Gene Gene information from NCBI Gene database.
Entrez ID 84656
Gene name Glyoxylate reductase 1 homolog
Gene symbol GLYR1
Synonyms (NCBI Gene)
BM045HIBDLN-PACNP60NPAChNDF
Chromosome 16
Chromosome location 16p13.3
miRNA miRNA information provided by mirtarbase database.
893
miRTarBase ID miRNA Experiments Reference
MIRT030400 hsa-miR-24-3p Microarray 19748357
MIRT046910 hsa-miR-221-3p CLASH 23622248
MIRT037154 hsa-miR-877-3p CLASH 23622248
MIRT628181 hsa-miR-8485 HITS-CLIP 23824327
MIRT628180 hsa-miR-6867-5p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin IBA
GO:0000785 Component Chromatin IDA 30970244
GO:0000786 Component Nucleosome IDA 23260659
GO:0003677 Function DNA binding IBA
GO:0003677 Function DNA binding IDA 29759984
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
610660 24434 ENSG00000140632
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q49A26
Protein name Cytokine-like nuclear factor N-PAC (NPAC) (3-hydroxyisobutyrate dehydrogenase-like protein) (Glyoxylate reductase 1 homolog) (Nuclear protein NP60) (Nuclear protein of 60 kDa) (Nucleosome-destabilizing factor) (hNDF) (Putative oxidoreductase GLYR1)
Protein function Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression (PubMed:23260659, PubMed:30970244). Acts as a nucleosome-destabilizing factor that is recruited to genes during
PDB 2UYY , 4GUR , 4GUS , 4GUT , 4GUU , 4HSU , 6R1U , 6R25
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00855 PWWP 6 91 PWWP domain Domain
PF03446 NAD_binding_2 269 430 NAD binding domain of 6-phosphogluconate dehydrogenase Domain
PF14833 NAD_binding_11 430 551 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Domain
Sequence
MAAVSLRLGDLVWGKLGRYPPWPGKIVNPPKDLKKPRGKKCFFVKFFGTEDHAWIKVEQL
KPYHAHKEEMIKINKGKRFQQAVDAVEEFLR
RAKGKDQTSSHNSSDDKNRRNSSEERSRP
NSGDEKRKLSLSEGKVKKNMGEGKKRVSSGSSERGSKSPLKRAQEQSPRKRGRPPKDEKD
LTIPESSTVKGMMAGPMAAFKWQPTASEPVKDADPHFHHFLLSQTEKPAVCYQAITKKLK
ICEEETGSTSIQAADSTAVNGSITPTDKKIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTA
EKCDLFIQEGARLGRTPAEVVSTCDITFACVSDPKAAKDLVLGPSGVLQGIRPGKCYVDM
STVDADTVTELAQVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLYEDCSSCFQAM
GKTSFFLGE
VGNAAKMMLIVNMVQGSFMATIAEGLTLAQVTGQSQQTLLDILNQGQLASI
FLDQKCQNILQGNFKPDFYLKYIQKDLRLAIALGDAVNHPTPMAAAANEVYKRAKALDQS
DNDMSAVYRAY
IH
Sequence length 553
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
GLYR1-related disorder Uncertain significance ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
TETRALOGY OF FALLOT CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Breast Carcinoma Breast Carcinoma BEFREE 29759984, 8617201
★☆☆☆☆
Found in Text Mining only
Colorectal Carcinoma Colorectal Cancer BEFREE 21544814
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 32370786 Inhibit
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent Diabetes Mellitus BEFREE 30557891
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of breast Breast Cancer BEFREE 29759984, 8617201
★☆☆☆☆
Found in Text Mining only
Malignant Neoplasms Malignant Neoplasm GWASCAT_DG 29299148
★☆☆☆☆
Found in Text Mining only
Neoplasms Neoplasms BEFREE 21544814
★☆☆☆☆
Found in Text Mining only