Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	84904
Gene name	Rho guanine nucleotide exchange factor 39
Gene symbol	ARHGEF39
Synonyms (NCBI Gene)	C9orf100XGEF
Chromosome	9
Chromosome location	9p13.3

123

Show/Hide all (123)

miRTarBase ID	miRNA	Experiments	Reference
MIRT624674	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT624673	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT680115	hsa-miR-764	HITS-CLIP	23824327
MIRT680114	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT624672	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT624671	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT680113	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT680112	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT680111	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT680110	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT680109	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT680108	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT680107	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT624670	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT680106	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT624669	hsa-miR-640	HITS-CLIP	23824327
MIRT678500	hsa-miR-582-3p	HITS-CLIP	23824327
MIRT678499	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT678498	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT678497	hsa-miR-5697	HITS-CLIP	23824327
MIRT678496	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT678495	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT678494	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT678493	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT678492	hsa-miR-1976	HITS-CLIP	23824327
MIRT678491	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT678490	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT678489	hsa-miR-1297	HITS-CLIP	23824327
MIRT678488	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT678487	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT678486	hsa-miR-4465	HITS-CLIP	23824327
MIRT678485	hsa-miR-513c-5p	HITS-CLIP	23824327
MIRT678484	hsa-miR-514b-5p	HITS-CLIP	23824327
MIRT678483	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT624674	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT624673	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT624672	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT624671	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT624670	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT624669	hsa-miR-640	HITS-CLIP	23824327
MIRT634838	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT634837	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT634836	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT634835	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT634834	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT634833	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT634832	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT634831	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT634830	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT634829	hsa-miR-4794	HITS-CLIP	23824327
MIRT634828	hsa-miR-664a-5p	HITS-CLIP	23824327
MIRT634827	hsa-miR-149-5p	HITS-CLIP	23824327
MIRT634826	hsa-miR-3064-5p	HITS-CLIP	23824327
MIRT634825	hsa-miR-6504-5p	HITS-CLIP	23824327
MIRT634824	hsa-miR-4284	HITS-CLIP	23824327
MIRT624674	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT624673	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT624672	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT624671	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT624670	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT624669	hsa-miR-640	HITS-CLIP	23824327
MIRT680114	hsa-miR-3934-5p	PAR-CLIP	27292025
MIRT624674	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT624673	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT680115	hsa-miR-764	HITS-CLIP	23824327
MIRT680114	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT624672	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT624671	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT680113	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT680112	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT680111	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT680110	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT680109	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT680108	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT680107	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT624670	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT680106	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT624669	hsa-miR-640	HITS-CLIP	23824327
MIRT678500	hsa-miR-582-3p	HITS-CLIP	23824327
MIRT678499	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT678498	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT678497	hsa-miR-5697	HITS-CLIP	23824327
MIRT678496	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT678495	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT678494	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT678493	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT678492	hsa-miR-1976	HITS-CLIP	23824327
MIRT678491	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT678490	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT678489	hsa-miR-1297	HITS-CLIP	23824327
MIRT678488	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT678487	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT678486	hsa-miR-4465	HITS-CLIP	23824327
MIRT678485	hsa-miR-513c-5p	HITS-CLIP	23824327
MIRT678484	hsa-miR-514b-5p	HITS-CLIP	23824327
MIRT678483	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT624674	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT624673	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT624672	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT624671	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT624670	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT624669	hsa-miR-640	HITS-CLIP	23824327
MIRT634838	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT634837	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT634836	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT634835	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT634834	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT634833	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT634832	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT634831	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT634830	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT634829	hsa-miR-4794	HITS-CLIP	23824327
MIRT634828	hsa-miR-664a-5p	HITS-CLIP	23824327
MIRT634827	hsa-miR-149-5p	HITS-CLIP	23824327
MIRT634826	hsa-miR-3064-5p	HITS-CLIP	23824327
MIRT634825	hsa-miR-6504-5p	HITS-CLIP	23824327
MIRT634824	hsa-miR-4284	HITS-CLIP	23824327
MIRT624674	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT624673	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT624672	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT624671	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT624670	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT624669	hsa-miR-640	HITS-CLIP	23824327

Show/Hide all (8)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 31515488, 33961781
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	22327280
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0030335	Process	Positive regulation of cell migration	IBA
GO:0030335	Process	Positive regulation of cell migration	IDA	22327280

MIM	HGNC	e!Ensembl
621172	25909	ENSG00000137135

Q8N4T4

Protein name

Rho guanine nucleotide exchange factor 39

Protein function

Promotes cell proliferation.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00621	RhoGEF	26 → 195	RhoGEF domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Strongly expressed in hepatocellular carcinoma (HCC) compared with their non-cancerous counterparts. {ECO:0000269|PubMed:22327280}.

Sequence

MELSCPGSRCPVQEQRARWERKRACTARELLETERRYQEQLGLVATYFLGILKAKGTLRP
PERQALFGSWELIYGASQELLPYLEGGCWGQGLEGFCRHLELYNQFAANSERSQTTLQEQ
LKKNKGFRRFVRLQEGRPEFGGLQLQDLLPLPLQRLQQYENLVVALAENTGPNSPDHQQL
TRAARLISETAQRVHTIGQKQKNDQHLRRVQALLSGRQAKGLTSGRWFLRQGWLLVVPPH
GEPRPRMFFLFTDVLLMAKPRPPLHLLRSGTFACKALYPMAQCHLSRVFGHSGGPCGGLL
SLSFPHEKLLLMSTDQEELSRWYHSLTWAISSQKN

Sequence length

335

Interactions

View interactions

	Reactome
			NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CARCINOMA, HEPATOCELLULAR	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (14)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Bipolar Disorder	Bipolar disorder	Pubtator	28289279	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	33413557	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	31626606	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Language Disorders	Language development disorders	Pubtator	28289279	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	22327280, 28871449, 29382922, 31626606		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	CTD_human_DG	28284560		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	34731623	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	28871449		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	31626606		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	29382922		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	29382922		★★★★★ ★☆☆☆☆ Found in Text Mining only
Specific Language Disorder	Specific language disorder	Pubtator	28289279	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Specific language impairment	Specific Language Impairment	BEFREE	28289279		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	28871449		★★★★★ ★☆☆☆☆ Found in Text Mining only

ARHGEF39 (Rho guanine nucleotide exchange factor 39)