Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	8509
Gene name	N-deacetylase and N-sulfotransferase 2
Gene symbol	NDST2
Synonyms (NCBI Gene)	HSST2N-HSST 2NST2
Chromosome	10
Chromosome location	10q22.2
Summary	This gene encodes a member of the N-deacetylase/N-sulfotransferase subfamily of the sulfotransferase 1 proteins. The encoded enzyme has dual functions in processing glucosamine and heparin polymers, including N-deacetylation and N-sulfation. The encoded p

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miRTarBase ID	miRNA	Experiments
MIRT1178437	hsa-miR-1909	CLIP-seq
MIRT1178438	hsa-miR-2355-3p	CLIP-seq
MIRT1178439	hsa-miR-3153	CLIP-seq
MIRT1178440	hsa-miR-3162-5p	CLIP-seq
MIRT1178441	hsa-miR-4318	CLIP-seq
MIRT1178442	hsa-miR-4646-3p	CLIP-seq
MIRT1178443	hsa-miR-4648	CLIP-seq
MIRT1178444	hsa-miR-4654	CLIP-seq
MIRT1178445	hsa-miR-4668-5p	CLIP-seq
MIRT1178446	hsa-miR-4769-5p	CLIP-seq
MIRT2051660	hsa-miR-150	CLIP-seq
MIRT1178438	hsa-miR-2355-3p	CLIP-seq
MIRT1178439	hsa-miR-3153	CLIP-seq
MIRT1178440	hsa-miR-3162-5p	CLIP-seq
MIRT1178441	hsa-miR-4318	CLIP-seq
MIRT1178442	hsa-miR-4646-3p	CLIP-seq
MIRT1178443	hsa-miR-4648	CLIP-seq
MIRT1178444	hsa-miR-4654	CLIP-seq
MIRT1178445	hsa-miR-4668-5p	CLIP-seq
MIRT1178446	hsa-miR-4769-5p	CLIP-seq
MIRT2051660	hsa-miR-150	CLIP-seq
MIRT2280715	hsa-miR-4728-5p	CLIP-seq
MIRT2454988	hsa-miR-1291	CLIP-seq
MIRT2454989	hsa-miR-1913	CLIP-seq
MIRT2454990	hsa-miR-3173-5p	CLIP-seq
MIRT2454991	hsa-miR-3194-3p	CLIP-seq
MIRT2454992	hsa-miR-324-3p	CLIP-seq
MIRT2454993	hsa-miR-378	CLIP-seq
MIRT2454994	hsa-miR-378b	CLIP-seq
MIRT2454995	hsa-miR-378c	CLIP-seq
MIRT2454996	hsa-miR-378d	CLIP-seq
MIRT2454997	hsa-miR-378e	CLIP-seq
MIRT2454998	hsa-miR-378f	CLIP-seq
MIRT2454999	hsa-miR-378h	CLIP-seq
MIRT2455000	hsa-miR-378i	CLIP-seq
MIRT2455001	hsa-miR-422a	CLIP-seq
MIRT2455002	hsa-miR-4535	CLIP-seq
MIRT2455003	hsa-miR-4638-3p	CLIP-seq
MIRT2455004	hsa-miR-4749-3p	CLIP-seq
MIRT2455005	hsa-miR-492	CLIP-seq
MIRT2579175	hsa-miR-103b	CLIP-seq
MIRT2579176	hsa-miR-1224-3p	CLIP-seq
MIRT2579177	hsa-miR-1254	CLIP-seq
MIRT2579178	hsa-miR-1321	CLIP-seq
MIRT2579179	hsa-miR-1470	CLIP-seq
MIRT2051660	hsa-miR-150	CLIP-seq
MIRT2579180	hsa-miR-181a	CLIP-seq
MIRT2579181	hsa-miR-181b	CLIP-seq
MIRT2579182	hsa-miR-181c	CLIP-seq
MIRT2579183	hsa-miR-181d	CLIP-seq
MIRT2579184	hsa-miR-3116	CLIP-seq
MIRT2579185	hsa-miR-3156-3p	CLIP-seq
MIRT1178440	hsa-miR-3162-5p	CLIP-seq
MIRT2579186	hsa-miR-3620	CLIP-seq
MIRT2579187	hsa-miR-3690	CLIP-seq
MIRT2579188	hsa-miR-374c	CLIP-seq
MIRT2579189	hsa-miR-3927	CLIP-seq
MIRT2579190	hsa-miR-3936	CLIP-seq
MIRT2579191	hsa-miR-4262	CLIP-seq
MIRT2579192	hsa-miR-4286	CLIP-seq
MIRT2579193	hsa-miR-4301	CLIP-seq
MIRT2579194	hsa-miR-4509	CLIP-seq
MIRT2579195	hsa-miR-451b	CLIP-seq
MIRT2579196	hsa-miR-4667-3p	CLIP-seq
MIRT2579197	hsa-miR-4676-5p	CLIP-seq
MIRT2579198	hsa-miR-4691-5p	CLIP-seq
MIRT2579199	hsa-miR-4708-3p	CLIP-seq
MIRT2579200	hsa-miR-4713-5p	CLIP-seq
MIRT2579201	hsa-miR-4739	CLIP-seq
MIRT2579202	hsa-miR-4756-5p	CLIP-seq
MIRT2579203	hsa-miR-4794	CLIP-seq
MIRT2579204	hsa-miR-532-3p	CLIP-seq
MIRT2579205	hsa-miR-548m	CLIP-seq
MIRT2579206	hsa-miR-575	CLIP-seq
MIRT2579207	hsa-miR-615-5p	CLIP-seq
MIRT2579208	hsa-miR-655	CLIP-seq
MIRT2579209	hsa-miR-661	CLIP-seq
MIRT2579210	hsa-miR-711	CLIP-seq
MIRT2579176	hsa-miR-1224-3p	CLIP-seq
MIRT2579177	hsa-miR-1254	CLIP-seq
MIRT2579178	hsa-miR-1321	CLIP-seq
MIRT2051660	hsa-miR-150	CLIP-seq
MIRT2579180	hsa-miR-181a	CLIP-seq
MIRT2579181	hsa-miR-181b	CLIP-seq
MIRT2579182	hsa-miR-181c	CLIP-seq
MIRT2579183	hsa-miR-181d	CLIP-seq
MIRT2579184	hsa-miR-3116	CLIP-seq
MIRT2579185	hsa-miR-3156-3p	CLIP-seq
MIRT1178440	hsa-miR-3162-5p	CLIP-seq
MIRT2579186	hsa-miR-3620	CLIP-seq
MIRT2579187	hsa-miR-3690	CLIP-seq
MIRT2579188	hsa-miR-374c	CLIP-seq
MIRT2579189	hsa-miR-3927	CLIP-seq
MIRT2579191	hsa-miR-4262	CLIP-seq
MIRT2579192	hsa-miR-4286	CLIP-seq
MIRT2579193	hsa-miR-4301	CLIP-seq
MIRT2579194	hsa-miR-4509	CLIP-seq
MIRT2579198	hsa-miR-4691-5p	CLIP-seq
MIRT2579201	hsa-miR-4739	CLIP-seq
MIRT2579202	hsa-miR-4756-5p	CLIP-seq
MIRT2579203	hsa-miR-4794	CLIP-seq
MIRT2579205	hsa-miR-548m	CLIP-seq
MIRT2579208	hsa-miR-655	CLIP-seq
MIRT2579209	hsa-miR-661	CLIP-seq
MIRT2579210	hsa-miR-711	CLIP-seq

Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0002002	Process	Regulation of angiotensin levels in blood	IEA
GO:0002448	Process	Mast cell mediated immunity	IEA
GO:0003824	Function	Catalytic activity	IEA
GO:0005794	Component	Golgi apparatus	IBA
GO:0005794	Component	Golgi apparatus	IEA
GO:0008146	Function	Sulfotransferase activity	IEA
GO:0015012	Process	Heparan sulfate proteoglycan biosynthetic process	IBA
GO:0015012	Process	Heparan sulfate proteoglycan biosynthetic process	IEA
GO:0015012	Process	Heparan sulfate proteoglycan biosynthetic process	TAS
GO:0015016	Function	Heparan sulfate N-sulfotransferase activity	IBA
GO:0015016	Function	Heparan sulfate N-sulfotransferase activity	IEA
GO:0015016	Function	Heparan sulfate N-sulfotransferase activity	TAS
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	9601056
GO:0016740	Function	Transferase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0019213	Function	Deacetylase activity	IBA
GO:0019213	Function	Deacetylase activity	IEA
GO:0030210	Process	Heparin proteoglycan biosynthetic process	IEA
GO:0050119	Function	N-acetylglucosamine deacetylase activity	IEA
GO:0050119	Function	N-acetylglucosamine deacetylase activity	TAS
GO:0102140	Function	Heparan sulfate N-deacetylase activity	IEA

MIM	HGNC	e!Ensembl
603268	7681	ENSG00000166507

P52849

Protein name

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 (EC 2.8.2.8) (Glucosaminyl N-deacetylase/N-sulfotransferase 2) (NDST-2) (N-heparan sulfate sulfotransferase 2) (N-HSST 2) [Includes: Heparan sulfate N-deacetylase 2 (EC 3.-.-.-); Heparan sulf

Protein function

Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated hepa

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12062	HSNSD	24 → 514	heparan sulfate-N-deacetylase	Family
PF00685	Sulfotransfer_1	603 → 866	Sulfotransferase domain	Domain

Sequence

MLQLWKVVRPARQLELHRLILLLIAFSLGSMGFLAYYVSTSPKAKEPLPLPLGDCSSGGA
AGPGPARPPVPPRPPRPPETARTEPVVLVFVESAYSQLGQEIVAILESSRFRYSTELAPG
RGDMPTLTDNTHGRYVLVIYENLLKYVNLDAWSRELLDRYCVEYGVGIIGFFRAHEHSLL
SAQLKGFPLFLHSNLGLRDYQVNPSAPLLHLTRPSRLEPGPLPGDDWTIFQSNHSTYEPV
LLASLRPAEPAVPGPVLRRARLPTVVQDLGLHDGIQRVLFGHGLSFWLHKLIFVDAVAYL
TGKRLCLDLDRYILVDIDDIFVGKEGTRMKVADVEALLTTQNKLRTLVPNFTFNLGFSGK
FYHTGTEEEDAGDDMLLKHRKEFWWFPHMWSHMQPHLFHNRSVLADQMRLNKQFALEHGI
PTDLGYAVAPHHSGVYPIHTQLYEAWKSVWGIQVTSTEEYPHLRPARYRRGFIHNGIMVL
PRQTCGLFTHTIFYNEYPGGSRELDRSIRGGELFLTVLLNPISIFMTHLSNYGNDRLGLY
TFESLVRFLQCWTRLRLQTLPPVPLAQKYFELFPQERSPLWQNPCDDKRHKDIWSKEKTC
DRLPKFLIVGPQKTGTTAIHFFLSLHPAVTSSFPSPSTFEEIQFFNSPNYHKGIDWYMDF
FPVPSNASTDFLFEKSATYFDSEVVPRRGAALLPRAKIITVLTNPADRAYSWYQHQRAHG
DPVALNYTFYQVISASSQTPLALRSLQNRCLVPGYYSTHLQRWLTYYPSGQLLIVDGQEL
RTNPAASMESIQKFLGITPFLNYTRTLRFDDDKGFWCQGLEGGKTRCLGRSKGRRYPDMD
TESRLFLTDFFRNHNLELSKLLSRLGQPVPSWLREELQHSSLG

Sequence length

883

Interactions

View interactions

	KEGG		Reactome
	Glycosaminoglycan biosynthesis - heparan sulfate / heparin Metabolic pathways		HS-GAG biosynthesis

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Anophthalmia-microphthalmia syndrome	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATIC NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Glioma	Glioma	Pubtator	29104277	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	34637697	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	CTD_human_DG	29610475		★★★★★ ★☆☆☆☆ Found in Text Mining only
Meningioma	Meningioma	Pubtator	11535722	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	CTD_human_DG	29610475		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

NDST2 (N-deacetylase and N-sulfotransferase 2)