Gene Gene information from NCBI Gene database.
Entrez ID 84912
Gene name Solute carrier family 35 member B4
Gene symbol SLC35B4
Synonyms (NCBI Gene)
YEAYEA4
Chromosome 7
Chromosome location 7q33
Summary Glycosyltransferases, such as SLC35B4, transport nucleotide sugars from the cytoplasm where they are synthesized, to the Golgi apparatus where they are utilized in the synthesis of glycoproteins, glycolipids, and proteoglycans (Ashikov et al., 2005 [PubMe
miRNA miRNA information provided by mirtarbase database.
907
miRTarBase ID miRNA Experiments Reference
MIRT019777 hsa-miR-375 Microarray 20215506
MIRT024912 hsa-miR-215-5p Microarray 19074876
MIRT025111 hsa-miR-181a-5p Sequencing 20371350
MIRT026219 hsa-miR-192-5p Microarray 19074876
MIRT050066 hsa-miR-26a-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
19
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IBA
GO:0000139 Component Golgi membrane TAS
GO:0005462 Function UDP-N-acetylglucosamine transmembrane transporter activity IBA
GO:0005462 Function UDP-N-acetylglucosamine transmembrane transporter activity IDA 15911612
GO:0005462 Function UDP-N-acetylglucosamine transmembrane transporter activity TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
610923 20584 ENSG00000205060
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q969S0
Protein name Nucleotide sugar transporter SLC35B4 (Solute carrier family 35 member B4) (UDP-xylose and UDP-N-acetylglucosamine transporter) (YEA4 homolog)
Protein function Antiporter that transports nucleotide sugars across the endoplasmic reticulum (ER) membrane in exchange for another nucleotide sugar. May couple UDP-alpha-D-glucuronate (UDP-GlcA) or UDP-alpha-D-xylose (UDP-Xyl) efflux to UDP-alpha-D-glucuronate
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08449 UAA 2 314 UAA transporter family Family
Sequence
Sequence length 331
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Transport of nucleotide sugars
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
INSOMNIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Diabetes Mellitus Diabetes mellitus Pubtator 29867058 Associate
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus Type 2 Diabetes mellitus, type 2 Pubtator 24455749 Associate
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of prostate Prostate cancer BEFREE 29682886
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of stomach Stomach Neoplasms BEFREE 31175271
★☆☆☆☆
Found in Text Mining only
Obesity Obesity BEFREE 21507882
★☆☆☆☆
Found in Text Mining only
Obesity Obesity Pubtator 24455749 Associate
★☆☆☆☆
Found in Text Mining only
Prostate carcinoma Prostate cancer BEFREE 29682886
★☆☆☆☆
Found in Text Mining only
Prostatic Neoplasms Prostatic neoplasm Pubtator 29682886 Associate
★☆☆☆☆
Found in Text Mining only
Stomach Carcinoma Stomach Carcinoma BEFREE 31175271
★☆☆☆☆
Found in Text Mining only