Gene Gene information from NCBI Gene database.
Entrez ID 85477
Gene name Scinderin
Gene symbol SCIN
Synonyms (NCBI Gene)
-
Chromosome 7
Chromosome location 7p21.3
Summary SCIN is a Ca(2+)-dependent actin-severing and -capping protein (Zunino et al., 2001 [PubMed 11568009]).[supplied by OMIM, May 2010]
miRNA miRNA information provided by mirtarbase database.
354
miRTarBase ID miRNA Experiments Reference
MIRT017918 hsa-miR-335-5p Microarray 18185580
MIRT518246 hsa-miR-8485 HITS-CLIP 21572407
MIRT518244 hsa-miR-329-3p HITS-CLIP 21572407
MIRT518243 hsa-miR-362-3p HITS-CLIP 21572407
MIRT518242 hsa-miR-603 HITS-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
44
GO ID Ontology Definition Evidence Reference
GO:0001786 Function Phosphatidylserine binding ISS
GO:0002102 Component Podosome IEA
GO:0003779 Function Actin binding IEA
GO:0003779 Function Actin binding ISS
GO:0003779 Function Actin binding TAS 11568009
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
613416 21695 ENSG00000006747
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9Y6U3
Protein name Scinderin (Adseverin)
Protein function Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:26365202, PubMed:8547642). Severing activity is inhib
PDB 3FG6 , 5A1K , 5A1M
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00626 Gelsolin 26 108 Gelsolin repeat Domain
PF00626 Gelsolin 146 221 Gelsolin repeat Domain
PF00626 Gelsolin 263 341 Gelsolin repeat Domain
PF00626 Gelsolin 405 483 Gelsolin repeat Domain
PF00626 Gelsolin 521 590 Gelsolin repeat Domain
PF00626 Gelsolin 626 704 Gelsolin repeat Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in megakaryocytes. {ECO:0000269|PubMed:11568009}.
Sequence
Sequence length 715
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Fc gamma R-mediated phagocytosis
Regulation of actin cytoskeleton
Viral carcinogenesis
 
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
SCOLIOSIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SMALL CELL LUNG CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute Megakaryocytic Leukemias Megakaryocytic Leukemia BEFREE 11568009
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 21999571
★☆☆☆☆
Found in Text Mining only
B-Cell Lymphomas B-Cell Lymphoma BEFREE 29744289
★☆☆☆☆
Found in Text Mining only
Bladder Neoplasm Bladder Neoplasm BEFREE 31369818
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 30127916
★☆☆☆☆
Found in Text Mining only
Carcinoma of bladder Bladder carcinoma BEFREE 31369818
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma BEFREE 25303873
★☆☆☆☆
Found in Text Mining only
Colonic Neoplasms Colonic neoplasm Pubtator 33646276, 34850851 Associate
★☆☆☆☆
Found in Text Mining only
Colorectal Carcinoma Colorectal Cancer BEFREE 31736743
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 36148682 Associate
★☆☆☆☆
Found in Text Mining only