TMEM60 (transmembrane protein 60)

Gene

• Entrez ID: 85025
• Gene name: Transmembrane protein 60
• Gene symbol: TMEM60
• Synonyms (NCBI Gene): C7orf35, DC32
• Chromosome: 7
• Chromosome location: 7q11.23

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT439428	ebv-miR-BART13-3p	HITS-CLIP	22473208
MIRT439428	ebv-miR-BART13-3p	HITS-CLIP	22473208
MIRT1438228	hsa-miR-105	CLIP-seq
MIRT1438229	hsa-miR-127-5p	CLIP-seq
MIRT1438230	hsa-miR-197	CLIP-seq
MIRT1438231	hsa-miR-2117	CLIP-seq
MIRT1438232	hsa-miR-3120-3p	CLIP-seq
MIRT1438233	hsa-miR-3163	CLIP-seq
MIRT1438234	hsa-miR-320e	CLIP-seq
MIRT1438235	hsa-miR-326	CLIP-seq
MIRT1438236	hsa-miR-330-5p	CLIP-seq
MIRT1438237	hsa-miR-3942-5p	CLIP-seq
MIRT1438238	hsa-miR-4277	CLIP-seq
MIRT1438239	hsa-miR-4427	CLIP-seq
MIRT1438240	hsa-miR-4446-5p	CLIP-seq
MIRT1438241	hsa-miR-4490	CLIP-seq
MIRT1438242	hsa-miR-4635	CLIP-seq
MIRT1438243	hsa-miR-4703-5p	CLIP-seq
MIRT1438244	hsa-miR-4728-3p	CLIP-seq
MIRT1438245	hsa-miR-4755-5p	CLIP-seq
MIRT1438246	hsa-miR-4774-5p	CLIP-seq
MIRT1438247	hsa-miR-526b	CLIP-seq
MIRT1438248	hsa-miR-548a-3p	CLIP-seq
MIRT1438249	hsa-miR-548e	CLIP-seq
MIRT1438250	hsa-miR-548f	CLIP-seq
MIRT1438251	hsa-miR-563	CLIP-seq
MIRT1438252	hsa-miR-630	CLIP-seq
MIRT1438253	hsa-miR-642a	CLIP-seq
MIRT1438254	hsa-miR-653	CLIP-seq
MIRT1438255	hsa-miR-888	CLIP-seq
MIRT2131292	hsa-miR-143	CLIP-seq
MIRT1438231	hsa-miR-2117	CLIP-seq
MIRT1438232	hsa-miR-3120-3p	CLIP-seq
MIRT2131293	hsa-miR-3171	CLIP-seq
MIRT1438235	hsa-miR-326	CLIP-seq
MIRT1438236	hsa-miR-330-5p	CLIP-seq
MIRT1438237	hsa-miR-3942-5p	CLIP-seq
MIRT1438238	hsa-miR-4277	CLIP-seq
MIRT2131294	hsa-miR-4428	CLIP-seq
MIRT1438240	hsa-miR-4446-5p	CLIP-seq
MIRT1438241	hsa-miR-4490	CLIP-seq
MIRT1438243	hsa-miR-4703-5p	CLIP-seq
MIRT1438245	hsa-miR-4755-5p	CLIP-seq
MIRT2131295	hsa-miR-4770	CLIP-seq
MIRT1438246	hsa-miR-4774-5p	CLIP-seq
MIRT1438253	hsa-miR-642a	CLIP-seq
MIRT1438254	hsa-miR-653	CLIP-seq
MIRT1438229	hsa-miR-127-5p	CLIP-seq
MIRT1438242	hsa-miR-4635	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0016020	Component	Membrane	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q9H2L4
• Protein name: Transmembrane protein 60
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10269	Tmemb_185A	25 → 132	Transmembrane Fragile-X-F protein	Family

• Sequence:

  MRMSLAQRVLLTWLFTLLFLIMLVLKLDEKAPWNWFLIFIPVWIFDTILLVLLIVKMAGR
  CKSGFDPRHGSHNIKKKAWYLIAMLLKLAFCLALCAKLEQFTTMNLSYVFIPLWALLAGA
  LTELGYNVFFVRD

• Sequence length: 133

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CHRONIC KIDNEY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Arthritis	Arthritis	BEFREE	30336338		★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune Diseases	BEFREE	30336338		★☆☆☆☆ Found in Text Mining only
Chronic Kidney Diseases	Kidney Disease	BEFREE	20383146		★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	BEFREE	31228817		★☆☆☆☆ Found in Text Mining only
Pulmonary Arterial Hypertension	Pulmonary arterial hypertension	Pubtator	33680092	Associate	★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	30336338		★☆☆☆☆ Found in Text Mining only
Scleroderma Systemic	Systemic sclerosis	Pubtator	33680092	Associate	★☆☆☆☆ Found in Text Mining only
Synovitis	Synovitis	BEFREE	30336338, 31228817		★☆☆☆☆ Found in Text Mining only