Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	84875
Gene name	Poly(ADP-ribose) polymerase family member 10
Gene symbol	PARP10
Synonyms (NCBI Gene)	ARTD10
Chromosome	8
Chromosome location	8q24.3
Summary	Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]).[supplied by OM

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SNP ID	Visualize variation	Clinical significance	Consequence
rs1587459606	AG>-	Likely-pathogenic	Non coding transcript variant, coding sequence variant, frameshift variant

Show/Hide all (38)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019078	hsa-miR-335-5p	Microarray	18185580
MIRT045838	hsa-miR-132-3p	CLASH	23622248
MIRT039387	hsa-miR-421	CLASH	23622248
MIRT1214361	hsa-miR-1275	CLIP-seq
MIRT1214362	hsa-miR-1908	CLIP-seq
MIRT1214363	hsa-miR-3180	CLIP-seq
MIRT1214364	hsa-miR-3180-3p	CLIP-seq
MIRT1214365	hsa-miR-3196	CLIP-seq
MIRT1214366	hsa-miR-4259	CLIP-seq
MIRT1214367	hsa-miR-4488	CLIP-seq
MIRT1214368	hsa-miR-4665-5p	CLIP-seq
MIRT1214369	hsa-miR-4697-5p	CLIP-seq
MIRT1214370	hsa-miR-4706	CLIP-seq
MIRT1214371	hsa-miR-4711-5p	CLIP-seq
MIRT1214372	hsa-miR-4749-5p	CLIP-seq
MIRT1214373	hsa-miR-663	CLIP-seq
MIRT1214374	hsa-miR-939	CLIP-seq
MIRT2061666	hsa-miR-4459	CLIP-seq
MIRT2061667	hsa-miR-4646-5p	CLIP-seq
MIRT2061668	hsa-miR-4695-5p	CLIP-seq
MIRT2061669	hsa-miR-4722-5p	CLIP-seq
MIRT2061670	hsa-miR-4747-5p	CLIP-seq
MIRT2290029	hsa-miR-3192	CLIP-seq
MIRT2290030	hsa-miR-4300	CLIP-seq
MIRT2290031	hsa-miR-4487	CLIP-seq
MIRT2061667	hsa-miR-4646-5p	CLIP-seq
MIRT2061670	hsa-miR-4747-5p	CLIP-seq
MIRT2290032	hsa-miR-661	CLIP-seq
MIRT2290033	hsa-miR-920	CLIP-seq
MIRT2588050	hsa-miR-323-5p	CLIP-seq
MIRT2588051	hsa-miR-331-3p	CLIP-seq
MIRT2588052	hsa-miR-3649	CLIP-seq
MIRT2588053	hsa-miR-4456	CLIP-seq
MIRT2588054	hsa-miR-4505	CLIP-seq
MIRT2588055	hsa-miR-541	CLIP-seq
MIRT2588056	hsa-miR-615-5p	CLIP-seq
MIRT2588057	hsa-miR-654-5p	CLIP-seq
MIRT2588058	hsa-miR-876-3p	CLIP-seq

Show/Hide all (45)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003714	Function	Transcription corepressor activity	IBA
GO:0003950	Function	NAD+ poly-ADP-ribosyltransferase activity	IBA
GO:0003950	Function	NAD+ poly-ADP-ribosyltransferase activity	IEA
GO:0003950	Function	NAD+ poly-ADP-ribosyltransferase activity	IMP	23473667, 23575687
GO:0003950	Function	NAD+ poly-ADP-ribosyltransferase activity	TAS
GO:0005515	Function	Protein binding	IPI	22176891, 23473667, 23481255, 24695737
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	15674325, 22176891, 23473667
GO:0005634	Component	Nucleus	IEA
GO:0005730	Component	Nucleolus	IDA
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	15674325, 22176891, 23473667
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006281	Process	DNA repair	IEA
GO:0006325	Process	Chromatin organization	IDA	15674325
GO:0006974	Process	DNA damage response	IEA
GO:0010629	Process	Negative regulation of gene expression	IBA
GO:0010629	Process	Negative regulation of gene expression	IMP	23575687
GO:0016740	Function	Transferase activity	IEA
GO:0016757	Function	Glycosyltransferase activity	IEA
GO:0016779	Function	Nucleotidyltransferase activity	IEA
GO:0019082	Process	Viral protein processing	TAS
GO:0019985	Process	Translesion synthesis	IDA	24695737
GO:0032088	Process	Negative regulation of NF-kappaB transcription factor activity	IMP	23575687
GO:0034355	Process	NAD+ biosynthetic process via the salvage pathway	TAS
GO:0045892	Process	Negative regulation of DNA-templated transcription	IEA
GO:0048147	Process	Negative regulation of fibroblast proliferation	IDA	15674325
GO:0070212	Process	Protein poly-ADP-ribosylation	IDA	15674325
GO:0070212	Process	Protein poly-ADP-ribosylation	IEA
GO:0070212	Process	Protein poly-ADP-ribosylation	IMP	23473667
GO:0070213	Process	Protein auto-ADP-ribosylation	IDA	25043379
GO:0070213	Process	Protein auto-ADP-ribosylation	IMP	23575687
GO:0070530	Function	K63-linked polyubiquitin modification-dependent protein binding	IMP	23575687
GO:0140297	Function	DNA-binding transcription factor binding	IPI	15674325
GO:0140804	Function	NAD+-protein-lysine ADP-ribosyltransferase activity	IEA
GO:0140806	Function	NAD+-protein-aspartate ADP-ribosyltransferase activity	IEA
GO:0140807	Function	NAD+-protein-glutamate ADP-ribosyltransferase activity	IEA
GO:1900045	Process	Negative regulation of protein K63-linked ubiquitination	IMP	23575687
GO:1990404	Function	NAD+-protein mono-ADP-ribosyltransferase activity	IDA	18851833, 25043379
GO:1990404	Function	NAD+-protein mono-ADP-ribosyltransferase activity	IEA
GO:1990404	Function	NAD+-protein mono-ADP-ribosyltransferase activity	IMP	24695737

MIM	HGNC	e!Ensembl
609564	25895	ENSG00000178685

Q53GL7

Protein name

Protein mono-ADP-ribosyltransferase PARP10 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 10) (ARTD10) (Poly [ADP-ribose] polymerase 10) (PARP-10)

Protein function

ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins (PubMed:18851833, PubMed:23332125, PubMed:23474714, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate pol

PDB

2DHX , 3HKV , 5LX6 , 6FXI

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00644	PARP	827 → 1006	Poly(ADP-ribose) polymerase catalytic domain	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in spleen and thymus (PubMed:15674325). Intermediate levels in liver, kidney, pancreas, prostate, testis, ovary, intestine, and leukocytes (PubMed:15674325). Low expression in heart, brain, placenta, lung, skeletal mus

Sequence

MVAMAEAEAGVAVEVRGLPPAVPDELLTLYFENRRRSGGGPVLSWQRLGCGGVLTFREPA
DAERVLAQADHELHGAQLSLRPAPPRAPARLLLQGLPPGTTPQRLEQHVQALLRASGLPV
QPCCALASPRPDRALVQLPKPLSEADVRVLEEQAQNLGLEGTLVSLARVPQARAVRVVGD
GASVDLLLLELYLENERRSGGGPLEDLQRLPGPLGTVASFQQWQVAERVLQQEHRLQGSE
LSLVPHYDILEPEELAENTSGGDHPSTQGPRATKHALLRTGGLVTALQGAGTVTMGSGEE
PGQSGASLRTGPMVQGRGIMTTGSGQEPGQSGTSLRTGPMGSLGQAEQVSSMPMGSLEHE
GLVSLRPVGLQEQEGPMSLGPVGSAGPVETSKGLLGQEGLVEIAMDSPEQEGLVGPMEIT
MGSLEKAGPVSPGCVKLAGQEGLVEMVLLMEPGAMRFLQLYHEDLLAGLGDVALLPLEGP
DMTGFRLCGAQASCQAAEEFLRSLLGSISCHVLCLEHPGSARFLLGPEGQHLLQGLEAQF
QCVFGTERLATATLDTGLEEVDPTEALPVLPGNAHTLWTPDSTGGDQEDVSLEEVRELLA
TLEGLDLDGEDWLPRELEEEGPQEQPEEEVTPGHEEEEPVAPSTVAPRWLEEEAALQLAL
HRSLEPQGQVAEQEEAAALRQALTLSLLEQPPLEAEEPPDGGTDGKAQLVVHSAFEQDVE
ELDRALRAALEVHVQEETVGPWRRTLPAELRARLERCHGVSVALRGDCTILRGFGAHPAR
AARHLVALLAGPWDQSLAFPLAASGPTLAGQTLKGPWNNLERLAENTGEFQEVVRAFYDT
LDAARSSIRVVRVERVSHPLLQQQYELYRERLLQRCERRPVEQVLYHGTTAPAVPDICAH
GFNRSFCGRNATVYGKGVYFARRASLSVQDRYSPPNADGHKAVFVARVLTGDYGQGRRGL
RAPPLRGPGHVLLRYDSAVDCICQPSIFVIFHDTQALPTHLITCEHVPRASPDDPSGLPG
RSPDT

Sequence length

1025

Interactions

View interactions

	Reactome
			Nicotinamide salvaging

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Developmental delay	Likely pathogenic	rs1587459606	RCV000991392	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BIPOLAR DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR I DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ULCERATIVE COLITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VENOUS THROMBOEMBOLISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (13)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Ataxia Telangiectasia	Ataxia Telangiectasia	BEFREE	27624574		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar Disorder	GWASCAT_DG	31043756		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cockayne Syndrome	Cockayne syndrome	Pubtator	27624574	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Depressed bipolar I disorder	Depressed bipolar disorder	GWASCAT_DG	31043756		★★★★★ ★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Developmental disability	Pubtator	27624574	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	BEFREE	27624574		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hereditary Breast and Ovarian Cancer Syndrome	Hereditary breast and ovarian cancer syndrome	Pubtator	36187556	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	37506247	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	29515234		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma Follicular	Lymphoma	Pubtator	34791836	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	29293500		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	27624574		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	29293500		★★★★★ ★☆☆☆☆ Found in Text Mining only

PARP10 (poly(ADP-ribose) polymerase family member 10)