Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	8459
Gene name	Tyrosylprotein sulfotransferase 2
Gene symbol	TPST2
Synonyms (NCBI Gene)	TANGO13BTPST-2
Chromosome	22
Chromosome location	22q12.1
Summary	The protein encoded by this gene catalyzes the O-sulfation of tyrosine residues within acidic regions of proteins. The encoded protein is a type II integral membrane protein found in the Golgi body. Alternative splicing produces multiple transcript varian

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miRTarBase ID	miRNA	Experiments	Reference
MIRT022368	hsa-miR-124-3p	Microarray	18668037
MIRT027431	hsa-miR-98-5p	Microarray	19088304
MIRT042125	hsa-miR-484	CLASH	23622248
MIRT039710	hsa-miR-615-3p	CLASH	23622248
MIRT619752	hsa-miR-4438	HITS-CLIP	23824327
MIRT619751	hsa-miR-941	HITS-CLIP	23824327
MIRT619750	hsa-miR-6504-3p	HITS-CLIP	23824327
MIRT619749	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT619748	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT619747	hsa-miR-5095	HITS-CLIP	23824327
MIRT619746	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT619745	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT619744	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT619752	hsa-miR-4438	HITS-CLIP	23824327
MIRT619751	hsa-miR-941	HITS-CLIP	23824327
MIRT619750	hsa-miR-6504-3p	HITS-CLIP	23824327
MIRT619749	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT619748	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT619747	hsa-miR-5095	HITS-CLIP	23824327
MIRT619746	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT619745	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT619744	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT449938	hsa-miR-148a-5p	PAR-CLIP	22100165
MIRT449937	hsa-miR-6783-5p	PAR-CLIP	22100165
MIRT449936	hsa-miR-5584-3p	PAR-CLIP	22100165
MIRT449935	hsa-miR-302a-5p	PAR-CLIP	22100165
MIRT449934	hsa-miR-3184-5p	PAR-CLIP	22100165
MIRT449933	hsa-miR-423-5p	PAR-CLIP	22100165
MIRT449932	hsa-miR-1914-3p	PAR-CLIP	22100165
MIRT449930	hsa-miR-5194	PAR-CLIP	22100165
MIRT449931	hsa-miR-6738-5p	PAR-CLIP	22100165
MIRT449929	hsa-miR-6895-3p	PAR-CLIP	22100165
MIRT449928	hsa-miR-593-3p	PAR-CLIP	22100165
MIRT449927	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT449926	hsa-miR-6834-5p	PAR-CLIP	22100165
MIRT449925	hsa-miR-1226-5p	PAR-CLIP	22100165
MIRT449924	hsa-miR-6734-5p	PAR-CLIP	22100165
MIRT449923	hsa-miR-6818-3p	PAR-CLIP	22100165
MIRT022368	hsa-miR-124-3p	Luciferase reporter assayMicroarrayqRT-PCRWestern blotting	34007334
MIRT619752	hsa-miR-4438	HITS-CLIP	23824327
MIRT619751	hsa-miR-941	HITS-CLIP	23824327
MIRT619750	hsa-miR-6504-3p	HITS-CLIP	23824327
MIRT619749	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT619748	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT619747	hsa-miR-5095	HITS-CLIP	23824327
MIRT619746	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT619745	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT619744	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT619752	hsa-miR-4438	HITS-CLIP	23824327
MIRT619751	hsa-miR-941	HITS-CLIP	23824327
MIRT619750	hsa-miR-6504-3p	HITS-CLIP	23824327
MIRT619749	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT619748	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT619747	hsa-miR-5095	HITS-CLIP	23824327
MIRT619746	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT619745	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT619744	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT449938	hsa-miR-148a-5p	PAR-CLIP	22100165
MIRT449937	hsa-miR-6783-5p	PAR-CLIP	22100165
MIRT449936	hsa-miR-5584-3p	PAR-CLIP	22100165
MIRT449935	hsa-miR-302a-5p	PAR-CLIP	22100165
MIRT449934	hsa-miR-3184-5p	PAR-CLIP	22100165
MIRT449933	hsa-miR-423-5p	PAR-CLIP	22100165
MIRT449932	hsa-miR-1914-3p	PAR-CLIP	22100165
MIRT449930	hsa-miR-5194	PAR-CLIP	22100165
MIRT449931	hsa-miR-6738-5p	PAR-CLIP	22100165
MIRT449929	hsa-miR-6895-3p	PAR-CLIP	22100165
MIRT449928	hsa-miR-593-3p	PAR-CLIP	22100165
MIRT449927	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT449926	hsa-miR-6834-5p	PAR-CLIP	22100165
MIRT449925	hsa-miR-1226-5p	PAR-CLIP	22100165
MIRT449924	hsa-miR-6734-5p	PAR-CLIP	22100165
MIRT449923	hsa-miR-6818-3p	PAR-CLIP	22100165
MIRT1450416	hsa-miR-124	CLIP-seq
MIRT1450417	hsa-miR-3714	CLIP-seq
MIRT1450418	hsa-miR-3910	CLIP-seq
MIRT1450419	hsa-miR-506	CLIP-seq
MIRT1450420	hsa-miR-548a-5p	CLIP-seq
MIRT1450421	hsa-miR-548ab	CLIP-seq
MIRT1450422	hsa-miR-548ak	CLIP-seq
MIRT1450423	hsa-miR-548b-5p	CLIP-seq
MIRT1450424	hsa-miR-548c-5p	CLIP-seq
MIRT1450425	hsa-miR-548d-5p	CLIP-seq
MIRT1450426	hsa-miR-548h	CLIP-seq
MIRT1450427	hsa-miR-548i	CLIP-seq
MIRT1450428	hsa-miR-548j	CLIP-seq
MIRT1450429	hsa-miR-548k	CLIP-seq
MIRT1450430	hsa-miR-548l	CLIP-seq
MIRT1450431	hsa-miR-548w	CLIP-seq
MIRT1450432	hsa-miR-548y	CLIP-seq
MIRT1450433	hsa-miR-559	CLIP-seq
MIRT1450434	hsa-miR-656	CLIP-seq
MIRT1450435	hsa-miR-1910	CLIP-seq
MIRT1450436	hsa-miR-2682	CLIP-seq
MIRT1450437	hsa-miR-3173-3p	CLIP-seq
MIRT1450417	hsa-miR-3714	CLIP-seq
MIRT1450438	hsa-miR-4428	CLIP-seq
MIRT1450439	hsa-miR-4477b	CLIP-seq
MIRT1450440	hsa-miR-449c	CLIP-seq
MIRT1555174	hsa-miR-1236	CLIP-seq
MIRT1555175	hsa-miR-182	CLIP-seq
MIRT1555176	hsa-miR-4659a-3p	CLIP-seq
MIRT1555177	hsa-miR-4659b-3p	CLIP-seq
MIRT1555178	hsa-miR-4753-3p	CLIP-seq
MIRT1555179	hsa-miR-4778-3p	CLIP-seq
MIRT1555180	hsa-miR-586	CLIP-seq
MIRT1555181	hsa-miR-942	CLIP-seq
MIRT2134648	hsa-miR-196a	CLIP-seq
MIRT2134649	hsa-miR-196b	CLIP-seq
MIRT2134650	hsa-miR-3150b-3p	CLIP-seq
MIRT2134651	hsa-miR-3927	CLIP-seq
MIRT2134652	hsa-miR-4650-3p	CLIP-seq
MIRT2134653	hsa-miR-4689	CLIP-seq
MIRT2134654	hsa-miR-4784	CLIP-seq
MIRT2134648	hsa-miR-196a	CLIP-seq
MIRT2134649	hsa-miR-196b	CLIP-seq
MIRT2134650	hsa-miR-3150b-3p	CLIP-seq
MIRT2134651	hsa-miR-3927	CLIP-seq
MIRT2134652	hsa-miR-4650-3p	CLIP-seq
MIRT2134653	hsa-miR-4689	CLIP-seq
MIRT2134654	hsa-miR-4784	CLIP-seq

Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005794	Component	Golgi apparatus	IBA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005796	Component	Golgi lumen	IEA
GO:0005802	Component	Trans-Golgi network	IEA
GO:0006478	Process	Peptidyl-tyrosine sulfation	IDA	9733778, 23481380
GO:0007342	Process	Fusion of sperm to egg plasma membrane involved in single fertilization	IEA
GO:0008476	Function	Protein-tyrosine sulfotransferase activity	IBA
GO:0008476	Function	Protein-tyrosine sulfotransferase activity	IDA	9733778, 23481380
GO:0008476	Function	Protein-tyrosine sulfotransferase activity	IEA
GO:0008476	Function	Protein-tyrosine sulfotransferase activity	TAS
GO:0016020	Component	Membrane	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0042803	Function	Protein homodimerization activity	IPI	23481380
GO:0050427	Process	3'-phosphoadenosine 5'-phosphosulfate metabolic process	IEA
GO:0050427	Process	3'-phosphoadenosine 5'-phosphosulfate metabolic process	TAS
GO:0060468	Process	Prevention of polyspermy	IEA

MIM	HGNC	e!Ensembl
603126	12021	ENSG00000128294

O60704

Protein name

Protein-tyrosine sulfotransferase 2 (EC 2.8.2.20) (Tyrosylprotein sulfotransferase 2) (TPST-2)

Protein function

Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.

PDB

3AP1 , 3AP2 , 3AP3

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13469	Sulfotransfer_3	69 → 262		Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:9733778, ECO:0000269|PubMed:9736702}.

Sequence

MRLSVRRVLLAAGCALVLVLAVQLGQQVLECRAVLAGLRSPRGAMRPEQEELVMVGTNHV
EYRYGKAMPLIFVGGVPRSGTTLMRAMLDAHPEVRCGEETRIIPRVLAMRQAWSKSGREK
LRLDEAGVTDEVLDAAMQAFILEVIAKHGEPARVLCNKDPFTLKSSVYLSRLFPNSKFLL
MVRDGRASVHSMITRKVTIAGFDLSSYRDCLTKWNKAIEVMYAQCMEVGKEKCLPVYYEQ
LVLHPRRSLKLILDFLGIAWSDAVLHHEDLIGKPGGVSLSKIERSTDQVIKPVNLEALSK
WTGHIPGDVVRDMAQIAPMLAQLGYDPYANPPNYGNPDPFVINNTQRVLKGDYKTPANLK
GYFQVNQNSTSSHLGSS

Sequence length

377

Interactions

View interactions

	Reactome
			Cytosolic sulfonation of small molecules

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AUTISM SPECTRUM DISORDER	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OCULAR HYPOTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SPECIFIC LANGUAGE IMPAIRMENT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Hereditary pancreatitis	Pancreatitis	Pubtator	20460947	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertension	Hypertension	Pubtator	38042639	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatitis, Chronic	Pancreatitis	BEFREE	20460947		★★★★★ ★☆☆☆☆ Found in Text Mining only

TPST2 (tyrosylprotein sulfotransferase 2)