Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	85443
Gene name	Doublecortin like kinase 3
Gene symbol	DCLK3
Synonyms (NCBI Gene)	CLRDCAMKL3DCDC3CDCK3
Chromosome	3
Chromosome location	3p22.2

158

Show/Hide all (158)

miRTarBase ID	miRNA	Experiments	Reference
MIRT721220	hsa-miR-548at-5p	HITS-CLIP	19536157
MIRT721219	hsa-miR-186-3p	HITS-CLIP	19536157
MIRT721218	hsa-miR-6793-3p	HITS-CLIP	19536157
MIRT721217	hsa-miR-6892-3p	HITS-CLIP	19536157
MIRT721216	hsa-miR-2276-5p	HITS-CLIP	19536157
MIRT721215	hsa-miR-877-3p	HITS-CLIP	19536157
MIRT721214	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT721213	hsa-miR-2355-5p	HITS-CLIP	19536157
MIRT721212	hsa-miR-642a-5p	HITS-CLIP	19536157
MIRT643789	hsa-miR-362-5p	HITS-CLIP	23824327
MIRT643788	hsa-miR-500b-5p	HITS-CLIP	23824327
MIRT643787	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT643786	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT643785	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT643784	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT643783	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT643782	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT643781	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT643780	hsa-miR-3191-5p	HITS-CLIP	23824327
MIRT643779	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT643778	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT643777	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT721220	hsa-miR-548at-5p	HITS-CLIP	19536157
MIRT721219	hsa-miR-186-3p	HITS-CLIP	19536157
MIRT721218	hsa-miR-6793-3p	HITS-CLIP	19536157
MIRT721217	hsa-miR-6892-3p	HITS-CLIP	19536157
MIRT721216	hsa-miR-2276-5p	HITS-CLIP	19536157
MIRT721215	hsa-miR-877-3p	HITS-CLIP	19536157
MIRT721214	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT721213	hsa-miR-2355-5p	HITS-CLIP	19536157
MIRT721212	hsa-miR-642a-5p	HITS-CLIP	19536157
MIRT643789	hsa-miR-362-5p	HITS-CLIP	23824327
MIRT643788	hsa-miR-500b-5p	HITS-CLIP	23824327
MIRT643787	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT643786	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT643785	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT643784	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT643783	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT643782	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT643781	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT643780	hsa-miR-3191-5p	HITS-CLIP	23824327
MIRT643779	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT643778	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT643777	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT926189	hsa-miR-1226	CLIP-seq
MIRT926190	hsa-miR-129-5p	CLIP-seq
MIRT926191	hsa-miR-2113	CLIP-seq
MIRT926192	hsa-miR-218	CLIP-seq
MIRT926193	hsa-miR-4289	CLIP-seq
MIRT926194	hsa-miR-4474-3p	CLIP-seq
MIRT926195	hsa-miR-451b	CLIP-seq
MIRT926196	hsa-miR-4640-3p	CLIP-seq
MIRT926197	hsa-miR-4687-3p	CLIP-seq
MIRT926198	hsa-miR-4733-3p	CLIP-seq
MIRT926199	hsa-miR-556-3p	CLIP-seq
MIRT926200	hsa-miR-605	CLIP-seq
MIRT926201	hsa-miR-626	CLIP-seq
MIRT926202	hsa-miR-634	CLIP-seq
MIRT926203	hsa-miR-664	CLIP-seq
MIRT926204	hsa-miR-885-5p	CLIP-seq
MIRT926189	hsa-miR-1226	CLIP-seq
MIRT926191	hsa-miR-2113	CLIP-seq
MIRT926192	hsa-miR-218	CLIP-seq
MIRT926198	hsa-miR-4733-3p	CLIP-seq
MIRT926201	hsa-miR-626	CLIP-seq
MIRT926202	hsa-miR-634	CLIP-seq
MIRT926189	hsa-miR-1226	CLIP-seq
MIRT926191	hsa-miR-2113	CLIP-seq
MIRT926192	hsa-miR-218	CLIP-seq
MIRT926198	hsa-miR-4733-3p	CLIP-seq
MIRT926201	hsa-miR-626	CLIP-seq
MIRT926202	hsa-miR-634	CLIP-seq
MIRT926189	hsa-miR-1226	CLIP-seq
MIRT926191	hsa-miR-2113	CLIP-seq
MIRT926192	hsa-miR-218	CLIP-seq
MIRT926198	hsa-miR-4733-3p	CLIP-seq
MIRT926201	hsa-miR-626	CLIP-seq
MIRT926202	hsa-miR-634	CLIP-seq
MIRT1974385	hsa-let-7a	CLIP-seq
MIRT1974386	hsa-let-7b	CLIP-seq
MIRT1974387	hsa-let-7c	CLIP-seq
MIRT1974388	hsa-let-7d	CLIP-seq
MIRT1974389	hsa-let-7e	CLIP-seq
MIRT1974390	hsa-let-7f	CLIP-seq
MIRT1974391	hsa-let-7g	CLIP-seq
MIRT1974392	hsa-let-7i	CLIP-seq
MIRT1974393	hsa-miR-1285	CLIP-seq
MIRT1974394	hsa-miR-202	CLIP-seq
MIRT926192	hsa-miR-218	CLIP-seq
MIRT1974395	hsa-miR-3065-3p	CLIP-seq
MIRT1974396	hsa-miR-3187-5p	CLIP-seq
MIRT1974397	hsa-miR-370	CLIP-seq
MIRT1974398	hsa-miR-4458	CLIP-seq
MIRT1974399	hsa-miR-4461	CLIP-seq
MIRT1974400	hsa-miR-4500	CLIP-seq
MIRT1974401	hsa-miR-4731-5p	CLIP-seq
MIRT1974402	hsa-miR-4763-5p	CLIP-seq
MIRT1974403	hsa-miR-4775	CLIP-seq
MIRT1974404	hsa-miR-514	CLIP-seq
MIRT1974405	hsa-miR-514b-3p	CLIP-seq
MIRT1974406	hsa-miR-612	CLIP-seq
MIRT926201	hsa-miR-626	CLIP-seq
MIRT1974407	hsa-miR-98	CLIP-seq
MIRT1974385	hsa-let-7a	CLIP-seq
MIRT1974386	hsa-let-7b	CLIP-seq
MIRT1974387	hsa-let-7c	CLIP-seq
MIRT1974388	hsa-let-7d	CLIP-seq
MIRT1974389	hsa-let-7e	CLIP-seq
MIRT1974390	hsa-let-7f	CLIP-seq
MIRT1974391	hsa-let-7g	CLIP-seq
MIRT1974392	hsa-let-7i	CLIP-seq
MIRT1974394	hsa-miR-202	CLIP-seq
MIRT2209860	hsa-miR-203	CLIP-seq
MIRT2209861	hsa-miR-3652	CLIP-seq
MIRT2209862	hsa-miR-4430	CLIP-seq
MIRT2209863	hsa-miR-4432	CLIP-seq
MIRT1974398	hsa-miR-4458	CLIP-seq
MIRT1974399	hsa-miR-4461	CLIP-seq
MIRT2209864	hsa-miR-4488	CLIP-seq
MIRT2209865	hsa-miR-4492	CLIP-seq
MIRT2209866	hsa-miR-4498	CLIP-seq
MIRT2209867	hsa-miR-4499	CLIP-seq
MIRT1974400	hsa-miR-4500	CLIP-seq
MIRT2209868	hsa-miR-4638-3p	CLIP-seq
MIRT2209869	hsa-miR-4697-5p	CLIP-seq
MIRT2209870	hsa-miR-499-5p	CLIP-seq
MIRT1974404	hsa-miR-514	CLIP-seq
MIRT1974405	hsa-miR-514b-3p	CLIP-seq
MIRT2209871	hsa-miR-548g	CLIP-seq
MIRT2209872	hsa-miR-637	CLIP-seq
MIRT2209873	hsa-miR-642b	CLIP-seq
MIRT2209874	hsa-miR-762	CLIP-seq
MIRT1974407	hsa-miR-98	CLIP-seq
MIRT1974385	hsa-let-7a	CLIP-seq
MIRT1974386	hsa-let-7b	CLIP-seq
MIRT1974387	hsa-let-7c	CLIP-seq
MIRT1974388	hsa-let-7d	CLIP-seq
MIRT1974389	hsa-let-7e	CLIP-seq
MIRT1974390	hsa-let-7f	CLIP-seq
MIRT1974391	hsa-let-7g	CLIP-seq
MIRT1974392	hsa-let-7i	CLIP-seq
MIRT2386776	hsa-miR-1236	CLIP-seq
MIRT2386777	hsa-miR-145	CLIP-seq
MIRT2386778	hsa-miR-1825	CLIP-seq
MIRT2386779	hsa-miR-190	CLIP-seq
MIRT2386780	hsa-miR-190b	CLIP-seq
MIRT2386781	hsa-miR-199a-5p	CLIP-seq
MIRT2386782	hsa-miR-199b-5p	CLIP-seq
MIRT1974394	hsa-miR-202	CLIP-seq
MIRT1974398	hsa-miR-4458	CLIP-seq
MIRT1974399	hsa-miR-4461	CLIP-seq
MIRT1974400	hsa-miR-4500	CLIP-seq
MIRT1974404	hsa-miR-514	CLIP-seq
MIRT1974405	hsa-miR-514b-3p	CLIP-seq
MIRT2386783	hsa-miR-593	CLIP-seq
MIRT2209873	hsa-miR-642b	CLIP-seq
MIRT2386784	hsa-miR-654-3p	CLIP-seq
MIRT1974407	hsa-miR-98	CLIP-seq

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0034504	Process	Protein localization to nucleus	IBA
GO:0106310	Function	Protein serine kinase activity	IEA

MIM	HGNC	e!Ensembl
613167	19005	ENSG00000163673

Q9C098

Protein name

Serine/threonine-protein kinase DCLK3 (EC 2.7.11.1) (Doublecortin domain-containing protein 3C) (Doublecortin-like and CAM kinase-like 3) (Doublecortin-like kinase 3)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	356 → 613	Protein kinase domain	Domain

Sequence

MGKEPLTLKSIQVAVEELYPNKARALTLAQHSRAPSPRLRSRLFSKALKGDHRCGETETP
KSCSEVAGCKAAMRHQGKIPEELSLDDRARTQKKWGRGKWEPEPSSKPPREATLEERHAR
GEKHLGVEIEKTSGEIIRCEKCKRERELQQSLERERLSLGTSELDMGKGPMYDVEKLVRT
RSCRRSPEANPASGEEGWKGDSHRSSPRNPTQELRRPSKSMDKKEDRGPEDQESHAQGAA
KAKKDLVEVLPVTEEGLREVKKDTRPMSRSKHGGWLLREHQAGFEKLRRTRGEEKEAEKE
KKPCMSGGRRMTLRDDQPAKLEKEPKTRPEENKPERPSGRKPRPMGIIAANVEKHYETGR
VIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKEDMVDSEILIIQSLSHPNIVKLHEV
YETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKALVHMHDKSIVHRDLKP
ENLLVQRNEDKSTTLKLADFGLAKHVVRPIFTVCGTPTYVAPEILSEKGYGLEVDMWAAG
VILYILLCGFPPFRSPERDQDELFNIIQLGHFEFLPPYWDNISDAAKDLVSRLLVVDPKK
RYTAHQVLQHPWIETAGKTNTVKRQKQVSPSSEGHFRSQHKRVVEQVS

Sequence length

648

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (30)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma of large intestine	Colorectal Cancer	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Angle Closure Glaucoma	Angle Closure Glaucoma	BEFREE	17608625		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arteriosclerosis	Arteriosclerosis	BEFREE	30867470		★★★★★ ★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	BEFREE	25010197		★★★★★ ★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	BEFREE	30867470		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar disorder	Pubtator	40562893	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinomatosis of peritoneal cavity	Peritoneal Carcinomatosis	BEFREE	30224373		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	BEFREE	28904253		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cervical Intraepithelial Neoplasia	Cervical Intraepithelial Neoplasia	BEFREE	23024775		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	28195176	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	23969937		★★★★★ ★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	BEFREE	26400621		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ewings sarcoma	Ewing sarcoma	BEFREE	30926646		★★★★★ ★☆☆☆☆ Found in Text Mining only
Huntington Disease	Huntington Disease	BEFREE	29534157		★★★★★ ★☆☆☆☆ Found in Text Mining only
Immune System Diseases	Immune System Diseases	BEFREE	15771576		★★★★★ ★☆☆☆☆ Found in Text Mining only
Infiltrating duct carcinoma of female breast	Infiltrating Duct Carcinoma Of Female Breast	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Large cell carcinoma of lung	Lung Carcinoma	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	30224373		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	23969937, 28195176, 29534157		★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	36353633, 37991344	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Migraine Disorders	Migraine	BEFREE	30550780		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	17914117, 19610056, 23969937, 26762744, 30224373, 30926646, 31150417		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	30926646		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pilocytic Astrocytoma	Astrocytoma	BEFREE	21458987		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	26275430		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of lung	Lung carcinoma	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	29641256		★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	36131933	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Varicosity	Vulval varices	BEFREE	22484227		★★★★★ ★☆☆☆☆ Found in Text Mining only

DCLK3 (doublecortin like kinase 3)