ZBTB45 (zinc finger and BTB domain containing 45)

Gene

• Entrez ID: 84878
• Gene name: Zinc finger and BTB domain containing 45
• Gene symbol: ZBTB45
• Synonyms (NCBI Gene): ZNF499
• Chromosome: 19
• Chromosome location: 19q13.43

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT041924	hsa-miR-484	CLASH	23622248
MIRT457308	hsa-miR-524-3p	PAR-CLIP	23592263
MIRT457307	hsa-miR-525-3p	PAR-CLIP	23592263
MIRT457306	hsa-miR-4802-3p	PAR-CLIP	23592263
MIRT457305	hsa-miR-942-3p	PAR-CLIP	23592263
MIRT457304	hsa-miR-4747-3p	PAR-CLIP	23592263
MIRT457303	hsa-miR-4802-5p	PAR-CLIP	23592263
MIRT457302	hsa-miR-5697	PAR-CLIP	23592263
MIRT457301	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT457300	hsa-miR-4784	PAR-CLIP	23592263
MIRT457299	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT457298	hsa-miR-7154-3p	PAR-CLIP	23592263
MIRT457297	hsa-miR-765	PAR-CLIP	23592263
MIRT457296	hsa-miR-6894-5p	PAR-CLIP	23592263
MIRT457294	hsa-miR-5704	PAR-CLIP	23592263
MIRT457295	hsa-miR-1295a	PAR-CLIP	23592263
MIRT457293	hsa-miR-1297	PAR-CLIP	23592263
MIRT457292	hsa-miR-26a-5p	PAR-CLIP	23592263
MIRT457291	hsa-miR-26b-5p	PAR-CLIP	23592263
MIRT457289	hsa-miR-4465	PAR-CLIP	23592263
MIRT457308	hsa-miR-524-3p	PAR-CLIP	23592263
MIRT457307	hsa-miR-525-3p	PAR-CLIP	23592263
MIRT457306	hsa-miR-4802-3p	PAR-CLIP	23592263
MIRT457305	hsa-miR-942-3p	PAR-CLIP	23592263
MIRT457304	hsa-miR-4747-3p	PAR-CLIP	23592263
MIRT457303	hsa-miR-4802-5p	PAR-CLIP	23592263
MIRT457302	hsa-miR-5697	PAR-CLIP	23592263
MIRT457301	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT457300	hsa-miR-4784	PAR-CLIP	23592263
MIRT457299	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT457298	hsa-miR-7154-3p	PAR-CLIP	23592263
MIRT457297	hsa-miR-765	PAR-CLIP	23592263
MIRT457296	hsa-miR-6894-5p	PAR-CLIP	23592263
MIRT457294	hsa-miR-5704	PAR-CLIP	23592263
MIRT457295	hsa-miR-1295a	PAR-CLIP	23592263
MIRT457293	hsa-miR-1297	PAR-CLIP	23592263
MIRT457292	hsa-miR-26a-5p	PAR-CLIP	23592263
MIRT457291	hsa-miR-26b-5p	PAR-CLIP	23592263
MIRT457289	hsa-miR-4465	PAR-CLIP	23592263
MIRT1504092	hsa-miR-26a	CLIP-seq
MIRT1504093	hsa-miR-26b	CLIP-seq
MIRT1504094	hsa-miR-3940-3p	CLIP-seq
MIRT1504095	hsa-miR-4254	CLIP-seq
MIRT1504096	hsa-miR-619	CLIP-seq
MIRT1555692	hsa-miR-1272	CLIP-seq
MIRT1555693	hsa-miR-1322	CLIP-seq
MIRT1555694	hsa-miR-3943	CLIP-seq
MIRT1555695	hsa-miR-4740-3p	CLIP-seq
MIRT1555692	hsa-miR-1272	CLIP-seq
MIRT1555693	hsa-miR-1322	CLIP-seq
MIRT2151731	hsa-miR-139-5p	CLIP-seq
MIRT2151732	hsa-miR-1910	CLIP-seq
MIRT1504092	hsa-miR-26a	CLIP-seq
MIRT1504093	hsa-miR-26b	CLIP-seq
MIRT2151733	hsa-miR-3189-5p	CLIP-seq
MIRT2151734	hsa-miR-361-3p	CLIP-seq
MIRT1504094	hsa-miR-3940-3p	CLIP-seq
MIRT1555694	hsa-miR-3943	CLIP-seq
MIRT1504095	hsa-miR-4254	CLIP-seq
MIRT2151735	hsa-miR-4323	CLIP-seq
MIRT2151736	hsa-miR-4436b-5p	CLIP-seq
MIRT1555695	hsa-miR-4740-3p	CLIP-seq
MIRT1504096	hsa-miR-619	CLIP-seq
MIRT2151737	hsa-miR-627	CLIP-seq
MIRT2151738	hsa-miR-924	CLIP-seq
MIRT2151731	hsa-miR-139-5p	CLIP-seq
MIRT2151732	hsa-miR-1910	CLIP-seq
MIRT1555694	hsa-miR-3943	CLIP-seq
MIRT1555695	hsa-miR-4740-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA
GO:0001817	Process	Regulation of cytokine production	IBA
GO:0002682	Process	Regulation of immune system process	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0007399	Process	Nervous system development	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IEA

Other IDs

• MIM: 621256
• HGNC: 23715
• e!Ensembl: ENSG00000119574

Protein

• UniProt ID: Q96K62
• Protein name: Zinc finger and BTB domain-containing protein 45 (Zinc finger protein 499)
• Protein function: May be involved in transcriptional regulation (Probable). In the central nervous system, may play a role in glial cell differentiation (By similarity).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00651	BTB	23 → 125	BTB/POZ domain	Domain
  PF00096	zf-C2H2	403 → 425	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	431 → 453	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	459 → 481	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	487 → 508	Zinc finger, C2H2 type	Domain

• Sequence:

  MAAAEAVHHIHLQNFSRSLLETLNGQRLGGHFCDVTVRIREASLRAHRCVLAAGSPFFQD
  KLLLGHSEIRVPPVVPAQTVRQLVEFLYSGSLVVAQGEALQVLTAASVLRIQTVIDECTQ
  IIARARAPGTSAPTPLPTPVPPPLAPAQLRHRLRHLLAARPPGHPGAAHSRKQRQPARLQ
  LPAPPTPAKAEGPDADPSLSAAPDDRGDEDDEESDDETDGEDGEGGGPGEGQAPPSFPDC
  AAGFLTAAADSACEEPPAPTGLADYSGAGRDFLRGAGSAEDVFPDSYVSTWHDEDGAVPE
  GCPTETPVQPDCILSGSRPPGVKTPGPPVALFPFHLGAPGPPAPPPSAPSGPAPAPPPAF
  YPTLQPEAAPSTQLGEVPAPSAAPTTAPSGTPARTPGAEPPTYECSHCRKTFSSRKNYTK
  HMFIHSGEKPHQCAVCWRSFSLRDYLLKHMVTHTGVRAFQCAVCAKRFTQKSSLNVHMRT
  HRPERAPCPACGKVFSHRALLERHLAAHPAP

• Sequence length: 511

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Obesity	Obesity	Pubtator	34638758	Associate	★☆☆☆☆ Found in Text Mining only