LAMTOR3 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 3)

Gene

• Entrez ID: 8649
• Gene name: Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
• Gene symbol: LAMTOR3
• Synonyms (NCBI Gene): MAP2K1IP1, MAPBP, MAPKSP1, MP1, PRO0633, Ragulator3
• Chromosome: 4
• Chromosome location: 4q23
• Summary: This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT005437	hsa-miR-16-5p	pSILAC	18668040
MIRT030592	hsa-miR-24-3p	Microarray	19748357
MIRT005437	hsa-miR-16-5p	Proteomics	18668040
MIRT639164	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT639163	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT639162	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT639161	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT639160	hsa-miR-6844	HITS-CLIP	23824327
MIRT639159	hsa-miR-489-3p	HITS-CLIP	23824327
MIRT639158	hsa-miR-3977	HITS-CLIP	23824327
MIRT639157	hsa-miR-514a-3p	HITS-CLIP	23824327
MIRT639156	hsa-miR-514b-3p	HITS-CLIP	23824327
MIRT639164	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT639163	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT639162	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT639161	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT639160	hsa-miR-6844	HITS-CLIP	23824327
MIRT639159	hsa-miR-489-3p	HITS-CLIP	23824327
MIRT639158	hsa-miR-3977	HITS-CLIP	23824327
MIRT639157	hsa-miR-514a-3p	HITS-CLIP	23824327
MIRT639156	hsa-miR-514b-3p	HITS-CLIP	23824327
MIRT543438	hsa-miR-548ag	PAR-CLIP	21572407
MIRT543437	hsa-miR-548ai	PAR-CLIP	21572407
MIRT543436	hsa-miR-548ba	PAR-CLIP	21572407
MIRT543435	hsa-miR-570-5p	PAR-CLIP	21572407
MIRT543434	hsa-miR-8485	PAR-CLIP	21572407
MIRT543433	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT543432	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT543431	hsa-miR-603	PAR-CLIP	21572407
MIRT543430	hsa-miR-378j	PAR-CLIP	21572407
MIRT543429	hsa-miR-6839-5p	PAR-CLIP	21572407
MIRT543428	hsa-miR-4699-5p	PAR-CLIP	21572407
MIRT543427	hsa-miR-3145-3p	PAR-CLIP	21572407
MIRT543426	hsa-miR-3135b	PAR-CLIP	21572407
MIRT543425	hsa-miR-1287-5p	PAR-CLIP	21572407
MIRT543424	hsa-miR-3941	PAR-CLIP	21572407
MIRT543423	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT543422	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT474295	hsa-miR-6849-3p	PAR-CLIP	23592263
MIRT474294	hsa-miR-6748-3p	PAR-CLIP	23592263
MIRT474293	hsa-miR-4421	PAR-CLIP	23592263
MIRT474292	hsa-miR-5699-3p	PAR-CLIP	23592263
MIRT474291	hsa-miR-3190-5p	PAR-CLIP	23592263
MIRT474290	hsa-miR-3926	PAR-CLIP	23592263
MIRT474289	hsa-miR-4452	PAR-CLIP	23592263
MIRT474288	hsa-miR-548s	PAR-CLIP	23592263
MIRT474287	hsa-miR-7152-5p	PAR-CLIP	23592263
MIRT440344	hsa-miR-136-5p	HITS-CLIP	24374217
MIRT440344	hsa-miR-136-5p	HITS-CLIP	24374217
MIRT639164	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT639163	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT639162	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT639161	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT639160	hsa-miR-6844	HITS-CLIP	23824327
MIRT639159	hsa-miR-489-3p	HITS-CLIP	23824327
MIRT639158	hsa-miR-3977	HITS-CLIP	23824327
MIRT639157	hsa-miR-514a-3p	HITS-CLIP	23824327
MIRT639156	hsa-miR-514b-3p	HITS-CLIP	23824327
MIRT639164	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT639163	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT639162	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT639161	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT639160	hsa-miR-6844	HITS-CLIP	23824327
MIRT639159	hsa-miR-489-3p	HITS-CLIP	23824327
MIRT639158	hsa-miR-3977	HITS-CLIP	23824327
MIRT639157	hsa-miR-514a-3p	HITS-CLIP	23824327
MIRT639156	hsa-miR-514b-3p	HITS-CLIP	23824327
MIRT543438	hsa-miR-548ag	PAR-CLIP	21572407
MIRT543437	hsa-miR-548ai	PAR-CLIP	21572407
MIRT543436	hsa-miR-548ba	PAR-CLIP	21572407
MIRT543435	hsa-miR-570-5p	PAR-CLIP	21572407
MIRT543434	hsa-miR-8485	PAR-CLIP	21572407
MIRT543433	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT543432	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT543431	hsa-miR-603	PAR-CLIP	21572407
MIRT543430	hsa-miR-378j	PAR-CLIP	21572407
MIRT543429	hsa-miR-6839-5p	PAR-CLIP	21572407
MIRT543428	hsa-miR-4699-5p	PAR-CLIP	21572407
MIRT543427	hsa-miR-3145-3p	PAR-CLIP	21572407
MIRT543426	hsa-miR-3135b	PAR-CLIP	21572407
MIRT543425	hsa-miR-1287-5p	PAR-CLIP	21572407
MIRT543424	hsa-miR-3941	PAR-CLIP	21572407
MIRT543423	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT543422	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT474295	hsa-miR-6849-3p	PAR-CLIP	23592263
MIRT474294	hsa-miR-6748-3p	PAR-CLIP	23592263
MIRT474293	hsa-miR-4421	PAR-CLIP	23592263
MIRT474292	hsa-miR-5699-3p	PAR-CLIP	23592263
MIRT474291	hsa-miR-3190-5p	PAR-CLIP	23592263
MIRT474290	hsa-miR-3926	PAR-CLIP	23592263
MIRT474289	hsa-miR-4452	PAR-CLIP	23592263
MIRT474288	hsa-miR-548s	PAR-CLIP	23592263
MIRT474287	hsa-miR-7152-5p	PAR-CLIP	23592263
MIRT543434	hsa-miR-8485	Luciferase reporter assay, Western blotting, qRT-PCR	35959437
MIRT1103768	hsa-miR-103a	CLIP-seq
MIRT1103769	hsa-miR-107	CLIP-seq
MIRT1103770	hsa-miR-1179	CLIP-seq
MIRT1103771	hsa-miR-1183	CLIP-seq
MIRT1103772	hsa-miR-1267	CLIP-seq
MIRT1103773	hsa-miR-1272	CLIP-seq
MIRT1103774	hsa-miR-1279	CLIP-seq
MIRT1103775	hsa-miR-1284	CLIP-seq
MIRT1103776	hsa-miR-1285	CLIP-seq
MIRT1103777	hsa-miR-1304	CLIP-seq
MIRT1103778	hsa-miR-132	CLIP-seq
MIRT1103779	hsa-miR-1322	CLIP-seq
MIRT1103780	hsa-miR-141	CLIP-seq
MIRT1103781	hsa-miR-146a	CLIP-seq
MIRT1103782	hsa-miR-146b-5p	CLIP-seq
MIRT1103783	hsa-miR-1827	CLIP-seq
MIRT1103784	hsa-miR-200a	CLIP-seq
MIRT1103785	hsa-miR-203	CLIP-seq
MIRT1103786	hsa-miR-2115	CLIP-seq
MIRT1103787	hsa-miR-212	CLIP-seq
MIRT1103788	hsa-miR-217	CLIP-seq
MIRT1103789	hsa-miR-2467-3p	CLIP-seq
MIRT1103790	hsa-miR-3120-3p	CLIP-seq
MIRT1103791	hsa-miR-3122	CLIP-seq
MIRT1103792	hsa-miR-3165	CLIP-seq
MIRT1103793	hsa-miR-3185	CLIP-seq
MIRT1103794	hsa-miR-3187-5p	CLIP-seq
MIRT1103795	hsa-miR-330-3p	CLIP-seq
MIRT1103796	hsa-miR-337-5p	CLIP-seq
MIRT1103797	hsa-miR-342-5p	CLIP-seq
MIRT1103798	hsa-miR-3545-3p	CLIP-seq
MIRT1103799	hsa-miR-3612	CLIP-seq
MIRT1103800	hsa-miR-3665	CLIP-seq
MIRT1103801	hsa-miR-3681	CLIP-seq
MIRT1103802	hsa-miR-3689a-3p	CLIP-seq
MIRT1103803	hsa-miR-3689c	CLIP-seq
MIRT1103804	hsa-miR-3913-5p	CLIP-seq
MIRT1103805	hsa-miR-3920	CLIP-seq
MIRT1103806	hsa-miR-3945	CLIP-seq
MIRT1103807	hsa-miR-409-5p	CLIP-seq
MIRT1103808	hsa-miR-4251	CLIP-seq
MIRT1103809	hsa-miR-4253	CLIP-seq
MIRT1103810	hsa-miR-4257	CLIP-seq
MIRT1103811	hsa-miR-4294	CLIP-seq
MIRT1103812	hsa-miR-4310	CLIP-seq
MIRT1103813	hsa-miR-4316	CLIP-seq
MIRT1103814	hsa-miR-4326	CLIP-seq
MIRT1103815	hsa-miR-4418	CLIP-seq
MIRT1103816	hsa-miR-4423-5p	CLIP-seq
MIRT1103817	hsa-miR-4459	CLIP-seq
MIRT1103818	hsa-miR-4463	CLIP-seq
MIRT1103819	hsa-miR-4485	CLIP-seq
MIRT1103820	hsa-miR-4494	CLIP-seq
MIRT1103821	hsa-miR-4501	CLIP-seq
MIRT1103822	hsa-miR-4505	CLIP-seq
MIRT1103823	hsa-miR-4517	CLIP-seq
MIRT1103824	hsa-miR-4528	CLIP-seq
MIRT1103825	hsa-miR-4539	CLIP-seq
MIRT1103826	hsa-miR-4638-5p	CLIP-seq
MIRT1103827	hsa-miR-4651	CLIP-seq
MIRT1103828	hsa-miR-4664-5p	CLIP-seq
MIRT1103829	hsa-miR-4685-5p	CLIP-seq
MIRT1103830	hsa-miR-4695-5p	CLIP-seq
MIRT1103831	hsa-miR-4724-5p	CLIP-seq
MIRT1103832	hsa-miR-4728-5p	CLIP-seq
MIRT1103833	hsa-miR-4731-5p	CLIP-seq
MIRT1103834	hsa-miR-4773	CLIP-seq
MIRT1103835	hsa-miR-4790-3p	CLIP-seq
MIRT1103836	hsa-miR-4793-3p	CLIP-seq
MIRT1103837	hsa-miR-4802-3p	CLIP-seq
MIRT1103838	hsa-miR-487a	CLIP-seq
MIRT1103839	hsa-miR-489	CLIP-seq
MIRT1103840	hsa-miR-494	CLIP-seq
MIRT1103841	hsa-miR-508-5p	CLIP-seq
MIRT1103842	hsa-miR-509-3-5p	CLIP-seq
MIRT1103843	hsa-miR-509-3p	CLIP-seq
MIRT1103844	hsa-miR-509-5p	CLIP-seq
MIRT1103845	hsa-miR-513a-3p	CLIP-seq
MIRT1103846	hsa-miR-514	CLIP-seq
MIRT1103847	hsa-miR-518a-5p	CLIP-seq
MIRT1103848	hsa-miR-527	CLIP-seq
MIRT1103849	hsa-miR-552	CLIP-seq
MIRT1103850	hsa-miR-580	CLIP-seq
MIRT1103851	hsa-miR-582-5p	CLIP-seq
MIRT1103852	hsa-miR-589	CLIP-seq
MIRT1103853	hsa-miR-590-3p	CLIP-seq
MIRT1103854	hsa-miR-593	CLIP-seq
MIRT1103855	hsa-miR-608	CLIP-seq
MIRT1103856	hsa-miR-612	CLIP-seq
MIRT1103857	hsa-miR-640	CLIP-seq
MIRT1103858	hsa-miR-650	CLIP-seq
MIRT1103859	hsa-miR-653	CLIP-seq
MIRT1103860	hsa-miR-664	CLIP-seq
MIRT1103861	hsa-miR-665	CLIP-seq
MIRT1103862	hsa-miR-764	CLIP-seq
MIRT1103863	hsa-miR-885-3p	CLIP-seq
MIRT2028355	hsa-miR-1266	CLIP-seq
MIRT2028356	hsa-miR-1276	CLIP-seq
MIRT2028357	hsa-miR-15a	CLIP-seq
MIRT2028358	hsa-miR-15b	CLIP-seq
MIRT2028359	hsa-miR-16	CLIP-seq
MIRT2028360	hsa-miR-195	CLIP-seq
MIRT1103786	hsa-miR-2115	CLIP-seq
MIRT2028361	hsa-miR-219-5p	CLIP-seq
MIRT2028362	hsa-miR-2276	CLIP-seq
MIRT2028363	hsa-miR-300	CLIP-seq
MIRT2028364	hsa-miR-302f	CLIP-seq
MIRT1103790	hsa-miR-3120-3p	CLIP-seq
MIRT2028365	hsa-miR-3140-3p	CLIP-seq
MIRT2028366	hsa-miR-3144-3p	CLIP-seq
MIRT1103797	hsa-miR-342-5p	CLIP-seq
MIRT1103798	hsa-miR-3545-3p	CLIP-seq
MIRT2028367	hsa-miR-3664-3p	CLIP-seq
MIRT2028368	hsa-miR-3664-5p	CLIP-seq
MIRT2028369	hsa-miR-381	CLIP-seq
MIRT2028370	hsa-miR-424	CLIP-seq
MIRT2028371	hsa-miR-4311	CLIP-seq
MIRT1103816	hsa-miR-4423-5p	CLIP-seq
MIRT2028372	hsa-miR-4432	CLIP-seq
MIRT2028373	hsa-miR-4445	CLIP-seq
MIRT1103820	hsa-miR-4494	CLIP-seq
MIRT1103822	hsa-miR-4505	CLIP-seq
MIRT2028374	hsa-miR-4509	CLIP-seq
MIRT2028375	hsa-miR-4518	CLIP-seq
MIRT2028376	hsa-miR-451b	CLIP-seq
MIRT2028377	hsa-miR-4522	CLIP-seq
MIRT1103825	hsa-miR-4539	CLIP-seq
MIRT1103827	hsa-miR-4651	CLIP-seq
MIRT1103828	hsa-miR-4664-5p	CLIP-seq
MIRT2028378	hsa-miR-4666-3p	CLIP-seq
MIRT1103829	hsa-miR-4685-5p	CLIP-seq
MIRT2028379	hsa-miR-4696	CLIP-seq
MIRT2028380	hsa-miR-4717-3p	CLIP-seq
MIRT2028381	hsa-miR-4718	CLIP-seq
MIRT1103831	hsa-miR-4724-5p	CLIP-seq
MIRT1103833	hsa-miR-4731-5p	CLIP-seq
MIRT2028382	hsa-miR-4744	CLIP-seq
MIRT2028383	hsa-miR-4772-3p	CLIP-seq
MIRT2028384	hsa-miR-4782-3p	CLIP-seq
MIRT2028385	hsa-miR-4795-3p	CLIP-seq
MIRT2028386	hsa-miR-497	CLIP-seq
MIRT2028387	hsa-miR-500a	CLIP-seq
MIRT2028388	hsa-miR-508-3p	CLIP-seq
MIRT2028389	hsa-miR-513c	CLIP-seq
MIRT1103846	hsa-miR-514	CLIP-seq
MIRT2028390	hsa-miR-514b-5p	CLIP-seq
MIRT2028391	hsa-miR-548n	CLIP-seq
MIRT2028392	hsa-miR-579	CLIP-seq
MIRT1103850	hsa-miR-580	CLIP-seq
MIRT2028393	hsa-miR-583	CLIP-seq
MIRT1103855	hsa-miR-608	CLIP-seq
MIRT1103857	hsa-miR-640	CLIP-seq
MIRT1103770	hsa-miR-1179	CLIP-seq
MIRT2259482	hsa-miR-1228	CLIP-seq
MIRT1103772	hsa-miR-1267	CLIP-seq
MIRT1103774	hsa-miR-1279	CLIP-seq
MIRT1103775	hsa-miR-1284	CLIP-seq
MIRT1103776	hsa-miR-1285	CLIP-seq
MIRT2259483	hsa-miR-24	CLIP-seq
MIRT2259484	hsa-miR-27a	CLIP-seq
MIRT2259485	hsa-miR-27b	CLIP-seq
MIRT2028363	hsa-miR-300	CLIP-seq
MIRT2028364	hsa-miR-302f	CLIP-seq
MIRT1103791	hsa-miR-3122	CLIP-seq
MIRT2028365	hsa-miR-3140-3p	CLIP-seq
MIRT1103792	hsa-miR-3165	CLIP-seq
MIRT1103794	hsa-miR-3187-5p	CLIP-seq
MIRT1103795	hsa-miR-330-3p	CLIP-seq
MIRT1103796	hsa-miR-337-5p	CLIP-seq
MIRT2259486	hsa-miR-342-3p	CLIP-seq
MIRT1103797	hsa-miR-342-5p	CLIP-seq
MIRT1103798	hsa-miR-3545-3p	CLIP-seq
MIRT1103800	hsa-miR-3665	CLIP-seq
MIRT1103801	hsa-miR-3681	CLIP-seq
MIRT1103802	hsa-miR-3689a-3p	CLIP-seq
MIRT2259487	hsa-miR-3689a-5p	CLIP-seq
MIRT2259488	hsa-miR-3689b	CLIP-seq
MIRT1103803	hsa-miR-3689c	CLIP-seq
MIRT2259489	hsa-miR-3689e	CLIP-seq
MIRT2259490	hsa-miR-3689f	CLIP-seq
MIRT2259491	hsa-miR-371-5p	CLIP-seq
MIRT2028369	hsa-miR-381	CLIP-seq
MIRT1103804	hsa-miR-3913-5p	CLIP-seq
MIRT2259492	hsa-miR-3919	CLIP-seq
MIRT1103806	hsa-miR-3945	CLIP-seq
MIRT2259493	hsa-miR-4284	CLIP-seq
MIRT1103811	hsa-miR-4294	CLIP-seq
MIRT2259494	hsa-miR-4300	CLIP-seq
MIRT2259495	hsa-miR-4422	CLIP-seq
MIRT1103816	hsa-miR-4423-5p	CLIP-seq
MIRT1103817	hsa-miR-4459	CLIP-seq
MIRT1103818	hsa-miR-4463	CLIP-seq
MIRT1103819	hsa-miR-4485	CLIP-seq
MIRT1103820	hsa-miR-4494	CLIP-seq
MIRT1103822	hsa-miR-4505	CLIP-seq
MIRT1103824	hsa-miR-4528	CLIP-seq
MIRT1103825	hsa-miR-4539	CLIP-seq
MIRT1103827	hsa-miR-4651	CLIP-seq
MIRT1103828	hsa-miR-4664-5p	CLIP-seq
MIRT2028378	hsa-miR-4666-3p	CLIP-seq
MIRT2259496	hsa-miR-4679	CLIP-seq
MIRT1103829	hsa-miR-4685-5p	CLIP-seq
MIRT1103831	hsa-miR-4724-5p	CLIP-seq
MIRT1103832	hsa-miR-4728-5p	CLIP-seq
MIRT1103833	hsa-miR-4731-5p	CLIP-seq
MIRT2259497	hsa-miR-4756-3p	CLIP-seq
MIRT2259498	hsa-miR-4764-3p	CLIP-seq
MIRT2028385	hsa-miR-4795-3p	CLIP-seq
MIRT2028387	hsa-miR-500a	CLIP-seq
MIRT2259499	hsa-miR-513a-5p	CLIP-seq
MIRT2028389	hsa-miR-513c	CLIP-seq
MIRT1103846	hsa-miR-514	CLIP-seq
MIRT2028390	hsa-miR-514b-5p	CLIP-seq
MIRT2028391	hsa-miR-548n	CLIP-seq
MIRT2259500	hsa-miR-548t	CLIP-seq
MIRT2259501	hsa-miR-561	CLIP-seq
MIRT1103851	hsa-miR-582-5p	CLIP-seq
MIRT1103854	hsa-miR-593	CLIP-seq
MIRT1103855	hsa-miR-608	CLIP-seq
MIRT1103856	hsa-miR-612	CLIP-seq
MIRT1103857	hsa-miR-640	CLIP-seq
MIRT2259502	hsa-miR-654-3p	CLIP-seq
MIRT2259503	hsa-miR-657	CLIP-seq
MIRT1103863	hsa-miR-885-3p	CLIP-seq
MIRT2259504	hsa-miR-920	CLIP-seq
MIRT1103797	hsa-miR-342-5p	CLIP-seq
MIRT1103816	hsa-miR-4423-5p	CLIP-seq
MIRT1103818	hsa-miR-4463	CLIP-seq
MIRT1103820	hsa-miR-4494	CLIP-seq
MIRT1103822	hsa-miR-4505	CLIP-seq
MIRT1103827	hsa-miR-4651	CLIP-seq
MIRT1103828	hsa-miR-4664-5p	CLIP-seq
MIRT1103833	hsa-miR-4731-5p	CLIP-seq
MIRT1103855	hsa-miR-608	CLIP-seq
MIRT2430549	hsa-miR-219-2-3p	CLIP-seq
MIRT2430550	hsa-miR-3143	CLIP-seq
MIRT2430551	hsa-miR-3978	CLIP-seq
MIRT2430552	hsa-miR-4261	CLIP-seq
MIRT2430553	hsa-miR-543	CLIP-seq
MIRT1103853	hsa-miR-590-3p	CLIP-seq
MIRT1103772	hsa-miR-1267	CLIP-seq
MIRT2452861	hsa-miR-139-3p	CLIP-seq
MIRT1103797	hsa-miR-342-5p	CLIP-seq
MIRT1103811	hsa-miR-4294	CLIP-seq
MIRT1103816	hsa-miR-4423-5p	CLIP-seq
MIRT1103822	hsa-miR-4505	CLIP-seq
MIRT1103827	hsa-miR-4651	CLIP-seq
MIRT1103828	hsa-miR-4664-5p	CLIP-seq
MIRT1103833	hsa-miR-4731-5p	CLIP-seq
MIRT1103854	hsa-miR-593	CLIP-seq
MIRT1103855	hsa-miR-608	CLIP-seq
MIRT1103772	hsa-miR-1267	CLIP-seq
MIRT2452861	hsa-miR-139-3p	CLIP-seq
MIRT1103811	hsa-miR-4294	CLIP-seq
MIRT1103816	hsa-miR-4423-5p	CLIP-seq
MIRT1103822	hsa-miR-4505	CLIP-seq
MIRT1103833	hsa-miR-4731-5p	CLIP-seq
MIRT1103854	hsa-miR-593	CLIP-seq
MIRT1103770	hsa-miR-1179	CLIP-seq
MIRT2259482	hsa-miR-1228	CLIP-seq
MIRT2028356	hsa-miR-1276	CLIP-seq
MIRT2559839	hsa-miR-1298	CLIP-seq
MIRT2559840	hsa-miR-1303	CLIP-seq
MIRT2559841	hsa-miR-139-5p	CLIP-seq
MIRT2559842	hsa-miR-151-3p	CLIP-seq
MIRT2559843	hsa-miR-186	CLIP-seq
MIRT2559844	hsa-miR-188-5p	CLIP-seq
MIRT2559845	hsa-miR-194	CLIP-seq
MIRT2559846	hsa-miR-197	CLIP-seq
MIRT2559847	hsa-miR-214	CLIP-seq
MIRT2559848	hsa-miR-218	CLIP-seq
MIRT2028361	hsa-miR-219-5p	CLIP-seq
MIRT2559849	hsa-miR-224	CLIP-seq
MIRT1103791	hsa-miR-3122	CLIP-seq
MIRT2028365	hsa-miR-3140-3p	CLIP-seq
MIRT2559850	hsa-miR-3146	CLIP-seq
MIRT2559851	hsa-miR-3148	CLIP-seq
MIRT2559852	hsa-miR-3152-5p	CLIP-seq
MIRT1103792	hsa-miR-3165	CLIP-seq
MIRT2559853	hsa-miR-323-3p	CLIP-seq
MIRT2559854	hsa-miR-329	CLIP-seq
MIRT1103795	hsa-miR-330-3p	CLIP-seq
MIRT1103797	hsa-miR-342-5p	CLIP-seq
MIRT1103798	hsa-miR-3545-3p	CLIP-seq
MIRT2559855	hsa-miR-3607-5p	CLIP-seq
MIRT2559856	hsa-miR-3619-5p	CLIP-seq
MIRT2559857	hsa-miR-3651	CLIP-seq
MIRT2559858	hsa-miR-3663-3p	CLIP-seq
MIRT1103800	hsa-miR-3665	CLIP-seq
MIRT2559859	hsa-miR-3667-5p	CLIP-seq
MIRT2559860	hsa-miR-3675-3p	CLIP-seq
MIRT1103802	hsa-miR-3689a-3p	CLIP-seq
MIRT2259487	hsa-miR-3689a-5p	CLIP-seq
MIRT2259488	hsa-miR-3689b	CLIP-seq
MIRT1103803	hsa-miR-3689c	CLIP-seq
MIRT2259489	hsa-miR-3689e	CLIP-seq
MIRT2259490	hsa-miR-3689f	CLIP-seq
MIRT2559861	hsa-miR-382	CLIP-seq
MIRT2559862	hsa-miR-3907	CLIP-seq
MIRT1103804	hsa-miR-3913-5p	CLIP-seq
MIRT2559863	hsa-miR-3914	CLIP-seq
MIRT2430551	hsa-miR-3978	CLIP-seq
MIRT2559864	hsa-miR-4264	CLIP-seq
MIRT2259494	hsa-miR-4300	CLIP-seq
MIRT2259495	hsa-miR-4422	CLIP-seq
MIRT1103816	hsa-miR-4423-5p	CLIP-seq
MIRT2559865	hsa-miR-4427	CLIP-seq
MIRT2559866	hsa-miR-4433	CLIP-seq
MIRT2028373	hsa-miR-4445	CLIP-seq
MIRT1103817	hsa-miR-4459	CLIP-seq
MIRT2559867	hsa-miR-4461	CLIP-seq
MIRT1103818	hsa-miR-4463	CLIP-seq
MIRT2559868	hsa-miR-448	CLIP-seq
MIRT2559869	hsa-miR-4499	CLIP-seq
MIRT1103822	hsa-miR-4505	CLIP-seq
MIRT2559870	hsa-miR-450b-5p	CLIP-seq
MIRT1103824	hsa-miR-4528	CLIP-seq
MIRT2559871	hsa-miR-4536	CLIP-seq
MIRT1103825	hsa-miR-4539	CLIP-seq
MIRT2559872	hsa-miR-455-5p	CLIP-seq
MIRT2559873	hsa-miR-4633-5p	CLIP-seq
MIRT1103827	hsa-miR-4651	CLIP-seq
MIRT2559874	hsa-miR-4652-3p	CLIP-seq
MIRT2559875	hsa-miR-4659a-3p	CLIP-seq
MIRT2559876	hsa-miR-4659b-3p	CLIP-seq
MIRT1103828	hsa-miR-4664-5p	CLIP-seq
MIRT2559877	hsa-miR-4668-5p	CLIP-seq
MIRT2259496	hsa-miR-4679	CLIP-seq
MIRT2559878	hsa-miR-4680-3p	CLIP-seq
MIRT2559879	hsa-miR-4684-3p	CLIP-seq
MIRT2559880	hsa-miR-4684-5p	CLIP-seq
MIRT1103829	hsa-miR-4685-5p	CLIP-seq
MIRT2559881	hsa-miR-4687-3p	CLIP-seq
MIRT2559882	hsa-miR-4695-3p	CLIP-seq
MIRT2559883	hsa-miR-4714-5p	CLIP-seq
MIRT2559884	hsa-miR-4719	CLIP-seq
MIRT1103831	hsa-miR-4724-5p	CLIP-seq
MIRT1103832	hsa-miR-4728-5p	CLIP-seq
MIRT2559885	hsa-miR-4731-3p	CLIP-seq
MIRT1103833	hsa-miR-4731-5p	CLIP-seq
MIRT2559886	hsa-miR-4742-3p	CLIP-seq
MIRT2259498	hsa-miR-4764-3p	CLIP-seq
MIRT2559887	hsa-miR-4768-3p	CLIP-seq
MIRT1103834	hsa-miR-4773	CLIP-seq
MIRT2559888	hsa-miR-4778-3p	CLIP-seq
MIRT2028384	hsa-miR-4782-3p	CLIP-seq
MIRT2559889	hsa-miR-4789-5p	CLIP-seq
MIRT2028385	hsa-miR-4795-3p	CLIP-seq
MIRT2559890	hsa-miR-4797-3p	CLIP-seq
MIRT2559891	hsa-miR-4801	CLIP-seq
MIRT1103837	hsa-miR-4802-3p	CLIP-seq
MIRT1103840	hsa-miR-494	CLIP-seq
MIRT2559892	hsa-miR-499-3p	CLIP-seq
MIRT2559893	hsa-miR-499a-3p	CLIP-seq
MIRT2028387	hsa-miR-500a	CLIP-seq
MIRT2559894	hsa-miR-507	CLIP-seq
MIRT2028388	hsa-miR-508-3p	CLIP-seq
MIRT2559895	hsa-miR-5096	CLIP-seq
MIRT2028389	hsa-miR-513c	CLIP-seq
MIRT2028390	hsa-miR-514b-5p	CLIP-seq
MIRT1103847	hsa-miR-518a-5p	CLIP-seq
MIRT2559896	hsa-miR-526b	CLIP-seq
MIRT1103848	hsa-miR-527	CLIP-seq
MIRT2559897	hsa-miR-532-5p	CLIP-seq
MIRT2559898	hsa-miR-548a-3p	CLIP-seq
MIRT2559899	hsa-miR-548ae	CLIP-seq
MIRT2559900	hsa-miR-548aj	CLIP-seq
MIRT2559901	hsa-miR-548am	CLIP-seq
MIRT2559902	hsa-miR-548c-3p	CLIP-seq
MIRT2559903	hsa-miR-548e	CLIP-seq
MIRT2559904	hsa-miR-548f	CLIP-seq
MIRT2559905	hsa-miR-548g	CLIP-seq
MIRT2559906	hsa-miR-548x	CLIP-seq
MIRT1103849	hsa-miR-552	CLIP-seq
MIRT2559907	hsa-miR-557	CLIP-seq
MIRT2559908	hsa-miR-578	CLIP-seq
MIRT1103850	hsa-miR-580	CLIP-seq
MIRT2559909	hsa-miR-582-3p	CLIP-seq
MIRT2559910	hsa-miR-587	CLIP-seq
MIRT1103854	hsa-miR-593	CLIP-seq
MIRT2559911	hsa-miR-606	CLIP-seq
MIRT1103855	hsa-miR-608	CLIP-seq
MIRT2559912	hsa-miR-618	CLIP-seq
MIRT2559913	hsa-miR-621	CLIP-seq
MIRT2559914	hsa-miR-636	CLIP-seq
MIRT1103857	hsa-miR-640	CLIP-seq
MIRT2559915	hsa-miR-645	CLIP-seq
MIRT2559916	hsa-miR-647	CLIP-seq
MIRT2259503	hsa-miR-657	CLIP-seq
MIRT2559917	hsa-miR-761	CLIP-seq
MIRT1103862	hsa-miR-764	CLIP-seq
MIRT2559918	hsa-miR-873	CLIP-seq
MIRT2259504	hsa-miR-920	CLIP-seq
MIRT2559919	hsa-miR-944	CLIP-seq
MIRT1103770	hsa-miR-1179	CLIP-seq
MIRT2259482	hsa-miR-1228	CLIP-seq
MIRT2559839	hsa-miR-1298	CLIP-seq
MIRT2559840	hsa-miR-1303	CLIP-seq
MIRT2559842	hsa-miR-151-3p	CLIP-seq
MIRT2559844	hsa-miR-188-5p	CLIP-seq
MIRT2559849	hsa-miR-224	CLIP-seq
MIRT1103791	hsa-miR-3122	CLIP-seq
MIRT2028365	hsa-miR-3140-3p	CLIP-seq
MIRT2559850	hsa-miR-3146	CLIP-seq
MIRT2559851	hsa-miR-3148	CLIP-seq
MIRT1103792	hsa-miR-3165	CLIP-seq
MIRT2559854	hsa-miR-329	CLIP-seq
MIRT1103795	hsa-miR-330-3p	CLIP-seq
MIRT1103797	hsa-miR-342-5p	CLIP-seq
MIRT1103798	hsa-miR-3545-3p	CLIP-seq
MIRT2559857	hsa-miR-3651	CLIP-seq
MIRT2559858	hsa-miR-3663-3p	CLIP-seq
MIRT1103800	hsa-miR-3665	CLIP-seq
MIRT2559859	hsa-miR-3667-5p	CLIP-seq
MIRT1103802	hsa-miR-3689a-3p	CLIP-seq
MIRT2259487	hsa-miR-3689a-5p	CLIP-seq
MIRT2259488	hsa-miR-3689b	CLIP-seq
MIRT1103803	hsa-miR-3689c	CLIP-seq
MIRT2259489	hsa-miR-3689e	CLIP-seq
MIRT2259490	hsa-miR-3689f	CLIP-seq
MIRT2559861	hsa-miR-382	CLIP-seq
MIRT2559862	hsa-miR-3907	CLIP-seq
MIRT1103804	hsa-miR-3913-5p	CLIP-seq
MIRT2559863	hsa-miR-3914	CLIP-seq
MIRT2430551	hsa-miR-3978	CLIP-seq
MIRT2559864	hsa-miR-4264	CLIP-seq
MIRT2259494	hsa-miR-4300	CLIP-seq
MIRT2259495	hsa-miR-4422	CLIP-seq
MIRT1103816	hsa-miR-4423-5p	CLIP-seq
MIRT2559866	hsa-miR-4433	CLIP-seq
MIRT1103817	hsa-miR-4459	CLIP-seq
MIRT2559867	hsa-miR-4461	CLIP-seq
MIRT1103818	hsa-miR-4463	CLIP-seq
MIRT2559868	hsa-miR-448	CLIP-seq
MIRT2559869	hsa-miR-4499	CLIP-seq
MIRT1103822	hsa-miR-4505	CLIP-seq
MIRT1103824	hsa-miR-4528	CLIP-seq
MIRT2559871	hsa-miR-4536	CLIP-seq
MIRT1103825	hsa-miR-4539	CLIP-seq
MIRT2559873	hsa-miR-4633-5p	CLIP-seq
MIRT1103827	hsa-miR-4651	CLIP-seq
MIRT2559874	hsa-miR-4652-3p	CLIP-seq
MIRT1103828	hsa-miR-4664-5p	CLIP-seq
MIRT2259496	hsa-miR-4679	CLIP-seq
MIRT2559880	hsa-miR-4684-5p	CLIP-seq
MIRT1103829	hsa-miR-4685-5p	CLIP-seq
MIRT2559881	hsa-miR-4687-3p	CLIP-seq
MIRT2559882	hsa-miR-4695-3p	CLIP-seq
MIRT2028380	hsa-miR-4717-3p	CLIP-seq
MIRT2559884	hsa-miR-4719	CLIP-seq
MIRT1103831	hsa-miR-4724-5p	CLIP-seq
MIRT1103832	hsa-miR-4728-5p	CLIP-seq
MIRT2559885	hsa-miR-4731-3p	CLIP-seq
MIRT1103833	hsa-miR-4731-5p	CLIP-seq
MIRT2259498	hsa-miR-4764-3p	CLIP-seq
MIRT2559887	hsa-miR-4768-3p	CLIP-seq
MIRT2559888	hsa-miR-4778-3p	CLIP-seq
MIRT2028385	hsa-miR-4795-3p	CLIP-seq
MIRT2559890	hsa-miR-4797-3p	CLIP-seq
MIRT2559891	hsa-miR-4801	CLIP-seq
MIRT1103837	hsa-miR-4802-3p	CLIP-seq
MIRT2683745	hsa-miR-490-5p	CLIP-seq
MIRT1103840	hsa-miR-494	CLIP-seq
MIRT2028387	hsa-miR-500a	CLIP-seq
MIRT2028389	hsa-miR-513c	CLIP-seq
MIRT2028390	hsa-miR-514b-5p	CLIP-seq
MIRT2559896	hsa-miR-526b	CLIP-seq
MIRT2559897	hsa-miR-532-5p	CLIP-seq
MIRT2559902	hsa-miR-548c-3p	CLIP-seq
MIRT1103849	hsa-miR-552	CLIP-seq
MIRT2559908	hsa-miR-578	CLIP-seq
MIRT1103850	hsa-miR-580	CLIP-seq
MIRT1103854	hsa-miR-593	CLIP-seq
MIRT1103855	hsa-miR-608	CLIP-seq
MIRT2559913	hsa-miR-621	CLIP-seq
MIRT1103857	hsa-miR-640	CLIP-seq
MIRT2559915	hsa-miR-645	CLIP-seq
MIRT1103862	hsa-miR-764	CLIP-seq
MIRT2559918	hsa-miR-873	CLIP-seq
MIRT2259504	hsa-miR-920	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	22980980
GO:0005515	Function	Protein binding	IPI	20381137, 21516116, 21988832, 22980980, 25416956, 25561175, 29123114, 32296183, 33961781, 35271311, 37398436
GO:0005737	Component	Cytoplasm	IEA
GO:0005765	Component	Lysosomal membrane	IDA	29158492
GO:0005765	Component	Lysosomal membrane	NAS	22980980
GO:0005765	Component	Lysosomal membrane	TAS
GO:0005768	Component	Endosome	IEA
GO:0005770	Component	Late endosome	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0008104	Process	Intracellular protein localization	IMP	20381137
GO:0010008	Component	Endosome membrane	TAS
GO:0016020	Component	Membrane	IEA
GO:0019209	Function	Kinase activator activity	IEA
GO:0031902	Component	Late endosome membrane	IEA
GO:0031902	Component	Late endosome membrane	NAS	20381137
GO:0032006	Process	Regulation of TOR signaling	IEA
GO:0032008	Process	Positive regulation of TOR signaling	IBA
GO:0032008	Process	Positive regulation of TOR signaling	IMP	20381137
GO:0035579	Component	Specific granule membrane	TAS
GO:0038202	Process	TORC1 signaling	NAS	22980980
GO:0043410	Process	Positive regulation of MAPK cascade	IEA
GO:0060090	Function	Molecular adaptor activity	IDA	22980980
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0070821	Component	Tertiary granule membrane	TAS
GO:0071230	Process	Cellular response to amino acid stimulus	IBA
GO:0071230	Process	Cellular response to amino acid stimulus	IDA	22980980
GO:0071230	Process	Cellular response to amino acid stimulus	IMP	20381137
GO:0071986	Component	Ragulator complex	IBA
GO:0071986	Component	Ragulator complex	IDA	20381137, 28935770, 29123114, 29158492, 31601708
GO:0071986	Component	Ragulator complex	IPI	28935770
GO:1902414	Process	Protein localization to cell junction	IEA
GO:1902533	Process	Positive regulation of intracellular signal transduction	IEA
GO:1904263	Process	Positive regulation of TORC1 signaling	IDA	28935770, 29123114, 29158492
GO:1990877	Component	FNIP-folliculin RagC/D GAP	IDA	36103527

Other IDs

• MIM: 603296
• HGNC: 15606
• e!Ensembl: ENSG00000109270

Protein

• UniProt ID: Q9UHA4
• Protein name: Ragulator complex protein LAMTOR3 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3) (MEK-binding partner 1) (Mp1) (Mitogen-activated protein kinase kinase 1-interacting protein 1) (Mitogen-activated protein kinase scaffold protein 1)
• Protein function: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:20381137, PubMed:22980980, PubMed:289
• PDB: 1SKO, 2ZL1, 3CPT, 5X6U, 5X6V, 5Y39, 5Y3A, 5YK3, 6B9X, 6EHP, 6EHR, 6NZD, 6U62, 6ULG, 6WJ2, 6WJ3, 7T3A, 7T3B, 7T3C, 7UX2, 7UXC, 7UXH, 8DHB
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08923	MAPKK1_Int	3 → 121	Mitogen-activated protein kinase kinase 1 interacting	Domain

• Sequence:

  MADDLKRFLYKKLPSVEGLHAIVVSDRDGVPVIKVANDNAPEHALRPGFLSTFALATDQG
  SKLGLSKNKSIICYYNTYQVVQFNRLPLVVSFIASSSANTGLIVSLEKELAPLFEELRQV
  VEVS

• Sequence length: 124

Pathways

KEGG:

MAPK signaling pathway
mTOR signaling pathway

Reactome:

Macroautophagy
mTOR signalling
mTORC1-mediated signalling
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
MAP2K and MAPK activation
Neutrophil degranulation
Regulation of PTEN gene transcription
Amino acids regulate mTORC1

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
PERIPHERAL ARTERIAL DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Brain Neoplasms	Brain neoplasms	Pubtator	28830458	Associate	★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	23341997		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	23341997, 33275232	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	28606806		★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	36082464	Associate	★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	28830458	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	30936070	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	23341997		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	28606806		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	25661340		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28830458		★☆☆☆☆ Found in Text Mining only
Myelodysplastic Syndromes	Myelodysplastic syndrome	Pubtator	30936070	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	23341997		★☆☆☆☆ Found in Text Mining only
Sepsis	Sepsis	Pubtator	33182754	Associate	★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	25661340		★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	24914957	Associate	★☆☆☆☆ Found in Text Mining only