Gene Gene information from NCBI Gene database.
Entrez ID 85865
Gene name GTP binding protein 10
Gene symbol GTPBP10
Synonyms (NCBI Gene)
ObgH2UG0751c10
Chromosome 7
Chromosome location 7q21.13
Summary Small G proteins, such as GTPBP10, act as molecular switches that play crucial roles in the regulation of fundamental cellular processes such as protein synthesis, nuclear transport, membrane trafficking, and signal transduction (Hirano et al., 2006 [PubM
miRNA miRNA information provided by mirtarbase database.
677
miRTarBase ID miRNA Experiments Reference
MIRT462440 hsa-miR-302f HITS-CLIP 23313552
MIRT462439 hsa-miR-6753-5p HITS-CLIP 23313552
MIRT462438 hsa-miR-6808-5p HITS-CLIP 23313552
MIRT462437 hsa-miR-6893-5p HITS-CLIP 23313552
MIRT462436 hsa-miR-940 HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
14
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000287 Function Magnesium ion binding IEA
GO:0003723 Function RNA binding HDA 22658674
GO:0003924 Function GTPase activity IBA
GO:0003924 Function GTPase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
610920 25106 ENSG00000105793
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
A4D1E9
Protein name GTP-binding protein 10 (Protein obg homolog 2) (ObgH2)
Protein function May be involved in the ribosome maturation process. Complements an ObgE(CgtA) function in E.coli ribosome maturation. Plays a role of GTPase in vitro. When missing, disorganization of the nucleolar architecture is observed. {ECO:0000269|PubMed:1
PDB 7OI6 , 8PK0
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01018 GTP1_OBG 16 143 GTP1/OBG Domain
PF01926 MMR_HSR1 150 279 50S ribosome-binding GTPase Family
Sequence
Sequence length 387
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
COLONIC NEOPLASM GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Glioblastoma Glioblastoma Pubtator 26863628 Associate
★☆☆☆☆
Found in Text Mining only
Huntington Disease Huntington disease Pubtator 35210471 Associate
★☆☆☆☆
Found in Text Mining only
Leukemia Leukemia Pubtator 36595475 Associate
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of prostate Prostate cancer BEFREE 27409348
★☆☆☆☆
Found in Text Mining only
Prostate carcinoma Prostate cancer BEFREE 27409348
★☆☆☆☆
Found in Text Mining only
Prostatic Neoplasms Prostatic neoplasm Pubtator 27409348 Associate
★☆☆☆☆
Found in Text Mining only