Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	84624
Gene name	Fibronectin type III domain containing 1
Gene symbol	FNDC1
Synonyms (NCBI Gene)	AGS8FNDC2MEL4B3bA243O10.1dJ322A24.1
Chromosome	6
Chromosome location	6q25.3

Show/Hide all (82)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017697	hsa-miR-335-5p	Microarray	18185580
MIRT1000273	hsa-miR-1297	CLIP-seq
MIRT1000274	hsa-miR-1343	CLIP-seq
MIRT1000275	hsa-miR-26a	CLIP-seq
MIRT1000276	hsa-miR-26b	CLIP-seq
MIRT1000277	hsa-miR-3123	CLIP-seq
MIRT1000278	hsa-miR-3925-5p	CLIP-seq
MIRT1000279	hsa-miR-4436b-3p	CLIP-seq
MIRT1000280	hsa-miR-4465	CLIP-seq
MIRT1000281	hsa-miR-4508	CLIP-seq
MIRT1000282	hsa-miR-4656	CLIP-seq
MIRT1000283	hsa-miR-4761-3p	CLIP-seq
MIRT1000284	hsa-miR-4781-5p	CLIP-seq
MIRT1000285	hsa-miR-498	CLIP-seq
MIRT1000286	hsa-miR-513a-3p	CLIP-seq
MIRT1000287	hsa-miR-548n	CLIP-seq
MIRT1000288	hsa-miR-744	CLIP-seq
MIRT1000289	hsa-miR-885-3p	CLIP-seq
MIRT1548856	hsa-miR-103a	CLIP-seq
MIRT1548857	hsa-miR-107	CLIP-seq
MIRT1548858	hsa-miR-1179	CLIP-seq
MIRT1548859	hsa-miR-1207-5p	CLIP-seq
MIRT1548860	hsa-miR-1285	CLIP-seq
MIRT1548861	hsa-miR-1301	CLIP-seq
MIRT1548862	hsa-miR-1914	CLIP-seq
MIRT1548863	hsa-miR-3151	CLIP-seq
MIRT1548864	hsa-miR-3187-5p	CLIP-seq
MIRT1548865	hsa-miR-4283	CLIP-seq
MIRT1548866	hsa-miR-4327	CLIP-seq
MIRT1548867	hsa-miR-4422	CLIP-seq
MIRT1548868	hsa-miR-4489	CLIP-seq
MIRT1548869	hsa-miR-4492	CLIP-seq
MIRT1548870	hsa-miR-4498	CLIP-seq
MIRT1548871	hsa-miR-4505	CLIP-seq
MIRT1548872	hsa-miR-4763-3p	CLIP-seq
MIRT1548873	hsa-miR-5047	CLIP-seq
MIRT1548874	hsa-miR-612	CLIP-seq
MIRT1548875	hsa-miR-762	CLIP-seq
MIRT1548858	hsa-miR-1179	CLIP-seq
MIRT2230451	hsa-miR-1972	CLIP-seq
MIRT2230452	hsa-miR-3199	CLIP-seq
MIRT2230453	hsa-miR-451b	CLIP-seq
MIRT2230454	hsa-miR-4648	CLIP-seq
MIRT2230455	hsa-miR-4682	CLIP-seq
MIRT2230456	hsa-miR-4740-5p	CLIP-seq
MIRT2230457	hsa-miR-4795-5p	CLIP-seq
MIRT2449836	hsa-miR-3074-3p	CLIP-seq
MIRT2449837	hsa-miR-4461	CLIP-seq
MIRT2449838	hsa-miR-4698	CLIP-seq
MIRT2449839	hsa-miR-580	CLIP-seq
MIRT2449836	hsa-miR-3074-3p	CLIP-seq
MIRT2449837	hsa-miR-4461	CLIP-seq
MIRT2449838	hsa-miR-4698	CLIP-seq
MIRT2449839	hsa-miR-580	CLIP-seq
MIRT2681074	hsa-miR-1178	CLIP-seq
MIRT1548860	hsa-miR-1285	CLIP-seq
MIRT2681075	hsa-miR-3064-5p	CLIP-seq
MIRT1548863	hsa-miR-3151	CLIP-seq
MIRT1548864	hsa-miR-3187-5p	CLIP-seq
MIRT2681076	hsa-miR-3663-3p	CLIP-seq
MIRT2681077	hsa-miR-4259	CLIP-seq
MIRT1548865	hsa-miR-4283	CLIP-seq
MIRT1000279	hsa-miR-4436b-3p	CLIP-seq
MIRT1548868	hsa-miR-4489	CLIP-seq
MIRT1548869	hsa-miR-4492	CLIP-seq
MIRT1548870	hsa-miR-4498	CLIP-seq
MIRT1548871	hsa-miR-4505	CLIP-seq
MIRT1000281	hsa-miR-4508	CLIP-seq
MIRT1000282	hsa-miR-4656	CLIP-seq
MIRT2681078	hsa-miR-4663	CLIP-seq
MIRT2681079	hsa-miR-4687-3p	CLIP-seq
MIRT2681080	hsa-miR-4715-5p	CLIP-seq
MIRT1000283	hsa-miR-4761-3p	CLIP-seq
MIRT1000284	hsa-miR-4781-5p	CLIP-seq
MIRT2681081	hsa-miR-511	CLIP-seq
MIRT2681082	hsa-miR-541	CLIP-seq
MIRT1548874	hsa-miR-612	CLIP-seq
MIRT2681083	hsa-miR-626	CLIP-seq
MIRT2681084	hsa-miR-654-5p	CLIP-seq
MIRT1000288	hsa-miR-744	CLIP-seq
MIRT1548875	hsa-miR-762	CLIP-seq
MIRT1000289	hsa-miR-885-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005576	Component	Extracellular region	IEA

MIM	HGNC	e!Ensembl
609991	21184	ENSG00000164694

Q4ZHG4

Protein name

Fibronectin type III domain-containing protein 1 (Activation-associated cDNA protein) (Expressed in synovial lining protein)

Protein function

May be an activator of G protein signaling.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00041	fn3	41 → 122	Fibronectin type III domain	Domain
PF00041	fn3	261 → 347	Fibronectin type III domain	Domain
PF00041	fn3	361 → 447	Fibronectin type III domain	Domain
PF00041	fn3	1657 → 1742	Fibronectin type III domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Almost absent from healthy skin; especially in epidermal keratinocytes, skin fibroblasts or endothelial cells and is barely detectable in benign melanocytic naevi. Expressed in the stroma close to skin tumors, in the tumor cells themse

Sequence

MAPEAGATLRAPRRLSWAALLLLAALLPVASSAAASVDHPLKPRHVKLLSTKMGLKVTWD
PPKDATSRPVEHYNIAYGKSLKSLKYIKVNAETYSFLIEDVEPGVVYFVLLTAENHSGVS
RPVYRAESPPGGEWIEIDGFPIKGPGPFNETVTEKEVPNKPLRVRVRSSDDRLSVAWKAP
RLSGAKSPRRSRGFLLGYGESGRKMNYVPLTRDERTHEIKKLASESVYVVSLQSMNSQGR
SQPVYRAALTKRKISEEDELDVPDDISVRVMSSQSVLVSWVDPVLEKQKKVVASRQYTVR
YREKGELARWDYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPT
TAPENLNVWPVNGKPTVVAASWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGDTTSA
LVDGLQPGERYLFKIRATNRRGLGPHSKAFIVAMPTTSKADVEQNTEDNGKPEKPEPSSP
SPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEELDLQSTEI
TGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHSVVAPGRTAVRARMPALPRREGVDKP
GFSLATQPRPGAPPSASASPAHHASTQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPK
GAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSSASAPPSRLS
PPHGGSSRLLPTQPHLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEG
AEASDGESHGDGDREDGGRQAEATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRG
PRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQ
PISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADT
EGHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQ
SRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYD
DDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSR
PGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSV
PKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPSR
LPPRSAATVSPVAGTHPWPQYTTRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPARPSY
RQGYNGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNP
LRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGLEVI
KKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTT
TTPTPTTPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEAYVI
YDEDYEFETSRPPTTTEPSTTATTPRVIPEEGAISSFPEEEFDLAGRKRFVAPYVTYLNK
DPSAPCSLTDALDHFQVDSLDEIIPNDLKKSDLPPQHAPRNITVVAVEGCHSFVIVDWDK
ATPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNTRYYFKVQAQNPHGYGP
ISPSVSFVTESDNPLLVVRPPGGEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKFVGVVL
CNSLRYKIYLSDNLKDTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYR
QYRQEPVRFGNIGFGTPYYYVGWYECGVSIPGKW

Sequence length

1894

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of urinary bladder	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (20)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Age related macular degeneration	Age-related macular degeneration	BEFREE	30733465		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	33899120	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	33899120	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	35255438	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary heart disease	Coronary Heart Disease	GWASDB_DG	21606135		★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary heart disease	Coronary Heart Disease	GWASCAT_DG	21606135		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	25150869, 27064407		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	Pubtator	21088137	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	27693493		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	30402143, 30588242, 31530096		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	30588242		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteopenia	Osteopenia	BEFREE	31737218		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	BEFREE	31737218		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoporosis, Postmenopausal	Osteoporosis	BEFREE	31737218		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	36420274	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	27693493		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	27693493	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	37232821	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	30402143, 30588242, 31530096		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	31530096, 34968391	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

FNDC1 (fibronectin type III domain containing 1)