophthalmopathy	Pubtator	28485799	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hereditary Breast and Ovarian Cancer Syndrome	Hereditary breast and ovarian cancer syndrome	Pubtator	15492044, 21041478	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	27104832	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Idiopathic Pulmonary Fibrosis	Pulmonary Fibrosis	BEFREE	27104832		★★★★★ ★☆☆☆☆ Found in Text Mining only
Idiopathic Pulmonary Fibrosis	Idiopathic pulmonary fibrosis	Pubtator	27104832	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Intrahepatic Cholangiocarcinoma	Intrahepatic Cholangiocarcinoma	BEFREE	29721172		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid	Myeloid leukemia	Pubtator	21084860	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Accelerated Phase	Myeloid leukemia	Pubtator	21084860	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	22784712	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	22784712		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver Cirrhosis	Liver Cirrhosis	BEFREE	15115436		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	21041478	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	25889998	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	32774060	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Glioma	Glioma	BEFREE	21939656		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	16865239, 18172499, 19795205, 27345400, 29747452		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	26174965		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	21939656, 24332178		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	27092875		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	28751447		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	19795205, 21122105, 22196886, 24332178, 27302072, 27345400, 27824903, 28153862, 28379442, 29721172		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of cervix	Cervical Tumor	BEFREE	16865239		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	18172499		★★★★★ ★☆☆☆☆ Found in Text Mining only
Medulloblastoma	Medulloblastoma	Pubtator	30197333	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	22593191, 27311960	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	27311960		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mesothelioma Malignant	Mesothelioma	Pubtator	30197333	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mouth Neoplasms	Mouth neoplasm	Pubtator	24302991, 34769160	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
MYELODYSPLASTIC SYNDROME	Myelodysplastic Syndrome	BEFREE	22784712		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myelodysplastic Syndromes	Myelodysplastic syndrome	Pubtator	22784712	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myeloid Leukemia, Chronic	Myeloid Leukemia	BEFREE	26944313		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal carcinoma	Nasopharyngeal Carcinoma	BEFREE	31271505		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	31271505	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	16865239, 18172499, 21041478, 21939656, 23140583, 24302991, 24332178, 24525742, 24704446, 24980814, 26174965, 26261495, 29507685, 30726988		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	27310305		★★★★★ ★☆☆☆☆ Found in Text Mining only
Noncompaction cardiomyopathy	Noncompaction cardiomyopathy	BEFREE	28067668		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	26264115	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	27092875		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Ductal Adenocarcinoma	Pancreatic adenocarcinoma	BEFREE	26261495		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	30724469, 31898732, 35197444, 35345586	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	28751447		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	34045601	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	20132067		★★★★★ ★☆☆☆☆ Found in Text Mining only
Salivary Gland Neoplasms	Salivary gland neoplasms	Pubtator	18179751	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Skin Neoplasms	Skin neoplasm	Pubtator	25994834	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Small Cell Lung Carcinoma	Small cell lung carcinoma	Pubtator	28060745	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	24980814, 28095111		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	24302991, 27349552, 34769160	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Tongue Neoplasms	Tongue cancer	Pubtator	31023264	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	32501652	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uveal melanoma	Uveal melanoma	Pubtator	27449031	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

NUMB (NUMB endocytic adaptor protein)