Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	8487
Gene name	Gem nuclear organelle associated protein 2
Gene symbol	GEMIN2
Synonyms (NCBI Gene)	SIP1SIP1-delta
Chromosome	14
Chromosome location	14q21.1
Summary	This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled

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miRTarBase ID	miRNA	Experiments	Reference
MIRT002481	hsa-miR-200a-3p	Reporter assay	18381893
MIRT000725	hsa-miR-200c-3p	Reporter assay	18381893
MIRT069979	hsa-miR-4426	PAR-CLIP	21572407
MIRT069981	hsa-miR-4647	PAR-CLIP	21572407
MIRT069982	hsa-miR-4662b	PAR-CLIP	21572407
MIRT069976	hsa-miR-576-3p	PAR-CLIP	21572407
MIRT069968	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT069969	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT069971	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT069972	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT069970	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT069975	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT069980	hsa-miR-4427	PAR-CLIP	21572407
MIRT069985	hsa-miR-5187-3p	PAR-CLIP	21572407
MIRT069984	hsa-miR-4680-3p	PAR-CLIP	21572407
MIRT069983	hsa-miR-219b-3p	PAR-CLIP	21572407
MIRT543841	hsa-miR-219a-2-3p	PAR-CLIP	21572407
MIRT069979	hsa-miR-4426	PAR-CLIP	21572407
MIRT069981	hsa-miR-4647	PAR-CLIP	21572407
MIRT069982	hsa-miR-4662b	PAR-CLIP	21572407
MIRT069976	hsa-miR-576-3p	PAR-CLIP	21572407
MIRT069968	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT069969	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT069971	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT069972	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT069970	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT069975	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT069980	hsa-miR-4427	PAR-CLIP	21572407
MIRT069985	hsa-miR-5187-3p	PAR-CLIP	21572407
MIRT069984	hsa-miR-4680-3p	PAR-CLIP	21572407
MIRT069983	hsa-miR-219b-3p	PAR-CLIP	21572407
MIRT543841	hsa-miR-219a-2-3p	PAR-CLIP	21572407
MIRT069979	hsa-miR-4426	PAR-CLIP	21572407
MIRT069981	hsa-miR-4647	PAR-CLIP	21572407
MIRT069982	hsa-miR-4662b	PAR-CLIP	21572407
MIRT069976	hsa-miR-576-3p	PAR-CLIP	21572407
MIRT069968	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT069969	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT069971	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT069972	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT069970	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT069975	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT069980	hsa-miR-4427	PAR-CLIP	21572407
MIRT069985	hsa-miR-5187-3p	PAR-CLIP	21572407
MIRT069984	hsa-miR-4680-3p	PAR-CLIP	21572407
MIRT069983	hsa-miR-219b-3p	PAR-CLIP	21572407
MIRT543841	hsa-miR-219a-2-3p	PAR-CLIP	21572407
MIRT069979	hsa-miR-4426	PAR-CLIP	21572407
MIRT069981	hsa-miR-4647	PAR-CLIP	21572407
MIRT069982	hsa-miR-4662b	PAR-CLIP	21572407
MIRT069976	hsa-miR-576-3p	PAR-CLIP	21572407
MIRT069968	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT069969	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT069971	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT069972	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT069970	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT069975	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT069980	hsa-miR-4427	PAR-CLIP	21572407
MIRT069985	hsa-miR-5187-3p	PAR-CLIP	21572407
MIRT069984	hsa-miR-4680-3p	PAR-CLIP	21572407
MIRT069983	hsa-miR-219b-3p	PAR-CLIP	21572407
MIRT543841	hsa-miR-219a-2-3p	PAR-CLIP	21572407

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000245	Process	Spliceosomal complex assembly	IEA
GO:0000245	Process	Spliceosomal complex assembly	TAS	9323129
GO:0000375	Process	RNA splicing, via transesterification reactions	TAS	9323129
GO:0000387	Process	Spliceosomal snRNP assembly	EXP	12067652
GO:0000387	Process	Spliceosomal snRNP assembly	IBA
GO:0000387	Process	Spliceosomal snRNP assembly	IDA	18984161, 31799625
GO:0000387	Process	Spliceosomal snRNP assembly	IEA
GO:0005515	Function	Protein binding	IPI	10500148, 11714716, 17178713, 18984161, 19928837, 21816274, 21900206, 22607171, 23022347, 24981860, 26092730, 31799625, 32296183, 33961781, 35271311
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	9323130
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IEA
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	18984161
GO:0005829	Component	Cytosol	TAS
GO:0006397	Process	MRNA processing	IEA
GO:0006397	Process	MRNA processing	TAS	9323130
GO:0008380	Process	RNA splicing	IEA
GO:0008380	Process	RNA splicing	TAS	9323129
GO:0016604	Component	Nuclear body	IDA
GO:0032797	Component	SMN complex	IBA
GO:0032797	Component	SMN complex	IDA	17178713, 18984161
GO:0032797	Component	SMN complex	IPI	17178713
GO:0034719	Component	SMN-Sm protein complex	IDA	18984161
GO:0065003	Process	Protein-containing complex assembly	IDA	21816274
GO:0097504	Component	Gemini of Cajal bodies	IDA	20513430
GO:0097504	Component	Gemini of Cajal bodies	IEA

MIM	HGNC	e!Ensembl
602595	10884	ENSG00000092208

O14893

Protein name

Gem-associated protein 2 (Gemin-2) (Component of gems 2) (Survival of motor neuron protein-interacting protein 1) (SMN-interacting protein 1)

Protein function

The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:18984161, PubMed:9323129). Most splice

PDB

2LEH , 5XJL , 5XJQ , 5XJR , 5XJS , 5XJT , 5XJU

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04938	SIP1	37 → 273	Survival motor neuron (SMN) interacting protein 1 (SIP1)	Family

Sequence

MRRAELAGLKTMAWVPAESAVEELMPRLLPVEPCDLTEGFDPSVPPRTPQEYLRRVQIEA
AQCPDVVVAQIDPKKLKRKQSVNISLSGCQPAPEGYSPTLQWQQQQVAQFSTVRQNVNKH
RSHWKSQQLDSNVTMPKSEDEEGWKKFCLGEKLCADGAVGPATNESPGIDYVQIGFPPLL
SIVSRMNQATVTSVLEYLSNWFGERDFTPELGRWLYALLACLEKPLLPEAHSLIRQLARR
CSEVRLLVDSKDDERVPALNLLICLVSRYFDQRDLADEPS

Sequence length

280

Interactions

View interactions

	Reactome
			snRNP Assembly

GEMIN2 (gem nuclear organelle associated protein 2)