PPP1R15B (protein phosphatase 1 regulatory subunit 15B)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID 84919
Gene name Protein phosphatase 1 regulatory subunit 15B
Gene symbol PPP1R15B
Synonyms (NCBI Gene)
CREPMSSGM2
Chromosome 1
Chromosome location 1q32.1
Summary This gene encodes a protein phosphatase I-interacting protein that promotes the dephosphorylation of eukaryotic translation initiation factor 2A to regulate translation under conditions of cellular stress. The transcribed messenger RNA contains two upstre
miRNA miRNA information provided by mirtarbase database.
2097
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (2097)
miRTarBase ID miRNA Experiments Reference
MIRT016665 hsa-miR-425-5p Sequencing 20371350
MIRT020212 hsa-miR-130b-3p Sequencing 20371350
MIRT024204 hsa-miR-221-3p Sequencing 20371350
MIRT028000 hsa-miR-93-5p Sequencing 20371350
MIRT031169 hsa-miR-19b-3p Sequencing 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (17)
GO ID Ontology Definition Evidence Reference
GO:0000164 Component Protein phosphatase type 1 complex IBA
GO:0000164 Component Protein phosphatase type 1 complex IDA 26307080
GO:0000164 Component Protein phosphatase type 1 complex IEA
GO:0000164 Component Protein phosphatase type 1 complex ISS
GO:0001933 Process Negative regulation of protein phosphorylation IMP 26307080
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
613257 14951 ENSG00000158615
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q5SWA1
Protein name Protein phosphatase 1 regulatory subunit 15B
Protein function Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1.
PDB 4V0U , 4V0V , 4V0W , 4V0X
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF10472 CReP_N 1 → 410 Domain
PF10488 PP1c_bdg 413 → 699 Phosphatase-1 catalytic subunit binding region Domain
Sequence
Sequence length 713
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (6)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Cervical cancer Benign; Likely benign ClinVar
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Microcephaly, short stature, and impaired glucose metabolism 2 Uncertain significance; Conflicting classifications of pathogenicity ClinVar
CTD, ClinVar, Disgenet, GenCC, HPO
CTD, ClinVar, Disgenet, GenCC, HPO
CTD, ClinVar, Disgenet, GenCC, HPO
CTD, ClinVar, Disgenet, GenCC, HPO
★★★★★
★★★☆☆
Reported in Unknown/Other Associations (≥2 sources)
PPP1R15B-related disorder Uncertain significance; Conflicting classifications of pathogenicity; Benign; Likely benign ClinVar
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PRIMARY MICROCEPHALY, MILD INTELLECTUAL DISABILITY, YOUNG-ONSET DIABETES SYNDROME — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (29)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acquired Kyphoscoliosis Acquired Kyphoscoliosis HPO_DG
★★★★★
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 23169272
★★★★★
★☆☆☆☆
Found in Text Mining only
Congenital kyphoscoliosis Congenital kyphoscoliosis HPO_DG
★★★★★
★☆☆☆☆
Found in Text Mining only
Congenital pectus excavatum Congenital Pectus Excavatum HPO_DG
★★★★★
★☆☆☆☆
Found in Text Mining only
Diabetes Diabetes BEFREE 26159176, 31615341
★★★★★
★☆☆☆☆
Found in Text Mining only
Diabetes Gestational Gestational diabetes Pubtator 34190178 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus Diabetes Mellitus BEFREE 26159176, 31615341
★★★★★
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus Diabetes mellitus Pubtator 26159176 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Dwarfism Dwarfism BEFREE 26307080
★★★★★
★☆☆☆☆
Found in Text Mining only
Dwarfism Dwarfism HPO_DG
★★★★★
★☆☆☆☆
Found in Text Mining only