Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	847
Gene name	Catalase
Gene symbol	CAT
Synonyms (NCBI Gene)	-
Chromosome	11
Chromosome location	11p13
Summary	This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide t

Show/Hide all (2)

SNP ID	Visualize variation	Clinical significance	Consequence
rs761650208	G>A	Pathogenic	Intron variant
rs1590302115	T>-	Pathogenic	Coding sequence variant, frameshift variant

123

Show/Hide all (123)

miRTarBase ID	miRNA	Experiments	Reference
MIRT007067	hsa-miR-30b-5p	Luciferase reporter assayqRT-PCRWestern blot	22880027
MIRT007067	hsa-miR-30b-5p	Luciferase reporter assayqRT-PCRWestern blot	22880027
MIRT020866	hsa-miR-155-5p	Proteomics	18668040
MIRT028614	hsa-miR-30a-5p	Proteomics	18668040
MIRT047237	hsa-miR-181b-5p	CLASH	23622248
MIRT864422	hsa-miR-1179	CLIP-seq
MIRT864423	hsa-miR-1250	CLIP-seq
MIRT864424	hsa-miR-1267	CLIP-seq
MIRT864425	hsa-miR-146a	CLIP-seq
MIRT864426	hsa-miR-146b-5p	CLIP-seq
MIRT864427	hsa-miR-148a	CLIP-seq
MIRT864428	hsa-miR-148b	CLIP-seq
MIRT864429	hsa-miR-152	CLIP-seq
MIRT864430	hsa-miR-190	CLIP-seq
MIRT864431	hsa-miR-190b	CLIP-seq
MIRT864432	hsa-miR-2110	CLIP-seq
MIRT864433	hsa-miR-30a	CLIP-seq
MIRT864434	hsa-miR-30b	CLIP-seq
MIRT864435	hsa-miR-30c	CLIP-seq
MIRT864436	hsa-miR-30d	CLIP-seq
MIRT864437	hsa-miR-30e	CLIP-seq
MIRT864438	hsa-miR-3143	CLIP-seq
MIRT864439	hsa-miR-337-3p	CLIP-seq
MIRT864440	hsa-miR-3611	CLIP-seq
MIRT864441	hsa-miR-361-5p	CLIP-seq
MIRT864442	hsa-miR-3646	CLIP-seq
MIRT864443	hsa-miR-3662	CLIP-seq
MIRT864444	hsa-miR-3685	CLIP-seq
MIRT864445	hsa-miR-3689a-5p	CLIP-seq
MIRT864446	hsa-miR-3689b	CLIP-seq
MIRT864447	hsa-miR-3689e	CLIP-seq
MIRT864448	hsa-miR-3689f	CLIP-seq
MIRT864449	hsa-miR-369-3p	CLIP-seq
MIRT864450	hsa-miR-374a	CLIP-seq
MIRT864451	hsa-miR-374b	CLIP-seq
MIRT864452	hsa-miR-380	CLIP-seq
MIRT864453	hsa-miR-384	CLIP-seq
MIRT864454	hsa-miR-3907	CLIP-seq
MIRT864455	hsa-miR-4271	CLIP-seq
MIRT864456	hsa-miR-4275	CLIP-seq
MIRT864457	hsa-miR-4282	CLIP-seq
MIRT864458	hsa-miR-4297	CLIP-seq
MIRT864459	hsa-miR-4303	CLIP-seq
MIRT864460	hsa-miR-4495	CLIP-seq
MIRT864461	hsa-miR-4667-5p	CLIP-seq
MIRT864462	hsa-miR-4680-3p	CLIP-seq
MIRT864463	hsa-miR-4682	CLIP-seq
MIRT864464	hsa-miR-4700-5p	CLIP-seq
MIRT864465	hsa-miR-4712-3p	CLIP-seq
MIRT864466	hsa-miR-4717-5p	CLIP-seq
MIRT864467	hsa-miR-4725-3p	CLIP-seq
MIRT864468	hsa-miR-4762-3p	CLIP-seq
MIRT864469	hsa-miR-4795-3p	CLIP-seq
MIRT864470	hsa-miR-512-3p	CLIP-seq
MIRT864471	hsa-miR-513a-3p	CLIP-seq
MIRT864472	hsa-miR-543	CLIP-seq
MIRT864473	hsa-miR-548c-3p	CLIP-seq
MIRT864474	hsa-miR-576-5p	CLIP-seq
MIRT864475	hsa-miR-589	CLIP-seq
MIRT864476	hsa-miR-873	CLIP-seq
MIRT864477	hsa-miR-889	CLIP-seq
MIRT864478	hsa-miR-944	CLIP-seq
MIRT1956212	hsa-miR-1825	CLIP-seq
MIRT864430	hsa-miR-190	CLIP-seq
MIRT864431	hsa-miR-190b	CLIP-seq
MIRT1956213	hsa-miR-199a-5p	CLIP-seq
MIRT1956214	hsa-miR-199b-5p	CLIP-seq
MIRT864433	hsa-miR-30a	CLIP-seq
MIRT864434	hsa-miR-30b	CLIP-seq
MIRT864435	hsa-miR-30c	CLIP-seq
MIRT864436	hsa-miR-30d	CLIP-seq
MIRT864437	hsa-miR-30e	CLIP-seq
MIRT864438	hsa-miR-3143	CLIP-seq
MIRT864445	hsa-miR-3689a-5p	CLIP-seq
MIRT864446	hsa-miR-3689b	CLIP-seq
MIRT864447	hsa-miR-3689e	CLIP-seq
MIRT864448	hsa-miR-3689f	CLIP-seq
MIRT864452	hsa-miR-380	CLIP-seq
MIRT1956215	hsa-miR-3925-3p	CLIP-seq
MIRT864460	hsa-miR-4495	CLIP-seq
MIRT1956216	hsa-miR-4718	CLIP-seq
MIRT1956217	hsa-miR-4742-3p	CLIP-seq
MIRT864468	hsa-miR-4762-3p	CLIP-seq
MIRT1956218	hsa-miR-4764-3p	CLIP-seq
MIRT1956219	hsa-miR-508-5p	CLIP-seq
MIRT864472	hsa-miR-543	CLIP-seq
MIRT2193853	hsa-miR-3117-5p	CLIP-seq
MIRT1956216	hsa-miR-4718	CLIP-seq
MIRT1956217	hsa-miR-4742-3p	CLIP-seq
MIRT864425	hsa-miR-146a	CLIP-seq
MIRT864426	hsa-miR-146b-5p	CLIP-seq
MIRT2193853	hsa-miR-3117-5p	CLIP-seq
MIRT864439	hsa-miR-337-3p	CLIP-seq
MIRT2497103	hsa-miR-3651	CLIP-seq
MIRT864444	hsa-miR-3685	CLIP-seq
MIRT864453	hsa-miR-384	CLIP-seq
MIRT864457	hsa-miR-4282	CLIP-seq
MIRT864459	hsa-miR-4303	CLIP-seq
MIRT864463	hsa-miR-4682	CLIP-seq
MIRT864465	hsa-miR-4712-3p	CLIP-seq
MIRT1956216	hsa-miR-4718	CLIP-seq
MIRT1956217	hsa-miR-4742-3p	CLIP-seq
MIRT864468	hsa-miR-4762-3p	CLIP-seq
MIRT864471	hsa-miR-513a-3p	CLIP-seq
MIRT864473	hsa-miR-548c-3p	CLIP-seq
MIRT864475	hsa-miR-589	CLIP-seq
MIRT864477	hsa-miR-889	CLIP-seq
MIRT864425	hsa-miR-146a	CLIP-seq
MIRT864426	hsa-miR-146b-5p	CLIP-seq
MIRT2193853	hsa-miR-3117-5p	CLIP-seq
MIRT864439	hsa-miR-337-3p	CLIP-seq
MIRT864444	hsa-miR-3685	CLIP-seq
MIRT864453	hsa-miR-384	CLIP-seq
MIRT864457	hsa-miR-4282	CLIP-seq
MIRT864459	hsa-miR-4303	CLIP-seq
MIRT864463	hsa-miR-4682	CLIP-seq
MIRT864465	hsa-miR-4712-3p	CLIP-seq
MIRT1956216	hsa-miR-4718	CLIP-seq
MIRT1956217	hsa-miR-4742-3p	CLIP-seq
MIRT864468	hsa-miR-4762-3p	CLIP-seq
MIRT864471	hsa-miR-513a-3p	CLIP-seq
MIRT864473	hsa-miR-548c-3p	CLIP-seq
MIRT864475	hsa-miR-589	CLIP-seq

Show/Hide all (6)

Transcription factor	Regulation	Reference
EGR3	Activation	1906159
ETV1	Unknown	19763505
NFE2L2	Activation	22493435
PPARD	Activation	18048767
PPARG	Unknown	20075562
SP1	Unknown	11479230

Show/Hide all (80)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000302	Process	Response to reactive oxygen species	IEA
GO:0000302	Process	Response to reactive oxygen species	IMP	16644728
GO:0001649	Process	Osteoblast differentiation	HDA	16210410
GO:0001657	Process	Ureteric bud development	IEA
GO:0001666	Process	Response to hypoxia	IEA
GO:0001822	Process	Kidney development	IEA
GO:0004046	Function	Aminoacylase activity	IEA
GO:0004096	Function	Catalase activity	IBA
GO:0004096	Function	Catalase activity	IDA	7882369, 16644728, 18312938, 18379038
GO:0004096	Function	Catalase activity	IEA
GO:0004601	Function	Peroxidase activity	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005739	Component	Mitochondrion	IBA
GO:0005777	Component	Peroxisome	IBA
GO:0005777	Component	Peroxisome	IDA	8769411
GO:0005777	Component	Peroxisome	IDA	2895531, 9053548, 18379038, 19479899
GO:0005777	Component	Peroxisome	IEA
GO:0005778	Component	Peroxisomal membrane	IEA
GO:0005778	Component	Peroxisomal membrane	ISS
GO:0005782	Component	Peroxisomal matrix	IEA
GO:0005782	Component	Peroxisomal matrix	TAS
GO:0005829	Component	Cytosol	TAS
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006641	Process	Triglyceride metabolic process	IEA
GO:0006979	Process	Response to oxidative stress	IEA
GO:0006979	Process	Response to oxidative stress	IEA
GO:0008203	Process	Cholesterol metabolic process	IEA
GO:0009060	Process	Aerobic respiration	IEA
GO:0009410	Process	Response to xenobiotic stimulus	IEA
GO:0009411	Process	Response to UV	IEA
GO:0009636	Process	Response to toxic substance	IEA
GO:0009642	Process	Response to light intensity	IEA
GO:0009650	Process	UV protection	IMP	16644728, 17053817
GO:0010193	Process	Response to ozone	IEA
GO:0010288	Process	Response to lead ion	IEA
GO:0014823	Process	Response to activity	IEA
GO:0014854	Process	Response to inactivity	IEA
GO:0016020	Component	Membrane	HDA	16210410, 19946888
GO:0016209	Function	Antioxidant activity	IDA	10514471
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016684	Function	Oxidoreductase activity, acting on peroxide as acceptor	IEA
GO:0016684	Function	Oxidoreductase activity, acting on peroxide as acceptor	ISS
GO:0019899	Function	Enzyme binding	IPI	16781659
GO:0020027	Process	Hemoglobin metabolic process	IEA
GO:0020037	Function	Heme binding	IBA
GO:0020037	Function	Heme binding	IDA	10656833, 11134921
GO:0020037	Function	Heme binding	IEA
GO:0032355	Process	Response to estradiol	IEA
GO:0032868	Process	Response to insulin	IEA
GO:0032991	Component	Protein-containing complex	IPI	21976670
GO:0033189	Process	Response to vitamin A	IEA
GO:0033197	Process	Response to vitamin E	IEA
GO:0033591	Process	Response to L-ascorbic acid	IEA
GO:0034774	Component	Secretory granule lumen	TAS
GO:0042542	Process	Response to hydrogen peroxide	IBA
GO:0042744	Process	Hydrogen peroxide catabolic process	IBA
GO:0042744	Process	Hydrogen peroxide catabolic process	IDA	18379038
GO:0042744	Process	Hydrogen peroxide catabolic process	IEA
GO:0042744	Process	Hydrogen peroxide catabolic process	IEA
GO:0042802	Function	Identical protein binding	IPI	21976670, 21988832, 29568061
GO:0042803	Function	Protein homodimerization activity	IDA	10656833
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IMP	16644728
GO:0045471	Process	Response to ethanol	IEA
GO:0046686	Process	Response to cadmium ion	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0050661	Function	NADP binding	IDA	10656833
GO:0051781	Process	Positive regulation of cell division	IEA
GO:0051897	Process	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA
GO:0055093	Process	Response to hyperoxia	IEA
GO:0061692	Process	Cellular detoxification of hydrogen peroxide	IDA	18379038
GO:0062151	Component	Catalase complex	IPI	10656833
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0070542	Process	Response to fatty acid	IEA
GO:0071363	Process	Cellular response to growth factor stimulus	IEA
GO:0072722	Process	Response to amitrole	IEA
GO:0080184	Process	Response to phenylpropanoid	IEA
GO:1904813	Component	Ficolin-1-rich granule lumen	TAS

MIM	HGNC	e!Ensembl
115500	1516	ENSG00000121691

P04040

Protein name

Catalase (EC 1.11.1.6)

Protein function

Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide (PubMed:7882369). Promotes growth of cells including T-cells, B

PDB

1DGB , 1DGF , 1DGG , 1DGH , 1F4J , 1QQW , 7P8W , 7VD9 , 8EL9 , 8HID , 8PVD , 8SGV , 8WZH , 8WZJ , 8WZK , 8WZM

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00199	Catalase	28 → 411	Catalase	Domain
PF06628	Catalase-rel	434 → 497	Catalase-related immune-responsive	Family

Sequence

MADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPLLVQDVVFTDE
MAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYSKAKVFEHIGKKTPIAVRFSTVAGES
GSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDPILFPSFIHSQKRNPQTHLKDPD
MVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNANGEAVYCKFHYKTDQ
GIKNLSVEDAARLSQEDPDYGIRDLFNAIATGKYPSWTFYIQVMTFNQAETFPFNPFDLT
KVWPHKDYPLIPVGKLVLNRNPVNYFAEVEQIAFDPSNMPPGIEASPDKMLQGRLFAYPD
THRHRLGPNYLHIPVNCPYRARVANYQRDGPMCMQDNQGGAPNYYPNSFGAPEQQPSALE
HSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIAGHLKDAQIFIQKKAVK
NFTEVHPDYGSHIQALLDKYNAEKPKNAIHTFVQSGSHLAAREKANL

Sequence length

527

Interactions

View interactions

	KEGG		Reactome
	Tryptophan metabolism Glyoxylate and dicarboxylate metabolism Metabolic pathways Carbon metabolism FoxO signaling pathway Peroxisome Longevity regulating pathway Longevity regulating pathway - multiple species Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases Chemical carcinogenesis - reactive oxygen species		Detoxification of Reactive Oxygen Species Neutrophil degranulation Peroxisomal protein import

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Acatalasemia, japanese type	Pathogenic	rs761650208, rs1590302115	RCV000019165 RCV000022461	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Acatalasia	Pathogenic	rs2133181057	RCV000022462	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (92)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANGLE CLOSURE GLAUCOMA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AORTIC DISEASES	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ARTHRITIS, EXPERIMENTAL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ARTHRITIS, RHEUMATOID	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASEPTIC NECROSIS OF HEAD AND/OR NECK OF FEMUR	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASPHYXIA NEONATORUM	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTHMA	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATOPIC RHINITIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISTIC DISORDER	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AVASCULAR NECROSIS OF BONE	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BEHCET SYNDROME	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BONNEVIE-ULLRICH SYNDROME	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BRAIN ISCHEMIA	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, HEPATOCELLULAR	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, NON-SMALL-CELL LUNG	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, RENAL CELL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIOMYOPATHIES	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CAT-related disorder	Likely benign; Benign; Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHOLESTASIS	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC PERSISTENT HEPATITIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONGESTIVE HEART FAILURE	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEPRESSIVE DISORDER, MAJOR	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS, EXPERIMENTAL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS, INSULIN-DEPENDENT	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS, NON-INSULIN-DEPENDENT	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS, TYPE 1	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS, TYPE 2	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETIC NEUROPATHIES	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DYSKINESIA, DRUG-INDUCED	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EDEMA	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESSENTIAL HYPERTENSION	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
FATTY LIVER	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
FATTY LIVER, ALCOHOLIC	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTRIC ULCER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GENETIC PREDISPOSITION TO DISEASE	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEART FAILURE	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEPATITIS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEPATITIS, CHRONIC	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPEREMIA	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSIVE DISEASE	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTHYROIDISM	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPOTENSION	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Intellectual disability	Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
KERATOSIS	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
KIDNEY FAILURE, CHRONIC	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, ALCOHOLIC	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG DISEASES	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUPUS ERYTHEMATOSUS, SYSTEMIC	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LYMPHOMA, LARGE B-CELL, DIFFUSE	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSION, SINGLE EPISODE	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	Disgenet, GWAS catalog Disgenet, GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MARFAN SYNDROME	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MESOTHELIOMA	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NECROSIS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-ALCOHOLIC FATTY LIVER DISEASE	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NONALCOHOLIC STEATOHEPATITIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OPTIC NEURITIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEONECROSIS OF MEDIAL FEMORAL CONDYLE	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOPOROSIS, POSTMENOPAUSAL	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PRIMARY CARDIOMYOPATHY	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PRIMARY HYPERTHYROIDISM	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PULMONARY EDEMA	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PULMONARY FIBROSIS	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RECURRENT MAJOR DEPRESSIVE EPISODES	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RETINITIS PIGMENTOSA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RETINITIS PIGMENTOSA 1	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHINITIS, ALLERGIC	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEIZURES	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SENILE CATARACT	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STATUS EPILEPTICUS	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Uncertain significance; Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TURNER SYNDROME	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UNIPOLAR DEPRESSION	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
URETERAL CALCULI	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
URINARY BLADDER NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VITILIGO	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

CAT (catalase)