Gene Gene information from NCBI Gene database.
Entrez ID 8614
Gene name Stanniocalcin 2
Gene symbol STC2
Synonyms (NCBI Gene)
STC-2STCRP
Chromosome 5
Chromosome location 5q35.2
Summary This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is
miRNA miRNA information provided by mirtarbase database.
914
miRTarBase ID miRNA Experiments Reference
MIRT022465 hsa-miR-124-3p Microarray 18668037
MIRT027537 hsa-miR-98-5p Microarray 19088304
MIRT028041 hsa-miR-93-5p Sequencing 20371350
MIRT046093 hsa-miR-125b-5p CLASH 23622248
MIRT438359 hsa-miR-206 qRT-PCR 24855559
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
27
GO ID Ontology Definition Evidence Reference
GO:0005179 Function Hormone activity IEA
GO:0005576 Component Extracellular region IEA
GO:0005615 Component Extracellular space HDA 16502470
GO:0005615 Component Extracellular space IBA
GO:0005783 Component Endoplasmic reticulum IDA 22503972
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603665 11374 ENSG00000113739
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O76061
Protein name Stanniocalcin-2 (STC-2) (Stanniocalcin-related protein) (STC-related protein) (STCRP)
Protein function Has an anti-hypocalcemic action on calcium and phosphate homeostasis.
PDB 7Y5Q , 8A7D , 8A7E , 8HGH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03298 Stanniocalcin 12 215 Stanniocalcin family Family
Tissue specificity TISSUE SPECIFICITY: Expressed in a variety of tissues including muscle, heart, pancreas, kidney, spleen, prostate, small intestine, colon and peripheral blood leukocytes.
Sequence
Sequence length 302
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BREAST NEOPLASMS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Cervical cancer Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ENDOMETRIOSIS CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
NON-ALCOHOLIC FATTY LIVER DISEASE CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma of colon Adenocarcinoma Of Colon BEFREE 31236000
★☆☆☆☆
Found in Text Mining only
Amyloidosis cutis dyschromia Amyloidosis Cutis Dyschromia BEFREE 29748538
★☆☆☆☆
Found in Text Mining only
Arteriosclerosis Arteriosclerosis BEFREE 26983002, 27346255, 31173256
★☆☆☆☆
Found in Text Mining only
Arthritis Rheumatoid Rheumatoid arthritis Pubtator 27141097 Associate
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis BEFREE 26983002, 27346255, 31173256
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis Pubtator 31173256 Associate
★☆☆☆☆
Found in Text Mining only
Avellino corneal dystrophy Avellino Corneal Dystrophy BEFREE 29748538
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 11888893, 18492817, 29593009, 30993707, 31845230
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma CTD_human_DG 18492817
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 15546506, 24505115, 27556857, 29593009 Associate
★★☆☆☆
Found in Text Mining + Unknown/Other Associations