CDC14B (cell division cycle 14B)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 8555 |
| Gene name | Cell division cycle 14B |
| Gene symbol | CDC14B |
| Synonyms (NCBI Gene) |
CDC14B3Cdc14B1Cdc14B2hCDC14B
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| Chromosome | 9 |
| Chromosome location | 9q22.32-q22.33 |
| Summary | The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation |
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miRNA
miRNA information provided by mirtarbase database.
444
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
33
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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O60729 | |||||||||||||||
| Protein name | Dual specificity protein phosphatase CDC14B (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog B) | |||||||||||||||
| Protein function | Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting comple | |||||||||||||||
| PDB | 1OHC , 1OHD , 1OHE | |||||||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 498 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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