Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	84674
Gene name	Caspase recruitment domain family member 6
Gene symbol	CARD6
Synonyms (NCBI Gene)	CINCIN1
Chromosome	5
Chromosome location	5p13.1
Summary	This gene encodes a protein that contains a caspase recruitment domain (CARD), an antiparallel six-helical bundle that mediates homotypic protein-protein interactions. The encoded protein is a microtubule-associated protein that has been shown to interact

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Show/Hide all (208)

miRTarBase ID	miRNA	Experiments	Reference
MIRT664949	hsa-miR-34b-3p	HITS-CLIP	23313552
MIRT664948	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT664947	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT664946	hsa-miR-940	HITS-CLIP	23313552
MIRT664945	hsa-miR-3929	HITS-CLIP	23313552
MIRT664944	hsa-miR-4419b	HITS-CLIP	23313552
MIRT664943	hsa-miR-4478	HITS-CLIP	23313552
MIRT696319	hsa-miR-5690	HITS-CLIP	23313552
MIRT664942	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT664941	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT664940	hsa-miR-1827	HITS-CLIP	23313552
MIRT664939	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT664938	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT664937	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT664936	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT664935	hsa-miR-4503	HITS-CLIP	23313552
MIRT664949	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT664948	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT664947	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT664946	hsa-miR-940	HITS-CLIP	23824327
MIRT664945	hsa-miR-3929	HITS-CLIP	23824327
MIRT664944	hsa-miR-4419b	HITS-CLIP	23824327
MIRT664943	hsa-miR-4478	HITS-CLIP	23824327
MIRT664942	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT664941	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT664940	hsa-miR-1827	HITS-CLIP	23824327
MIRT664939	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT664938	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT664937	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT664936	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT664935	hsa-miR-4503	HITS-CLIP	23824327
MIRT664949	hsa-miR-34b-3p	HITS-CLIP	23313552
MIRT664948	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT664947	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT664946	hsa-miR-940	HITS-CLIP	23313552
MIRT664945	hsa-miR-3929	HITS-CLIP	23313552
MIRT664944	hsa-miR-4419b	HITS-CLIP	23313552
MIRT664943	hsa-miR-4478	HITS-CLIP	23313552
MIRT696319	hsa-miR-5690	HITS-CLIP	23313552
MIRT664942	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT664941	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT664940	hsa-miR-1827	HITS-CLIP	23313552
MIRT664939	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT664938	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT664937	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT664936	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT664935	hsa-miR-4503	HITS-CLIP	23313552
MIRT664949	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT664948	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT664947	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT664946	hsa-miR-940	HITS-CLIP	23824327
MIRT664945	hsa-miR-3929	HITS-CLIP	23824327
MIRT664944	hsa-miR-4419b	HITS-CLIP	23824327
MIRT664943	hsa-miR-4478	HITS-CLIP	23824327
MIRT664942	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT664941	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT664940	hsa-miR-1827	HITS-CLIP	23824327
MIRT664939	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT664938	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT664937	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT664936	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT664935	hsa-miR-4503	HITS-CLIP	23824327
MIRT862792	hsa-miR-323-5p	CLIP-seq
MIRT862793	hsa-miR-3622a-3p	CLIP-seq
MIRT862794	hsa-miR-3622b-3p	CLIP-seq
MIRT862795	hsa-miR-4293	CLIP-seq
MIRT862796	hsa-miR-4802-3p	CLIP-seq
MIRT862797	hsa-miR-541	CLIP-seq
MIRT862798	hsa-miR-544b	CLIP-seq
MIRT862799	hsa-miR-654-5p	CLIP-seq
MIRT862800	hsa-miR-876-3p	CLIP-seq
MIRT1546157	hsa-miR-1285	CLIP-seq
MIRT1546158	hsa-miR-25	CLIP-seq
MIRT1546159	hsa-miR-32	CLIP-seq
MIRT1546160	hsa-miR-363	CLIP-seq
MIRT1546161	hsa-miR-367	CLIP-seq
MIRT1546162	hsa-miR-766	CLIP-seq
MIRT1546163	hsa-miR-92a	CLIP-seq
MIRT1546164	hsa-miR-92b	CLIP-seq
MIRT1546157	hsa-miR-1285	CLIP-seq
MIRT1546158	hsa-miR-25	CLIP-seq
MIRT1546159	hsa-miR-32	CLIP-seq
MIRT862792	hsa-miR-323-5p	CLIP-seq
MIRT1546160	hsa-miR-363	CLIP-seq
MIRT1546161	hsa-miR-367	CLIP-seq
MIRT862795	hsa-miR-4293	CLIP-seq
MIRT1955908	hsa-miR-4434	CLIP-seq
MIRT1955909	hsa-miR-4455	CLIP-seq
MIRT1955910	hsa-miR-4516	CLIP-seq
MIRT1955911	hsa-miR-4531	CLIP-seq
MIRT862796	hsa-miR-4802-3p	CLIP-seq
MIRT862797	hsa-miR-541	CLIP-seq
MIRT1955912	hsa-miR-609	CLIP-seq
MIRT862799	hsa-miR-654-5p	CLIP-seq
MIRT1546162	hsa-miR-766	CLIP-seq
MIRT862800	hsa-miR-876-3p	CLIP-seq
MIRT1546163	hsa-miR-92a	CLIP-seq
MIRT1546164	hsa-miR-92b	CLIP-seq
MIRT1546157	hsa-miR-1285	CLIP-seq
MIRT2193491	hsa-miR-1324	CLIP-seq
MIRT2193492	hsa-miR-2467-3p	CLIP-seq
MIRT1546158	hsa-miR-25	CLIP-seq
MIRT2193493	hsa-miR-3135	CLIP-seq
MIRT1546159	hsa-miR-32	CLIP-seq
MIRT862792	hsa-miR-323-5p	CLIP-seq
MIRT2193494	hsa-miR-329	CLIP-seq
MIRT862793	hsa-miR-3622a-3p	CLIP-seq
MIRT862794	hsa-miR-3622b-3p	CLIP-seq
MIRT2193495	hsa-miR-362-3p	CLIP-seq
MIRT1546160	hsa-miR-363	CLIP-seq
MIRT1546161	hsa-miR-367	CLIP-seq
MIRT2193496	hsa-miR-3941	CLIP-seq
MIRT2193497	hsa-miR-4257	CLIP-seq
MIRT862795	hsa-miR-4293	CLIP-seq
MIRT2193498	hsa-miR-4318	CLIP-seq
MIRT2193499	hsa-miR-4330	CLIP-seq
MIRT1955908	hsa-miR-4434	CLIP-seq
MIRT1955909	hsa-miR-4455	CLIP-seq
MIRT2193500	hsa-miR-4474-3p	CLIP-seq
MIRT1955910	hsa-miR-4516	CLIP-seq
MIRT1955911	hsa-miR-4531	CLIP-seq
MIRT2193501	hsa-miR-466	CLIP-seq
MIRT2193502	hsa-miR-4672	CLIP-seq
MIRT2193503	hsa-miR-4738-3p	CLIP-seq
MIRT862796	hsa-miR-4802-3p	CLIP-seq
MIRT2193504	hsa-miR-516b	CLIP-seq
MIRT862797	hsa-miR-541	CLIP-seq
MIRT862798	hsa-miR-544b	CLIP-seq
MIRT2193505	hsa-miR-603	CLIP-seq
MIRT1955912	hsa-miR-609	CLIP-seq
MIRT862799	hsa-miR-654-5p	CLIP-seq
MIRT1546162	hsa-miR-766	CLIP-seq
MIRT2193506	hsa-miR-875-5p	CLIP-seq
MIRT862800	hsa-miR-876-3p	CLIP-seq
MIRT2193507	hsa-miR-891b	CLIP-seq
MIRT1546163	hsa-miR-92a	CLIP-seq
MIRT1546164	hsa-miR-92b	CLIP-seq
MIRT2446162	hsa-miR-3120-5p	CLIP-seq
MIRT2446163	hsa-miR-3664-5p	CLIP-seq
MIRT2446164	hsa-miR-371-5p	CLIP-seq
MIRT2446165	hsa-miR-371b-5p	CLIP-seq
MIRT2193503	hsa-miR-4738-3p	CLIP-seq
MIRT2446166	hsa-miR-495	CLIP-seq
MIRT2193491	hsa-miR-1324	CLIP-seq
MIRT2446162	hsa-miR-3120-5p	CLIP-seq
MIRT2193493	hsa-miR-3135	CLIP-seq
MIRT2496639	hsa-miR-3140-3p	CLIP-seq
MIRT2496640	hsa-miR-3145-3p	CLIP-seq
MIRT862792	hsa-miR-323-5p	CLIP-seq
MIRT2193494	hsa-miR-329	CLIP-seq
MIRT862793	hsa-miR-3622a-3p	CLIP-seq
MIRT862794	hsa-miR-3622b-3p	CLIP-seq
MIRT2193495	hsa-miR-362-3p	CLIP-seq
MIRT2446163	hsa-miR-3664-5p	CLIP-seq
MIRT2446164	hsa-miR-371-5p	CLIP-seq
MIRT2446165	hsa-miR-371b-5p	CLIP-seq
MIRT2193496	hsa-miR-3941	CLIP-seq
MIRT862795	hsa-miR-4293	CLIP-seq
MIRT2193499	hsa-miR-4330	CLIP-seq
MIRT1955908	hsa-miR-4434	CLIP-seq
MIRT1955909	hsa-miR-4455	CLIP-seq
MIRT1955910	hsa-miR-4516	CLIP-seq
MIRT1955911	hsa-miR-4531	CLIP-seq
MIRT2193501	hsa-miR-466	CLIP-seq
MIRT2496641	hsa-miR-4662a-3p	CLIP-seq
MIRT2193502	hsa-miR-4672	CLIP-seq
MIRT2496642	hsa-miR-4733-5p	CLIP-seq
MIRT2193503	hsa-miR-4738-3p	CLIP-seq
MIRT862796	hsa-miR-4802-3p	CLIP-seq
MIRT2446166	hsa-miR-495	CLIP-seq
MIRT2496643	hsa-miR-514	CLIP-seq
MIRT2496644	hsa-miR-514b-3p	CLIP-seq
MIRT2193504	hsa-miR-516b	CLIP-seq
MIRT862797	hsa-miR-541	CLIP-seq
MIRT862798	hsa-miR-544b	CLIP-seq
MIRT2496645	hsa-miR-548c-3p	CLIP-seq
MIRT2193505	hsa-miR-603	CLIP-seq
MIRT1955912	hsa-miR-609	CLIP-seq
MIRT862799	hsa-miR-654-5p	CLIP-seq
MIRT2193506	hsa-miR-875-5p	CLIP-seq
MIRT862800	hsa-miR-876-3p	CLIP-seq
MIRT2446162	hsa-miR-3120-5p	CLIP-seq
MIRT2193493	hsa-miR-3135	CLIP-seq
MIRT2193494	hsa-miR-329	CLIP-seq
MIRT862793	hsa-miR-3622a-3p	CLIP-seq
MIRT862794	hsa-miR-3622b-3p	CLIP-seq
MIRT2193495	hsa-miR-362-3p	CLIP-seq
MIRT2446163	hsa-miR-3664-5p	CLIP-seq
MIRT2446164	hsa-miR-371-5p	CLIP-seq
MIRT2446165	hsa-miR-371b-5p	CLIP-seq
MIRT2193496	hsa-miR-3941	CLIP-seq
MIRT862795	hsa-miR-4293	CLIP-seq
MIRT1955908	hsa-miR-4434	CLIP-seq
MIRT1955909	hsa-miR-4455	CLIP-seq
MIRT1955910	hsa-miR-4516	CLIP-seq
MIRT1955911	hsa-miR-4531	CLIP-seq
MIRT2193501	hsa-miR-466	CLIP-seq
MIRT2193502	hsa-miR-4672	CLIP-seq
MIRT2496642	hsa-miR-4733-5p	CLIP-seq
MIRT2193503	hsa-miR-4738-3p	CLIP-seq
MIRT862796	hsa-miR-4802-3p	CLIP-seq
MIRT2446166	hsa-miR-495	CLIP-seq
MIRT862797	hsa-miR-541	CLIP-seq
MIRT862798	hsa-miR-544b	CLIP-seq
MIRT2496645	hsa-miR-548c-3p	CLIP-seq
MIRT2193505	hsa-miR-603	CLIP-seq
MIRT1955912	hsa-miR-609	CLIP-seq
MIRT862799	hsa-miR-654-5p	CLIP-seq

Show/Hide all (3)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16418290
GO:0006915	Process	Apoptotic process	IEA
GO:0042981	Process	Regulation of apoptotic process	IEA

MIM	HGNC	e!Ensembl
609986	16394	ENSG00000132357

Q9BX69

Protein name

Caspase recruitment domain-containing protein 6

Protein function

May be involved in apoptosis.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00619	CARD	8 → 91	Caspase recruitment domain	Domain

Sequence

MATESTPSEIIERERKKLLEILQHDPDSILDTLTSRRLISEEEYETLENVTDLLKKSRKL
LILVQKKGEATCQHFLKCLFSTFPQSAAICGLRHEVLKHENTVPPQSMGASSNSEDAFSP
GIKQPEAPEITVFFSEKEHLDLETSEFFRDKKTSYRETALSARKNEKEYDTPEVTLSYSV
EKVGCEVPATITYIKDGQRYEELDDSLYLGKEEYLGSVDTPEDAEATVEEEVYDDPEHVG
YDGEEDFENSETTEFSGEEPSYEGSETSLSLEEEQEKSIEERKKVFKDVLLCLNMDRSRK
VLPDFVKQFSLDRGCKWTPESPGDLAWNFLMKVQARDVTARDSILSHKVLDEDSKEDLLA
GVENLEIRDIQTINPLDVLCATMLCSDSSLQRQVMSNMYQCQFALPLLLPDAENNKSILM
LGAMKDIVKKQSTQFSGGPTEDTEKFLTLMKMPVISFVRLGYCSFSKSRILNTLLSPAQL
KLHKIFLHQDLPLLVLPRQISDGLVEITWCFPDSDDRKENPFFQKPVALANLRGNLESFW
TQFGFLMEVSSAVFFFTDCLGEKEWDLLMFLGEAAIERCYFVLSSQARESEEAQIFQRIL
NLKPAQLLFWERGDAGDRRKNMEGLQAALQEVMFSSCLRCVSVEDMAALARELGIQVDED
FENTQRIQVSSGENMAGTAEGEGQQRHSQLKSSSKSQALMPIQEPGTQCELSQNLQNLYG
TPVFRPVLENSWLFPTRIGGNFNHVSLKASWVMGRPFGSEQRPKWFHPLPFQNAGAQGRG
KSFGIQSFHPQIFYSGERFMKFSRVARGCHSNGTFGRLPRPICQHVQACPERPQMMGTLE
RSRAVASKIGHSYSLDSQPARAVGKPWPQQACTRVTELTEATGKLIRTSHIGKPHPQSFQ
PAAATQKLRPASQQGVQMKTQGGASNPALQIGSHPMCKSSQFKSDQSNPSTVKHSQPKPF
HSVPSQPKSSQTKSCQSQPSQTKPSPCKSTQPKPSQPWPPQSKPSQPRPPQPKSSSTNPS
QAKAHHSKAGQKRGGKH

Sequence length

1037

Interactions

View interactions

	KEGG
	NOD-like receptor signaling pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Cervical cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cholangiocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE SYSTEM ATROPHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Cerebral Infarction	Ischemic stroke	Pubtator	35962388	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Fatty Liver	Fatty Liver	BEFREE	29729191		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-alcoholic Fatty Liver Disease	Non-Alcoholic Fatty Liver Disease	BEFREE	29729191		★★★★★ ★☆☆☆☆ Found in Text Mining only
Steatohepatitis	Fatty Liver	BEFREE	29729191		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ventricular hypertrophy	Ventricular hypertrophy	BEFREE	24777975		★★★★★ ★☆☆☆☆ Found in Text Mining only

CARD6 (caspase recruitment domain family member 6)