Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	84967
Gene name	LSM10, U7 small nuclear RNA associated
Gene symbol	LSM10
Synonyms (NCBI Gene)	MST074MSTP074
Chromosome	1
Chromosome location	1p34.3

111

Show/Hide all (111)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022146	hsa-miR-124-3p	Microarray	18668037
MIRT031396	hsa-miR-16-5p	Proteomics	18668040
MIRT718678	hsa-miR-6817-3p	HITS-CLIP	19536157
MIRT718677	hsa-miR-518c-5p	HITS-CLIP	19536157
MIRT718676	hsa-miR-326	HITS-CLIP	19536157
MIRT718675	hsa-miR-330-5p	HITS-CLIP	19536157
MIRT718674	hsa-miR-6764-3p	HITS-CLIP	19536157
MIRT718673	hsa-miR-6824-3p	HITS-CLIP	19536157
MIRT718672	hsa-miR-4502	HITS-CLIP	19536157
MIRT718671	hsa-miR-378j	HITS-CLIP	19536157
MIRT718670	hsa-miR-6839-5p	HITS-CLIP	19536157
MIRT718669	hsa-miR-6715b-3p	HITS-CLIP	19536157
MIRT718668	hsa-miR-3191-5p	HITS-CLIP	19536157
MIRT718667	hsa-miR-4782-5p	HITS-CLIP	19536157
MIRT718666	hsa-miR-5706	HITS-CLIP	19536157
MIRT718665	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT656578	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT656576	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT656577	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT656575	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT718678	hsa-miR-6817-3p	HITS-CLIP	19536157
MIRT718677	hsa-miR-518c-5p	HITS-CLIP	19536157
MIRT718676	hsa-miR-326	HITS-CLIP	19536157
MIRT718675	hsa-miR-330-5p	HITS-CLIP	19536157
MIRT718674	hsa-miR-6764-3p	HITS-CLIP	19536157
MIRT718673	hsa-miR-6824-3p	HITS-CLIP	19536157
MIRT718672	hsa-miR-4502	HITS-CLIP	19536157
MIRT718671	hsa-miR-378j	HITS-CLIP	19536157
MIRT718670	hsa-miR-6839-5p	HITS-CLIP	19536157
MIRT718669	hsa-miR-6715b-3p	HITS-CLIP	19536157
MIRT718668	hsa-miR-3191-5p	HITS-CLIP	19536157
MIRT718667	hsa-miR-4782-5p	HITS-CLIP	19536157
MIRT718666	hsa-miR-5706	HITS-CLIP	19536157
MIRT718665	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT656578	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT656576	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT656577	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT656575	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT1121411	hsa-miR-219-1-3p	CLIP-seq
MIRT1121412	hsa-miR-3192	CLIP-seq
MIRT1121413	hsa-miR-3613-3p	CLIP-seq
MIRT1121414	hsa-miR-3942-3p	CLIP-seq
MIRT1121415	hsa-miR-4525	CLIP-seq
MIRT1121416	hsa-miR-4716-3p	CLIP-seq
MIRT1121417	hsa-miR-570	CLIP-seq
MIRT1121418	hsa-miR-606	CLIP-seq
MIRT2034344	hsa-miR-4455	CLIP-seq
MIRT2034345	hsa-miR-4683	CLIP-seq
MIRT1121411	hsa-miR-219-1-3p	CLIP-seq
MIRT1121412	hsa-miR-3192	CLIP-seq
MIRT1121417	hsa-miR-570	CLIP-seq
MIRT2264855	hsa-miR-587	CLIP-seq
MIRT1121418	hsa-miR-606	CLIP-seq
MIRT2442326	hsa-miR-3159	CLIP-seq
MIRT2442327	hsa-miR-3922-5p	CLIP-seq
MIRT2442328	hsa-miR-4314	CLIP-seq
MIRT2442329	hsa-miR-4320	CLIP-seq
MIRT2442330	hsa-miR-4717-5p	CLIP-seq
MIRT2442331	hsa-miR-4753-5p	CLIP-seq
MIRT2563759	hsa-miR-10a	CLIP-seq
MIRT2563760	hsa-miR-10b	CLIP-seq
MIRT2442326	hsa-miR-3159	CLIP-seq
MIRT2563761	hsa-miR-3174	CLIP-seq
MIRT1121412	hsa-miR-3192	CLIP-seq
MIRT2563762	hsa-miR-3689a-3p	CLIP-seq
MIRT2563763	hsa-miR-3689c	CLIP-seq
MIRT2563764	hsa-miR-3689d	CLIP-seq
MIRT2563765	hsa-miR-3714	CLIP-seq
MIRT2442327	hsa-miR-3922-5p	CLIP-seq
MIRT2442328	hsa-miR-4314	CLIP-seq
MIRT2442329	hsa-miR-4320	CLIP-seq
MIRT2563766	hsa-miR-4646-5p	CLIP-seq
MIRT2442330	hsa-miR-4717-5p	CLIP-seq
MIRT2563767	hsa-miR-4728-5p	CLIP-seq
MIRT2442331	hsa-miR-4753-5p	CLIP-seq
MIRT2563768	hsa-miR-488	CLIP-seq
MIRT2563769	hsa-miR-514	CLIP-seq
MIRT2563770	hsa-miR-514b-3p	CLIP-seq
MIRT2563771	hsa-miR-548an	CLIP-seq
MIRT2563772	hsa-miR-552	CLIP-seq
MIRT2563773	hsa-miR-627	CLIP-seq
MIRT2563774	hsa-miR-759	CLIP-seq
MIRT2563775	hsa-miR-924	CLIP-seq
MIRT2563759	hsa-miR-10a	CLIP-seq
MIRT2563760	hsa-miR-10b	CLIP-seq
MIRT2684251	hsa-miR-224	CLIP-seq
MIRT2442326	hsa-miR-3159	CLIP-seq
MIRT2563761	hsa-miR-3174	CLIP-seq
MIRT1121412	hsa-miR-3192	CLIP-seq
MIRT2563762	hsa-miR-3689a-3p	CLIP-seq
MIRT2563763	hsa-miR-3689c	CLIP-seq
MIRT2563764	hsa-miR-3689d	CLIP-seq
MIRT2563765	hsa-miR-3714	CLIP-seq
MIRT2684252	hsa-miR-3919	CLIP-seq
MIRT2442327	hsa-miR-3922-5p	CLIP-seq
MIRT1121414	hsa-miR-3942-3p	CLIP-seq
MIRT2442328	hsa-miR-4314	CLIP-seq
MIRT2442329	hsa-miR-4320	CLIP-seq
MIRT2563766	hsa-miR-4646-5p	CLIP-seq
MIRT2442330	hsa-miR-4717-5p	CLIP-seq
MIRT2563767	hsa-miR-4728-5p	CLIP-seq
MIRT2442331	hsa-miR-4753-5p	CLIP-seq
MIRT2684253	hsa-miR-4756-3p	CLIP-seq
MIRT2563768	hsa-miR-488	CLIP-seq
MIRT2563769	hsa-miR-514	CLIP-seq
MIRT2563770	hsa-miR-514b-3p	CLIP-seq
MIRT2563771	hsa-miR-548an	CLIP-seq
MIRT2264855	hsa-miR-587	CLIP-seq
MIRT2563773	hsa-miR-627	CLIP-seq
MIRT2563774	hsa-miR-759	CLIP-seq
MIRT2563775	hsa-miR-924	CLIP-seq

Show/Hide all (20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	12975319, 15231747, 16087681, 16189514, 19060904, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005683	Component	U7 snRNP	IDA	11574479
GO:0006397	Process	MRNA processing	IEA
GO:0006398	Process	MRNA 3'-end processing by stem-loop binding and cleavage	IBA
GO:0008380	Process	RNA splicing	IEA
GO:0015030	Component	Cajal body	IDA	11574479
GO:0016604	Component	Nuclear body	IBA
GO:0016604	Component	Nuclear body	IDA
GO:0071208	Function	Histone pre-mRNA DCP binding	IBA
GO:0071208	Function	Histone pre-mRNA DCP binding	IEA
GO:0071208	Function	Histone pre-mRNA DCP binding	ISS
GO:0071209	Function	U7 snRNA binding	IBA
GO:0071209	Function	U7 snRNA binding	IPI	18082603
GO:0071254	Component	Cytoplasmic U snRNP body	IBA
GO:1900087	Process	Positive regulation of G1/S transition of mitotic cell cycle	IMP	16914750
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
617909	17562	ENSG00000181817

Q969L4

Protein name

U7 snRNA-associated Sm-like protein LSm10

Protein function

Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases

PDB

6V4X

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01423	LSM	19 → 84	LSM domain	Domain

Sequence

MAVSHSVKERTISENSLIILLQGLQGRVTTVDLRDESVAHGRIDNVDAFMNIRLAKVTYT
DRWGHQVKLDDLFVTGRNVRYVHIPDDVNITSTIEQQLQIIHRVRNFGGKGQGRWEFPPK
NCK

Sequence length

123

Interactions

View interactions

	Reactome
			SLBP independent Processing of Histone Pre-mRNAs RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
DIVERTICULITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Fraser syndrome 3	Uncertain significance	ClinVar Disgenet	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)

LSM10 (LSM10, U7 small nuclear RNA associated)