Gene Gene information from NCBI Gene database.
Entrez ID 85463
Gene name Zinc finger CCCH-type containing 12C
Gene symbol ZC3H12C
Synonyms (NCBI Gene)
MCPIP3
Chromosome 11
Chromosome location 11q22.3
miRNA miRNA information provided by mirtarbase database.
809
miRTarBase ID miRNA Experiments Reference
MIRT020100 hsa-miR-361-5p Sequencing 20371350
MIRT026502 hsa-miR-192-5p Microarray 19074876
MIRT028024 hsa-miR-93-5p Sequencing 20371350
MIRT028230 hsa-miR-33a-5p Sequencing 20371350
MIRT049897 hsa-miR-31-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
13
GO ID Ontology Definition Evidence Reference
GO:0003674 Function Molecular_function ND
GO:0003729 Function MRNA binding IBA
GO:0004518 Function Nuclease activity IEA
GO:0004519 Function Endonuclease activity IEA
GO:0004521 Function RNA endonuclease activity IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
615001 29362 ENSG00000149289
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9C0D7
Protein name Probable ribonuclease ZC3H12C (EC 3.1.-.-) (MCP-induced protein 3) (Zinc finger CCCH domain-containing protein 12C)
Protein function May function as RNase and regulate the levels of target RNA species.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF18039 UBA_6 162 203 UBA-like domain Domain
PF11977 RNase_Zc3h12a 244 400 Zc3h12a-like Ribonuclease NYN domain Domain
PF18561 Regnase_1_C 833 878 Endoribonuclease Regnase 1/ ZC3H12 C-terminal domain Domain
Sequence
MPGGGSQEYGVLCIQEYRKNSKVESSTRNNFMGLKDHLGHDLGHLYVESTDPQLSPAVPW
STVENPSMDTVNVGKDEKEASEENASSGDSEENTNSDHESEQLGSISVEPGLITKTHRQL
CRSPCLEPHILKRNEILQDFKPEESQTTSKEAKKPPDVVREYQTKLEFALKLGYSEEQVQ
LVLNKLGTDALINDILGELVKLG
NKSEADQTVSTINTITRETSSLESQRSESPMQEIVTD
DGENLRPIVIDGSNVAMSHGNKEVFSCRGIKLAVDWFLERGHKDITVFVPAWRKEQSRPD
ALITDQEILRKLEKEKILVFTPSRRVQGRRVVCYDDRFIVKLAFESDGIIVSNDNYRDLA
NEKPEWKKFIDERLLMYSFVNDKFMPPDDPLGRHGPSLDN
FLRKKPIVPEHKKQPCPYGK
KCTYGHKCKYYHPERGSQPQRSVADELRAMSRNTAAKTANEGGLVKSNSVPCSTKADSTS
DVKRGAPKRQSDPSIRTQVYQDLEEKLPTKNKLETRSVPSLVSIPATSTAKPQSTTSLSN
GLPSGVHFPPQDQRPQGQYPSMMMATKNHGTPMPYEQYPKCDSPVDIGYYSMLNAYSNLS
LSGPRSPERRFSLDTDYRISSVASDCSSEGSMSCGSSDSYVGYNDRSYVSSPDPQLEENL
KCQHMHPHSRLNPQPFLQNFHDPLTRGQSYSHEEPKFHHKPPLPHLALHLPHSAVGARSS
CPGDYPSPPSSAHSKAPHLGRSLVATRIDSISDSRLYDSSPSRQRKPYSRQEGLGSWERP
GYGIDAYGYRQTYSLPDNSTQPCYEQFTFQSLPEQQEPAWRIPYCGMPQDPPRYQDNREK
IYINLCNIFPPDLVRIVMKRNPHMTDAQQLAAAILVEK
SQLGY
Sequence length 883
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Nonpapillary renal cell carcinoma Uncertain significance ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PSORIASIS CTD, Disgenet, GWAS catalog
CTD, Disgenet, GWAS catalog
CTD, Disgenet, GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
X-linked Alport syndrome Uncertain significance ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Alzheimer Disease Alzheimer disease Pubtator 25391383 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Renal Cell Renal cell carcinoma Pubtator 35795311 Associate
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 29751537 Inhibit
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 34080453, 38267865 Associate
★☆☆☆☆
Found in Text Mining only
Psoriasis Psoriasis CTD_human_DG 23143594
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Pustulosis of Palms and Soles Palmoplantar Pustules CTD_human_DG 23143594
★☆☆☆☆
Found in Text Mining only
Vascular Diseases Vascular disease Pubtator 23360436 Associate
★☆☆☆☆
Found in Text Mining only