Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	85450
Gene name	Inositol 1,4,5-trisphosphate receptor interacting protein
Gene symbol	ITPRIP
Synonyms (NCBI Gene)	D1ADANGERKIAA1754bA127L20bA127L20.2
Chromosome	10
Chromosome location	10q25.1
Summary	This gene encodes a membrane-associated protein that binds the inositol 1,4,5-trisphosphate receptor (ITPR). The encoded protein enhances the sensitivity of ITPR to intracellular calcium signaling. Alternative splicing results in multiple transcript varia

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Show/Hide all (215)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019219	hsa-miR-335-5p	Microarray	18185580
MIRT022688	hsa-miR-124-3p	Microarray	18668037
MIRT028624	hsa-miR-30a-5p	Proteomics	18668040
MIRT038902	hsa-miR-93-3p	CLASH	23622248
MIRT687824	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT687823	hsa-miR-6792-5p	HITS-CLIP	23313552
MIRT687822	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT529717	hsa-miR-4494	PAR-CLIP	22012620
MIRT529716	hsa-miR-5587-3p	PAR-CLIP	22012620
MIRT529715	hsa-miR-2276-3p	PAR-CLIP	22012620
MIRT457822	hsa-miR-4640-5p	PAR-CLIP	22012620
MIRT457821	hsa-miR-4726-5p	PAR-CLIP	22012620
MIRT457820	hsa-miR-6508-3p	PAR-CLIP	22012620
MIRT457833	hsa-miR-4660	PAR-CLIP	23592263
MIRT457832	hsa-miR-8077	PAR-CLIP	23592263
MIRT457831	hsa-miR-3944-5p	PAR-CLIP	23592263
MIRT457830	hsa-miR-1301-3p	PAR-CLIP	23592263
MIRT457829	hsa-miR-5047	PAR-CLIP	23592263
MIRT457828	hsa-miR-548an	PAR-CLIP	23592263
MIRT457827	hsa-miR-3910	PAR-CLIP	23592263
MIRT457826	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT457825	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT457824	hsa-miR-4772-5p	PAR-CLIP	23592263
MIRT457823	hsa-miR-3622b-5p	PAR-CLIP	23592263
MIRT457822	hsa-miR-4640-5p	PAR-CLIP	23592263
MIRT457821	hsa-miR-4726-5p	PAR-CLIP	23592263
MIRT457820	hsa-miR-6508-3p	PAR-CLIP	23592263
MIRT457819	hsa-miR-4709-3p	PAR-CLIP	23592263
MIRT687824	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT687823	hsa-miR-6792-5p	HITS-CLIP	23313552
MIRT687822	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT529717	hsa-miR-4494	PAR-CLIP	22012620
MIRT529716	hsa-miR-5587-3p	PAR-CLIP	22012620
MIRT529715	hsa-miR-2276-3p	PAR-CLIP	22012620
MIRT457822	hsa-miR-4640-5p	PAR-CLIP	22012620
MIRT457821	hsa-miR-4726-5p	PAR-CLIP	22012620
MIRT457820	hsa-miR-6508-3p	PAR-CLIP	22012620
MIRT457833	hsa-miR-4660	PAR-CLIP	23592263
MIRT457832	hsa-miR-8077	PAR-CLIP	23592263
MIRT457831	hsa-miR-3944-5p	PAR-CLIP	23592263
MIRT457830	hsa-miR-1301-3p	PAR-CLIP	23592263
MIRT457829	hsa-miR-5047	PAR-CLIP	23592263
MIRT457828	hsa-miR-548an	PAR-CLIP	23592263
MIRT457827	hsa-miR-3910	PAR-CLIP	23592263
MIRT457826	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT457825	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT457824	hsa-miR-4772-5p	PAR-CLIP	23592263
MIRT457823	hsa-miR-3622b-5p	PAR-CLIP	23592263
MIRT457822	hsa-miR-4640-5p	PAR-CLIP	23592263
MIRT457821	hsa-miR-4726-5p	PAR-CLIP	23592263
MIRT457820	hsa-miR-6508-3p	PAR-CLIP	23592263
MIRT457819	hsa-miR-4709-3p	PAR-CLIP	23592263
MIRT1075143	hsa-miR-1253	CLIP-seq
MIRT1075144	hsa-miR-1321	CLIP-seq
MIRT1075145	hsa-miR-1827	CLIP-seq
MIRT1075146	hsa-miR-199a-5p	CLIP-seq
MIRT1075147	hsa-miR-199b-5p	CLIP-seq
MIRT1075148	hsa-miR-214	CLIP-seq
MIRT1075149	hsa-miR-3136-3p	CLIP-seq
MIRT1075150	hsa-miR-3153	CLIP-seq
MIRT1075151	hsa-miR-3160-5p	CLIP-seq
MIRT1075152	hsa-miR-3162-5p	CLIP-seq
MIRT1075153	hsa-miR-3179	CLIP-seq
MIRT1075154	hsa-miR-342-5p	CLIP-seq
MIRT1075155	hsa-miR-3619-5p	CLIP-seq
MIRT1075156	hsa-miR-3622a-3p	CLIP-seq
MIRT1075157	hsa-miR-3622b-3p	CLIP-seq
MIRT1075158	hsa-miR-3688-5p	CLIP-seq
MIRT1075159	hsa-miR-371b-3p	CLIP-seq
MIRT1075160	hsa-miR-3928	CLIP-seq
MIRT1075161	hsa-miR-3936	CLIP-seq
MIRT1075162	hsa-miR-4254	CLIP-seq
MIRT1075163	hsa-miR-4280	CLIP-seq
MIRT1075164	hsa-miR-4291	CLIP-seq
MIRT1075165	hsa-miR-4302	CLIP-seq
MIRT1075166	hsa-miR-4303	CLIP-seq
MIRT1075167	hsa-miR-4308	CLIP-seq
MIRT1075168	hsa-miR-4446-3p	CLIP-seq
MIRT1075169	hsa-miR-4470	CLIP-seq
MIRT1075170	hsa-miR-4492	CLIP-seq
MIRT1075171	hsa-miR-4498	CLIP-seq
MIRT1075172	hsa-miR-4519	CLIP-seq
MIRT1075173	hsa-miR-4649-3p	CLIP-seq
MIRT1075174	hsa-miR-4651	CLIP-seq
MIRT1075175	hsa-miR-4664-5p	CLIP-seq
MIRT1075176	hsa-miR-4715-3p	CLIP-seq
MIRT1075177	hsa-miR-4739	CLIP-seq
MIRT1075178	hsa-miR-4756-5p	CLIP-seq
MIRT1075179	hsa-miR-4762-3p	CLIP-seq
MIRT1075180	hsa-miR-4765	CLIP-seq
MIRT1075181	hsa-miR-4773	CLIP-seq
MIRT1075182	hsa-miR-513c	CLIP-seq
MIRT1075183	hsa-miR-514b-5p	CLIP-seq
MIRT1075184	hsa-miR-608	CLIP-seq
MIRT1075185	hsa-miR-625	CLIP-seq
MIRT1075186	hsa-miR-644	CLIP-seq
MIRT1075187	hsa-miR-761	CLIP-seq
MIRT1075188	hsa-miR-762	CLIP-seq
MIRT1075189	hsa-miR-765	CLIP-seq
MIRT1075190	hsa-miR-922	CLIP-seq
MIRT1075191	hsa-miR-940	CLIP-seq
MIRT1075192	hsa-miR-942	CLIP-seq
MIRT2018615	hsa-miR-1238	CLIP-seq
MIRT2018616	hsa-miR-1301	CLIP-seq
MIRT2018617	hsa-miR-1972	CLIP-seq
MIRT2018618	hsa-miR-3158-5p	CLIP-seq
MIRT1075163	hsa-miR-4280	CLIP-seq
MIRT2018619	hsa-miR-4650-5p	CLIP-seq
MIRT2018620	hsa-miR-4652-3p	CLIP-seq
MIRT1075180	hsa-miR-4765	CLIP-seq
MIRT2018621	hsa-miR-4778-5p	CLIP-seq
MIRT2250485	hsa-miR-2276	CLIP-seq
MIRT1075168	hsa-miR-4446-3p	CLIP-seq
MIRT2438045	hsa-miR-3187-3p	CLIP-seq
MIRT2438046	hsa-miR-4435	CLIP-seq
MIRT2438047	hsa-miR-4529-5p	CLIP-seq
MIRT2438048	hsa-miR-4701-5p	CLIP-seq
MIRT1075176	hsa-miR-4715-3p	CLIP-seq
MIRT2438049	hsa-miR-548s	CLIP-seq
MIRT2438050	hsa-miR-588	CLIP-seq
MIRT2452043	hsa-miR-1243	CLIP-seq
MIRT2452044	hsa-miR-3192	CLIP-seq
MIRT2452045	hsa-miR-4314	CLIP-seq
MIRT2452046	hsa-miR-4463	CLIP-seq
MIRT2452047	hsa-miR-4646-5p	CLIP-seq
MIRT2452043	hsa-miR-1243	CLIP-seq
MIRT2554023	hsa-miR-146b-3p	CLIP-seq
MIRT2554024	hsa-miR-1913	CLIP-seq
MIRT1075146	hsa-miR-199a-5p	CLIP-seq
MIRT1075147	hsa-miR-199b-5p	CLIP-seq
MIRT2554025	hsa-miR-2110	CLIP-seq
MIRT2554026	hsa-miR-22	CLIP-seq
MIRT2554027	hsa-miR-298	CLIP-seq
MIRT2554028	hsa-miR-3130-5p	CLIP-seq
MIRT2554029	hsa-miR-3150a-3p	CLIP-seq
MIRT1075150	hsa-miR-3153	CLIP-seq
MIRT2554030	hsa-miR-3154	CLIP-seq
MIRT2554031	hsa-miR-3157-3p	CLIP-seq
MIRT2554032	hsa-miR-3173-5p	CLIP-seq
MIRT1075153	hsa-miR-3179	CLIP-seq
MIRT2554033	hsa-miR-3189-5p	CLIP-seq
MIRT2452044	hsa-miR-3192	CLIP-seq
MIRT2554034	hsa-miR-3202	CLIP-seq
MIRT2554035	hsa-miR-324-3p	CLIP-seq
MIRT2554036	hsa-miR-337-3p	CLIP-seq
MIRT1075154	hsa-miR-342-5p	CLIP-seq
MIRT1075158	hsa-miR-3688-5p	CLIP-seq
MIRT2554037	hsa-miR-4271	CLIP-seq
MIRT1075165	hsa-miR-4302	CLIP-seq
MIRT2452045	hsa-miR-4314	CLIP-seq
MIRT2554038	hsa-miR-4456	CLIP-seq
MIRT2452046	hsa-miR-4463	CLIP-seq
MIRT2554039	hsa-miR-4464	CLIP-seq
MIRT1075169	hsa-miR-4470	CLIP-seq
MIRT2554040	hsa-miR-4482	CLIP-seq
MIRT2554041	hsa-miR-4533	CLIP-seq
MIRT2452047	hsa-miR-4646-5p	CLIP-seq
MIRT1075175	hsa-miR-4664-5p	CLIP-seq
MIRT2554042	hsa-miR-4712-5p	CLIP-seq
MIRT2554043	hsa-miR-4725-3p	CLIP-seq
MIRT2554044	hsa-miR-4733-3p	CLIP-seq
MIRT2554045	hsa-miR-4748	CLIP-seq
MIRT2554046	hsa-miR-4758-3p	CLIP-seq
MIRT1075182	hsa-miR-513c	CLIP-seq
MIRT1075183	hsa-miR-514b-5p	CLIP-seq
MIRT2554047	hsa-miR-516a-3p	CLIP-seq
MIRT2554048	hsa-miR-541	CLIP-seq
MIRT2554049	hsa-miR-558	CLIP-seq
MIRT1075186	hsa-miR-644	CLIP-seq
MIRT2554050	hsa-miR-654-5p	CLIP-seq
MIRT2554051	hsa-miR-659	CLIP-seq
MIRT2554052	hsa-miR-711	CLIP-seq
MIRT2554053	hsa-miR-770-5p	CLIP-seq
MIRT2554054	hsa-miR-874	CLIP-seq
MIRT1075190	hsa-miR-922	CLIP-seq
MIRT1075192	hsa-miR-942	CLIP-seq
MIRT2452043	hsa-miR-1243	CLIP-seq
MIRT2554023	hsa-miR-146b-3p	CLIP-seq
MIRT2554024	hsa-miR-1913	CLIP-seq
MIRT2554026	hsa-miR-22	CLIP-seq
MIRT2250485	hsa-miR-2276	CLIP-seq
MIRT2683054	hsa-miR-2861	CLIP-seq
MIRT2683055	hsa-miR-300	CLIP-seq
MIRT2554031	hsa-miR-3157-3p	CLIP-seq
MIRT1075151	hsa-miR-3160-5p	CLIP-seq
MIRT2554032	hsa-miR-3173-5p	CLIP-seq
MIRT2554033	hsa-miR-3189-5p	CLIP-seq
MIRT2452044	hsa-miR-3192	CLIP-seq
MIRT2554034	hsa-miR-3202	CLIP-seq
MIRT2554035	hsa-miR-324-3p	CLIP-seq
MIRT2554036	hsa-miR-337-3p	CLIP-seq
MIRT2683056	hsa-miR-381	CLIP-seq
MIRT2452045	hsa-miR-4314	CLIP-seq
MIRT2554038	hsa-miR-4456	CLIP-seq
MIRT2452046	hsa-miR-4463	CLIP-seq
MIRT2554039	hsa-miR-4464	CLIP-seq
MIRT2554041	hsa-miR-4533	CLIP-seq
MIRT2452047	hsa-miR-4646-5p	CLIP-seq
MIRT2683057	hsa-miR-4666-3p	CLIP-seq
MIRT2554044	hsa-miR-4733-3p	CLIP-seq
MIRT2554045	hsa-miR-4748	CLIP-seq
MIRT2554046	hsa-miR-4758-3p	CLIP-seq
MIRT2683058	hsa-miR-4789-5p	CLIP-seq
MIRT1075182	hsa-miR-513c	CLIP-seq
MIRT1075183	hsa-miR-514b-5p	CLIP-seq
MIRT2683059	hsa-miR-515-5p	CLIP-seq
MIRT2554047	hsa-miR-516a-3p	CLIP-seq
MIRT2554048	hsa-miR-541	CLIP-seq
MIRT2554049	hsa-miR-558	CLIP-seq
MIRT2683060	hsa-miR-579	CLIP-seq
MIRT2683061	hsa-miR-624	CLIP-seq
MIRT2554050	hsa-miR-654-5p	CLIP-seq
MIRT2554051	hsa-miR-659	CLIP-seq
MIRT2554054	hsa-miR-874	CLIP-seq
MIRT1075192	hsa-miR-942	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004860	Function	Protein kinase inhibitor activity	IBA
GO:0004860	Function	Protein kinase inhibitor activity	IEA
GO:0005515	Function	Protein binding	IPI	25464930, 32296183, 35271311
GO:0005634	Component	Nucleus	IEA
GO:0005640	Component	Nuclear outer membrane	IEA
GO:0005640	Component	Nuclear outer membrane	ISS
GO:0005886	Component	Plasma membrane	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0008625	Process	Extrinsic apoptotic signaling pathway via death domain receptors	IEA
GO:0009968	Process	Negative regulation of signal transduction	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:1902042	Process	Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IEA

MIM	HGNC	e!Ensembl
620205	29370	ENSG00000148841

Q8IWB1

Protein name

Inositol 1,4,5-trisphosphate receptor-interacting protein (Protein DANGER)

Protein function

Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03281	Mab-21	280 → 483	Mab-21 protein	Family

Tissue specificity

TISSUE SPECIFICITY: Detected in brain where it is concentrated in cerebellar Purkinje cells (at protein level). {ECO:0000269|PubMed:16990268}.

Sequence

MAMGLFRVCLVVVTAIINHPLLFPRENATVPENEEEIIRKMQAHQEKLQLEQLRLEEEVA
RLAAEKEALEQVAEEGRQQNETRVAWDLWSTLCMILFLMIEVWRQDHQEGPSPECLGGEE
DELPGLGGAPLQGLTLPNKATLGHFYERCIRGATADAARTREFLEGFVDDLLEALRSLCN
RDTDMEVEDFIGVDSMYENWQVDRPLLCHLFVPFTPPEPYRFHPELWCSGRSVPLDRQGY
GQIKVVRADGDTLSCICGKTKLGEDMLCLLHGRNSMAPPCGDMENLLCATDSLYLDTMQV
MKWFQTALTRAWKGIAHKYEFDLAFGQLDSPGSLKIKFRSGKFMPFNLIPVIQCDDSDLY
FVSHLPREPSEGTPASSTDWLLSFAVYERHFLRTTLKALPEGACHLSCLQIASFLLSKQS
RLTGPSGLSSYHLKTALLHLLLLRQAADWKAGQLDARLHELLCFLEKSLLQKKLHHFFIG
NRKVPEAMGLPEAVLRAEPLNLFRPFVLQRSLYRKTLDSFYEMLKNAPALISEYSLHVPS
DQPTPKS

Sequence length

547

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
UTERINE FIBROID	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Lupus Nephritis	Lupus Nephritis	BEFREE	26223295		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28504304		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	BEFREE	26537080		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	26537080	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

ITPRIP (inositol 1,4,5-trisphosphate receptor interacting protein)