Gene Gene information from NCBI Gene database.
Entrez ID 8477
Gene name G protein-coupled receptor 65
Gene symbol GPR65
Synonyms (NCBI Gene)
TDAG8hTDAG8
Chromosome 14
Chromosome location 14q31.3
miRNA miRNA information provided by mirtarbase database.
507
miRTarBase ID miRNA Experiments Reference
MIRT1031648 hsa-miR-106a CLIP-seq
MIRT1031649 hsa-miR-106b CLIP-seq
MIRT1031650 hsa-miR-1202 CLIP-seq
MIRT1031651 hsa-miR-1251 CLIP-seq
MIRT1031652 hsa-miR-1261 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
27
GO ID Ontology Definition Evidence Reference
GO:0004930 Function G protein-coupled receptor activity IBA
GO:0004930 Function G protein-coupled receptor activity IDA 15326175, 15618224, 20855608, 33478938, 39753132
GO:0004930 Function G protein-coupled receptor activity IEA
GO:0005768 Component Endosome IEA
GO:0005886 Component Plasma membrane IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604620 4517 ENSG00000140030
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8IYL9
Protein name G-protein coupled receptor 65 (Psychosine receptor) (T-cell death-associated gene 8 protein)
Protein function Proton-sensing G-protein coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions (PubMed:15326175, PubMed:15618224, PubMed:20855608, PubMed:33478938, PubMed:37722051, PubMed:3975313
PDB 9BHL
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 31 290 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Predominantly expressed in thymus, spleen, lymph nodes, small intestine, lung, placenta and peripheral blood leukocytes. {ECO:0000269|PubMed:11309421, ECO:0000269|PubMed:9655242}.
Sequence
Sequence length 337
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CHRONIC LEFT-SIDED ULCERATIVE COLITIS Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLITIS, ULCERATIVE CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Ankylosing spondylitis Ankylosing Spondylitis BEFREE 30529363
★☆☆☆☆
Found in Text Mining only
Asthma Asthma GWASDB_DG 21907864
★☆☆☆☆
Found in Text Mining only
Asthma Asthma BEFREE 24876173, 30532529
★☆☆☆☆
Found in Text Mining only
Asthma Asthma Pubtator 24876173, 30532529 Associate
★☆☆☆☆
Found in Text Mining only
Autoimmune Diseases Autoimmune Diseases BEFREE 29363187, 30535144
★☆☆☆☆
Found in Text Mining only
Celiac Disease Celiac disease Pubtator 40650227 Stimulate
★☆☆☆☆
Found in Text Mining only
Chronic Obstructive Airway Disease Chronic Obstructive Pulmonary Disease BEFREE 24876173
★☆☆☆☆
Found in Text Mining only
Colitis Colitis BEFREE 27287411, 30535144
★☆☆☆☆
Found in Text Mining only
Crohn Disease Crohn Disease GWASCAT_DG 21102463, 26192919, 28067908
★☆☆☆☆
Found in Text Mining only
Crohn Disease Crohn Disease GWASDB_DG 21102463
★☆☆☆☆
Found in Text Mining only