Gene Gene information from NCBI Gene database.
Entrez ID 8550
Gene name MAPK activated protein kinase 5
Gene symbol MAPKAPK5
Synonyms (NCBI Gene)
MAPKAP-K5MK-5MK5NCFDPRAK
Chromosome 12
Chromosome location 12q24.12-q24.13
Summary The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK,
miRNA miRNA information provided by mirtarbase database.
879
miRTarBase ID miRNA Experiments Reference
MIRT039763 hsa-miR-615-3p CLASH 23622248
MIRT708475 hsa-miR-548an HITS-CLIP 19536157
MIRT708474 hsa-miR-6768-3p HITS-CLIP 19536157
MIRT708473 hsa-miR-4484 HITS-CLIP 19536157
MIRT708472 hsa-miR-106a-5p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
47
GO ID Ontology Definition Evidence Reference
GO:0000165 Process MAPK cascade IEA
GO:0000166 Function Nucleotide binding IEA
GO:0002039 Function P53 binding IDA 17254968
GO:0002039 Function P53 binding IEA
GO:0004672 Function Protein kinase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606723 6889 ENSG00000089022
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8IW41
Protein name MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK)
Protein function Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 22 304 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed ubiquitously. {ECO:0000269|PubMed:9628874}.
Sequence
MSEESDMDKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKAR
NEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHF
TEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDL
MTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPP
FYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLD
HPWL
NSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPIL
RKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGKGENEDEKLNEVMQ
EAWKYNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ
Sequence length 473
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  MAPK signaling pathway   Oxidative Stress Induced Senescence
MAPK6/MAPK4 signaling
Regulation of TP53 Activity through Phosphorylation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
11
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession Evidence Score
Neurocardiofaciodigital syndrome Pathogenic rs2069655229, rs2136153237, rs751979756, rs2542499808, rs2542533195, rs1012399660 RCV002248407
RCV002248408
RCV003228821
RCV003228822
RCV003228823
View all (1 more)
★★★★★
ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHRONIC KIDNEY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CIRRHOSIS OF LIVER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Alzheimer Disease Alzheimer disease Pubtator 26080319 Associate
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Arthritis Rheumatoid Rheumatoid arthritis Pubtator 32569434, 38225924 Associate
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 21329882 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 26492393, 34095306, 35210216, 35264707, 35844789 Associate
★☆☆☆☆
Found in Text Mining only
Cerebellar Hypoplasia Cerebellar hypoplasia Pubtator 36581449 Associate
★☆☆☆☆
Found in Text Mining only
Colonic Neoplasms Colonic neoplasm Pubtator 21329882 Inhibit
★☆☆☆☆
Found in Text Mining only
Congenital Abnormalities Congenital abnormalities Pubtator 33442026, 35575217 Associate
★☆☆☆☆
Found in Text Mining only
Craniosynostoses Craniosynostosis Pubtator 36581449 Associate
★☆☆☆☆
Found in Text Mining only
Demyelinating Diseases Demyelinating diseases Pubtator 36581449 Associate
★☆☆☆☆
Found in Text Mining only
Developmental Disabilities Developmental disability Pubtator 33442026, 35575217, 36581449 Associate
★☆☆☆☆
Found in Text Mining only