Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	85456
Gene name	Tankyrase 1 binding protein 1
Gene symbol	TNKS1BP1
Synonyms (NCBI Gene)	CNOT12TAB182
Chromosome	11
Chromosome location	11q12.1

137

Show/Hide all (137)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020157	hsa-miR-130b-3p	Sequencing	20371350
MIRT020675	hsa-miR-155-5p	Proteomics	18668040
MIRT023682	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT028048	hsa-miR-93-5p	Sequencing	20371350
MIRT047207	hsa-miR-182-5p	CLASH	23622248
MIRT046043	hsa-miR-125b-5p	CLASH	23622248
MIRT042235	hsa-miR-484	CLASH	23622248
MIRT040966	hsa-miR-18a-3p	CLASH	23622248
MIRT036104	hsa-miR-1296-5p	CLASH	23622248
MIRT052664	hsa-miR-3157-5p	CLASH	23622248
MIRT438073	hsa-miR-26b-5p	pSILAC	23939832
MIRT438073	hsa-miR-26b-5p	pSILAC	23939832
MIRT1443737	hsa-miR-1207-5p	CLIP-seq
MIRT1443738	hsa-miR-1224-3p	CLIP-seq
MIRT1443739	hsa-miR-1245	CLIP-seq
MIRT1443740	hsa-miR-1260	CLIP-seq
MIRT1443741	hsa-miR-1260b	CLIP-seq
MIRT1443742	hsa-miR-1280	CLIP-seq
MIRT1443743	hsa-miR-1321	CLIP-seq
MIRT1443744	hsa-miR-3125	CLIP-seq
MIRT1443745	hsa-miR-3135b	CLIP-seq
MIRT1443746	hsa-miR-3151	CLIP-seq
MIRT1443747	hsa-miR-3652	CLIP-seq
MIRT1443748	hsa-miR-3916	CLIP-seq
MIRT1443749	hsa-miR-4430	CLIP-seq
MIRT1443750	hsa-miR-4475	CLIP-seq
MIRT1443751	hsa-miR-4476	CLIP-seq
MIRT1443752	hsa-miR-4739	CLIP-seq
MIRT1443753	hsa-miR-4756-5p	CLIP-seq
MIRT1443754	hsa-miR-4763-3p	CLIP-seq
MIRT1443755	hsa-miR-485-5p	CLIP-seq
MIRT1443756	hsa-miR-660	CLIP-seq
MIRT1443757	hsa-miR-765	CLIP-seq
MIRT1443758	hsa-miR-940	CLIP-seq
MIRT1443755	hsa-miR-485-5p	CLIP-seq
MIRT2353851	hsa-miR-106a	CLIP-seq
MIRT2353852	hsa-miR-106b	CLIP-seq
MIRT1443737	hsa-miR-1207-5p	CLIP-seq
MIRT1443738	hsa-miR-1224-3p	CLIP-seq
MIRT1443740	hsa-miR-1260	CLIP-seq
MIRT1443741	hsa-miR-1260b	CLIP-seq
MIRT1443742	hsa-miR-1280	CLIP-seq
MIRT2353853	hsa-miR-17	CLIP-seq
MIRT2353854	hsa-miR-1827	CLIP-seq
MIRT2353855	hsa-miR-20a	CLIP-seq
MIRT2353856	hsa-miR-20b	CLIP-seq
MIRT2353857	hsa-miR-2355-5p	CLIP-seq
MIRT2353858	hsa-miR-3163	CLIP-seq
MIRT2353859	hsa-miR-340	CLIP-seq
MIRT2353860	hsa-miR-342-5p	CLIP-seq
MIRT2353861	hsa-miR-3661	CLIP-seq
MIRT2353862	hsa-miR-3672	CLIP-seq
MIRT2353863	hsa-miR-4257	CLIP-seq
MIRT2353864	hsa-miR-4268	CLIP-seq
MIRT2353865	hsa-miR-4276	CLIP-seq
MIRT2353866	hsa-miR-4316	CLIP-seq
MIRT2353867	hsa-miR-4324	CLIP-seq
MIRT2353868	hsa-miR-4329	CLIP-seq
MIRT2353869	hsa-miR-4528	CLIP-seq
MIRT2353870	hsa-miR-455-5p	CLIP-seq
MIRT2353871	hsa-miR-4651	CLIP-seq
MIRT2353872	hsa-miR-4664-5p	CLIP-seq
MIRT2353873	hsa-miR-4710	CLIP-seq
MIRT2353874	hsa-miR-4755-3p	CLIP-seq
MIRT1443754	hsa-miR-4763-3p	CLIP-seq
MIRT1443755	hsa-miR-485-5p	CLIP-seq
MIRT2353875	hsa-miR-519a	CLIP-seq
MIRT2353876	hsa-miR-519b-3p	CLIP-seq
MIRT2353877	hsa-miR-519c-3p	CLIP-seq
MIRT2353878	hsa-miR-519d	CLIP-seq
MIRT2353879	hsa-miR-520g	CLIP-seq
MIRT2353880	hsa-miR-520h	CLIP-seq
MIRT2353881	hsa-miR-548b-3p	CLIP-seq
MIRT2353882	hsa-miR-550a	CLIP-seq
MIRT2353883	hsa-miR-608	CLIP-seq
MIRT2353884	hsa-miR-631	CLIP-seq
MIRT1443756	hsa-miR-660	CLIP-seq
MIRT2353885	hsa-miR-769-5p	CLIP-seq
MIRT2353886	hsa-miR-93	CLIP-seq
MIRT1443758	hsa-miR-940	CLIP-seq
MIRT2353862	hsa-miR-3672	CLIP-seq
MIRT2353867	hsa-miR-4324	CLIP-seq
MIRT2353868	hsa-miR-4329	CLIP-seq
MIRT2353874	hsa-miR-4755-3p	CLIP-seq
MIRT2353881	hsa-miR-548b-3p	CLIP-seq
MIRT1443737	hsa-miR-1207-5p	CLIP-seq
MIRT1443738	hsa-miR-1224-3p	CLIP-seq
MIRT1443740	hsa-miR-1260	CLIP-seq
MIRT1443741	hsa-miR-1260b	CLIP-seq
MIRT1443742	hsa-miR-1280	CLIP-seq
MIRT1443743	hsa-miR-1321	CLIP-seq
MIRT2353854	hsa-miR-1827	CLIP-seq
MIRT2647975	hsa-miR-3119	CLIP-seq
MIRT2353858	hsa-miR-3163	CLIP-seq
MIRT2353859	hsa-miR-340	CLIP-seq
MIRT2353860	hsa-miR-342-5p	CLIP-seq
MIRT2353861	hsa-miR-3661	CLIP-seq
MIRT2353866	hsa-miR-4316	CLIP-seq
MIRT2353869	hsa-miR-4528	CLIP-seq
MIRT2353871	hsa-miR-4651	CLIP-seq
MIRT2353872	hsa-miR-4664-5p	CLIP-seq
MIRT2353873	hsa-miR-4710	CLIP-seq
MIRT1443752	hsa-miR-4739	CLIP-seq
MIRT1443753	hsa-miR-4756-5p	CLIP-seq
MIRT1443754	hsa-miR-4763-3p	CLIP-seq
MIRT2647976	hsa-miR-548c-3p	CLIP-seq
MIRT2353883	hsa-miR-608	CLIP-seq
MIRT2353884	hsa-miR-631	CLIP-seq
MIRT1443756	hsa-miR-660	CLIP-seq
MIRT2353885	hsa-miR-769-5p	CLIP-seq
MIRT1443758	hsa-miR-940	CLIP-seq
MIRT1443737	hsa-miR-1207-5p	CLIP-seq
MIRT1443738	hsa-miR-1224-3p	CLIP-seq
MIRT1443740	hsa-miR-1260	CLIP-seq
MIRT1443741	hsa-miR-1260b	CLIP-seq
MIRT1443742	hsa-miR-1280	CLIP-seq
MIRT1443743	hsa-miR-1321	CLIP-seq
MIRT2353854	hsa-miR-1827	CLIP-seq
MIRT2647975	hsa-miR-3119	CLIP-seq
MIRT2353858	hsa-miR-3163	CLIP-seq
MIRT2353859	hsa-miR-340	CLIP-seq
MIRT2353860	hsa-miR-342-5p	CLIP-seq
MIRT2353861	hsa-miR-3661	CLIP-seq
MIRT2353866	hsa-miR-4316	CLIP-seq
MIRT2353869	hsa-miR-4528	CLIP-seq
MIRT2353871	hsa-miR-4651	CLIP-seq
MIRT2353872	hsa-miR-4664-5p	CLIP-seq
MIRT2353873	hsa-miR-4710	CLIP-seq
MIRT1443752	hsa-miR-4739	CLIP-seq
MIRT1443753	hsa-miR-4756-5p	CLIP-seq
MIRT1443754	hsa-miR-4763-3p	CLIP-seq
MIRT2647976	hsa-miR-548c-3p	CLIP-seq
MIRT2353883	hsa-miR-608	CLIP-seq
MIRT2353884	hsa-miR-631	CLIP-seq
MIRT1443756	hsa-miR-660	CLIP-seq
MIRT2353885	hsa-miR-769-5p	CLIP-seq
MIRT1443758	hsa-miR-940	CLIP-seq

Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000289	Process	Nuclear-transcribed mRNA poly(A) tail shortening	NAS	31320642
GO:0000792	Component	Heterochromatin	IBA
GO:0000792	Component	Heterochromatin	IDA	11854288
GO:0005515	Function	Protein binding	IPI	11854288, 12080061, 17452450, 18377426, 22153077, 25749521, 28514442, 33787085, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	11854288
GO:0005634	Component	Nucleus	IEA
GO:0005694	Component	Chromosome	IEA
GO:0005737	Component	Cytoplasm	IDA	11854288
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005912	Component	Adherens junction	IDA	11854288
GO:0006302	Process	Double-strand break repair	IBA
GO:0006302	Process	Double-strand break repair	IMP	25749521
GO:0007004	Process	Telomere maintenance via telomerase	NAS	11854288
GO:0019899	Function	Enzyme binding	IDA	11854288
GO:0030014	Component	CCR4-NOT complex	IDA	19558367
GO:0030014	Component	CCR4-NOT complex	NAS	19558367
GO:0043539	Function	Protein serine/threonine kinase activator activity	IMP	25749521
GO:0044877	Function	Protein-containing complex binding	IPI	25749521
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0071479	Process	Cellular response to ionizing radiation	IBA
GO:0071479	Process	Cellular response to ionizing radiation	IMP	25749521
GO:0071532	Function	Ankyrin repeat binding	IMP	11854288
GO:0071532	Function	Ankyrin repeat binding	IPI	11854288

MIM	HGNC	e!Ensembl
607104	19081	ENSG00000149115

Q9C0C2

Protein name

182 kDa tankyrase-1-binding protein

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15327	Tankyrase_bdg_C	1556 → 1726	Tankyrase binding protein C terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Detected in testis, ovary, lung, skeletal muscle, heart, prostate and pancreas, and at very low levels in brain and peripheral blood leukocytes.

Sequence

MKVSTLRESSAMASPLPREMEEELVPTGSEPGDTRAKPPVKPKPRALPAKPALPAKPSLL
VPVGPRPPRGPLAELPSARKMNMLAGPQPYGGSKRPLPFAPRPAVEASTGGEATQETGKE
EAGKEEPPPLTPPARCAAPGGVRKAPAPFRPASERFAATTVEEILAKMEQPRKEVLASPD
RLWGSRLTFNHDGSSRYGPRTYGTTTAPRDEDGSTLFRGWSQEGPVKSPAECREEHSKTP
EERSLPSDLAFNGDLAKAASSELPADISKPWIPSSPAPSSENGGPASPGLPAEASGSGPG
SPHLHPPDKSSPCHSQLLEAQTPEASQASPCPAVTPSAPSAALPDEGSRHTPSPGLPAEG
APEAPRPSSPPPEVLEPHSLDQPPATSPRPLIEVGELLDLTRTFPSGGEEEAKGDAHLRP
TSLVQRRFSEGVLQSPSQDQEKLGGSLAALPQGQGSQLALDRPFGAESNWSLSQSFEWTF
PTRPSGLGVWRLDSPPPSPITEASEAAEAAEAGNLAVSSREEGVSQQGQGAGSAPSGSGS
SWVQGDDPSMSLTQKGDGESQPQFPAVPLEPLPTTEGTPGLPLQQAEERYESQEPLAGQE
SPLPLATREAALPILEPVLGQEQPAAPDQPCVLFADAPEPGQALPVEEEAVTLARAETTQ
ARTEAQDLCRASPEPPGPESSSRWLDDLLASPPPSGGGARRGAGAELKDTQSPSTCSEGL
LGWSQKDLQSEFGITGDPQPSSFSPSSWCQGASQDYGLGGASPRGDPGLGERDWTSKYGQ
GAGEGSTREWASRCGIGQEEMEASSSQDQSKVSAPGVLTAQDRVVGKPAQLGTQRSQEAD
VQDWEFRKRDSQGTYSSRDAELQDQEFGKRDSLGTYSSRDVSLGDWEFGKRDSLGAYASQ
DANEQGQDLGKRDHHGRYSSQDADEQDWEFQKRDVSLGTYGSRAAEPQEQEFGKSAWIRD
YSSGGSSRTLDAQDRSFGTRPLSSGFSPEEAQQQDEEFEKKIPSVEDSLGEGSRDAGRPG
ERGSGGLFSPSTAHVPDGALGQRDQSSWQNSDASQEVGGHQERQQAGAQGPGSADLEDGE
MGKRGWVGEFSLSVGPQREAAFSPGQQDWSRDFCIEASERSYQFGIIGNDRVSGAGFSPS
SKMEGGHFVPPGKTTAGSVDWTDQLGLRNLEVSSCVGSGGSSEARESAVGQMGWSGGLSL
RDMNLTGCLESGGSEEPGGIGVGEKDWTSDVNVKSKDLAEVGEGGGHSQARESGVGQTDW
SGVEAGEFLKSRERGVGQADWTPDLGLRNMAPGAVCSPGESKELGVGQMDWGNNLGLRDL
EVTCDPDSGGSQGLRGCGVGQMDWTQDLAPQNVELFGAPSEAREHGVGGVSQCPEPGLRH
NGSLSPGLEARDPLEARELGVGETSGPETQGEDYSSSSLEPHPADPGMETGEALSFGASP
GRCPARPPPSGSQGLLEEMLAASSSKAVARRESAASGLGGLLEEEGAGAGAAQEEVLEPG
RDSPPSWRPQPDGEASQTEDVDGTWGSSAARWSDQGPAQTSRRPSQGPPARSPSQDFSFI
EDTEILDSAMYRSRANLGRKRGHRAPVIRPGGTLGLSEAADSDAHLFQDSTEPRASRVPS
SDEEVVEEPQSRRTRMSLGTKGLKVNLFPGLSPSALKAKLRPRNRSAEEGELAESKSSQK
ESAVQRSKSCKVPGLGKPLTLPPKPEKSSGSEGSSPNWLQALKLKKKKV

Sequence length

1729

Interactions

View interactions

	Reactome
			Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (15)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Adrenocortical carcinoma, hereditary	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTROPHIC CARDIOMYOPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myoepithelial tumor	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL LUNG CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (10)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	28058814		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	23939832	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophageal neoplasm	Pubtator	36289198	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	33787085, 36289198	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gastritis	Gastritis	Pubtator	37249580	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	28058814	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	28058814		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28058814, 28202517		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	Pubtator	34042246	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	37953246	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only

TNKS1BP1 (tankyrase 1 binding protein 1)