Gene Gene information from NCBI Gene database.
Entrez ID 8645
Gene name Potassium two pore domain channel subfamily K member 5
Gene symbol KCNK5
Synonyms (NCBI Gene)
K2p5.1KCNK5bTASK-2TASK2
Chromosome 6
Chromosome location 6p21.2
Summary This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is hi
miRNA miRNA information provided by mirtarbase database.
510
miRTarBase ID miRNA Experiments Reference
MIRT017258 hsa-miR-335-5p Microarray 18185580
MIRT722776 hsa-miR-4793-5p HITS-CLIP 19536157
MIRT722775 hsa-miR-6515-3p HITS-CLIP 19536157
MIRT722774 hsa-miR-1236-3p HITS-CLIP 19536157
MIRT722773 hsa-miR-29b-1-5p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
25
GO ID Ontology Definition Evidence Reference
GO:0005249 Function Voltage-gated potassium channel activity IEA
GO:0005267 Function Potassium channel activity IDA 9812978
GO:0005267 Function Potassium channel activity IEA
GO:0005267 Function Potassium channel activity ISS
GO:0005515 Function Protein binding IPI 32296183, 36063992
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603493 6280 ENSG00000164626
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O95279
Protein name Potassium channel subfamily K member 5 (Acid-sensitive potassium channel protein TASK-2) (TWIK-related acid-sensitive K(+) channel 2)
Protein function K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07885 Ion_trans_2 60 138 Ion channel Family
PF07885 Ion_trans_2 160 251 Ion channel Family
Tissue specificity TISSUE SPECIFICITY: Abundant expression in kidney, also detected in liver, placenta and small intestine. In the kidney, expression is restricted to the distal tubules and collecting ducts (PubMed:9812978). Not expressed in proximal tubules or glomeruli (P
Sequence
MVDRGPLLTSAIIFYLAIGAAIFEVLEEPHWKEAKKNYYTQKLHLLKEFPCLGQEGLDKI
LEVVSDAAGQGVAITGNQTFNNWNWPNAMIFAATVITTIGYGNVAPKTPAGRLFCVFYGL
FGVPLCLTWISALGKFFG
GRAKRLGQFLTKRGVSLRKAQITCTVIFIVWGVLVHLVIPPF
VFMVTEGWNYIEGLYYSFITISTIGFGDFVAGVNPSANYHALYRYFVELWIYLGLAWLSL
FVNWKVSMFVE
VHKAIKKRRRRRKESFESSPHSRKALQVKGSTASKDVNIFSFLSKKEET
YNDLIKQIGKKAMKTSGGGETGPGPGLGPQGGGLPALPPSLVPLVVYSKNRVPTLEEVSQ
TLRSKGHVSRSPDEEAVARAPEDSSPAPEVFMNQLDRISEECEPWDAQDYHPLIFQDASI
TFVNTEAGLSDEETSKSSLEDNLAGEESPQQGAEAKAPLNMGEFPSSSESTFTSTESELS
VPYEQLMNEYNKANSPKGT
Sequence length 499
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Taste transduction
Protein digestion and absorption
  Phase 4 - resting membrane potential
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
19
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ATOPIC ECZEMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARDIOVASCULAR DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
EATING DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Arthritis Rheumatoid Rheumatoid arthritis Pubtator 21314928, 35413058 Associate
★☆☆☆☆
Found in Text Mining only
Autoimmune Diseases Autoimmune Diseases BEFREE 20582984
★☆☆☆☆
Found in Text Mining only
Balkan Nephropathy Balkan Nephropathy BEFREE 24949484, 25725245, 26914156, 27228168
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 21680658
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 21680658 Associate
★☆☆☆☆
Found in Text Mining only
Complex Partial Status Epilepticus Status Epilepticus CTD_human_DG 19220408
★☆☆☆☆
Found in Text Mining only
Congenital central hypoventilation Congenital Central Hypoventilation BEFREE 20133877
★☆☆☆☆
Found in Text Mining only
Conn Adenoma Conn Adenoma BEFREE 24285684, 29293917
★☆☆☆☆
Found in Text Mining only
Conn Syndrome Conn Syndrome BEFREE 24285684, 29293917
★☆☆☆☆
Found in Text Mining only
Coronary Artery Disease Coronary artery disease GWASDB_DG 23202125
★★☆☆☆
Found in Text Mining + Unknown/Other Associations