Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	8476
Gene name	CDC42 binding protein kinase alpha
Gene symbol	CDC42BPA
Synonyms (NCBI Gene)	MRCKMRCKAMRCKalphaPK428
Chromosome	1
Chromosome location	1q42.13
Summary	The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also con

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Show/Hide all (301)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017761	hsa-miR-335-5p	Microarray	18185580
MIRT051756	hsa-let-7c-5p	CLASH	23622248
MIRT048711	hsa-miR-98-5p	CLASH	23622248
MIRT717678	hsa-miR-4311	HITS-CLIP	19536157
MIRT717677	hsa-miR-216b-5p	HITS-CLIP	19536157
MIRT717676	hsa-miR-6758-5p	HITS-CLIP	19536157
MIRT717675	hsa-miR-6856-5p	HITS-CLIP	19536157
MIRT717674	hsa-miR-8063	HITS-CLIP	19536157
MIRT717673	hsa-miR-130b-5p	HITS-CLIP	19536157
MIRT717672	hsa-miR-3124-3p	HITS-CLIP	19536157
MIRT717671	hsa-miR-1468-3p	HITS-CLIP	19536157
MIRT717670	hsa-miR-6868-3p	HITS-CLIP	19536157
MIRT717669	hsa-miR-4753-3p	HITS-CLIP	19536157
MIRT440974	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440972	hsa-miR-485-5p	HITS-CLIP	24374217
MIRT440974	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440972	hsa-miR-485-5p	HITS-CLIP	24374217
MIRT717678	hsa-miR-4311	HITS-CLIP	19536157
MIRT717677	hsa-miR-216b-5p	HITS-CLIP	19536157
MIRT717676	hsa-miR-6758-5p	HITS-CLIP	19536157
MIRT717675	hsa-miR-6856-5p	HITS-CLIP	19536157
MIRT717674	hsa-miR-8063	HITS-CLIP	19536157
MIRT717673	hsa-miR-130b-5p	HITS-CLIP	19536157
MIRT717672	hsa-miR-3124-3p	HITS-CLIP	19536157
MIRT717671	hsa-miR-1468-3p	HITS-CLIP	19536157
MIRT717670	hsa-miR-6868-3p	HITS-CLIP	19536157
MIRT717669	hsa-miR-4753-3p	HITS-CLIP	19536157
MIRT877737	hsa-miR-105	CLIP-seq
MIRT877738	hsa-miR-1253	CLIP-seq
MIRT877739	hsa-miR-125a-3p	CLIP-seq
MIRT877740	hsa-miR-1273g	CLIP-seq
MIRT877741	hsa-miR-1301	CLIP-seq
MIRT877742	hsa-miR-1343	CLIP-seq
MIRT877743	hsa-miR-140-5p	CLIP-seq
MIRT877744	hsa-miR-185	CLIP-seq
MIRT877745	hsa-miR-23a	CLIP-seq
MIRT877746	hsa-miR-23b	CLIP-seq
MIRT877747	hsa-miR-23c	CLIP-seq
MIRT877748	hsa-miR-29a	CLIP-seq
MIRT877749	hsa-miR-29b	CLIP-seq
MIRT877750	hsa-miR-29c	CLIP-seq
MIRT877751	hsa-miR-3074-5p	CLIP-seq
MIRT877752	hsa-miR-3120-5p	CLIP-seq
MIRT877753	hsa-miR-3122	CLIP-seq
MIRT877754	hsa-miR-3127-5p	CLIP-seq
MIRT877755	hsa-miR-3128	CLIP-seq
MIRT877756	hsa-miR-3140-5p	CLIP-seq
MIRT877757	hsa-miR-3150b-3p	CLIP-seq
MIRT877758	hsa-miR-3154	CLIP-seq
MIRT877759	hsa-miR-3167	CLIP-seq
MIRT877760	hsa-miR-3192	CLIP-seq
MIRT877761	hsa-miR-323b-5p	CLIP-seq
MIRT877762	hsa-miR-339-5p	CLIP-seq
MIRT877763	hsa-miR-3616-5p	CLIP-seq
MIRT877764	hsa-miR-3647-5p	CLIP-seq
MIRT877765	hsa-miR-3671	CLIP-seq
MIRT877766	hsa-miR-3680	CLIP-seq
MIRT877767	hsa-miR-3689a-3p	CLIP-seq
MIRT877768	hsa-miR-3689c	CLIP-seq
MIRT877769	hsa-miR-370	CLIP-seq
MIRT877770	hsa-miR-376c	CLIP-seq
MIRT877771	hsa-miR-3913-5p	CLIP-seq
MIRT877772	hsa-miR-3918	CLIP-seq
MIRT877773	hsa-miR-3934	CLIP-seq
MIRT877774	hsa-miR-425	CLIP-seq
MIRT877775	hsa-miR-4251	CLIP-seq
MIRT877776	hsa-miR-4306	CLIP-seq
MIRT877777	hsa-miR-4324	CLIP-seq
MIRT877778	hsa-miR-433	CLIP-seq
MIRT877779	hsa-miR-4330	CLIP-seq
MIRT877780	hsa-miR-4418	CLIP-seq
MIRT877781	hsa-miR-4427	CLIP-seq
MIRT877782	hsa-miR-4446-3p	CLIP-seq
MIRT877783	hsa-miR-4492	CLIP-seq
MIRT877784	hsa-miR-4498	CLIP-seq
MIRT877785	hsa-miR-4503	CLIP-seq
MIRT877786	hsa-miR-4509	CLIP-seq
MIRT877787	hsa-miR-4637	CLIP-seq
MIRT877788	hsa-miR-4644	CLIP-seq
MIRT877789	hsa-miR-4659a-3p	CLIP-seq
MIRT877790	hsa-miR-4659b-3p	CLIP-seq
MIRT877791	hsa-miR-4660	CLIP-seq
MIRT877792	hsa-miR-4680-3p	CLIP-seq
MIRT877793	hsa-miR-4689	CLIP-seq
MIRT877794	hsa-miR-4728-5p	CLIP-seq
MIRT877795	hsa-miR-4731-5p	CLIP-seq
MIRT877796	hsa-miR-4733-5p	CLIP-seq
MIRT877797	hsa-miR-4760-3p	CLIP-seq
MIRT877798	hsa-miR-4779	CLIP-seq
MIRT877799	hsa-miR-4784	CLIP-seq
MIRT877800	hsa-miR-4795-5p	CLIP-seq
MIRT877801	hsa-miR-4796-5p	CLIP-seq
MIRT877802	hsa-miR-4798-3p	CLIP-seq
MIRT877803	hsa-miR-498	CLIP-seq
MIRT877804	hsa-miR-5047	CLIP-seq
MIRT877805	hsa-miR-509-3-5p	CLIP-seq
MIRT877806	hsa-miR-509-5p	CLIP-seq
MIRT877807	hsa-miR-5096	CLIP-seq
MIRT877808	hsa-miR-511	CLIP-seq
MIRT877809	hsa-miR-539	CLIP-seq
MIRT877810	hsa-miR-548l	CLIP-seq
MIRT877811	hsa-miR-548n	CLIP-seq
MIRT877812	hsa-miR-573	CLIP-seq
MIRT877813	hsa-miR-607	CLIP-seq
MIRT877814	hsa-miR-640	CLIP-seq
MIRT877815	hsa-miR-762	CLIP-seq
MIRT877816	hsa-miR-764	CLIP-seq
MIRT877817	hsa-miR-765	CLIP-seq
MIRT877818	hsa-miR-876-5p	CLIP-seq
MIRT877819	hsa-miR-942	CLIP-seq
MIRT877820	hsa-miR-3136-5p	CLIP-seq
MIRT877821	hsa-miR-3148	CLIP-seq
MIRT877822	hsa-miR-4439	CLIP-seq
MIRT877823	hsa-miR-4502	CLIP-seq
MIRT877824	hsa-miR-4513	CLIP-seq
MIRT877825	hsa-miR-4659a-5p	CLIP-seq
MIRT877826	hsa-miR-4659b-5p	CLIP-seq
MIRT877827	hsa-miR-4776-3p	CLIP-seq
MIRT877828	hsa-miR-548c-3p	CLIP-seq
MIRT1960109	hsa-miR-1224-3p	CLIP-seq
MIRT877738	hsa-miR-1253	CLIP-seq
MIRT1960110	hsa-miR-1260	CLIP-seq
MIRT1960111	hsa-miR-1260b	CLIP-seq
MIRT1960112	hsa-miR-1280	CLIP-seq
MIRT1960113	hsa-miR-186	CLIP-seq
MIRT1960114	hsa-miR-19a	CLIP-seq
MIRT1960115	hsa-miR-19b	CLIP-seq
MIRT1960116	hsa-miR-203	CLIP-seq
MIRT1960117	hsa-miR-218	CLIP-seq
MIRT1960118	hsa-miR-3065-3p	CLIP-seq
MIRT1960119	hsa-miR-3125	CLIP-seq
MIRT1960120	hsa-miR-338-3p	CLIP-seq
MIRT1960121	hsa-miR-3622a-3p	CLIP-seq
MIRT1960122	hsa-miR-3622b-3p	CLIP-seq
MIRT877765	hsa-miR-3671	CLIP-seq
MIRT1960123	hsa-miR-3916	CLIP-seq
MIRT1960124	hsa-miR-4289	CLIP-seq
MIRT1960125	hsa-miR-4299	CLIP-seq
MIRT877777	hsa-miR-4324	CLIP-seq
MIRT1960126	hsa-miR-4530	CLIP-seq
MIRT1960127	hsa-miR-4652-3p	CLIP-seq
MIRT1960128	hsa-miR-4676-5p	CLIP-seq
MIRT1960129	hsa-miR-4720-3p	CLIP-seq
MIRT1960130	hsa-miR-4786-3p	CLIP-seq
MIRT1960131	hsa-miR-4804-3p	CLIP-seq
MIRT1960132	hsa-miR-575	CLIP-seq
MIRT1960133	hsa-miR-582-3p	CLIP-seq
MIRT1960134	hsa-miR-586	CLIP-seq
MIRT1960135	hsa-miR-636	CLIP-seq
MIRT1960136	hsa-miR-671-5p	CLIP-seq
MIRT2196983	hsa-miR-103a	CLIP-seq
MIRT2196984	hsa-miR-107	CLIP-seq
MIRT2196985	hsa-miR-1304	CLIP-seq
MIRT2196986	hsa-miR-1321	CLIP-seq
MIRT2196987	hsa-miR-1323	CLIP-seq
MIRT2196988	hsa-miR-1324	CLIP-seq
MIRT2196989	hsa-miR-134	CLIP-seq
MIRT2196990	hsa-miR-15a	CLIP-seq
MIRT2196991	hsa-miR-15b	CLIP-seq
MIRT2196992	hsa-miR-16	CLIP-seq
MIRT2196993	hsa-miR-195	CLIP-seq
MIRT1960116	hsa-miR-203	CLIP-seq
MIRT2196994	hsa-miR-2113	CLIP-seq
MIRT2196995	hsa-miR-3118	CLIP-seq
MIRT877752	hsa-miR-3120-5p	CLIP-seq
MIRT2196996	hsa-miR-3121-3p	CLIP-seq
MIRT877753	hsa-miR-3122	CLIP-seq
MIRT1960119	hsa-miR-3125	CLIP-seq
MIRT2196997	hsa-miR-3126-5p	CLIP-seq
MIRT2196998	hsa-miR-3130-3p	CLIP-seq
MIRT2196999	hsa-miR-3132	CLIP-seq
MIRT2197000	hsa-miR-3135	CLIP-seq
MIRT877821	hsa-miR-3148	CLIP-seq
MIRT2197001	hsa-miR-3150a-3p	CLIP-seq
MIRT877757	hsa-miR-3150b-3p	CLIP-seq
MIRT2197002	hsa-miR-3152-5p	CLIP-seq
MIRT2197003	hsa-miR-3159	CLIP-seq
MIRT2197004	hsa-miR-3162-5p	CLIP-seq
MIRT2197005	hsa-miR-3164	CLIP-seq
MIRT2197006	hsa-miR-3175	CLIP-seq
MIRT2197007	hsa-miR-339-3p	CLIP-seq
MIRT2197008	hsa-miR-34c-3p	CLIP-seq
MIRT1960121	hsa-miR-3622a-3p	CLIP-seq
MIRT1960122	hsa-miR-3622b-3p	CLIP-seq
MIRT2197009	hsa-miR-3652	CLIP-seq
MIRT877766	hsa-miR-3680	CLIP-seq
MIRT877770	hsa-miR-376c	CLIP-seq
MIRT2197010	hsa-miR-378g	CLIP-seq
MIRT877771	hsa-miR-3913-5p	CLIP-seq
MIRT1960123	hsa-miR-3916	CLIP-seq
MIRT2197011	hsa-miR-3935	CLIP-seq
MIRT2197012	hsa-miR-3942-3p	CLIP-seq
MIRT2197013	hsa-miR-424	CLIP-seq
MIRT2197014	hsa-miR-4284	CLIP-seq
MIRT2197015	hsa-miR-4294	CLIP-seq
MIRT2197016	hsa-miR-4307	CLIP-seq
MIRT877777	hsa-miR-4324	CLIP-seq
MIRT877779	hsa-miR-4330	CLIP-seq
MIRT2197017	hsa-miR-4430	CLIP-seq
MIRT2197018	hsa-miR-4437	CLIP-seq
MIRT2197019	hsa-miR-4477a	CLIP-seq
MIRT877785	hsa-miR-4503	CLIP-seq
MIRT2197020	hsa-miR-4504	CLIP-seq
MIRT2197021	hsa-miR-4505	CLIP-seq
MIRT2197022	hsa-miR-4519	CLIP-seq
MIRT2197023	hsa-miR-4638-3p	CLIP-seq
MIRT877825	hsa-miR-4659a-5p	CLIP-seq
MIRT877826	hsa-miR-4659b-5p	CLIP-seq
MIRT2197024	hsa-miR-4674	CLIP-seq
MIRT1960128	hsa-miR-4676-5p	CLIP-seq
MIRT877793	hsa-miR-4689	CLIP-seq
MIRT2197025	hsa-miR-4710	CLIP-seq
MIRT2197026	hsa-miR-4713-5p	CLIP-seq
MIRT877794	hsa-miR-4728-5p	CLIP-seq
MIRT877795	hsa-miR-4731-5p	CLIP-seq
MIRT2197027	hsa-miR-4739	CLIP-seq
MIRT2197028	hsa-miR-4756-5p	CLIP-seq
MIRT2197029	hsa-miR-4774-3p	CLIP-seq
MIRT877798	hsa-miR-4779	CLIP-seq
MIRT877799	hsa-miR-4784	CLIP-seq
MIRT1960130	hsa-miR-4786-3p	CLIP-seq
MIRT2197030	hsa-miR-4792	CLIP-seq
MIRT2197031	hsa-miR-4793-3p	CLIP-seq
MIRT877801	hsa-miR-4796-5p	CLIP-seq
MIRT2197032	hsa-miR-491-5p	CLIP-seq
MIRT2197033	hsa-miR-497	CLIP-seq
MIRT2197034	hsa-miR-515-5p	CLIP-seq
MIRT2197035	hsa-miR-542-3p	CLIP-seq
MIRT2197036	hsa-miR-544	CLIP-seq
MIRT877828	hsa-miR-548c-3p	CLIP-seq
MIRT877810	hsa-miR-548l	CLIP-seq
MIRT2197037	hsa-miR-548o	CLIP-seq
MIRT2197038	hsa-miR-570	CLIP-seq
MIRT1960132	hsa-miR-575	CLIP-seq
MIRT2197039	hsa-miR-577	CLIP-seq
MIRT2197040	hsa-miR-599	CLIP-seq
MIRT2197041	hsa-miR-647	CLIP-seq
MIRT1960136	hsa-miR-671-5p	CLIP-seq
MIRT2197042	hsa-miR-720	CLIP-seq
MIRT2197043	hsa-miR-758	CLIP-seq
MIRT2197044	hsa-miR-875-3p	CLIP-seq
MIRT2197045	hsa-miR-924	CLIP-seq
MIRT2197046	hsa-miR-939	CLIP-seq
MIRT2196986	hsa-miR-1321	CLIP-seq
MIRT2196989	hsa-miR-134	CLIP-seq
MIRT2196995	hsa-miR-3118	CLIP-seq
MIRT877752	hsa-miR-3120-5p	CLIP-seq
MIRT2196997	hsa-miR-3126-5p	CLIP-seq
MIRT2197004	hsa-miR-3162-5p	CLIP-seq
MIRT2197005	hsa-miR-3164	CLIP-seq
MIRT2197021	hsa-miR-4505	CLIP-seq
MIRT877794	hsa-miR-4728-5p	CLIP-seq
MIRT2197027	hsa-miR-4739	CLIP-seq
MIRT2197028	hsa-miR-4756-5p	CLIP-seq
MIRT2197042	hsa-miR-720	CLIP-seq
MIRT2436208	hsa-miR-3919	CLIP-seq
MIRT2500279	hsa-miR-1299	CLIP-seq
MIRT2196986	hsa-miR-1321	CLIP-seq
MIRT2196989	hsa-miR-134	CLIP-seq
MIRT2500280	hsa-miR-194	CLIP-seq
MIRT2196995	hsa-miR-3118	CLIP-seq
MIRT2196997	hsa-miR-3126-5p	CLIP-seq
MIRT877821	hsa-miR-3148	CLIP-seq
MIRT2197003	hsa-miR-3159	CLIP-seq
MIRT2197004	hsa-miR-3162-5p	CLIP-seq
MIRT2197005	hsa-miR-3164	CLIP-seq
MIRT2500281	hsa-miR-3689d	CLIP-seq
MIRT877779	hsa-miR-4330	CLIP-seq
MIRT2500282	hsa-miR-450b-3p	CLIP-seq
MIRT877825	hsa-miR-4659a-5p	CLIP-seq
MIRT877826	hsa-miR-4659b-5p	CLIP-seq
MIRT877794	hsa-miR-4728-5p	CLIP-seq
MIRT2197027	hsa-miR-4739	CLIP-seq
MIRT2197028	hsa-miR-4756-5p	CLIP-seq
MIRT2500283	hsa-miR-4757-5p	CLIP-seq
MIRT877827	hsa-miR-4776-3p	CLIP-seq
MIRT2500284	hsa-miR-4782-5p	CLIP-seq
MIRT2500285	hsa-miR-516b	CLIP-seq
MIRT877828	hsa-miR-548c-3p	CLIP-seq
MIRT2197042	hsa-miR-720	CLIP-seq
MIRT2500286	hsa-miR-769-3p	CLIP-seq
MIRT2500279	hsa-miR-1299	CLIP-seq
MIRT2196986	hsa-miR-1321	CLIP-seq
MIRT2196989	hsa-miR-134	CLIP-seq
MIRT2500280	hsa-miR-194	CLIP-seq
MIRT2196995	hsa-miR-3118	CLIP-seq
MIRT2196997	hsa-miR-3126-5p	CLIP-seq
MIRT2197003	hsa-miR-3159	CLIP-seq
MIRT2197004	hsa-miR-3162-5p	CLIP-seq
MIRT2197005	hsa-miR-3164	CLIP-seq
MIRT2500281	hsa-miR-3689d	CLIP-seq
MIRT877779	hsa-miR-4330	CLIP-seq
MIRT2500282	hsa-miR-450b-3p	CLIP-seq
MIRT877794	hsa-miR-4728-5p	CLIP-seq
MIRT2197027	hsa-miR-4739	CLIP-seq
MIRT2197028	hsa-miR-4756-5p	CLIP-seq
MIRT2500283	hsa-miR-4757-5p	CLIP-seq
MIRT2500284	hsa-miR-4782-5p	CLIP-seq
MIRT2500285	hsa-miR-516b	CLIP-seq
MIRT2197042	hsa-miR-720	CLIP-seq
MIRT2500286	hsa-miR-769-3p	CLIP-seq

Show/Hide all (35)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000287	Function	Magnesium ion binding	IDA	9092543
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	9092543, 11340065, 11399775, 21457715
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	TAS	9092543
GO:0005515	Function	Protein binding	IPI	9418861, 10644344, 15194684, 20936779, 35271311
GO:0005524	Function	ATP binding	IDA	9092543
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IBA
GO:0005911	Component	Cell-cell junction	ISS
GO:0006468	Process	Protein phosphorylation	IDA	9092543
GO:0006468	Process	Protein phosphorylation	TAS	9092543
GO:0007010	Process	Cytoskeleton organization	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016477	Process	Cell migration	IMP	18854160
GO:0016740	Function	Transferase activity	IEA
GO:0030027	Component	Lamellipodium	IEA
GO:0030027	Component	Lamellipodium	ISS
GO:0030036	Process	Actin cytoskeleton organization	IDA	9418861
GO:0031032	Process	Actomyosin structure organization	IBA
GO:0031032	Process	Actomyosin structure organization	IMP	18854160
GO:0031252	Component	Cell leading edge	ISS
GO:0042641	Component	Actomyosin	IBA
GO:0042641	Component	Actomyosin	IDA	18854160
GO:0042802	Function	Identical protein binding	IPI	11283256, 23414517
GO:0042995	Component	Cell projection	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0106310	Function	Protein serine kinase activity	IEA

MIM	HGNC	e!Ensembl
603412	1737	ENSG00000143776

Q5VT25

Protein name

Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha)

Protein function

Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9092543, PubMed:9418861). Regulates actin cytoskelet

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	77 → 343	Protein kinase domain	Domain
PF00433	Pkinase_C	362 → 404	Protein kinase C terminal domain	Family
PF15796	KELK	529 → 608	KELK-motif containing domain of MRCK Ser/Thr protein kinase	Coiled-coil
PF08826	DMPK_coil	881 → 941	DMPK coiled coil domain like	Coiled-coil
PF00130	C1_1	1013 → 1064	Phorbol esters/diacylglycerol binding domain (C1 domain)	Domain
PF00780	CNH	1232 → 1496	CNH domain	Family

Tissue specificity

TISSUE SPECIFICITY: Abundant in the heart, brain, skeletal muscle, kidney, and pancreas, with little or no expression in the lung and liver. {ECO:0000269|PubMed:9092543}.

Sequence

MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWA
KPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETA
CFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARF
YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGT
PDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKER
FQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIP
EVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTA
GPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGP
LTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTL
QQEREDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHTQKQKLARHV
RDKEEEVDLVMQKVESLRQELRRTERAKKELEVHTEALAAEASKDRKLREQSEHYSKQLE
NELEGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKSIFYEEELSKREGIHANEIKNLKK
ELHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLT
SELDKLTTLYENLSIHNQQLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQA
LASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEEL
NKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELRSEKGIEHQDSQHSFLAFLNTP
TDALDQFERSPSCTPASKGRRTVDSTPLSVHTPTLRKKGCPGSTGFPPKRKTHQFFVKSF
TTPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCVNKAPTTCPVPPEQTKGPLGIDPQKG
IGTAYEGHVRIPKPAGVKKGWQRALAIVCDFKLFLYDIAEGKASQPSVVISQVIDMRDEE
FSVSSVLASDVIHASRKDIPCIFRVTASQLSASNNKCSILMLADTENEKNKWVGVLSELH
KILKKNKFRDRSVYVPKEAYDSTLPLIKTTQAAAIIDHERIALGNEEGLFVVHVTKDEII
RVGDNKKIHQIELIPNDQLVAVISGRNRHVRLFPMSALDGRETDFYKLSETKGCQTVTSG
KVRHGALTCLCVAMKRQVLCYELFQSKTRHRKFKEIQVPYNVQWMAIFSEQLCVGFQSGF
LRYPLNGEGNPYSMLHSNDHTLSFIAHQPMDAICAVEISSKEYLLCFNSIGIYTDCQGRR
SRQQELMWPANPSSCCYNAPYLSVYSENAVDIFDVNSMEWIQTLPLKKVRPLNNEGSLNL
LGLETIRLIYFKNKMAEGDELVVPETSDNSRKQMVRNINNKRRYSFRVPEEERMQQRREM
LRDPEMRNKLISNPTNFNHIAHMGPGDGIQILKDLPMNPRPQESRTVFSGSVSIPSITKS
RPEPGRSMSASSGLSARSSAQNGSALKREFSGGSYSAKRQPMPSPSEGSLSSGGMDQGSD
APARDFDGEDSDSPRHSTASNSSNLSSPPSPASPRKTKSLSLESTDRGSWDP

Sequence length

1732

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATRIAL FIBRILLATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CATARACT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OPEN-ANGLE GLAUCOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (26)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Carcinoma	Breast Carcinoma	BEFREE	22464443		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	38164185	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	29072916		★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	Pubtator	32472697	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	30279244		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	30279244		★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart Diseases	Heart disease	Pubtator	32037394	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	BEFREE	9092543		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	36194576	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	Malignant lymphoma, lymphocytic, intermediate differentiation	BEFREE	27025456		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	22464443		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of skin	Skin cancer	BEFREE	29382705		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	16319398, 25796438, 29382705		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	29072916		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mantle cell lymphoma	Mantle Cell Lymphoma	BEFREE	27025456		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mental Retardation	Mental retardation	BEFREE	9092543		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial infarction	Pubtator	32472697	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myotonic Dystrophy	Myotonic dystrophy	LHGDN	18263588		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myotonic Dystrophy	Myotonic dystrophy	Pubtator	30667325, 32323808	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	29382705		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	32071169	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	21071578	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	36194576	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Rippling muscle disease	Rippling Muscle Disease	BEFREE	9092543		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	29759351		★★★★★ ★☆☆☆☆ Found in Text Mining only
Tetralogy of Fallot	Tetralogy of fallot	Pubtator	32037394	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

CDC42BPA (CDC42 binding protein kinase alpha)